BioRxiv 2025-01-05 Papers
| 标题 | 作者 | PDF链接 | 代码仓库 | Title |
|---|---|---|---|---|
| Ras激酶抑制因子2促进小细胞肺癌的自我更新和克隆形成能力。 | Huisman, D. H. | N/A | Kinase Suppressor of Ras 2 promotes self-renewal and clonogenicity of small-cell lung carcinoma | |
| 将大型语言模型用于基因组知识的基准测试——以GeneTuring为例 | Hou, W. | N/A | Benchmarking large language models for genomic knowledge with GeneTuring | |
| 将这段翻译成中文是：“神经几何学源自混合感觉运动选择性，用于预测性感觉运动控制。” | Zhang, Y. | N/A | Neural Geometry from Mixed Sensorimotor Selectivity for Predictive Sensorimotor Control | |
| 优化斑马鱼幼体脊髓损伤：年龄对损伤反应的影响 | Walker, W. J. | N/A | Optimizing spinal cord injury in zebrafish larvae: effects of age on the injury response | |
| 免疫球蛋白M独立于T辅助细胞2型过敏性炎症调节气道高反应性。 | Hadebe, S. | N/A | Immunoglobulin M regulates airway hyperresponsiveness independent of T helper 2 allergic inflammation. | |
| 生长抑制因子/金属硫蛋白-3是一种硫烷硫结合蛋白。 | Shinkai, Y. | N/A | Growth inhibitory factor/metallothionein-3 is a sulfane sulfur-binding protein | |
| 前运动皮层神经元间逐渐变化的共调制模式在执行动作和观察动作时携带了动态相似的信号。 | Zhao, Z. | N/A | Progressively shifting patterns of co-modulation among premotor cortex neurons carry dynamically similar signals during action execution and observation | |
| KSR1介导小细胞肺癌的肿瘤发生和顺铂耐药性 | Chatterjee, D. | N/A | KSR1 mediates small-cell lung carcinoma tumor initiation and cisplatin resistance | |
| IFNγ在心脏血管内皮中激活一种类似免疫的调控网络。 | Arthur, T. D. | N/A | IFNγ activates an immune-like regulatory network in the cardiac vascular endothelium | |
| 寡糖基转移酶参与靶向内质网相关降解途径。 | Shenkman, M. | N/A | Oligosaccharyltransferase is involved in targeting to ER-associated degradation | |
| 如何通过皮质-基底神经节-丘脑子网络来调整决策策略以最大化奖励率 | Bahuguna, J. | N/A | How cortico-basal ganglia-thalamic subnetworks can shift decision policies to maximize reward rate | |
| 咖啡因在睡眠期间诱导大脑复杂性和临界性随年龄增长而增加 | Thölke, P. | N/A | Caffeine induces age-dependent increases in brain complexity and criticality during sleep | |
| 结合色谱耦合的小角X射线散射（SAXS）和人工智能预测的结构，以解析ParB1-parS1分区组装形成的机制。 | ANU, A. | N/A | Combining chromatography coupled SAXS and AIpredicted structures to dissect the mechanism of ParB1parS1 partition assembly formation | |
| 拷贝数变异有助于入侵植物的平行局部适应 | Wilson, J. R. | N/A | Copy number variation contributes to parallel local adaptation in an invasive plant | |
| Bacillus toyonensis biovar Thuringiensis：一个被忽视的昆虫病原体？ | Sauka, D. H. | N/A | Bacillus toyonensis biovar Thuringiensis: an overlooked entomopathogen? | |
| 分类交配和性选择对基因流动的多基因障碍的影响 | Surendranadh, P. | N/A | Effect of assortative mating and sexual selection on polygenic barriers to gene flow | |
| 肿瘤抑制因子FRMD8的损失功能通过双重机制赋予对泰莫西芬治疗的抵抗性。 | Wu, W. | N/A | Loss function of tumor suppressor FRMD8 confers resistance to tamoxifen therapy via a dual mechanism | |
