2024-12-31 每日论文
| 来源 | 独立页面 |
|---|---|
| arXiv | arXiv |
| bioRxiv | bioRxiv |
| medRxiv | medRxiv |
arXiv
| 标题 | 作者 | PDF链接 | 代码仓库 | Title |
|---|---|---|---|---|
bioRxiv
| 标题 | 作者 | PDF链接 | 代码仓库 | Title |
|---|---|---|---|---|
| 使用结构图嵌入进行快速蛋白质结构搜索 | Greener, J. G. | N/A | Fast protein structure searching using structure graph embeddings | |
| 激酶IKK2的双特异性自磷酸化通过磷酸酶中间体使底物IκBα得以磷酸化。 | Borar, P. | N/A | Dual-specific autophosphorylation of kinase IKK2 enables phosphorylation of substrate IκBα through a phosphoenzyme intermediate | |
| 使用线性图像解码器和非线性噪声抑制技术从人类大脑活动中重建无语义的视觉图像 | Li, Q. | N/A | Visual Image Reconstructed Without Semantics from Human Brain Activity Using Linear Image Decoders and Nonlinear Noise Suppression | |
| KLP-19 控制着秀丽隐杆线虫（C. elegans）纺锤体中间区的微管长度，从而在有丝分裂过程中影响纺锤体动力学和力的传递。 | Zimyanin, V. | N/A | KLP-19 controls microtubule length in the spindle midzone of C. elegans, affecting spindle dynamics and force transmission during mitosis. | |
| FOXG1通过FGF信号通路在调控发育中新皮质胶质生成中的双重作用。 | Bose, M. | N/A | Dual role of FOXG1 in regulating gliogenesis in the developing neocortex via the FGF signalling pathway. | |
| 线粒体在轴突中的分布通过eIF2β在衰老过程中维持神经元自噬。 | Shinno, K. | N/A | Axonal distribution of mitochondria maintains neuronal autophagy during aging via eIF2β | |
| EGF/STAT1与IFNγ/NRF2信号通路之间的平衡调控ECM1表达并决定肝脏稳态与慢性肝病的关系 | Li, Y. | N/A | Balance Between EGF/STAT1 and IFNγ/NRF2 Signaling Controls ECM1 Expression and Determines Hepatic Homeostasis versus Chronic Liver Disease | |
| EGF/STAT1与IFNγ/NRF2信号通路之间的平衡调控ECM1表达并决定肝脏稳态与慢性肝病的发生 | Li, Y. | N/A | Balance Between EGF/STAT1 and IFNγ/NRF2 Signaling Controls ECM1 Expression and Determines Hepatic Homeostasis versus Chronic Liver Disease | |
| 新型基因编码探针用于通过偏振显微镜进行细胞信号传导的功能成像 | Miclea, P. S. | N/A | Novel Genetically Encoded Probes for Functional Imaging of Cell Signaling by Polarization Microscopy | |
| 为纪念非洲-哥伦比亚音乐文化，将一种来自太平洋雨林的青蛙命名为Epipedobates currulao sp. nov.（无尾目：箭毒蛙科）。 | Betancourth-Cundar, M. | N/A | Honoring the Afro-Colombian musical culture with the naming of Epipedobates currulao sp. nov. (Anura: Dendrobatidae), a frog from the Pacific rainforests | |
| 局部养分添加导致全球草地植物多样性丧失，但并未引起生物同质化。 | Chen, Q. | N/A | Local nutrient addition drives plant biodiversity losses but not biotic homogenization in global grasslands | |
| 戊型肝炎病毒通过ORF2蛋白调节浆细胞样树突状细胞诱导的抗病毒反应 | Joshi, G. | N/A | Hepatitis E Virus-induced antiviral response by plasmacytoid dendritic cells is modulated by the ORF2 protein | |
| FinaleToolkit：利用高速计算工具包加速无细胞DNA片段分析 | Li, J. W. | N/A | FinaleToolkit: Accelerating Cell-Free DNA Fragmentation Analysis with a High-Speed Computational Toolkit | |
| 磷酸饥饿诱导的CORNICHON同源物5作为内质网货物受体参与拟南芥中PHT1转运蛋白的运输 | Chiu, C.-Y. | N/A | Phosphate Starvation-Induced CORNICHON HOMOLOG 5 as Endoplasmic Reticulum Cargo Receptor for PHT1 Transporters in Arabidopsis | |
| 使用语言模型模拟5亿年的进化历程 | Hayes, T. | N/A | Simulating 500 million years of evolution with a language model | |
| 利用计算机化飞行磨研究栎树相关Agrilinae（鞘翅目：吉丁科）飞行性能的种内和种间差异 | Le Souchu, E. | N/A | Intra- and interspecific variations in flight performance of oak-associated Agrilinae (Coleoptera: Buprestidae) using computerised flight mills | |
