BioRxiv 2025-01-04 Papers
| 标题 | 作者 | PDF链接 | 代码仓库 | Title |
|---|---|---|---|---|
| 全基因组范围内的体内CRISPR筛选揭示GATOR1是MYC驱动淋巴瘤发生中的强效肿瘤抑制因子 | Potts, M. A. | N/A | Genome-wide in vivo CRISPR screens identify GATOR1 as a potent tumor suppressor in MYC-driven lymphomagenesis | |
| 多组学图谱辅助发现用于选择性T细胞状态编程的转录因子 | Chung, H. K. | N/A | Multi-Omics Atlas-Assisted Discovery of Transcription Factors for Selective T Cell State Programming | |
| 刺激的新颖性揭示了视觉皮层调查中的编码多样性 | Garrett, M. | N/A | Stimulus novelty uncovers coding diversity in survey of visual cortex | |
| 将多个单细胞多组学样本与Smmit进行整合 | Wan, C. | N/A | Integrating multiple single-cell multi-omics samples with Smmit | |
| 遗传和环境对人类免疫细胞表观基因组的独特影响 | Wang, W. | N/A | Genetics and Environment Distinctively Shape the Human Immune Cell Epigenome | |
| 中温升期间高山植物Wahlenbergia ceracea耐热性和敏感性的分子特征 | Notarnicola, R. F. | N/A | Molecular signatures of heat tolerance and sensitivity in the alpine plant Wahlenbergia ceracea during moderate warming | |
| 与动物相比，植物中物种屏障的快速建立 | Monnet, F. | N/A | Rapid establishment of species barriers in plants compared to animals | |
| 空间分辨的动态核极化辅助核磁共振技术揭示了完整活细胞内α-突触核蛋白的构象集合。 | Kragelj, J. | N/A | Spatially resolved DNP-assisted NMR illuminates the conformational ensemble of α-synuclein in intact viable cells. | |
| 在选择性注意过程中的神经语音追踪：一项空间逼真的视听研究 | Har-shai Yahav, P. | N/A | Neural Speech-Tracking During Selective Attention: A spatially realistic audiovisual study | |
| 评估大型多模态模型在生物医学图像分类中的一次性学习能力和可解释性 | Hou, W. | N/A | Assessing large multimodal models for one-shot learning and interpretability in biomedical image classification | |
| 一种新型LAMA2相关肌营养不良症小鼠模型：分子发病机制与临床表型分析 | Tan, D. | N/A | A Novel Mouse Model for LAMA2-Related Muscular Dystrophy: Analysis of Molecular Pathogenesis and Clinical Phenotype | |
| 基于表面的纤维束追踪揭示了前额叶皮层中的“是什么”和“在哪里”通路 | Bedini, M. | N/A | Surface-based Tractography uncovers 'What' and 'Where' Pathways in Prefrontal Cortex | |
| 冷冻电镜揭示反应性全长人类动力蛋白-1的机械化学循环 | Chai, P. | N/A | Cryo-EM Reveals the Mechanochemical Cycle of Reactive Full-length Human Dynein-1 | |
| 纳米基序：利用DNA甲基化基序从复杂微生物群落的宏基因组中进行基因组恢复和质粒宿主关联 | Heidelbach, S. | N/A | Nanomotif: Leveraging DNA Methylation Motifs for Genome Recovery and Host Association of Plasmids in Metagenomes from Complex Microbial Communities | |
| miRTarDS：利用Sentence-BERT从预测数据库中高精度精炼蛋白质水平的微RNA靶标相互作用 | Chen, B. | N/A | miRTarDS: High-Accuracy Refining Protein-level MicroRNA Target Interactions from Prediction Databases Using Sentence-BERT | |
| 跨组织的性别偏向基因表达揭示了刺鱼鳃中的意外分化 | Sylvestre, F. | N/A | Sex-biased gene expression across tissues reveals unexpected differentiation in the gills of the threespine stickleback | |
| IgStrand：一种用于研究免疫球蛋白组（Ig-Proteomes）和免疫球蛋白相互作用组（Ig-Interactomes）的通用免疫球蛋白折叠（Ig-fold）残基编号方案。 | Tawfeeq, C. | N/A | IgStrand: A universal residue numbering scheme for the Immunoglobulin-fold (Ig-fold) to study Ig-Proteomes and Ig-Interactomes | |
| 利用交联剂扩散在藻酸盐水凝胶中模板化刚度梯度 | Ostrowski, Z. | N/A | Leveraging Crosslinker Diffusion to Template Stiffness Gradients in Alginate Hydrogels | |
| 解剖学中的保守编码：大脑中的神经元通过其放电序列（spike trains）嵌入其解剖位置的稳健特征。 | Tolossa, G. B. | N/A | A conserved code for anatomy: Neurons throughout the brain embed robust signatures of their anatomical location into spike trains. | |
