BioRxiv 2025-01-02 Papers

标题	作者	PDF链接	代码仓库	Title
纤毛方向性揭示了大脑皮层中主要神经元的缓慢反向运动，用于定位和层状结构的精细化	Yang, J.	PDF	N/A	Cilia Directionality Reveals a Slow Reverse Movement of Principal Neurons for Positioning and Lamina Refinement in the Cerebral Cortex
精神分裂症风险基因在人类神经元中的收敛性和非加性影响	Deans, P. M.	PDF	N/A	Convergent and non-additive impact of schizophrenia risk genes in human neurons
人类生长的因果模型及其使用时序稀疏数据的估计	Bunce, J. A.	PDF	N/A	A causal model of human growth and its estimation using temporally-sparse data
结合统计与机械建模，将离子通道基因与皮质神经元类型的生理特性联系起来	Bernaerts, Y.	PDF	N/A	Combined statistical-mechanistic modeling links ionchannel genes to physiology of cortical neuron types
CaBLAM！一种高对比度的生物发光Ca2+指示剂，源自工程化的细臂萤光素酶（Oplophorus gracilirostris luciferase）。	Lambert, G. G.	PDF	N/A	CaBLAM! A high-contrast bioluminescent Ca2+ indicator derived from an engineered Oplophorus gracilirostris luciferase
将人类tau病变患者样本在细胞中传代会产生异质性的纤维，其中一部分纤维会形成与疾病相关的折叠结构。	Zeng, Z.	PDF	N/A	Passaging Human Tauopathy Patient Samples in Cells Generates Heterogeneous Fibrils with a Subpopulation Adopting Disease Folds
使用AlphaFold、Rosetta和副本交换进行可靠的蛋白质-蛋白质对接	Harmalkar, A.	PDF	N/A	Reliable protein-protein docking with AlphaFold, Rosetta and replica-exchange
拟南芥中自噬的氧化还原调控：活性氧的不同影响	Robert, G.	PDF	N/A	Redox regulation of autophagy in Arabidopsis: differential effects of reactive oxygen species
温暖温度通过拦截N-羟基哌啶酸的生物合成来抑制植物的系统获得性抗性。	Shields, A.	PDF	N/A	Warm temperature suppresses plant systemic acquired resistance by intercepting N-hydroxypipecolic acid biosynthesis
大脑老化速度与亚洲儿童和老年人未来的执行功能相关	Cheng, S. F.	PDF	N/A	Rate of brain aging associates with future executive function in Asian children and older adults
高效且准确地以单细胞分辨率检测病毒序列，揭示了可能干扰宿主基因表达的新型病毒。	Luebbert, L.	PDF	N/A	Efficient and accurate detection of viral sequences at single-cell resolution reveals putative novel viruses perturbing host gene expression
组蛋白H2A.Z去乙酰化与去分化在梗死/ Tip60缺失的心肌细胞中的作用	Wang, X.	PDF	N/A	Histone H2A.Z Deacetylation and Dedifferentiationin Infarcted/Tip60-depleted Cardiomyocytes
一个突变的ASXL1-EHMT复合物在克隆性造血和慢性单核细胞白血病中导致异染色质功能障碍。	Dong, Z.	PDF	N/A	A mutant ASXL1-EHMT complex contributes to heterochromatin dysfunction in clonal hematopoiesis and chronic monomyelocytic leukemia
与新颖探索期间θ振荡而非涟漪振荡相关的海马CA1锥体神经元的同步集合。	Chen, E.-L.	PDF	N/A	Synchronous ensembles of hippocampal CA1 pyramidal neurons associated with theta but not ripple oscillations during novel exploration
脑信号复杂性和非周期性预测人类皮质脊髓兴奋性	Frohlich, J.	PDF	N/A	Brain signal complexity and aperiodicity predict human corticospinal excitability
真核生物转录因子的共转录因子依赖性差异涉及多个影响激活和自抑制的内在无序区域	Snyder, L. F.	PDF	N/A	Divergence in a Eukaryotic Transcription Factor's co-TF Dependence Involves Multiple Intrinsically Disordered Regions Affecting Activation and Autoinhibition
人类视觉皮层中可预测运动的多阶段渐进外推	Turner, W.	PDF	N/A	Progressive multi-stage extrapolation of predictable motion in human visual cortex
前额叶多巴胺活动对于快速威胁回避学习至关重要	Zeidler, Z. E.	PDF	N/A	Prefrontal dopamine activity is critical for rapid threat avoidance learning
双脑微状态：一种用于量化任务驱动的脑间不对称性的新型超扫描-脑电图方法	Li, Q.	PDF	N/A	Two-brain microstates: A novel hyperscanning-EEG method for quantifying task-driven inter-brain asymmetry
解码可卡因自我给药过程中次级运动皮层神经元活动：来自纵向体内钙成像的见解	Chen, Y.	PDF	N/A	Decoding Secondary Motor Cortex Neuronal Activity during Cocaine Self-Administration: Insights from Longitudinal in vivo Calcium Imaging
以下是这段文字的中文翻译：