| 通过对海参再生肠道进行单细胞RNA测序，揭示了体腔上皮细胞的多能性。 | Medina-Feliciano, J. G. | N/A | Single-cell RNA sequencing of the holothurian regenerating intestine reveals the pluripotency of the coelomic epithelium | |
| 保守的ATP酶PCH-2通过抑制线虫（C. elegans）中交叉的形成，控制交叉的数量和分布。 | Patel, B. | N/A | The conserved ATPase PCH-2 controls the number and distribution of crossovers by antagonizing their formation in C. elegans | |
| 在Slc29a3/Unc5b基因座中，由TAD边界破坏引起的转录变化的方向和模式取决于组织特异性的表观遗传背景。 | Salnikov, P. A. | N/A | Direction and modality of transcription changes caused by TAD boundary disruption in Slc29a3/Unc5b locus depends on tissue-specific epigenetic context | |
| 《编排不可能的化学反应：B12依赖性甲硫氨酸合成酶催化舞蹈的结构快照》 |
这篇标题描述了一项科学研究，该研究通过捕捉B12依赖性甲硫氨酸合成酶在催化过程中的结构变化，揭示了其复杂的化学反应机制。标题中的“编排不可能的化学反应”强调了这一过程的复杂性和精妙性，而“结构快照”则指通过实验手段获取的酶在不同催化阶段的三维结构图像。 | Mendoza, J. | PDF | N/A | Orchestrating Improbable Chemistries: Structural Snapshots of B12-Dependent Methionine Synthase's Catalytic Choreography | | 尿液cf-核小体：窥探人体生理与疾病的无创窗口
这段翻译将“Urine cf-Nucleosomes”译为“尿液cf-核小体”，其中“cf”通常代表“cell-free”，即“无细胞的”，但在中文语境中，直接使用“cf”更为常见和简洁。“A Non-invasive Window into Human Physiology and Disease”则译为“窥探人体生理与疾病的无创窗口”，其中“Non-invasive”译为“无创的”，强调了这种检测方法的非侵入性特点，“Window”译为“窗口”，形象地表达了其作为观察和了解人体生理与疾病状态的途径。整个翻译保持了原文的科学性和准确性，同时符合中文的表达习惯。 | Lotem, M. | PDF | N/A | Urine cf-Nucleosomes: A Non-invasive Window into Human Physiology and Disease | | 在磷酸盐限制条件下，替代性脂质合成促进了革兰氏阴性ESKAPE病原菌的抗生素耐受性。 | Olea-Ozuna, R. J. | PDF | N/A | Alternative lipid synthesis in response to phosphate limitation promotes antibiotic tolerance in Gram-negative ESKAPE pathogens | | 一个MEF2C转录因子网络调控糖尿病肾病中肾小球内皮细胞的增殖。 | Melo Ferreira, R. | PDF | N/A | A MEF2C transcription factor network regulates proliferation of glomerular endothelial cells in diabetic kidney disease | | X射线衍射揭示小鼠新皮层的周期性结构 | Murokh, S. | PDF | N/A | X-ray Diffraction Reveals Periodicity in Murine Neocortex | | 空间转录组分析揭示晚期卵巢透明细胞癌的上皮-间质梯度内肿瘤异质性 | Truong Le, T. | PDF | N/A | Spatial Transcriptomic Profiling Of Advanced Ovarian Clear Cell Carcinoma Reveals Intra-Tumor Heterogeneity In Epithelial-Mesenchymal Gradient | | 自注释质粒 | Hernandez, S. I. | PDF | N/A | Self-Documenting Plasmids | | 评估阿尔茨海默病中淀粉样蛋白β和Tau寡聚体的联合神经毒性：一种新的细胞水平标准 | Kuznetsov, A. V. | PDF | N/A | Evaluating the Combined Neurotoxicity of Amyloid Beta and Tau Oligomers in Alzheimer's Disease: A Novel Cellular-Level Criterion | | 使用冷冻电子断层扫描技术对染色质生物分子凝聚体进行定量空间分析 | Zhou, H. | PDF | N/A | Quantitative Spatial Analysis of Chromatin Biomolecular Condensates using Cryo-Electron Tomography | | NFAT2通过利用MARCH8 E3连接酶在表观遗传景观上的差异，驱动了Orai3的转录和蛋白质降解。 | Raju, S. | PDF | N/A | NFAT2 drives both Orai3 transcription and protein degradation by harnessing the differences in epigenetic landscape of MARCH8 E3 ligase | | 用于晶体衍射数据质量评估的 I/σI 与 {Rmerg, Rmeas, Rpim, CC1/2} 的关系分析 | Fu, Z. | PDF | N/A | I/σI vs {Rmerg, Rmeas, Rpim, CC1/2} for Crystal Diffraction Data Quality Evaluation | | 对一种野生社会性哺乳动物的主要组织相容性复合体两类进行表征：以带状猫鼬为例 | Schubert, N. | PDF | N/A | Characterization of both major histocompatibility complex classes in a wild social mammal: the banded mongoose | | 主要组织相容性复合体多样性对社会性哺乳动物适应性的性别依赖性影响 | Schubert, N. | PDF | N/A | Sex-dependent influence of major histocompatibility complex diversity on fitness in a social mammal | | 复制压力增加了疟疾寄生虫基因组中的新生拷贝数变异（CNVs）。 | Brown, N. J. | PDF | N/A | Replication stress increases de novo CNVs across the malaria parasite genome | | 肼屈嗪通过抑制半胱胺双加氧酶来治疗先兆子痫和衰老性胶质母细胞瘤。 | Shishikura, K. | PDF | N/A | Hydralazine inhibits cysteamine dioxygenase to treat preeclampsia and senesce glioblastoma | | 一个无菌损伤的微生理系统通过巨噬细胞衍生的细胞外囊泡相互作用展示了中性粒细胞的反向迁移。 | Babatunde, K. A. | PDF | N/A | A microphysiological system of sterile injury demonstrates neutrophil reverse migration via macrophage-derived extracellular vesicle crosstalk. | | GnT基序：长度大于或等于8个碱基对的短核苷酸序列，在细菌中能够使T:A到G:C的突变率增加超过1000倍。 | Horton, J. S. | PDF | N/A | GnT motifs: short nucleotide tracts of >=8bp that can increase T:A->G:C mutation rates >1000-fold in bacteria | | 供体链互补和钙离子协调驱动古菌纤毛的无伴侣蛋白聚合 | Sleutel, M. | PDF | N/A | Donor Strand Complementation and Calcium Ion Coordination Drive the Chaperone-free Polymerization of Archaeal Cannulae | | 一种细菌间的半胱氨酸蛋白酶毒素通过靶向II型DNA拓扑异构酶GyrB和ParE抑制细胞生长 | Song, P.-Y. | PDF | N/A | An Interbacterial Cysteine Protease Toxin Inhibits Cell Growth by Targeting Type II DNA Topoisomerases GyrB and ParE | | 基于成像的筛选方法鉴定出新型天然化合物，这些化合物能够干扰莱茵衣藻的细胞和叶绿体分裂。 | Clark-Cotton, M. R. | PDF | N/A | Imaging-based screen identifies novel natural compounds that perturb cell and chloroplast division in Chlamydomonas reinhardtii | | 解读新热带地区 Melanastera 属（半翅目：木虱总科：Liviidae）的多样化模式与时间 | Serbina, L. | PDF | N/A | Deciphering the patterns and timing of diversification of the genus Melanastera (Hemiptera: Psylloidea: Liviidae) in the Neotropics | | 重写线粒体疾病中的核表观遗传脚本作为控制异质性的策略 | Perez, M. J. | PDF | N/A | Rewriting nuclear epigenetic scripts in mitochondrial diseases as a strategy for heteroplasmy control | | 在KPP小鼠模型中，胰腺癌诱导的恶病质表现出性别特异性的生存差异，但并未观察到组织消耗的差异。 | Weinzierl, N. | PDF | N/A | Sex-specific survival but not tissue wasting in the KPP mouse model of pancreatic cancer-induced cachexia | | 双相情感障碍和精神分裂症风险基因AKAP11编码一种自噬受体，该受体将PKA激酶网络稳态的调节与突触传递相耦合。 | Lee, Y.-K. | PDF | N/A | Bipolar and schizophrenia risk gene AKAP11 encodes an autophagy receptor coupling the regulation of PKA kinase network homeostasis to synaptic transmission | | 渗透压通过平行的化学感应和生物物理机制调控秀丽隐杆线虫的产卵行为 | Medrano, E. | PDF | N/A | Osmolarity regulates C. elegans egg-laying behavior via parallel chemosensory and biophysical mechanisms | | 脑电图揭示初学者与经验冥想者在Isha Kriya冥想中皮质变化的纵向试点研究
本研究通过脑电图技术，对初学者和经验丰富的冥想者在进行Isha Kriya冥想时的皮质变化进行了纵向观察，旨在探讨不同经验水平的冥想者在冥想过程中大脑活动的差异及其随时间的变化趋势。 | Vishnubhotla, R. V. | PDF | N/A | Cortical Changes Associated with Isha Kriya Meditation Revealed by Encephalography in Novice and Experienced Meditators - a Longitudinal Pilot Study | | 瞬时糖基化屏蔽减少诱导SHIV感染猕猴中CD4结合位点的广泛中和抗体 | Morris, D. J. | PDF | N/A | Transient glycan-shield reduction induces CD4-binding site broadly neutralizing antibodies in SHIV-infected macaques | | 以下是这段英文的中文翻译：
分析βB3-晶状体蛋白缺失后小鼠晶状体形态学和蛋白质组学异常
翻译说明： 1. "Analysis of" 翻译为“分析”。 2. "mouse lens" 翻译为“小鼠晶状体”。 3. "morphological and proteomic abnormalities" 翻译为“形态学和蛋白质组学异常”。 4. "following depletion of βB3-crystallin" 翻译为“βB3-晶状体蛋白缺失后”。
希望这段翻译对你有帮助！如果需要进一步调整或补充，请随时告诉我。 | Rayee, D. | PDF | N/A | Analysis of mouse lens morphological and proteomic abnormalities following depletion of βB3-crystallin | | 以下是将这段英文翻译成中文的结果：
全基因组关联分析：在多样化的野生苹果种质中筛选对扩展青霉（Penicillium expansum）引起的采后蓝霉病的抗性