| 共同更强大：利用天然藻类群落作为潜在益生菌以抑制水产养殖病原体 | Smahajcsik, D. | N/A | Stronger together: harnessing natural algal communities as potential probiotics for inhibition of aquaculture pathogens | |
| PEARL: 蛋白质释放藻酸盐与重组乳酸菌 | Tadimarri, V. S. | N/A | PEARL: Protein Eluting Alginate with Recombinant Lactobacilli | |
| 使用递归机制模型构建快速、可解释、数据驱动的神经动力学模型 | Burghi, T. B. | N/A | Rapid, interpretable, data-driven models of neural dynamics using Recurrent Mechanistic Models | |
| 叶片大小决定了玉米中由损害和食草动物诱导的挥发性物质排放。 | Waterman, J. M. | N/A | Leaf size determines damage- and herbivore-induced volatile emissions in maize | |
| 在细胞分裂过程中，染色体形状的渐进变化被量化。 | Kakui, Y. | N/A | Progressive chromosome shape changes quantified during cell divisions | |
| 烟草烟雾改变了肺腺癌中突变、选择和上位性的格局。 | Dasari, K. | N/A | Tobacco smoke alters the landscape of mutation, selection, and epistasis in lung adenocarcinoma | |
| 一种新型泛I类葡萄糖转运蛋白抑制剂DRB18在体外和体内与紫杉醇联合应用时，对人非小细胞肺癌展现出协同效应。 | Shriwas, P. | N/A | A novel pan class-I glucose transporter inhibitor DRB18 exhibits synergistic effects in vitro and in vivo with paclitaxel against human non-small cell lung cancer | |
| 阿片类药物效能的转换：用于外周镇痛的可逆光控技术 | Posa, L. | N/A | An opioid efficacy switch for reversible optical control of peripheral analgesia | |
| 通过位置记忆法与联结神经表征将项目绑定到情境中 | Huang, J. | N/A | Binding items to contexts through conjunctive neural representations with the Method of Loci | |
| FAIRSCAPE：一个不断发展的生物医学研究AI准备框架 | Al Manir, S. | N/A | FAIRSCAPE: An Evolving AI-readiness Framework for Biomedical Research | |
| 基于多轮肽结合实验与自由能回归相结合的SH2结构域的精确序列-亲和力模型 | Gagoski, D. | N/A | Accurate sequence-to-affinity models for SH2 domains from multi-round peptide binding assays coupled with free-energy regression | |
| TSvelo：通过建模基因调控、转录和剪接的级联反应实现全面的RNA速度分析 | Li, J. | N/A | TSvelo: Comprehensive RNA velocity by modeling cascade of gene regulation, transcription and splicing | |
| 最优异步布尔网络模型推断 | Karlebach, G. | N/A | Optimal Inference of Asynchronous Boolean Network Models | |
| 工程化活体胶水用于自主检测和按需治疗炎症性肠病 | Ge, C. | N/A | Engineered Living Glues for Autonomous Detection and On-Demand Treatment of Inflammatory Bowel Disease | |
| 循环中的γδ T细胞的检查点受体能够辨别癌症免疫疗法的效果。 | Catafal Tardos, E. | N/A | Checkpoint receptors in circulating γδ T cells can discern the outcome of cancer immunotherapy | |
| 生物年龄预测中IgG内老化相关糖基的绝对定量：来自糖组学和转录组学的洞见 | Huijuan, Z. | N/A | Absolute Quantification of Aging-Associated Glycans in IgG for Biological Age Prediction: Insights from Glycomics and Transcriptomics | |
| RNA触发的CRISPR-Cas12a2优先且协同切割侧链DNA | Hallmark, T. | N/A | RNA-triggered CRISPR-Cas12a2 Preferentially and Cooperatively Cleaves Collateral DNA | |
| 纳米多孔氮化硅膜与PDMS和聚丙烯在微流体ECMO中的氧传输比较 | Imtiaz, N. | N/A | Oxygen Transport in Nanoporous SiN Membrane Compared to PDMS and Polypropylene for Microfluidic ECMO | |