可扩展、高质量工程化干细胞来源的SIRPα-细胞外囊泡的双模式作用用于治疗急性肝衰竭

翻译说明： - Dual-mode action：双模式作用，指该治疗方法具有两种不同的作用机制。 - scalable：可扩展的，表示该技术可以大规模生产或应用。 - high-quality engineered：高质量工程化的，指通过工程技术手段改造的高质量产品。 - stem cell-derived：干细胞来源的，表示这些细胞外囊泡是从干细胞中提取或衍生的。 - SIRPα-extracellular vesicles：SIRPα-细胞外囊泡，SIRPα是一种蛋白质，这里指含有SIRPα的细胞外囊泡。 - treating acute liver failure：治疗急性肝衰竭，指该技术用于急性肝衰竭的治疗。

希望这个翻译对你有帮助！ | Kim, S. | PDF | N/A | Dual-mode action of scalable, high-quality engineered stem cell-derived SIRPα-extracellular vesicles for treating acute liver failure | | 增强系统发育独立对比：通过离群值和分布引导的相关性应对突发的进化转变 | Chen, Z.-L. | PDF | N/A | Enhancing Phylogenetic Independent Contrasts: Addressing Abrupt Evolutionary Shifts with Outlier- and Distribution-Guided Correlation | | 一种细胞可渗透的荧光探针揭示了由不同GPCR激动剂在神经元中引发的PI(4,5)P2动态的时间多样性 | Kundu, R. | PDF | N/A | A Cell-Permeable Fluorescent Probe Reveals Temporally Diverse PI(4,5)P2 Dynamics Evoked by Distinct GPCR Agonists in Neurons | | 胰腺β细胞中GLP-1R胆固醇结合位点的分子定位与功能验证 | Oqua, A. I. | PDF | N/A | Molecular mapping and functional validation of GLP-1R cholesterol binding sites in pancreatic beta cells | | 胰腺β细胞中GLP-1R胆固醇结合位点的分子定位与功能验证 | Oqua, A. I. | PDF | N/A | Molecular mapping and functional validation of GLP-1R cholesterol binding sites in pancreatic beta cells | | miR-184通过调控dilp8来控制正常生长条件下的发育时间，并在应对发育扰动时发挥作用。 | Fernandes, J. | PDF | N/A | miR-184 modulates dilp8 to control developmental timing during normal growth conditions and in response to developmental perturbations | | 一个动力简单步行模型修改了恢复率的定义：人类在双支撑阶段的步行与钟摆运动有显著差异 | Hosseini-Yazdi, S.-S. | PDF | N/A | A Powered Simple Walking Model Modifies the Rate of Recovery Definition: Human Walking Deviates Drastically from Pendular Motion During the Double Support Phase | | 直接RNA测序（RNA004）技术能够提升转录组分析的准确性，并实现近乎实时的甲基化追踪，这对于医学应用具有重要意义。 | Hewel, C. | PDF | N/A | Direct RNA sequencing (RNA004) allows for improved transcriptome assessment and near real-time tracking of methylation for medical applications | | 姜黄素和5-溴吲哚-3-甲醛对铜绿假单胞菌群体感应依赖性毒力因子抑制的影响 | Gonzalez, G. M. | PDF | N/A | Effect of curcumin and 5-bromoindole-3-carboxyaldehyde on the inhibition of Quorum sensig-dependent virulence factors in Pseudomonas aeruginosa | | 为了解决皮层数据集中的过度分割和快速状态转换问题，我们提出了一种粘性泊松隐马尔可夫模型。 | Li, T. | PDF | N/A | A sticky Poisson Hidden Markov Model for solving the problem of over-segmentation and rapid state switching in cortical datasets | | 《涡虫干细胞分化的调控逻辑》 | Perez-Posada, A. | PDF | N/A | The Regulatory Logic of Planarian Stem Cell Differentiation | | PAM识别的灵活性扩展了xCas9的DNA靶向能力 | Hossain, K. A. | PDF | N/A | Flexibility in PAM Recognition Expands DNA Targeting in xCas9 | | 基于人工智能的KATP通道药物伴侣的发现及冷冻电镜结构解析 | Elsheikh, A. | PDF | N/A | AI-Based Discovery and CryoEM Structural Elucidation of a KATP Channel Pharmacochaperone | | 三碘甲状腺原氨酸和黄芩素的双重干预双向上调Klotho，减轻老年BALB/c小鼠的慢性肾病及其并发症。 | Mohanty, S. K. | PDF | N/A | A Dual intervention of Triiodothyronine and Baicalein bi-directionally upregulates Klotho with attenuation of chronic kidney disease and its complications in aged BALB/c mice | | 在氧化还原梯度环境中，革兰氏阳性菌Microbacterium deferre sp. nov. A1-JK通过基于黄素的细胞外电子传递在含氧条件下进行电子转移。 | Lustermans, J. J. M. | PDF | N/A | Flavin-based extracellular electron transfer under oxic conditions by Gram-positive Microbacterium deferre sp. nov. A1-JK in redox-graded environments | | 听觉皮层通过选择性多感官增强学习区分视听线索 | Chang, S. | PDF | N/A | Auditory Cortex Learns to Discriminate Audiovisual Cues through Selective Multisensory Enhancement | | 作为宏蛋白质组学工具的数据非依赖性采集质谱：使用模型微生物组的实验室间比较 | Rajczewski, A. T. | PDF | N/A | Data-Independent Acquisition Mass Spectrometry as a Tool for Metaproteomics: Interlaboratory Comparison Using a Model Microbiome | | RanBALL：一种用于识别B细胞急性淋巴细胞白血病亚型的集成随机投影模型 | Li, L. | PDF | N/A | RanBALL: An Ensemble Random Projection Model for Identifying Subtypes of B-cell Acute Lymphoblastic Leukemia | | 成纤维细胞生长因子诱导的14在骨骼肌修复过程中调控卫星细胞的自我更新和扩增 | Tomaz Da Silva, M. | PDF | N/A | Fibroblast growth factor-inducible 14 regulates satellite cell self-renewal and expansion during skeletal muscle repair | | 皮肤通过天然保湿因子实现水合作用，这是一个关于氢键网络的故事 | MARTIN, M. | PDF | N/A | Skin hydration by natural moisturizing factors, a story of H-bond networking | | 由机械压缩引发的古菌中类似组织的多细胞发育 | Rados, T. | PDF | N/A | Tissue-Like Multicellular Development Triggered by Mechanical Compression in Archaea | | 突触小泡内吞作用缺陷是导致GBA相关帕金森病和路易体痴呆认知功能障碍的基础。 | Vidyadhara, D. J. | PDF | N/A | Synaptic vesicle endocytosis deficits underlie GBA-linked cognitive dysfunction in Parkinson's disease and Dementia with Lewy bodies | | WRAD核心扰动损害DNA复制保真度，促进胰腺癌中的免疫编辑 | Citron, F. | PDF | N/A | WRAD core perturbation impairs DNA replication fidelity promoting immunoediting in pancreatic cancer | | 记忆系统适应不良损害了自闭症Cntnap2基因敲除小鼠模型中CA1依赖性时间绑定和陈述性记忆

