BioRxiv 2025-01-07 Papers
| 标题 | 作者 | PDF链接 | 代码仓库 | Title |
|---|---|---|---|---|
| 改变的亨廷顿蛋白-染色质相互作用预测亨廷顿病小鼠模型中的转录和表观遗传变化 | Pearl, J. R. | N/A | Altered Huntingtin-Chromatin Interactions Predict Transcriptional and Epigenetic Changes in Huntington's Disease Mouse Models | |
| 从分类学归属估计共识蛋白质组和代谢功能 | Belcour, A. | N/A | Estimating consensus proteomes and metabolic functions from taxonomic affiliations | |
| MAIT细胞对胶质母细胞瘤有负面影响。 | keretsu, S. | N/A | MAIT cells have a negative impact on glioblastoma | |
| 在小鼠进行嗅觉引导行为期间，基底前脑中PV和SST GABA能神经元活动的不同模式 | Moss, E. H. | N/A | Distinct patterns of PV and SST GABAergic neuronal activity in the basal forebrain during olfactory-guided behavior in mice | |
| ARHGEF18是一种响应血流的交换因子，控制着内皮细胞的紧密连接和血管渗漏。 | Batta, S. P. R. | N/A | ARHGEF18 is a flow-responding exchange factor controlling endothelial tight junctions and vascular leakage | |
| 果蝇表皮细胞本质上是机械敏感的，并能调节伤害性行为输出。 | Yoshino, J. | N/A | Drosophila epidermal cells are intrinsically mechanosensitive and modulate nociceptive behavioral outputs | |
| PI(3,5)P2 控制 I 类 PI3K 的信号传导活性 | Sun, J. | N/A | PI(3,5)P2 Controls the Signaling Activity of Class I PI3K | |
| BiGPICC：一种基于图的方法，用于从突变数据中识别致癌基因组合 | Oles, V. | N/A | BiGPICC: a graph-based approach to identifying carcinogenic gene combinations from mutation data | |
| 内在无序蛋白的构象熵阻止外来分子进入生物分子凝聚体 | Grigorev, V. | N/A | Conformational entropy of intrinsically disordered proteins bars intruders from biomolecular condensates | |
| 基于图像的微核细胞识别与分离以解析细胞后果 | DiPeso, L. | N/A | Image-based identification and isolation of micronucleated cells to dissect cellular consequences | |
| 脂质转移蛋白和一种PI 4-激酶启动核内磷酸肌醇信号传导。 | Carrillo, N. D. | N/A | Lipid transfer proteins and a PI 4-kinase initiate nuclear phosphoinositide signaling | |
| 牛（Bos taurus）热应激反应的全基因组关联研究 | Czech, B. | N/A | Genome-wide association study of heat stress response in Bos taurus | |
| 在小鼠自然攀爬过程中，选择性直接运动皮层的影响 | Koh, N. | N/A | Selective direct motor cortical influence during naturalistic climbing in mice | |
| 衰老影响肺损伤后小鼠肺毛细血管内皮细胞的重编程 | Truchi, M. | N/A | Aging affects reprogramming of murine pulmonary capillary endothelial cells after lung injury | |
| 基于抗体系统的靶向蛋白质编辑 | Rimon, O. | N/A | Targeted protein editing with an antibody-based system | |
| 使用组合通道复用和深度学习进行高维成像的升级 | Ben-Uri, R. | N/A | Escalating High-dimensional Imaging using Combinatorial Channel Multiplexing and Deep Learning | |
| 肝窦内皮细胞构成了血红蛋白清除的主要途径。 | Zurawska, G. | N/A | Liver sinusoidal endothelial cells constitute a major route for hemoglobin clearance | |
| NF1调节微管修复及对抗体-药物偶联物的敏感性 | Achutti Duso, B. | N/A | NF1 modulates microtubule repair and sensitivity to antibody-drug conjugates | |
| 创伤性脑损伤后海马颗粒细胞的双相变化 | Danielewicz, J. | N/A | Biphasic Changes in Hippocampal Granule Cells after Traumatic Brain Injury | |
| 系统性发现与人类绝缘子位点相关的定向调控基序 | Osato, N. | N/A | Systematic discovery of directional regulatory motifs associated with human insulator sites | |
| 西欧亚的草原血统与日耳曼语言的传播 | McColl, H. | N/A | Steppe Ancestry in western Eurasia and the spread of the Germanic Languages | |
| 胚胎期II型神经母细胞谱系在大小和数量上的差异与甲虫和苍蝇之间中央复合体发育时间的差异相关 | Rethemeier, S. | N/A | Differences in size and number of embryonic type-II neuroblast lineages correlate with divergent timing of central complex development between beetle and fly | |