| γ-氨基丁酸治疗可减少雌二醇刺激的乳腺癌细胞生长和雌二醇诱导的乳腺癌发生 | Nakamura, A. | N/A | Gamma-aminobutyric acid treatment reduces estradiol-stimulated breast cancer cell growth and estradiol-induced breast tumorigenesis | |
| DeepPROTECTNeo：一种基于深度学习的个性化及RV指导的TCR-表位相互作用优化工具，采用上下文感知的Transformer模型 | Das, D. | N/A | DeepPROTECTNeo: A Deep learning-based Personalized and RV-guided Optimization tool for TCR Epitope interaction using Context-aware Transformers | |
| NfκBin: 一种基于机器学习的Nf-κB抑制剂筛选方法。 | Jain, S. | N/A | NfκBin: A Machine Learning based Method for Screening Nf-κB Inhibitors. | |
| 肿瘤抑制因子WT1及其相互作用蛋白RNA解旋酶DDX5在肾脏间质中调控微小RNA let7/Igf1r轴。 | Dey, S. | N/A | Tumour suppressor WT1 and its interacting protein RNA helicase DDX5 regulate the microRNA let7/Igf1r axis in the kidney mesenchyme | |
| 营养物质的可获得性决定了基于癌症代谢的非肿瘤药物的治疗反应 | Pyun, W. Y. | N/A | Nutrient availability dictates cancer metabolism-based therapeutic responses of non-oncology drugs | |
| 一个遗传的线粒体DNA（mtDNA）突变重塑了巨噬细胞和体内炎症细胞因子的反应。 | Marques, E. | N/A | An inherited mtDNA mutation remodels inflammatory cytokine responses in macrophages and in vivo | |
| 一个精氨酸开关驱动β-arrestin的逐步激活 | Ji, J. S. | N/A | An arginine switch drives the stepwise activation of β-arrestin | |
| 单次基于扰动的平衡训练对健康老年人恢复能力和动态步态稳定性的影响：渐进强度研究 | Zhu, R. T.-L. | N/A | Effects of Single-Session Perturbation-Based Balance Training with Progressive Intensities on Resilience and Dynamic Gait Stability in Healthy Older Adults | |
| 拼写错误单词阅读调节晚期皮层动态 | You, J. | N/A | Misspelled-word reading modulates late cortical dynamics | |
| 表征漂移反映了通过赫布学习对随机变化的持续平衡。 | Eppler, J.-B. | N/A | Representational drift reflects ongoing balancing of stochastic changes by Hebbian learning | |
| 线粒体作为生殖质中不可或缺但可替换的组成部分：对非硬骨鲟鱼原始生殖细胞特化的见解 | Gao, L. | N/A | Mitochondria as Indispensable Yet Replaceable Components of Germ Plasm: Insights into Primordial Germ Cell Specification in Non-Teleost Sturgeons | |
| 通过对麦角固醇代谢的剖析，揭示了一条优化膜相分离的代谢途径。 | Juarez-Contreras, I. | N/A | Dissection of ergosterol metabolism reveals a pathway optimized for membrane phase separation | |
| NF-κB介导HNRNPD的转录激活，导致PTEN的稳定性下降，并在口腔癌细胞中持续激活PI3K-AKT信号通路。 | Kumar, V. | N/A | NF-κB mediates transactivation of HNRNPD, resulting in PTEN destabilization and constitutive activation of the PI3K-AKT pathway in oral cancer cells | |
| 反复腹腔内给予GABAB受体激动剂巴氯芬可减少小鼠的体重。 | Ebenezer, I. S. | N/A | Repeated intraperitoneal administration of the GABAB receptor agonist baclofen reduces body weight in the mouse. | |
| 转录随机性揭示了Xist-Tsix位点长链非编码RNA调控的多种机制 | Kesler, B. K. | N/A | Transcriptional stochasticity reveals multiple mechanisms of long noncoding RNA regulation at the Xist - Tsix locus | |
| 秀丽隐杆线虫通过上下文依赖的血清素能调节来解释饮食质量。 | Feng, L. | N/A | C. elegans interprets dietary quality through context-dependent serotonergic modulation | |