在自闭症的Cntnap2基因敲除小鼠模型中，记忆系统的适应不良导致CA1依赖性时间绑定和陈述性记忆功能受损。 | Rawlinson, E. C. | PDF | N/A | Memory System Maladaptation Impairs CA1-Dependent Temporal Binding and Declarative Memory in the Cntnap2 Knockout Mouse Model of Autism | | 非网格蛋白依赖的内吞作用和癌细胞中的逆行运输促进细胞毒性CD8 T细胞的激活 | Xu, S. | PDF | N/A | Clathrin-independent endocytosis and retrograde transport in cancer cells promote cytotoxic CD8 T cell activation | | 热葡萄糖地芽孢杆菌（Parageobacillus thermoglucosidasius）中部分甲基营养的RuMP循环的觉醒 | Paredes-Barrada, M. | PDF | N/A | Awakening of the RuMP cycle for partial methylotrophy in the thermophile Parageobacillus thermoglucosidasius | | cOmicsArt - 一款可定制的组学分析与报告工具 | Seep, L. | PDF | N/A | cOmicsArt - a customizable Omics Analysis and reporting tool | | 使用时空子采样提高eBird数据可靠性来模拟美洲红隼数量下降 | Sharma, A. | PDF | N/A | Modeling American Kestrel Decline Using Spatiotemporal Subsampling to Improve eBird Data Reliability | | 前向工程肌肉组织驱动的软体机器人游泳器 | Drennan, W. C. | PDF | N/A | A forward-engineered muscle tissue driven soft robotic swimmer | | 重复磁刺激通过协同的前后突触活动诱导兴奋性突触的可塑性。 | Galanis, C. | PDF | N/A | Repetitive magnetic stimulation induces plasticity of excitatory synapses through cooperative pre- and postsynaptic activity. | | 多维度的社会关系塑造了猴子的社会注意力 | Liu, S. | PDF | N/A | Multi-dimensional social relationships shape social attention in monkeys | | FIDDLE：一种从串联质谱预测化学式的深度学习方法 | Hong, Y. | PDF | N/A | FIDDLE: a deep learning method for chemical formulas prediction from tandem mass spectra | | 将这段翻译成中文为：“PDB结构模型中结合位点的建模偏差” | Wankowicz, S. A. | PDF | N/A | Modeling Bias Toward Binding Sites in PDB Structural Models | | 重组皮钦德报告病毒作为一种安全且合适的替代品，用于高通量抗病毒筛选以对抗高致病性沙粒病毒。 | Sacramento, C. Q. | PDF | N/A | Recombinant Pichinde reporter virus as a safe and suitable surrogate for high-throughput antiviral screening against highly pathogenic arenaviruses | | GRN_modeler：一个用于构建和评估基因调控网络的直观工具及其在振荡器和光生物传感器中的应用 | Hollo, G. | PDF | N/A | GRN_modeler: An Intuitive Tool for Constructing and Evaluating Gene Regulatory Networks and its Applications to Oscillators and a Light Biosensor | | 以下是这段英文的中文翻译：