| 单价伪天然产物降解剂通过KLHDC3增强IDO1的天然降解能力。 | Hennes, E. | N/A | Monovalent Pseudo-Natural Product Degraders Supercharge the Native Degradation of IDO1 by KLHDC3 | |
| 微量元素提高了微生物生长的可重复性 | Shimoga Nadig, A. | N/A | Trace elements increase reproducibility of microbial growth | |
| 真实和误导性指令对自闭症谱系中统计学习的影响 | Angeletos Chrysaitis, N. | N/A | Influence of truthful and misleading instructions on statistical learning across the autism spectrum | |
| 灵活控制运动单位：运动单位流形的多维性是否是一个充分条件？ | Dernoncourt, F. | N/A | Flexible Control of Motor Units: Is the Multidimensionality of Motor Unit Manifolds a Sufficient Condition? | |
| 资源质量对水蚤与两种寄生虫的相互作用具有差异性影响 | Fearon, M. L. | N/A | Resource Quality Differentially Impacts Daphnia Interactions with Two Parasites | |
| 单细胞RNA测序揭示了在急性椎间盘损伤反应中，内源性和浸润性细胞类型的细胞功能和成熟度的变化。 | Clayton, S. W. | N/A | Single cell RNA sequencing reveals a shift in cell function and maturation of endogenous and infiltrating cell types in response to acute intervertebral disc injury | |
| 青春期前后对促肾上腺皮质激素释放因子受体1的拮抗作用会导致行为可塑性和杏仁核转录组谱的持续变化 | Martz, J. | N/A | Peripubertal antagonism of corticotropin-releasing factor receptor 1 results in sustained changes in behavioral plasticity and the transcriptomic profile of the amygdala | |
| AI驱动的耐碱性蛋白质进化技术应用于大规模生产 | Kang, L. | N/A | AI-enabled Alkaline-resistant Evolution of Protein to Apply in Mass Production | |
| 阿尔茨海默病小鼠模型中海马-前额叶神经动力学紊乱与风险决策行为的研究 | Kim, E. J. | N/A | Disruption of hippocampal-prefrontal neural dynamics and risky decision-making in a mouse model of Alzheimer's disease | |
| 与糖尿病及糖尿病肾病相关的尿路微生物组：一项系统性综述 | Graells, T. | N/A | The urinary microbiome in association with diabetes and diabetic kidney disease: A systematic review | |
| 多感官伽马刺激增强成年神经发生并改善唐氏综合症雄性小鼠的认知功能 | Islam, M. R. | N/A | Multisensory gamma stimulation enhances adult neurogenesis and improvescognitive function in male mice with Down Syndrome | |
| 高分辨率全基因组图谱揭示扭转绝缘的广泛存在 | Hall, P. M. | N/A | High-Resolution Genome-Wide Maps Reveal Widespread Presence of Torsional Insulation | |
| 以下是这段英文的中文翻译： |
关于草棉黄素抑制登革热病毒NS5甲基转移酶的机制研究
翻译说明： - "Mechanistic insights" 翻译为“机制研究”或“机制探讨”，表示对某种机制的理解或分析。 - "dengue virus NS5 methyltransferase" 指“登革热病毒NS5甲基转移酶”，是登革热病毒复制过程中的一个关键酶。 - "herbacetin" 是“草棉黄素”，一种天然黄酮类化合物，具有潜在的抗病毒活性。
如果需要进一步调整或补充，请告诉我！ | Bhutkar, M. | PDF | N/A | Mechanistic insights into the inhibition of dengue virus NS5 methyltransferase by herbacetin | | ALDH1亚型特异性抑制剂针对侵袭性乳腺癌亚型中的关键癌性上皮细胞群体 | PEREZ, M. | PDF | N/A | ALDH1 subtype-specific inhibitor targets key cancerous epithelial cell populations in aggressive subtypes of breast cancer | | 快速微流控灌注系统能够控制由Na+/H+交换体NHE1调控的细胞内pH值的动态变化。 | Tran, Q. D. | PDF | N/A | Rapid microfluidic perfusion system enables controlling dynamics of intracellular pH regulated by Na+/H+ exchanger NHE1 | | 发育中的哺乳动物视网膜机械特性的尺度不变性 | Shelton, E. R. | PDF | N/A | Scale invariance of mechanical properties in the developing mammalian retina | | 阿尔茨海默病患者大脑中长链非编码RNA的空间表达 | Ng, B. | PDF | N/A | Spatial Expression of Long Non-Coding RNAs in Human Brains of Alzheimer's Disease | | 上丘（Superior colliculus）在眼跳（saccadic）期间的周围场电位主要表现出对上视野（upper visual field）的视觉感觉偏好。 | Hafed, Z. M. | PDF | N/A | Superior colliculus peri-saccadic field potentials are dominated by a visual sensory preference for the upper visual field | | 改进顶点生物化学实验室并转型为基于课程的本科研究体验：从COVID-19在线教学模式中汲取的经验教训 | Rascon, A. A. | PDF | N/A | Improving the Capstone Biochemistry Lab and Evolution to a Course-Based Undergraduate Research Experience: Lessons Learned from the COVID-19 Online Modality | | 通过体内邻近标记揭示视网膜神经元中的电突触蛋白质组 | Tetenborg, S. | PDF | N/A | Uncovering the electrical synapse proteome in retinal neurons via in vivo proximity labeling | | 使用AlphaFold2预测肽的结构构象 | Ille, A. M. | PDF | N/A | Prediction of peptide structural conformations with AlphaFold2 | | 是什么让人类大脑皮层的锥体神经元在功能上如此复杂 | Aizenbud, I. | PDF | N/A | What makes human cortical pyramidal neurons functionally complex | | 卡西尼：一种用于RNA和蛋白质原位分析的简化且可扩展的方法 | Lapique, N. | PDF | N/A | Cassini: Streamlined and Scalable Method for in situ profiling of RNA and Protein | | 非洲霍乱弧菌分离株的基因组多样性与抗菌素耐药性：PulseNet非洲计划利用纳米孔测序加强基因组监测 | Foster-Nyarko, E. | PDF | N/A | Genomic Diversity and Antimicrobial Resistance of Vibrio cholerae Isolates from Africa: A PulseNet Africa Initiative Using Nanopore Sequencing to Enhance Genomic Surveillance | | DUSP6在转移过程中上调，并影响胰腺癌细胞的迁移和代谢。 | Tannus Ruckert, M. | PDF | N/A | DUSP6 is upregulated in metastasis and influences migration and metabolism in pancreatic cancer cells | | 肝脏微循环的激光散斑对比成像 | Zhukov, O. | PDF | N/A | Laser speckle contrast imaging of hepatic microcirculation | | 人类胰岛素降解酶构象动力学的表征与调控以控制酶活性 | Mancl, J. M. | PDF | N/A | Characterization and modulation of human insulin degrading enzyme conformational dynamics to control enzyme activity | | 将致癌信号重定向至RNA载体复制以治疗转移性癌症 | Lin, M. Z. | PDF | N/A | Rewiring oncogenic signaling to RNA vector replication for the treatment of metastatic cancer | | 40S核糖体亚基通过一维扩散扫描mRNA以寻找起始密码子。 | Wakabayashi, H. | PDF | N/A | 40S ribosomal subunits scan mRNA for the start codon by one-dimensional diffusion | | 长读长全基因组测序为研究与原发性脑黑色素真菌病相关的嗜神经性暗色真菌的生物学特性、应激适应机制及毒力提供了新的见解。 | Samaddar, A. | PDF | N/A | Long-read whole-genome sequencing offers novel insights into the biology, stress adaptation, and virulence of neurotropic dematiaceous fungi associated with primary cerebral phaeohyphomycosis | | LCORL和STC2基因变异可增加牛及其他动物的体型和生长速率 | Bai, F. | PDF | N/A | LCORL and STC2 variants increase body size and growth rate in cattle and other animals | | 高质量基因组组装：来自模式豆科植物百脉根（Lotus japonicus）的152种根际共生细菌 | Repolles, A. G. | PDF | N/A | High-quality genome assemblies of 152 root commensal bacteria from the model legume Lotus japonicus | | 神经元中的LAG3促进致病性α-突触核蛋白在神经元之间的传播 | Yang, X. | PDF | N/A | Neuronal LAG3 facilitates pathogenic α-synuclein neuron-to-neuron propagation | | 内源性阿片类镇痛作用的收敛状态控制 | Kimmey, B. A. | PDF | N/A | Convergent state-control of endogenous opioid analgesia | | 马查多-约瑟夫病（Machado-Joseph Disease）患者及临床前模型中的昼夜节律紊乱 | Ribeiro, R. F. | PDF | N/A | Circadian Rhythms are Disrupted in Patients and Preclinical Models of Machado-Joseph Disease | | 在壶菌生命周期中，中心粒和微管细胞骨架的动态重塑 | Long, A. F. | PDF | N/A | Dynamic remodeling of centrioles and the microtubule cytoskeleton in the lifecycle of chytrid fungi | | 在美国东北部通过创建和更新区域最需要保护的物种（RSGCN）清单进行战略保护优先排序 | Starking, M. D. | PDF | N/A | Strategic Conservation Prioritization Through Creating and Updating the Regional Species of Greatest Conservation Need (RSGCN) List in the Northeastern U.S. | | 对模型刺胞动物星虫（Nematostella vectensis）中RNA干扰机制的表征揭示了部分目标基因的沉默，但缺乏小RNA的扩增现象。 | Admoni, Y. | PDF | N/A | Characterization of RNA interference in the model cnidarian Nematostella vectensis reveals partial target silencing but lack of small RNA amplification | | RSPO3在雌激素介导的体脂分布性别差异中的作用：一项基于单细胞数据的研究 | Xu, Q. | PDF | N/A | Role of RSPO3 in Estrogen-mediated Sex Differences in Body Fat Distribution: A Single-cell Data-driven Study | | Semaphorin7A和PD-L1在乳腺退化和乳腺癌期间协同驱动免疫抑制 | Lyons, T. R. | PDF | N/A | Semaphorin7A and PD-L1 cooperatively drive immunosuppression during mammary involution and breast cancer | | 高级肝细胞癌的蛋白质组学分析揭示了治疗反应的预测性特征 | Delamarre, A. | PDF | N/A | Proteomic profiling of advanced hepatocellular carcinoma identifies predictive signatures of response to treatments | | 舞蹈：一个开源分析管道和低成本硬件，用于量化果蝇的攻击和求偶行为 | Yadav, R. S. P. | PDF | N/A | DANCE: An open-source analysis pipeline and low-cost hardware to quantify aggression and courtship in Drosophila | | 将神经群体格式化与功能联系起来 | Ruff, D. A. | PDF | N/A | Linking neural population formatting to function | | TSPO-PET显示在多发性硬化症中，被顺磁性边缘病变破坏的白质区域炎症水平更高。 | Tozlu, C. | PDF | N/A | TSPO-PET Reveals Higher Inflammation in White Matter Disrupted by Paramagnetic Rim Lesions in Multiple Sclerosis | | 微生物在分层湖泊的氧化还原过渡带中的氮去除与再循环及其与硫的耦合 | Tischer, J. | PDF | N/A | Microbial nitrogen removal versus recycling in the redox transition zone of a meromictic lake and its coupling to sulfur | | 新生链被核糖体相关质量控制复合物移除的机制 | Li, W. | PDF | N/A | Mechanism of nascent chain removal by the Ribosome-associated Quality Control complex | | RBPscan：一种用于分析RNA结合蛋白相互作用的定量体内工具 | Kretov, D. A. | PDF | N/A | RBPscan: A Quantitative, In Vivo Tool for Profiling RNA-Binding Protein Interactions | | 基于原子力显微镜（AFM）的单细胞水平下造血干细胞微环境中物理相互作用的纳米尺度表征 | Kubiak, A. J. | PDF | N/A | AFM-based nanoscale characterization of physical interaction within hematopoietic stem cells niche at single-cell level | | ORP2在MASH期间调节肝细胞中的游离胆固醇积累 | Wu, J. | PDF | N/A | ORP2 regulates free cholesterol accumulation in hepatocytes during MASH | | 分支与线性F-肌动蛋白网络调控对齐胶原纤维上的定向迁移转换行为 | Foroozandehfar, A. | PDF | N/A | Branched and Linear F-actin Networks Control Directional Migration Switching Behavior on Aligned Collagen Fibrils | | GRF转录因子的WRC结构域。结构与DNA识别。 | Biglione, F. A. | PDF | N/A | The WRC domain of GRF transcription factors. Structure and DNA recognition | | 氢键有机框架纳米转换器实现帕金森病大鼠的声光遗传学治疗 | Wang, W. | PDF | N/A | Hydrogen-bonded organic framework nanotransducers enabled sono-optogenetics for Parkinsonian rats | | 协同网络药理学与泛癌分析在中药重定位用于肿瘤治疗中的应用 | Yang, D. | PDF | N/A | Synergizing Network Pharmacology and Pan-Cancer Analysis in TCM Repositioning for Tumor Therapy | | 基于熵的模型选择方法及其在单细胞时间戳快照数据中的应用 | Stewart, W. C. | PDF | N/A | An Entropy-Based Approach to Model Selection with Application to Single-Cell Time-Stamped Snapshot Data | | 通过腹侧中线间质通道注射实现高效器官靶向运输：间质研究的新进展 | Song, X. | PDF | N/A | Highly efficient organ-targeting transport through the ventral midline interstitial channels injection: a new development of interstitium | | 细胞间信号传导稳定了单细胞水平的表型转变，并加速了异质性癌细胞群体平衡的重建。 | Lopez, D. | PDF | N/A | Intercellular signaling stabilizes single-cell level phenotypic transitions and accelerates the reestablishment of equilibrium of heterogeneous cancer cell populations | | 猕猴视觉皮层中自然纹理的对比不变性表征的出现 | Lee, G. M. | PDF | N/A | Emergence of a contrast-invariant representation of naturalistic texture in macaque visual cortex | | 抗抑郁药物通过重塑细胞外基质促进类似发育的可塑性 | Nguyen, P. T. | PDF | N/A | Antidepressants promote developmental-like plasticity through remodeling of extracellular matrix | | 短期街机动作视频游戏增强工作记忆精确性 | Asgari, A. | PDF | N/A | Short-Term Arcade-Action Video Gaming Enhances Working Memory Precision | | 早期噪音暴露与内侧橄榄耳蜗强度变化对听觉通路发育的影响 | Castagna, V. C. | PDF | N/A | Early Noise Exposure and Changes in Medial Olivocochlear Strength Alters Auditory Pathway Development | | 使用药物敏感酵母的mTOR抑制剂发现系统 | Breen, A. K. | PDF | N/A | An mTOR Inhibitor Discovery System Using Drug-Sensitized Yeast | | 开发一个模型系统以维持离体叶绿体功能 | Mohagheghi, M. V. | PDF | N/A | Developing a model system to sustain ex vivo chloroplast function | | 一种新型银钌基抗菌剂通过氧化应激诱导的大分子损伤杀死革兰氏阴性菌 | Tawiah, P. O. | PDF | N/A | A Novel Silver-Ruthenium-Based Antimicrobial Kills Gram-Negative Bacteria Through Oxidative Stress-Induced Macromolecular Damage | | 调控lncRNA malat1/Egr1轴通过Wnt、Notch和TGF-β信号通路：视网膜再生的关键机制
这段文字描述了一个科学研究的主题，涉及到长链非编码RNA（lncRNA）malat1与早期生长反应蛋白1（Egr1）之间的相互作用，以及Wnt、Notch和TGF-β这三种重要的细胞信号通路如何调控这一相互作用。这一调控机制被认为是视网膜再生过程中的一个关键环节。视网膜再生是指视网膜在受到损伤后，通过细胞增殖和分化等过程恢复其结构和功能的能力。这一研究可能有助于理解视网膜疾病的治疗和修复机制。 | Premraj, S. | PDF | N/A | Regulation of the lncRNA malat1/Egr1 Axis by Wnt, Notch and TGF-β signaling: A Key Mechanism in Retina Regeneration | | 布拉氏短螺旋体新型外膜蛋白的鉴定与特性分析 | Panda, A. | PDF | N/A | Identification and Characterization of Novel Outer Membrane Proteins of Brachyspira pilosicoli | | 开发质子密度脂肪分数微型MRI技术，用于无创定量评估小鼠模型中骨髓随年龄和辐射的变化 | Ghimire, H. M. | PDF | N/A | Development of Proton Density Fat Fraction Micro-MRI for Non-Invasive Quantitative Assessment of Bone Marrow Changes with Age and Radiation in Mouse Models | | 海草阿拉伯半乳糖蛋白：它们对适应海洋环境重要吗？ | Pfeifer, L. | PDF | N/A | Seagrass arabinogalactan-proteins: Are they important for adaptation to the marine environment? | | T淋巴细胞特异性删除SHP1和SHP2促进CD4+ T细胞的活化诱导细胞死亡并损害抗肿瘤反应 | Foster, C. J. | PDF | N/A | T Lymphocyte-Specific Deletion of SHP1 and SHP2 Promotes Activation-Induced Cell Death of CD4+ T Cells and Impairs Antitumor Response | | 使用聚焦离子束-扫描电子显微镜对伯纳特立克次体感染进行三维定量表征 | Botting, J. | PDF | N/A | Three-dimensional quantitative characterization of Coxiella burnetii infection using focused ion beam-scanning electron microscopy | | 通过注射重组EtpA糖蛋白进行肠外疫苗接种可抑制肠毒素性大肠杆菌的定植。 | Vickers, T. J. | PDF | N/A | Parenteral Vaccination with recombinant EtpA glycoprotein impairs enterotoxigenic E. coli colonization | | 手工奶酪加工环境中持久性和非持久性单核细胞增生李斯特菌的生物膜形成能力、消毒剂耐受性及遗传特征 | Aboagye, E. F. | PDF | N/A | Biofilm Forming Capacity, Sanitizer Tolerance and Genetic Characterization of Persistent and Non-Persistent Listeria monocytogenes from Artisanal Cheese Processing Environments | | 由寄生生活方式驱动的剧烈基因组缩减：可能由甲藻宿主的两株完整的内共生细菌基因组 | Nakayama, T. | PDF | N/A | Drastic genome reduction driven by parasitic lifestyle: Two complete genomes of endosymbiotic bacteria possibly hosted by a dinoflagellate | | RNA变性是环状RNA分离的基础 | Jiang, Y. | PDF | N/A | RNA denaturation underlies circular RNA separation | | 热力学不确定性关系限制了信息通过细胞信号系统的传输。 | Verma, S. | PDF | N/A | Thermodynamic uncertainty relation constraints information transmission through cell signaling systems | | 随着阿尔茨海默病进展检测到的脑-脑室耦合模式变化通过功能磁共振成像（fMRI）发现 | Campo, F. F. | PDF | N/A | Altered brain-ventricle coupling modes over Alzheimer's disease progression detected with fMRI | | 零相位延迟连接性提高了功能连接性指标的可靠性、与结构的一致性以及预测能力。 | Mehra, C. | PDF | N/A | Zero-phase-delay connectivity increases the reliability, concordance with structure, and prognostic ability of functional connectivity metrics | | 简单生长条件提高新型隐球菌中目标基因删除的效率 | Watson, R. G. | PDF | N/A | Simple Growth Conditions Improve Targeted Gene Deletion in Cryptococcus neoformans | | 沃尔巴克氏体及其pWCP质粒在库蚊发育过程中表现出不同的动态变化。 | Brunner, A. S. | PDF | N/A | Wolbachia and its pWCP plasmid show differential dynamics during the development of Culex mosquitoes | | 小脂蛋白LptM介导的脂多糖转运体组装的结构基础 | Miyazaki, R. | PDF | N/A | Structural basis of lipopolysaccharide translocon assembly mediated by the small lipoprotein LptM | | 胰岛素中的变构残基动力学：温度诱导从双六聚体向六聚体集体运动的转变 | Ayan, E. | PDF | N/A | Allosteric Residue Dynamics in Insulin: Temperature Induces Shift from Dihexamer to Hexamer Collective Motion | | 高压高尔基神经元染色用于X射线全脑成像 | Tang, Q. | PDF | N/A | High-pressure Golgi neuronal staining for X-ray whole-brain imaging | | 非小细胞肺癌原位微环境中的TCR克隆性和TCR克隆扩增 | Yu, H. | PDF | N/A | TCR clonality and TCR clonal expansion in the in situ microenvironment of non-small cell lung cancer | | 探索阿尔茨海默病严重程度中的社会认知衰退：来自比较分析的见解 | Martins, G. C. | PDF | N/A | EXPLORING SOCIAL COGNITION DECLINE ACROSS ALZHEIMER'S DISEASE SEVERITY: INSIGHTS FROM A COMPARATIVE ANALYSIS | | 通过对Candidozyma auris进行体外进化实验，使其产生对卡泊芬净的抗药性，这一过程主要通过FKS1热点I区域的突变实现。研究发现，这种抗药性的获得导致了适度的适应性代价，但并未降低其致病性。 | Ross, Z. K. | PDF | N/A | In vitro evolution of caspofungin resistance in Candidozyma auris via FKS1 hotspot I mutations results in moderate fitness trade-offs but no reduction in virulence | | 肺泡代谢物的可用性促进了铜绿假单胞菌在急性损伤肺部的继发感染。 | Baker, J. M. | PDF | N/A | Alveolar metabolite availability facilitates secondary infection by Pseudomonas aeruginosa in acutely injured lungs | | 探索新型拟杆菌门菌株：功能多样性及益生特性 | Ladewig, L. | PDF | N/A | Exploring new Bacteroidota strains: Functional Diversity and Probiotic Characteristics | | 将这段英文翻译成中文为：
全球表达谱：肠出血性大肠杆菌O157:H7在小鼠巨噬细胞吞噬体中的表达情况
这个翻译保留了原文的科学性和专业性，同时使其更符合中文的表达习惯。 | Riviere, N. A. | PDF | N/A | Global expression profile of Enterohemorrhagic Escherichia coli O157:H7 in phagosome of murine macrophages | | HIV-1 Vpr通过靶向PAF1复合物改变细胞转录 | Biguet, M. | PDF | N/A | HIV-1 Vpr alters cellular transcription by targeting the PAF1 complex | | 假丝酵母（Pseudozyma aphidis）生物活性提取物抑制植物病原体并激活番茄植株的诱导抗性。 | Harris, R. | PDF | N/A | Pseudozyma aphidis bio-active extract inhibit plant pathogens and activate induce resistance in tomato plants | | 对七种不同株系的恙虫病东方体（Orientia tsutsugamushi）进行的比较毒力分析揭示了导致疾病的多方面且复杂的毒力因子相互作用。 | Chaichana, P. | PDF | N/A | Comparative virulence analysis of seven diverse strains of Orientia tsutsugamushi reveals a multifaceted and complex interplay of virulence factors responsible for disease. | | 深入了解古菌病毒SEV1的线轴状结构及其感染策略 | Zhang, H. | PDF | N/A | Insights into the spool-like architecture and infectionstrategy of the archaeal virus SEV1 | | 化学合成作用增强了活跃微生物岩生态系统中的碳固定。 | Ricci, F. | PDF | N/A | Chemosynthesis enhances carbon fixation in an active microbialite ecosystem | | 识别非洲在基因组监测方面的差距，以应对西尼罗河病毒对全球公共卫生的威胁 | Moir, M. | PDF | N/A | Identifying genomic surveillance gaps in Africa for the global public health response to West Nile Virus | | Mettl15-Mettl17 调节从前早期到前晚期线粒体核糖体的转变。 | Zgadzay, Y. | PDF | N/A | Mettl15-Mettl17 modulates the transition from early to late pre-mitoribosome | | 识别控制策略以在12个月内消除美国养猪业中的非洲猪瘟 | Sykes, A. L. | PDF | N/A | Identifying control strategies to eliminate African swine fever from the United States swine industry in under 12 months | | 以下是这段英文的中文翻译：