翻译说明： 1. Genome-Wide Associations 翻译为“全基因组关联分析”，这是一种用于研究基因与性状之间关系的统计方法。 2. Diverse Wild Apple Germplasm 翻译为“多样化的野生苹果种质”，指的是具有遗传多样性的野生苹果资源。 3. Postharvest Blue Mold Resistance 翻译为“采后蓝霉病抗性”，指的是苹果在采收后对蓝霉病的抵抗能力。 4. Penicillium expansum 是蓝霉病的病原菌，翻译为“扩展青霉”。
希望这个翻译对你有帮助！ | Whitt, L. | PDF | N/A | Genome-Wide Associations within Diverse Wild Apple Germplasm for Postharvest Blue Mold Resistance to Penicillium expansum | | 工程化多重合成呼吸生物标志物作为诊断探针 | Wang, S.-T. | PDF | N/A | Engineering Multiplexed Synthetic Breath Biomarkers as Diagnostic Probes | | ProteoPlotter：一款与Perseus兼容的可执行蛋白质组学可视化工具 | Olabisi-Adeniyi, E. | PDF | N/A | ProteoPlotter: an executable proteomics visualization tool compatible with Perseus | | ProteoPlotter：一款与Perseus兼容的可执行蛋白质组学可视化工具 | Olabisi-Adeniyi, E. | PDF | N/A | ProteoPlotter: an executable proteomics visualization tool compatible with Perseus | | 针对AML耐药性，LY3009120-Sapanisertib和Ruxolitinib-Ulixertinib组合在FLT3、TP53和MUC4突变中展现出卓越疗效 | Gholizadeh, E. | PDF | N/A | Targeting AML Resistance with LY3009120-Sapanisertib and Ruxolitinib-Ulixertinib Combinations Demonstrate Superior Efficacy in FLT3, TP53, and MUC4 mutations | | 奥司他丁通过调节PRLR及JAK2/STAT3信号轴抑制前列腺癌进展 | Yan, L. | PDF | N/A | Osthole Suppresses Prostate Cancer Progression by Modulating PRLR and the JAK2/STAT3 Signaling Axis | | 《宫颈阴道标本的分子和病理学特征显示乳酸菌对HPV感染、细菌性阴道病和上皮细胞异常具有显著保护作用》
这项研究通过对宫颈阴道标本的分子和病理学分析，揭示了乳酸菌在预防人乳头瘤病毒（HPV）感染、细菌性阴道病以及上皮细胞异常方面的重要保护作用。研究结果表明，乳酸菌的存在与这些妇科常见问题的发生率降低显著相关，进一步强调了其在维护女性生殖健康中的关键角色。 | Osei Sekyere, J. | PDF | N/A | Molecular and Pathological Characterization of Cervicovaginal Specimens Evince Significant Protection Against HPV Infections, Bacterial Vaginosis, and Epithelial Cell Abnormalities by Lactobacillus species | | 对在小鼠和猪动物模型中视网膜下递送的Cas9核糖核蛋白的评估，突显了遗传医学治疗转化中的关键考虑因素。 | Wei, S. | PDF | N/A | Evaluation of subretinally delivered Cas9 ribonucleoproteins in murine and porcine animal models highlights key considerations for therapeutic translation of genetic medicines | | 多细胞网络模型预测糖尿病肾病中肾小球内皮结构的改变 | Patidar, K. | PDF | N/A | Multi-Cellular Network Model Predicts Alterations in Glomerular Endothelial Structure in Diabetic Kidney Disease | | 以单核苷酸分辨率解析人类肠道病毒组的遗传多样性和群体特异性 | Wang, X. | PDF | N/A | The genetic diversity and populational specificity of the human gut virome at single nucleotide resolution | | 冷冻电镜结构揭示了接合H菌毛的环状性质，特别是TrhA菌毛蛋白的环状结构。 | Ishimoto, N. | PDF | N/A | Cryo-EM structure of the conjugation H-pilus reveals the cyclic nature of the TrhA pilin | | 线粒体复合物I和活性氧（ROS）通过相反的突触前和突触后机制调控突触功能。 | Mallik, B. | PDF | N/A | Mitochondrial Complex I and ROS control synapse function through opposing pre- and postsynaptic mechanisms | | 核磷蛋白（Nucleophosmin）突变会导致异常的、但可逆的核仁结构和聚集体形成——这对针对NPM1的急性髓系白血病（AML）治疗策略具有重要意义。 | Grundy, M. | PDF | N/A | Nucleophosmin mutations lead to abnormal, but reversible, nucleoli architecture and aggregate formation - implications for NPM1-targeting therapies in AML | | RAB27A效应蛋白SYTL5调控线粒体自噬和线粒体代谢 | Lapao, A. | PDF | N/A | The RAB27A effector SYTL5 regulates mitophagy and mitochondrial metabolism | | 一种用于在合理设计的mRNA中增强细胞类型特异性的生成框架 | Khoroshkin, M. S. | PDF | N/A | A generative framework for enhanced cell-type specificity in rationally designed mRNAs | | 个性化线索反应性δ-θ振荡指导阿片类药物使用障碍的深部脑刺激 | Qiu, L. | PDF | N/A | Personalized cue-reactive delta-theta oscillations guide deep brain stimulation for opioid use disorder | | 预测压力恢复能力的睡眠模式因性别而异。 | Bush, B. J. | PDF | N/A | Sleep patterns predicting stress resilience are dependent on sex | | 图神经网络用于集成信息与主要复杂性估计 | Hosaka, T. | PDF | N/A | Graph neural networks for integrated information and major complex estimation | | 通过将全细胞重建与RNA表达谱配对来发现神经元细胞类型 | Ferreira, T. A. | PDF | N/A | Discovery of neuronal cell types by pairing whole cell reconstructions with RNA expression profiles | | 监督式尖峰排序在噪声单电极细胞外记录中的可行性研究：基于微神经图记录的人类C-伤害感受器的系统性研究
这段翻译将原文的标题进行了适当的调整，以符合中文的表达习惯，同时保留了原文的核心信息。具体来说： 1. "Supervised Spike Sorting" 翻译为 "监督式尖峰排序"，这是神经科学中常用的术语，指的是在有监督的情况下对神经元发放的尖峰信号进行分类和排序。 2. "Feasibility of Noisy Single-Electrode Extracellular Recordings" 翻译为 "在噪声单电极细胞外记录中的可行性研究"，强调了在噪声环境下使用单电极进行细胞外记录的可行性。 3. "Systematic Study of Human C-Nociceptors recorded via Microneurography" 翻译为 "基于微神经图记录的人类C-伤害感受器的系统性研究"，说明了研究对象是人类C-伤害感受器，并且是通过微神经图技术进行记录的。
整体翻译力求准确、专业，同时符合中文的阅读习惯。 | Troglio, A. | PDF | N/A | Supervised Spike Sorting Feasibility of Noisy Single-Electrode Extracellular Recordings: Systematic Study of Human C-Nociceptors recorded via Microneurography | | 在联想学习过程中，自上而下的输入由表达生长抑素的中间神经元控制。 | Studer, F. | PDF | N/A | Top-down inputs are controlled by somatostatin-expressing interneurons during associative learning | | 单细胞RNA测序分析揭示了山羊间性腺体启动及早期性别分化的新见解 | Cao, X. | PDF | N/A | Single-cell RNA sequencing analysis reveals new insights for intersex gonad initiation and early sex differentiation of goats | | 通过精炼的CRISPR/Cas9基因组编辑技术在豌豆蚜虫中的应用，揭示了Laccase2在越冬卵适应中的关键作用。 | Shigenobu, S. | PDF | N/A | Refined CRISPR/Cas9 genome editing in pea aphids uncovers the essential roles of Laccase2 in overwintering egg adaptation | | 齿状回为高效的空间导航提供了灵活性。 | Soldi, N. | PDF | N/A | The dentate gyrus provides flexibility for efficient spatial navigation | | 思考的食粮：玫瑰脸情侣鹦鹉（学名：Agapornis roseicollis）具备联想符号学习能力，并能通过推理进行数量辨别。 | Wang, S. | PDF | N/A | Food for thought: Rosy-faced lovebirds (Agapornis roseicollis) are capable of associative symbol learning and inference-based quantity discrimination | | 将握力映射到肌肉活动：利用新型握力模型理解上肢肌肉骨骼意图
这段翻译将英文标题“Mapping Grip Force to Muscular Activity Towards Understanding Upper Limb Musculoskeletal Intent using a Novel Grip Strength Model”转化为中文，保留了原意的同时，使其更符合中文表达习惯。 | Lai, Y. | PDF | N/A | Mapping Grip Force to Muscular Activity Towards Understanding Upper Limb Musculoskeletal Intent using a Novel Grip Strength Model | | 一种新的机械化学顶点模型，结合Ca2+信号传导，用于神经管闭合中的顶端收缩 | Chakraborty, A. | PDF | N/A | A new mechanochemical vertex model with Ca2+ signalling, for apical constriction in neural tube closure | | 预测性路由源自于自监督的随机神经可塑性。 | Nejat, H. | PDF | N/A | Predictive routing emerges from self-supervised stochastic neural plasticity | | 在吗啡依赖的怀孕大鼠中观察到的母性行为紊乱及其后代出现的快感缺失现象 | Searles, C. T. | PDF | N/A | Disrupted Maternal Behavior in Morphine-Dependent Pregnant Rats and Anhedonia in their Offspring | | 以下是这段英文的中文翻译：
证据表明，创伤后应激障碍的症状群由不同的网络支撑。
或者更详细地翻译为：
有证据表明，创伤后应激障碍的不同症状群背后存在独立的神经网络机制。