一个关于西北欧节肢动物生活史和生态特征的深入数据集

翻译说明： - "in-depth" 翻译为 "深入的" - "dataset" 翻译为 "数据集" - "northwestern European" 翻译为 "西北欧的" - "arthropod" 翻译为 "节肢动物" - "life histories" 翻译为 "生活史" - "ecological traits" 翻译为 "生态特征"

这段内容描述了一个专门为自由活动的大鼠设计的电子尼古丁输送系统，该系统能够实现鼻吸式电子烟气溶胶的吸入，并对其进行了描述和验证。 | Odum, A. L. | PDF | N/A | The Rodent Electronic Nicotine Delivery System: Description and Validationof an Apparatus for Nose-Only E-Cigarette Aerosol Inhalation in Freely Moving Rats | | 来自智利巴塔哥尼亚北部的Eleginops maclovinus的局部适应性基因组信号 | Claure, C. E. | PDF | N/A | Genomic signals of local adaptation in Eleginops maclovinus from Northern Chilean Patagonia | | 智利巴塔哥尼亚北部Eleginops maclovinus的局部适应性基因组信号 | Claure, C. E. | PDF | N/A | Genomic signals of local adaptation in Eleginops maclovinus from Northern Chilean Patagonia | | 蛋白质CREATE技术实现了从头合成蛋白质结合剂的闭环设计。 | Lourenco, A. L. | PDF | N/A | Protein CREATE enables closed-loop design of de novo synthetic protein binders | | 空间有序的合子基因组激活实现胚胎质量控制 | Qian, W. | PDF | N/A | Spatially ordered zygotic genome activation fulfills embryo quality control | | 新分离的基因组和全球海洋宏基因组解析了SAR11的生态相关单元 | Freel, K. C. | PDF | N/A | New isolate genomes and global marine metagenomes resolve ecologically relevant units of SAR11 | | 对单个线粒体成分的定量分析揭示了小线粒体网络在启动肿瘤形成中的早期作用。 | Saini, M. | PDF | N/A | Quantitative analyses of individual mitochondrial components reveal an early role of small-mitochondrial-networks in priming neoplasticity | | 通过海洋传播实现陆地植物的全球分布 | Vatanparast, M. | PDF | N/A | Global distribution of a land plant by means of oceanic dispersal | | 两种新型绿僵菌制剂在防治马铃薯种植中金针虫的效果 | Paluch, M. | PDF | N/A | The effectiveness of two new Metarhizium brunneum formulations against wireworms in potato cultivation | | 镉的摄入不会破坏亚社会性昆虫幼体间微生物群落的社会传播。 | Cheutin, M.-C. | PDF | N/A | Cadmium ingestion does not disrupt the social transmission of the microbiome in juveniles of a subsocial insect | | 核苷酸编码控制着Lis1解除动力蛋白自抑制的能力。 | Geohring, I. C. | PDF | N/A | A nucleotide code governs Lis1's ability to relieve dynein autoinhibition | | 将这段翻译成中文为：工程化多重合成呼吸生物标志物作为诊断探针。 | Wang, S.-T. | PDF | N/A | Engineering Multiplexed Synthetic Breath Biomarkers as Diagnostic Probes | | 预测压力恢复力的睡眠模式因性别而异。 | Bush, B. J. | PDF | N/A | Sleep patterns predicting stress resilience are dependent on sex | | 非核小体（CENP-A/H4）2 - DNA复合物作为着丝粒组织的可能平台 | Ali-Ahmad, A. | PDF | N/A | Non-nucleosomal (CENP-A/H4)2 - DNA complexes as a possible platform for centromere organization | | 核篮蛋白Mlp1和Nup2驱动热休克诱导的三维基因组重构 | Mohajan, S. | PDF | N/A | Nuclear basket proteins Mlp1 and Nup2 drive heat shock-induced 3D genome restructuring | | 胎儿癌基因NUAK2是胶质母细胞瘤中的一个新兴治疗靶点。 | Jo, H. | PDF | N/A | A fetal oncogene NUAK2 is an emerging therapeutic target in glioblastoma. | | 慢性退行性唾液腺功能衰竭可以通过恢复线粒体功能来逆转。 | Li, J. | PDF | N/A | Chronic degenerative failure of salivary glands can be reversed through restoring mitochondrial function | | TOR和热休克反应通路在蛋白质毒性应激期间调节过氧化物酶体的生物发生。 | Shukla, N. | PDF | N/A | TOR and heat shock response pathways regulate peroxisome biogenesis during proteotoxic stress | | STN β 振荡对帕金森病步态中下肢肌肉活动的作用 | Simpson, T. G. | PDF | N/A | The role of STN beta oscillations on lower extremity muscle activity in Parkinsonian stepping | | 评估BNST GABA神经元在后退条件抑制中的作用 | Ly, A. | PDF | N/A | Assessing the role of BNST GABA neurons in backward conditioned suppression | | 扰动全脑模型中的大脑层级结构：药物治疗后抑郁症的应用研究 | Socoro Garrigosa, M. | PDF | N/A | Perturbing whole-brain models of brain hierarchy: an application for depression following pharmacological treatment | | 机械敏感的DEG/ENaC通道DEGT-1是线虫前肠运动的本体感受器。 | Bayer, E. A. | PDF | N/A | The mechanosensory DEG/ENaC channel DEGT-1 is a proprioceptor of C. elegans foregut movement | | 机械敏感的DEG/ENaC通道DEGT-1是线虫前肠运动的感受器。 | Bayer, E. A. | PDF | N/A | The mechanosensory DEG/ENaC channel DEGT-1 is a proprioceptor of C. elegans foregut movement | | 《艺术家的头脑：一种数据融合方法以刻画专业视觉艺术家的神经基础》