II类醛缩酶/内收蛋白结构域内蛋白质相互作用的分子和进化决定因素
翻译说明： - "Molecular and evolutionary determinants" 翻译为 "分子和进化决定因素"。 - "protein interaction" 翻译为 "蛋白质相互作用"。 - "within a class II aldolase/Adducin domain" 翻译为 "在II类醛缩酶/内收蛋白结构域内"。
希望这个翻译对你有帮助！ | Seheon, M. E. | PDF | N/A | Molecular and evolutionary determinants for protein interaction within a class II aldolase/Adducin domain | | 映射NMD脱帽复合物内的相互作用揭示了Upf1如何将Dcp2招募到mRNA靶标上 | RUIZ GUTIERREZ, N. | PDF | N/A | Mapping interactions within the NMD decapping complex reveals how Upf1 recruits Dcp2 onto mRNA targets | | HeteroRepur：利用异构图神经网络高效建模抑郁症药物再利用的异质疾病图 | Lin, K.-H. | PDF | N/A | HeteroRepur: Efficient Modeling of Heterogeneous Disease Graph for Depression Drug Repurposing using Heterogeneous Graph Neural Networks | | 使用纳米聚合物靶向和治疗三阴性乳腺癌的药物耐药性：负载多柔比星和抗miR-21的A6肽-PLGA-PEG纳米颗粒在体外和体内模型中的疗效。 | Ibrahim, Z. | PDF | N/A | Targeting and combating drug resistance in triple-negative breast cancer using nano polymer: Efficacy of A6 peptide-PLGA-PEG nanoparticle loaded with doxorubicin and anti-miR-21 in in vitro and vivo model. | | 单分子成像技术在体内观察RecB蛋白的动态，揭示了大肠杆菌中DNA双链断裂修复的过程。 | Thedie, D. | PDF | N/A | Single molecule imaging of RecB in vivo reveals dynamics of DNA Double Strand Break repair in Escherichia coli | | 细菌Vibrio atlanticus的饥饿状态促进了其对甲藻Alexandrium pacificum的群体攻击行为。 | Rolland, J. L. | PDF | N/A | Starvation of the bacteria Vibrio atlanticus promotes lightning group-attacks on the dinoflagellate Alexandrium pacificum | | 雌激素受体调控结构域的结构演化 | McDougal, D. P. | PDF | N/A | Structural evolution of the estrogen receptor regulatory domain | | 自然变异影响拟南芥近着丝粒区域的减数分裂交叉频率和分离扭曲现象 | Gorringe, N. | PDF | N/A | Natural variation modifies centromere proximal meiotic crossover frequency and segregation distortion in Arabidopsis thaliana | | ModiDeC：一种用于直接纳米孔测序的多RNA修饰分类器 | Alagna, N. | PDF | N/A | ModiDeC: a multi-RNA modification classifier for direct nanopore sequencing | | 雌性埃及伊蚊（Aedes aegypti）吸血后神经肽释放和活动的动态变化 | Sajadi, F. | PDF | N/A | Dynamics of neuropeptide release and activity post-bloodmeal in the female mosquito, Aedes aegypti | | 基于合成数据训练的机器学习分割工具，用于追踪细胞骨架的聚合与解聚过程。 | Elangovan, K. | PDF | N/A | Machine learning segmentation tool trained on synthetic data for tracking cytoskeleton polymerisation and depolymerisation | | 下一代ACINUS介导的替代剪接机制图谱及其在拟南芥中通过O-糖基化调控的研究 | Shrestha, R. | PDF | N/A | Next-Generation Mapping of the ACINUS-Mediated Alternative Splicing Machinery and Its Regulation by O-glycosylation in Arabidopsis | | 豌豆保护伙伴：芽孢杆菌和假单胞菌联手对抗豌豆霜霉病 | Okechukwu, E. C. | PDF | N/A | Pea-Saving Partners: Bacillus and Pseudomonas combat downy mildew in pea crops | | 工程化活体胶水用于自主检测和按需治疗炎症性肠病 | An, B. | PDF | N/A | Engineered Living Glues for Autonomous Detection and On-Demand Treatment of Inflammatory Bowel Disease | | 单核转录组学揭示了裸盖菇素对基因表达的时间依赖性和细胞类型特异性影响。 | Liao, C. | PDF | N/A | Single-nucleus transcriptomics reveals time-dependent and cell-type-specific effects of psilocybin on gene expression | | 结构基础：经典抗原位点I抗体131-2a对呼吸道合胞病毒F蛋白的融合后特异性结合 | Peng, W. | PDF | N/A | Structural basis for postfusion-specific binding to Respiratory Syncytial Virus F protein by the canonical antigenic site I antibody 131-2a | | LAG3+ CD8+ T细胞亚群增强双特异性抗体武装的活化T细胞对激素受体阳性乳腺癌的细胞毒性 | Barnes, R. W. | PDF | N/A | LAG3+ CD8+ T cell Subset Boosts Bispecific Antibody Armed Activated T Cell Cytotoxicity Directed at Hormone Receptor+ Breast Cancers | | 与全血中中性粒细胞胞外陷阱（NET）形成相关的染色质变化反映了复杂的免疫信号传导 | Cayford, J. | PDF | N/A | Chromatin Changes Associated with Neutrophil Extracellular Trap (NET) Formation in Whole Blood Reflect Complex Immune Signaling | | 噬菌体Mu利用滑动夹进行晚期基因转录 | Ho, K. | PDF | N/A | Phage Mu Utilizes the Sliding Clamp for Late Gene Transcription | | 流感病毒微型病毒RNA激活RIG-I的两步机制 | Pitre, E. | PDF | N/A | A two-step mechanism for RIG-I activation by influenza virus mini viral RNAs | | BICD2是一种中心粒蛋白，它控制着母-子中心粒的结合以及复制的许可。 | Montes-Ruiz, L. | PDF | N/A | BICD2 is a centriolar protein that controls mother-daughter centriole engagement and the licensing of duplication | | 非对比显微CT分析揭示冷暴露对肥胖脂肪组织的性别特异性影响 | Eades, A. E. | PDF | N/A | Non-Contrast microCT Analysis of Obese Adipose in Response to Cold-Exposure Reveals Sex-Specific Alterations | | 马蹄蟹、蝎子、蜘蛛及其他螯肢动物物种中金属硫蛋白的进化历史。 | Palacios, O. | PDF | N/A | THE EVOLUTIONARY HISTORY OF METALLOTHIONEINS IN HORSESHOE CRABS, SCORPIONS, SPIDERS AND OTHER CHELICERATE SPECIES. | | 三方环逆转抗生素耐药性 | Chowdhury, F. R. | PDF | N/A | Tripartite loops reverse antibiotic resistance | | 高效Kemp消除酶通过完整计算设计 | Listov, D. | PDF | N/A | High-efficiency Kemp eliminases by complete computational design | | 关于全反式视黄酸在近视形成中的运输研究 | Chatterjee, S. | PDF | N/A | Studies of all-trans retinoic acid transport in myopigenesis | | 基于机制的硒氰酸盐对组蛋白去乙酰化酶6的抑制受氧化还原调控 | Goulart Stollmaier, J. | PDF | N/A | Mechanism-Based Inhibition of Histone Deacetylase 6 by a Selenocyanate is Subject to Redox Modulation | | 单细胞多组学数据整合与生成：scPairing | Niu, J. | PDF | N/A | Single-cell multiomics data integration and generation with scPairing | | 单细胞转录组学中的空间差异性分析 | Shi, Q. | PDF | N/A | Spatial dissimilarity analysis in single cell transcriptomics | | 湿度驱动的ABA（脱落酸）消耗决定了植物与病原体对叶片水分的竞争。 | Yasuda, S. | PDF | N/A | Humidity-driven ABA depletion determines plant-pathogen competition for leaf water | | 一个数据驱动的建模框架，用于将基因型映射到合成微生物群落功能 | Qian, Y. | PDF | N/A | A data-driven modeling framework for mapping genotypes to synthetic microbial community functions | | 在TSA数据库中发现的高度多样化的mesnidoviruses，特别是在蜘蛛中。 | Xie, J. | PDF | N/A | Highly divergent mesnidoviruses found in TSA database, especially in spiders | | c-di-GMP 是大肠杆菌群游运动所必需的。 | Hwang, Y. | PDF | N/A | c-di-GMP is required for swarming motility in E. coli | | 十种细菌占据了细菌学文献的一半，使得大多数细菌种类尚未被研究。 | Jensen, P. A. | PDF | N/A | Ten species comprise half of the bacteriology literature, leaving most species unstudied | | 病原共生体触发的上皮细胞IDO1诱导驱动炎症性肠病的区域易感性 | Spencer, P. N. | PDF | N/A | Pathobiont-triggered induction of epithelial IDO1 drives regional susceptibility to Inflammatory Bowel Disease | | 形态素在动态组织中的模式形成 | Plum, A. M. | PDF | N/A | Morphogen Patterning in Dynamic Tissues |