根据上下文，可以选择更简洁或更详细的表达方式。 | Hauner, K. K. | PDF | N/A | Evidence for distinct networks underlying symptom clusters of posttraumatic stress disorder | | 一种广泛存在的病毒海绵蛋白家族揭示了在抗噬菌体防御中对核苷酸信号的特异性抑制 | Chang, R. B. | PDF | N/A | A widespread family of viral sponge proteins reveals specific inhibition of nucleotide signals in anti-phage defense | | 根据英国生物银行（UK Biobank）的序列数据，人类平均基因转换片段长度估计为459个碱基对（bp）。 | Masaki, N. | PDF | N/A | Mean gene conversion tract length in humans estimated to be 459 bp from UK Biobank sequence data | | 利用基因组序列预测微生物转录组 | SHAO, B. | PDF | N/A | Predicting microbial transcriptome using genome sequence | | 在早期造血细胞区室内发生的快速克隆选择预示了伊沃西替尼联合治疗的结果。 | Turkalj, S. | PDF | N/A | Rapid clonal selection within early hematopoietic cell compartments presages outcome to ivosidenib combination therapy | | 细菌易位对卒中结局的影响：可溶性CD14作为早期临床标志物及TLR4的作用
在这项研究中，我们探讨了细菌易位（bacterial translocation）对卒中患者预后的影响，并分析了可溶性CD14（soluble CD14, sCD14）作为早期临床标志物的潜力，同时研究了Toll样受体4（TLR4）在其中的作用。细菌易位是指肠道细菌或其产物通过受损的肠道屏障进入血液循环，可能引发全身炎症反应，进而影响卒中患者的恢复。研究结果表明，sCD14水平在卒中早期显著升高，且与不良预后密切相关。此外，TLR4的激活在细菌易位引发的炎症反应中起到了关键作用。这些发现为卒中患者的早期诊断和治疗提供了新的思路。 | Granados-Martinez, C. | PDF | N/A | Impact of bacterial translocation in stroke outcome. Soluble CD14 as early clinical marker and effect of TLR4 | | scRepertoire 2：用于单细胞免疫分析的增强型高效工具包 | Yang, Q. | PDF | N/A | scRepertoire 2: Enhanced and Efficient Toolkit for Single-Cell Immune Profiling | | 免疫检查点分子作为金黄色葡萄球菌骨感染及临床预后的生物标志物 | Saito, M. | PDF | N/A | Immune Checkpoint Molecules as Biomarkers of Staphylococcus aureus Bone Infection and Clinical Outcome | | 埃塞俄比亚塔纳湖生物圈保护区沿岸湿地测绘：基于Sentinel-1A SAR与多源数据的应用 | Wondim, Y. K. | PDF | N/A | Mapping of Shore Area Wetlands in Lake Tana Biosphere Reserve, Ethiopia Using Sentinel-1A SAR and Multi-Source Data | | RNAGenesis：用于增强RNA序列生成和结构洞察的基础模型 | Zhang, Z. | PDF | N/A | RNAGenesis: Foundation Model for Enhanced RNA Sequence Generation and Structural Insights |
medRxiv
| 标题 | 作者 | PDF链接 | 代码仓库 | Title |
|---|---|---|---|---|
| 虚拟帕金森病患者 | Angiolelli, M. | N/A | The Virtual Parkinsonian Patient | |
| 老年人锻炼中的动机、社区参与与韧性：BELL试验的三年定性追踪研究 | Meigh, N. J. | N/A | Motivation, community, and resilience in older adults exercise: a three-year qualitative follow-up to the BELL trial | |
| 优化早期职业护士留任的有效干预措施特征：范围综述 | White, K. | N/A | Characteristics of effective interventions to optimise retention for early career nurses: a scoping review | |
| 评估大型语言模型聊天机器人生成的心理健康信息质量 | Porwal, G. | N/A | Evaluating the Quality of Mental Health Information Generated by Large Language Model Chatbots | |
| 一份关于从胸痛患者临床记录中提取症状发作日期和时间的试点报告 | George, A. | N/A | A Pilot Report on Extracting Symptom Onset Date and Time from Clinical Notes in Patients Presenting with Chest Pain | |
| 一个自动化便携式平台用于快速无细胞DNA分离及其在人类血样中微生物DNA测序的应用 | Marriott, L. | N/A | An Automated and Portable Platform for Rapid Cell-Free DNA Isolation and Its Application in Microbial DNA Sequencing from Human Blood Samples | |
| 由于家庭检测后医疗寻求行为的差异，COVID-19疫苗有效性研究中潜在偏倚的规模：对测试阴性设计研究的影响 | Qasmieh, S. A. | N/A | Magnitude of Potential Biases in COVID-19 Vaccine Effectiveness Studies due to Differential Healthcare seeking following Home Testing: Implications for Test Negative Design Studies | |
| 血浆蛋白质组学特征预测英国生物银行队列中冠状动脉疾病的风险 | Zhang, C. | N/A | Plasma Proteomic Profiles Predict the Risk of Coronary Artery Disease in the UK Biobank Cohort | |