这篇论文探讨了专业视觉艺术家的大脑活动特征，采用了一种数据融合的方法来研究艺术家在创作过程中的神经机制。通过整合多种神经影像数据，研究旨在揭示艺术家在视觉创作中独特的大脑活动模式，从而更好地理解艺术创作背后的神经科学基础。 | Taskiran, E. | PDF | N/A | The Artists' Brain: A Data Fusion Approach to Characterize the Neural Bases of Professional Visual Artists | | VGluT3 BNST神经元传递GABA并限制摄食，而不影响奖赏或厌恶处理 | Ly, A. | PDF | N/A | VGluT3 BNST neurons transmit GABA and restrict feeding without affecting rewarding or aversive processing | | 催眠-个人电脑：通过主成分分析和电生理信号的隐马尔可夫模型揭示睡眠动态 | Guendelman, M. | PDF | N/A | The Hypno-PC: Uncovering Sleep Dynamics through Principal Component Analysis and Hidden Markov Modeling of Electrophysiological Signals | | 额叶眼区神经元预测跨眼跳视觉稳定性的“反贝叶斯”判断，而非贝叶斯判断 | Subramanian, D. | PDF | N/A | Frontal eye field neurons predict "anti-Bayesian" but not Bayesian judgments of visual stability across saccades | | CLN5缺乏症会损害巴顿病中的葡萄糖摄取。 | MARCHESE, M. | PDF | N/A | CLN5 deficiency impairs glucose uptake in Batten disease | | CLN5缺乏症会影响巴顿病中的葡萄糖摄取。 | Marchese, M. | PDF | N/A | CLN5 deficiency impairs glucose uptake in Batten disease | | 这段文字的中文翻译是：

迷走神经节与肺神经内分泌细胞之间的神经回路调节肺部炎症反应

解释： - Neural circuits 翻译为 神经回路 - nodose ganglion 翻译为 迷走神经节（迷走神经的下神经节） - pulmonary neuroendocrine cells 翻译为 肺神经内分泌细胞 - regulate 翻译为调节 - lung inflammatory responses 翻译为 肺部炎症反应

在这项研究中，我们探讨了通过DCAF16招募的靶向胶选择性降解BRD9的机制，并在体内验证了这一概念。BRD9是一种与染色质重塑和基因表达调控相关的蛋白质，其异常表达与多种疾病有关。通过设计一种能够特异性结合BRD9并招募DCAF16的靶向胶，我们实现了对BRD9的选择性降解。研究详细阐明了这一过程的作用模式，并通过体内实验验证了其可行性和效果。这一发现为开发新型靶向治疗策略提供了重要的理论依据和实验支持。 | Hughes, S. J. | PDF | N/A | Selective degradation of BRD9 by a DCAF16-recruiting targeted glue: mode of action elucidation and in vivo proof of concept | | PRC1通过两种不同的阻力模式抵抗微管的滑动，这是由于重叠微管之间间距的变化所导致的。 | Steckhahn, D. | PDF | N/A | PRC1 resists microtubule sliding in two distinct resistive modes due to variations in the separation between overlapping microtubules | | Trogocytosis介导的FOLR2从护士样细胞向慢性淋巴细胞白血病（CLL）细胞的转移与其激活和增殖相关。 | Domagala, M. | PDF | N/A | Trogocytosis-mediated transfer of FOLR2 from Nurse-like cells to CLL cells is linked to their activation and proliferation | | 在蓝光和紫外线辐射下，拟南芥中UVR8和隐花色素对光合作用的保护 | Morales, L. O. | PDF | N/A | Protection of photosynthesis by UVR8 and cryptochromes in Arabidopsis under blue and UV radiation | | 异步布尔网络模型的最优推断 | Karlebach, G. | PDF | N/A | Optimal Inference of Asynchronous Boolean Network Models | | 使用绿色空间虚拟现实技术预防压力引起的工作记忆损伤 | Xu, Y. | PDF | N/A | Using green space virtual reality to prevent stress-induced working memory impairment | | 慢性金黄色葡萄球菌感染骨细胞会促进细胞内形成一种“存活但不可培养”的表型。 | Gunn, N. J. | PDF | N/A | Chronic Staphylococcus aureus infection of osteocytes promotes an intracellular viable-but-non-culturable phenotype | | 一个简单的硅胶弹性体定植模型揭示了白色念珠菌和金黄色葡萄球菌在生物膜形成过程中相互作用的复杂性。 | McConnell, G. | PDF | N/A | A simple silicone elastomer colonisation model highlights complexities of Candida albicans and Staphylococcus aureus interactions in biofilm formation. | | 碳源、细胞密度和微生物群落通过环境硝酸盐控制霍乱弧菌表面定植的抑制作用。 | James, J. | PDF | N/A | Carbon source, cell density, and the microbial community control inhibition of V. cholerae surface colonization by environmental nitrate | | 小基因组大小确保了高山姜的适应性灵活性。 | Xiao, Q.-S. | PDF | N/A | The small genome size ensures adaptive flexibility for an alpine ginger | | 以下是这段英文的中文翻译：