| 循环分子组装体用于选择性癌细胞高尔基体破坏 | Tan, W. | N/A | Cycling Molecular Assemblies for Selective Cancer Cell Golgi Disruption | |
| 面向开放世界：利用深度学习检测和分割孢粉学载玻片上的花粉 | Feng, J. T. | N/A | Addressing the open world: detecting and segmenting pollen on palynological slides with deep learning | |
| 伊立替康引起的黏膜炎与杯状细胞相关调控化合物表达的变化有关。 | Thorpe, D. W. | N/A | Irinotecan-induced mucositis is associated with variation in the expression of regulatory compounds associated with goblet cells | |
| 通过内在测量操纵环境可供性：来自感觉运动脑动力学的证据 | Wang, S. | N/A | Manipulating Environmental Affordances via Intrinsic Measurement: Evidence from Sensorimotor Brain Dynamics | |
| 缺乏ADAP1/Centaurin-α1可改善阿尔茨海默病小鼠模型的认知障碍和神经病理学特征 | Szatmari, E. M. | N/A | Lack of ADAP1/Centaurin-α1 Ameliorates Cognitive Impairment and Neuropathological Hallmarks in a Mouse Model of Alzheimer's Disease | |
| 加勒比海八放珊瑚群落：在树木中寻找森林？ | Lasker, H. R. | N/A | Caribbean octocoral communities: finding the forest for the trees? | |
| 澳大利亚盐沼蚊（Aedes vigilax）的种群在泛交和暂时稳定的局部遗传结构之间变化。 | Schmidt, T. L. | N/A | Populations of the Australian saltmarsh mosquito Aedes vigilax vary between panmixia and temporally stable local genetic structure | |
| Mumemto：跨泛基因组的高效最大匹配 | Shivakumar, V. S. | N/A | Mumemto: efficient maximal matching across pangenomes | |
| VISTA通过四个氨基酸的细胞内基序诱导肿瘤抑制 | Zhao, Y. | N/A | VISTA-induced tumor suppression by a four amino acid intracellular motif | |
| 设计一种专性共生关系，用于基于生物体的生物遏制 | Forti, A. M. | N/A | Design of an exclusive obligate symbiosis for organism-based biological containment | |
| 光谱声学对音乐愉悦感的贡献是由自主神经输入动态塑造的。 | Cheung, V. K. M. | N/A | Spectral acoustic contributions to musical pleasure are dynamically shaped by autonomic neural inputs | |
| 基于增强条件变分自编码器的神经影像分析规范模型 | Ho, M. P. | N/A | An Enhanced Conditional Variational Autoencoder-Based Normative Model for Neuroimaging Analysis | |
| 通过高通量蛋白质-脂质相互作用筛选进行脂质结合探针的合理工程 | NISHIMURA, T. | N/A | Rational engineering of lipid-binding probes via high-throughput protein-lipid interaction screening | |
| 印度贾姆谢德布尔地区自由放养犬类种群数量与健康状况的变化与捕捉-绝育-接种-放归计划的关系 |
这段内容描述了一项在印度贾姆谢德布尔地区实施的捕捉-绝育-接种-放归（CNVR）计划，该计划对自由放养犬类的种群数量和健康状况产生了影响。研究关注的是这一计划如何改变了犬类的种群结构和健康状态。 | Smith, L. M. | PDF | N/A | Changes in free-roaming dog population demographics and health associated with a catch-neuter-vaccinate-release program in Jamshedpur, India | | 将羟丙基壳聚糖纳米纤维的电纺丝技术应用于骨再生 | wang, j. | PDF | N/A | Electrospinning of hydroxypropyl chitosan nanofibers for bone regeneration application | | 钥匙切割机：一种用于定制蛋白质和肽设计的新型优化框架 | Leyva, Y. C. | PDF | N/A | Key-cutting machine: A novel optimization framework for tailored protein and peptide design | | 转录延伸的调控预示着细胞周期中替代基因表达策略的出现 | Maya-Miles, D. | PDF | N/A | Regulation of transcription elongation anticipates alternative gene expression strategies across the cell cycle |