| 老年急诊管理护士对三十天内急诊科再就诊率的影响：一项回顾性倾向评分匹配的病例对照研究 | Germain, N. | N/A | Impact of a geriatric emergency management nurse on thirty-day emergency department revisits: a retrospective propensity score matched case-control study | |
| 基于数据驱动的跨诊断精神科住院患者心理健康症状与脑功能连接特征的聚类分析。 | Aruldass, A. R. | N/A | Data-driven clustering of mental health symptoms and brain functional connectivity signatures in transdiagnostic psychiatric inpatients. | |
| 兴奋剂药物使用与多巴胺系统发育：一项针对ADHD男孩和男性的自然主义长期随访研究 | van der Pal, Z. | N/A | Stimulant medication use and development of the dopamine system: a naturalistic long-term follow-up of boys and men with ADHD | |
| 《在也门亚丁冲突地区登革热干预中的社区参与：基于CFIR框架2.0的实施研究》 | Dhaiban, M. M. | N/A | Community Engagement in Dengue Interventions in Conflict- affected Aden, Yemen: An Implementation Research Using CFIR Framework 2.0. | |
| 孟加拉国育龄女性焦虑和抑郁相关因素：基于2022年人口与健康调查的洞察 | Sheoti, I. H. | N/A | Factors Associated with Anxiety and Depression among Reproductive-aged Women in Bangladesh: Insights from the 2022 DHS | |
| 迈向全球健康研究的监测：透明度与利益相关者参与的探索性分析 | Yerunkar, S. S. | N/A | Towards Monitoring of Global Health Research: An Exploratory Analysis of Transparency and Stakeholder Engagement | |
| 多组学生物标志物在单卵双胞胎中区分类风湿性关节炎 | Blank, R. B. | N/A | Multi-omic Biomarkers Distinguish Rheumatoid Arthritis in Discordant Monozygotic Twins | |
| 利用多任务深度神经网络、临床特征和心电图预测心脏手术后的不良结果 | Ong, C. S. | N/A | Predicting adverse outcomes after cardiac surgery using multi-task deep neural networks, clinical features, and electrocardiograms | |
| 在神经科诊所进行行为的多模态数字表型分析：Neurobooth平台的开发及前两年数据收集 |
这段文字描述了一个在神经科诊所中用于行为分析的多模态数字表型分析项目，其中包括了Neurobooth平台的开发过程以及该项目在前两年内所进行的数据收集工作。 | Nunes, A. S. | PDF | N/A | Multimodal Digital Phenotyping of Behavior in a Neurology Clinic: Development of the Neurobooth Platform and the First Two Years of Data Collection | | 基于颅内脑电图数据的最优图表示与神经网络在癫痫检测中的应用 | Diaz-Montiel, A. A. | PDF | N/A | Optimal Graph Representations and Neural Networks for Seizure Detection Using Intracranial EEG Data | | 透明细胞肾细胞癌：揭示与年龄相关的遗传特征及疾病相对侵袭性 | Pace-Loscos, T. | PDF | N/A | Clear Cell Renal Cell Carcinoma: Unveiling Age-Linked Genetic Signatures and Relative Disease Aggressiveness | | 从文本到翻译：利用语言模型为临床审查优先排序变异体 | Li, W. | PDF | N/A | From Text to Translation: Using Language Models to Prioritize Variants for Clinical Review | | 对748,879名个体的基因负担荟萃分析揭示了LGI1-ADAM23蛋白复合物与癫痫的关联 | Lal, J. C. | PDF | N/A | Gene-Burden Meta-Analysis of 748,879 Individuals Identifies LGI1-ADAM23 Protein Complex Association with Epilepsy | | 从586人中获得关于DEPDC5相关癫痫的见解：变异外显率、表型谱及治疗结果 | Ochoa-Urrea, M. | PDF | N/A | Insights into DEPDC5-Related Epilepsy from 586 people: Variant Penetrance, Phenotypic Spectrum, and Treatment Outcomes | | 阿立哌唑每月一次注射剂与帕利哌酮棕榈酸酯每月一次注射剂在中国治疗精神分裂症的成本效用分析 | Yiping, A. | PDF | N/A | Cost-utility of aripiprazole once-monthly versus paliperidone palmitate once-monthly injectable for schizophrenia in China | | 推进医疗人工智能治理：基于系统综述的全面成熟度模型 | Hussein, R. | PDF | N/A | Advancing Healthcare AI Governance: A Comprehensive Maturity Model Based on Systematic Review | | 基于住院患者数据开发的感染预测模型，在控制数据集偏移的情况下，可以通过可穿戴设备的数据预测院外COVID-19感染情况。 | Feng, T. | PDF | N/A | An infection prediction model developed from inpatient data can predict out-of-hospital COVID-19 infections from wearable data when controlled for dataset shift | | 心脏手术后需要持续静脉-静脉血液滤过患者的短期和长期死亡率及生活质量研究 | Duong, M.