铜绿假单胞菌MsbA被Zn2+激活的分子基础

翻译说明： - "Molecular basis" 翻译为 "分子基础" - "activation" 翻译为 "激活" - "Pseudomonas aeruginosa" 是细菌名称，翻译为 "铜绿假单胞菌" - "MsbA" 是一种蛋白质，通常保留英文名称 - "Zn2+" 是锌离子，保留化学符号

希望这对你有帮助！ | Lyu, J. | PDF | N/A | Molecular basis for the activation of Pseudomonas aeruginosa MsbA by Zn2+ | | 具有增强亲水性、荧光性和亮度的醚基罗丹明用于超分辨率成像 | Fang, X. | PDF | N/A | Ether Rhodamines with Enhanced Hydrophilicity, Fluorogenicity, and Brightness for Super-Resolution Imaging | | 蛋白质条形码与下一代蛋白质测序技术在多路复用蛋白质选择、分析与追踪中的应用 | Chinnaraj, M. | PDF | N/A | Protein Barcoding and Next-Generation Protein Sequencing for Multiplexed Protein Selection, Analysis, and Tracking | | 肺炎克雷伯菌细菌微区室主要壳组件之间的混杂结构交叉兼容性 | Barthe, L. | PDF | N/A | Promiscuous structural cross-compatibilities between major shell components of Klebsiella pneumoniae bacterial microcompartments | | 前列腺素转运蛋白的结构与翻译后修饰 | Yu, P. | PDF | N/A | Structure and Post-Translational Modification of the Prostaglandin Transporter | | 埃及伊蚊中肠胰凝乳蛋白酶在血液餐蛋白质消化或繁殖力中没有显著作用。 | Rascon, A. A. | PDF | N/A | Aedes aegypti midgut chymotrypsin has no significant role in blood meal protein digestion or fecundity | | 冠状病毒主要蛋白酶的酶动力学模型，包括二聚化和配体结合 | La, V. N. T. | PDF | N/A | Enzyme kinetics model for the coronavirus main protease including dimerization and ligand binding | | A20的线性泛素结合基序抑制TH17/22细胞的致病性激活及IL-22驱动的肠炎 | Bowman, C. J. | PDF | N/A | A20's Linear Ubiquitin Binding Motif Restrains Pathogenic Activation of TH17/22 cells and IL-22 Driven Enteritis | | 使用傅里叶变换红外光谱法区分结核分枝杆菌和牛分枝杆菌 | Guterres, K. B. | PDF | N/A | Discrimination between Mycobacterium tuberculosis and Mycobacterium bovis using Fourier Transform Infrared Spectroscopy | | 产甲烷菌与短链脂肪酸的微生物产量变化及人体可代谢能量的变化有关。 | Dirks, B. | PDF | N/A | Methanogens are associated with altered microbial production of short-chain fatty acids and human-host metabolizable energy | | 脓肿分枝杆菌促进铜绿假单胞菌生物膜形成和抗生素耐受性 | McDaniel, M. S. | PDF | N/A | Mycobacterium abscessus promotes Pseudomonas aeruginosa biofilm formation and antibiotic tolerance | | 解析急性蛙病毒（MRV）感染对鳜鱼幽门盲囊的全球响应揭示浆膜炎及随后腹水的形成过程 | Zhang, W. | PDF | N/A | Dissection of the Global Responses of Mandarin Fish Pyloric Caecum to An Acute Ranavirus (MRV) Infection Reveals the Formation of Serositis and Then Ascites | | 脑炎性虫媒病毒受体识别转变的分子基础 | Fan, X. | PDF | N/A | Molecular basis for shifted receptor recognition by an encephalitic arbovirus | | 霉菌膜以差异化和异质性的方式限制抗生素的渗透。 | Lepori, I. | PDF | N/A | The mycomembrane differentially and heterogeneously restricts antibiotic permeation | | 霸凌噬菌体：一种编码志贺毒素的原噬菌体干扰共宿主原噬菌体的诱导 | Litvak, Y. | PDF | N/A | The bully phage: A Shiga toxin-encoding prophage interferes with the induction of co-hosted prophages | | 副转基因技术：工程化肠杆菌共生体及产Cry1Ac蛋白肠杆菌在农作物生产中用于生物防治棉铃虫害虫的动态研究 | Ojha, A. | PDF | N/A | Paratransgenesis: The dynamics of engineered Enterobacter symbionts and Cry1Ac-producing Enterobacter for biocontrol of Helicoverpa insect pests in crop production | | 聚合酶14缺乏小鼠中沙门氏菌病的恶化 | Vedantham, M. | PDF | N/A | Exacerbated salmonellosis in poly(ADP-ribose) polymerase 14 deficient mice | | 自噬介导的AXL和TIM-1下调促进持续寨卡病毒感染 | Liu, S.-L. | PDF | N/A | Autophagy-Mediated Downregulation of AXL and TIM-1 Promotes Sustained Zika Virus Infection | | 单碱基m6A表观转录组学揭示了原代CD4+ T细胞中HIV-1与宿主相互作用的新靶点 | Huang, S. | PDF | N/A | Single-base m6A epitranscriptomics reveals novel HIV-1 host interaction targets in primary CD4+ T cells | | 长读长全基因组测序为研究与原发性脑型暗色丝孢霉病相关的嗜神经性暗色真菌的生物学特性、应激适应及毒力提供了新的见解。 | Samaddar, A. | PDF | N/A | Long-read whole-genome sequencing offers novel insights into the biology, stress adaptation, and virulence of neurotropic dematiaceous fungi associated with primary cerebral phaeohyphomycosis | | LGR二聚体的结构——糖蛋白激素受体的进化前体 | Gong, Z. | PDF | N/A | Structure of an LGR dimer - an evolutionary predecessor of glycoprotein hormone receptors | | 生长激素/胰岛素样生长因子信号通过调节酮己糖激酶的表达来拮抗肝脏果糖代谢。 | Elsaid, S. A. | PDF | N/A | Hepatic fructose metabolism is antagonized by growth hormone/insulin-like growth factor signaling via regulation of ketohexokinase expression | | 陆源有机物加剧密西西比河源头沉积物中的甲烷排放 | Sauer, H. M. | PDF | N/A | Terrestrial Organic Matter Amplifies Methane Emissions Across Sediments of the Mississippi River Headwaters | | 对空中热成像视频技术估算大型哺乳动物种群数量的实验评估 | McElhinny, J. S. | PDF | N/A | Experimental assessment of large mammal population estimates from airborne thermal videography | | SSARP：一个R语言包，用于利用网络数据库轻松创建物种-面积关系和物种形成-面积关系 | Martinet, K. M. | PDF | N/A | SSARP: An R Package for Easily Creating Species- and Speciation- Area Relationships Using Web Databases | | 《水韭属（水韭目）的孢子形态与进化》 | Larsen, E. | PDF | N/A | Spore morphology and evolution in Isoetes (Isoetales) | | 社会寄生蚂蚁基因组创新与缺失的趋同进化痕迹 | Harrison, M. C. | PDF | N/A | Convergent Evolutionary Traces of Genomic Innovations and Depletions in Socially Parasitic Ants | | 在早期卵泡发生过程中，卵母细胞中线粒体DNA完整性的跨代维持 | Xie, Q. | PDF | N/A | Trans-generational maintenance of mitochondrial DNA integrity in oocytes during early folliculogenesis | | 在脑血管疾病的Mthfr677C>T小鼠模型中视网膜血管功能障碍 | Reagan, A. M. | PDF | N/A | Retinal vascular dysfunction in the Mthfr677C>T mouse model of cerebrovascular disease | | 单细胞调控DNA-蛋白质相互作用图谱 | Chi, W. Y. | PDF | N/A | Single-cell mapping of regulatory DNA:Protein interactions | | 实验室规模麦芽质量评估的低成本台式麦芽制备方案的开发与质量评价 | Rani, H. | PDF | N/A | Development and quality assessment of low-cost benchtop malting protocol for laboratory-scale malt quality evaluation | | 识别和表征由RNA替代质子化引起的移位GU摆动对 | Saon, M. S. | PDF | N/A | Identification and characterization of shifted GU wobble pairs resulting from alternative protonation of RNA | | 托马斯克拉维利亚分支菌（Thomasclavelia ramosa）免疫球蛋白A蛋白酶的结构揭示了其模块化和可最小化的架构，与其他免疫球蛋白A蛋白酶明显不同。 | Tran, N. | PDF | N/A | Structure of the Thomasclavelia ramosa immunoglobulin A protease reveals a modular and minimizable architecture distinct from other immunoglobulin A proteases | | 平衡EL222的剂量和光照可以改善在Komagataella phaffii中光遗传学诱导蛋白质生产的效果。 | Hoffman, S. M. | PDF | N/A | Balancing doses of EL222 and light improves optogenetic induction of protein production in Komagataella phaffii | | 鳞尾器官在Pel's鳞尾飞鼠的树栖运动中增强了静态稳定性 | Schulz, A. K. | PDF | N/A | Scaly-Tail Organ Enhances Static Stability during Pel's Scaly-tailed Flying Squirrels' Arboreal Locomotion | | 微环境在PDAC肿瘤类器官表型、代谢和耐药性中作用的定量评估 | Sorzabal, I. | PDF | N/A | Quantitative evaluation of the role of the microenvironment in the phenotype, metabolism, and drug resistance of PDAC tumor organoids | | 对斑马鱼遗传的lncRNA和circRNA库进行全面分析 | Joshi, D. C. | PDF | N/A | A comprehensive analysis of the inherited lncRNA and circRNA repertoire of zebrafish | | 使用ColabFold推动无序区域结构预测的极限：进展与见解 | Rieth, M. | PDF | N/A | Pushing the limits of structure prediction in regions of disorder using ColabFold: Progress and insights | | 这段文字可以翻译为：

“受体酪氨酸激酶超家族中的结构保守性与差异性”

解释： - Structural conservation 指的是在不同蛋白质或分子中，某些结构特征在进化过程中保持相对不变。 - Divergence 指的是在进化过程中出现的差异或变化。 - Receptor Tyrosine Kinase (RTK) 是一类重要的细胞表面受体，参与细胞信号传导。 - Superfamily 指的是具有相似结构和功能的一类蛋白质家族。

整体意思是研究受体酪氨酸激酶超家族中，不同成员之间在结构上的保守性（相似性）和差异性（变化）。 | Fassler Bakhman, A. | PDF | N/A | Structural conservation and divergence across the Receptor Tyrosine Kinase superfamily | | 酶负载囊泡中通过增强扩散产生力的机制 | Eberhard, E. | PDF | N/A | Force Generation by Enhanced Diffusion in Enzyme-Loaded Vesicles | | 探索包含APP C99的三元脂质混合物中相分离的动力学和机制：原子级与粗粒度分子动力学模拟的对比 | Pantelopulos, G. A. | PDF | N/A | Exploring the kinetics and mechanism of phase separation in ternary lipid mixtures containing APP C99 using atomistic vs coarse-grained MD simulations | | 超螺旋对拓扑域中细菌转录的差异效应 | Goldberg, B. I. | PDF | N/A | Differential effect of supercoiling on bacterial transcription in topological domains | | Snf2型ATP酶介导染色质重塑的机制 | Malik, D. | PDF | N/A | Mechanisms of chromatin remodeling by a Snf2-type ATPase | | 一款开源的3D打印显微镜，配备大型CNC载物台 | Degut, C. | PDF | N/A | An open-sourced 3D printable microscope with a large CNC stage | | 缺氧诱导的活跃动力学促进早期肿瘤发生 | Wang, Z. | PDF | N/A | Hypoxia-Induced Active Dynamics Promotes Early Tumorigenesis | | 一个整合了多尺度计算机模拟建模和实验数据的框架，能够预测CD33 CAR-NK细胞在不同靶细胞类型中的细胞毒性。 | Ahmad, S. | PDF | N/A | A framework integrating multiscale in-silico modeling and experimental data predicts CD33 CAR-NK cytotoxicity across target cell types | | 转录机制将ecDNAs锚定在有丝分裂染色体上进行分离 | Xie, Y. | PDF | N/A | Transcription Machinery Anchors ecDNAs to Mitotic Chromosomes for Segregation | | RAGE信号和2型糖尿病对小鼠皮质骨力学、结构和材料特性的性别特异性影响 | Hung, T. | PDF | N/A | The sex-specific effects of RAGE signaling and Type 2 Diabetes on mouse cortical bone mechanics, structure, and material properties | | 评估治疗MFN2相关脂肪营养不良的候选“生死抉择”策略 | Luijten, I. | PDF | N/A | Evaluation of Candidate ''Kill or Cure'' Strategies to Treat MFN2-related Lipodystrophy | | 苹果果实形状的差异与果实大小无关。 | DeViller, K. | PDF | N/A | Differences in apple fruit shape are independent of fruit size | | 通过机器学习支持的非靶向代谢组学揭示植物对干旱和二氧化碳升高的营养和代谢反应 | Chang, H.-F. | PDF | N/A | Plant nutritional and metabolic responses to drought and elevated CO2 revealed by machine learning-enabled non-targeted metabolomics | | 稳定表达膜锚定流感神经氨酸酶的荧光条形码细胞系 | Finney, J. | PDF | N/A | Fluorescence-barcoded cell lines stably expressing membrane-anchored influenza neuraminidases | | 巨噬细胞活化过程中鞘脂代谢的解决与非解决动态：时间分辨代谢分析 | Chiappa, N. | PDF | N/A | Resolving vs. Non-resolving Sphingolipid Dynamics During Macrophage Activation: A Time-resolved Metabolic Analysis | | 体内衣康酸追踪揭示了其降解途径和周转动力学 | Cordes, T. F. | PDF | N/A | In vivo itaconate tracing reveals degradation pathway and turnover kinetics | | 从实验线索到理论建模：生命早期阶段与膜接管相关的进化 | Ma, W. | PDF | N/A | From experimental clues to theoretical modeling: Evolution associated with the membrane-takeover at an early stage of life | | 这段文字可以翻译为：

“具有表型多样性和环境波动的种群模型展示了适应与灭绝的参数机制”

其中： - Population Models 指的是“种群模型” - Phenotypic Diversity 指的是“表型多样性” - Fluctuating Environment 指的是“环境波动” - Parameter Regimes 指的是“参数机制”或“参数范围” - Adaptation vs. Extinction 指的是“适应与灭绝”

通过聚乙烯醇水凝胶珠固定蓝藻（Synechocystis）实现持续异丁烯生产

翻译说明： - Sustained：持续的 - Isobutene Production：异丁烯生产 - Synechocystis：蓝藻（一种光合微生物） - Entrapped：固定、包埋 - Polyvinyl Alcohol Hydrogel Beads：聚乙烯醇水凝胶珠