-T. | PDF | N/A | Short and Late Term Mortality and Quality of Life in Patients Requiring Continuous Veno-Venous Hemofiltration after Cardiac Surgery | | 在英格兰冬季冠状病毒（COVID-19）感染研究队列中，COVID-19疫苗对SARS-CoV-2感染及有症状感染的有效性研究 | Abdul Aziz, N. | PDF | N/A | Effectiveness of COVID-19 vaccines against SARS-CoV-2 infection and symptomatic infection in the England Winter Coronavirus (COVID-19) Infection Study cohort | | 越南全民结核病筛查干预措施的潜在影响、成本与效益：一项数学模型研究 | Schwalb, A. | PDF | N/A | Potential impact, costs, and benefits of population-wide screening interventions for tuberculosis in Viet Nam: a mathematical modelling study | | 2020年至2023年加拿大采用多样化招募策略的SARS-CoV-2血清监测研究的社会人口学特征 | Knight, M. J. | PDF | N/A | Sociodemographic characteristics of SARS-CoV-2 serosurveillance studies with diverse recruitment strategies, Canada, 2020 to 2023 | | 学术绿地对人类健康、植物和传粉者多样性的社会生态效益：一项混合方法研究方案 | Kehinde, T. | PDF | N/A | Socioecological benefits of academic greenspace for human health, plant, and pollinator diversity: a mixed-method study protocol | | 研究COVID-19封锁期间远程学习对本科生学业成功和心理健康的影响 | Nano, J. P. | PDF | N/A | Investigating the Impact of Remote Learning on Undergraduate Students Academic Success and Mental Health during the COVID-19 Lockdown | | 在马拉维农村地区，将较低和较高金额的月度现金转移支付与营养敏感型农业、男性参与以及心理社会干预相结合对母亲抑郁症状的影响：一项集群随机对照试验的二次分析 | Bliznashka, L. | PDF | N/A | Effect of combining lower- and higher-value monthly cash transfers with nutrition-sensitive agriculture, male engagement, and psychosocial intervention on maternal depressive symptoms in rural Malawi: a secondary analysis of a cluster-randomised controlled trial | | 探索针对发育性协调障碍儿童和青少年的可能干预措施：我们取得了哪些进展？——一项范围综述
在这项范围综述中，我们深入研究了针对发育性协调障碍（Developmental Coordination Disorder, DCD）儿童和青少年的各种干预措施，并评估了当前的研究进展。发育性协调障碍是一种影响儿童运动技能发展的神经发育障碍，可能导致日常活动、学习和社交方面的困难。通过系统梳理现有文献，我们旨在识别有效的干预策略，评估其效果，并探讨未来研究的方向。本文不仅总结了当前的研究成果，还指出了研究中的空白和挑战，为临床实践和进一步研究提供了有价值的参考。 | Panciroli, M. C. | PDF | N/A | Exploring the possible interventions in children and adolescents with Developmental Coordination Disorder. How far have we come? A Scoping Review | | 使用单受试者形态学网络来阐明与中风后功能障碍和恢复相关的断开模式及断开组学。 | Yuan, B. | PDF | N/A | Using single-subject morphological networks to elucidate the patterns of disconnection and disconnectome associated with post-stroke deficits and recovery | | 在帕金森病的前驱期和早期表现中，中枢胆碱能退化：与认知、临床表型及未来转化的关系 | Eisenstein, T. | PDF | N/A | Central cholinergic degeneration in prodromal and early manifest Parkinsons disease: relation to cognition, clinical phenotype, and future conversion | | 妊娠中期母体血清中的胎盘生物标志物与产后出血相关：对NuMoM2b数据集的二次分析 | Rutherford, J. N. | PDF | N/A | Placental biomarkers in second trimester maternal serum are associated with postpartum hemorrhage: a secondary analysis of the NuMoM2b dataset | | 针对富含精氨酸序列的自身抗体在COVID-19后及肌痛性脑脊髓炎/慢性疲劳综合征中模拟爱泼斯坦-巴尔病毒 | Hoheisel, F. | PDF | N/A | Autoantibodies to Arginine-rich Sequences Mimicking Epstein-Barr Virus in Post-COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome | | 跑步的阴暗面：探讨休闲跑者在打破长期跑步习惯后可能产生的反效果。 | Ingalls, E. | PDF | N/A | The dark side of streaking: Examining the backfire potential of run streaking in recreational runners who broke a long-term streak. |