| HIF2α抑制线粒体中谷氨酰胺酶的聚集，以维持透明细胞肾细胞癌的生长 | Zhao, W. | N/A | HIF2α inhibits glutaminase clustering in mitochondria to sustain growth of clear cell Renal Cell Carcinoma | |
| 使用信息性先验来解决具有识别错误的占用模型中的可识别性问题 | Monchy, C. | N/A | Using informative priors to account for identifiability issues in occupancy models with identification errors | |
| 免疫挑战下的Disc1+/-小鼠出现发育性嗅觉功能障碍和异常气味记忆 | Parbst, F. | N/A | Developmental olfactory dysfunction and abnormal odor memory in immune-challenged Disc1+/- mice | |
| 健康老年人中循环血小板直接控制神经血管功能的证据 | Rossetti, G. M. K. | N/A | Evidence for direct control of neurovascular function by circulating platelets in healthy older adults | |
| 以下是这段英文的中文翻译： |
通过水平基因转移从植物中获得的功能性碳水化合物活性酶在烟粉虱（Bemisia tabaci）中的作用
翻译说明： - Functional carbohydrate-active enzymes：功能性碳水化合物活性酶 - acquired by horizontal gene transfer：通过水平基因转移获得 - from plants：从植物中 - in the whitefly Bemisia tabaci：在烟粉虱（Bemisia tabaci）中
希望这个翻译对你有帮助！ | Colinet, D. | PDF | N/A | Functional carbohydrate-active enzymes acquired by horizontal gene transfer from plants in the whitefly Bemisia tabaci | | 在大样本中的同源片段 | Temple, S. D. | PDF | N/A | Identity-by-descent segments in large samples | | 通过一次性基因编辑App C端在体内长期拯救阿尔茨海默病缺陷。 | Aulston, B. | PDF | N/A | Long term rescue of Alzheimer deficits in vivo by one-time gene-editing of App C-terminus. | | 阿尔茨海默病基因SORL1调控人类小胶质细胞中溶酶体的功能 | Mishra, S. | PDF | N/A | The Alzheimer's disease gene SORL1 regulates lysosome function in human microglia | | 多组学与深度表型整合分析为马铃薯对多重非生物胁迫的响应提供了新的见解 | Zagorscak, M. | PDF | N/A | Integration of multi-omics and deep phenotyping provides novel insights into multiple abiotic stress responses in potato | | 在行为神经科学实验中评估成功率时，在保持小样本量的同时提高统计功效 | Theo, D. | PDF | N/A | Enhancing Statistical Power While Maintaining Small Sample Sizes in Behavioral Neuroscience Experiments Evaluating Success Rates | | 迈向基于自然语言的全新蛋白质设计 | Dai, F. | PDF | N/A | Toward De Novo Protein Design from Natural Language | | 在大鼠内侧颞叶中感觉和恐惧记忆的整合 | Wong, F. S. | PDF | N/A | Integration of sensory and fear memories in the rat medial temporal lobe | | 使用扩展平铺光片显微镜对无性涡虫神经元异速生长和神经肌肉投射的3D重建 | Lu, J. | PDF | N/A | 3D Reconstruction of Neuronal Allometry and Neuromuscular Projections in Asexual Planarians Using Expansion Tiling Light Sheet Microscopy | | 使用扩展平铺光片显微镜对无性生殖涡虫的神经元异速生长和神经肌肉投射进行三维重建 | Lu, J. | PDF | N/A | 3D Reconstruction of Neuronal Allometry and Neuromuscular Projections in Asexual Planarians Using Expansion Tiling Light Sheet Microscopy | | ORMDL3通过促进RIG-I的降解来抑制I型干扰素信号传导和抗肿瘤免疫。 | zeng, q. | PDF | N/A | ORMDL3 restrains type-I interferon signaling and anti-tumor immunity by promoting RIG-I degradation | | 通过适应性实验揭示的真菌交配型染色体中的庇护负载 | Guyot, L. | PDF | N/A | Sheltered load in fungal mating-type chromosomes revealed by fitness experiments | | 强选择但低重复性：温度特异性对基因组预测适应性的影响 | Rego, A. | PDF | N/A | Strong Selection, but low repeatability: Temperature-specific effects on genomic predictions of adaptation | | 以下是这段英文的中文翻译：
丙戊酸对髓母细胞瘤神经球干性和分化调节因子的调控
翻译说明： - "Modulation" 译为“调控” - "Stemness" 译为“干性”（指干细胞的特性） - "Differentiation Regulators" 译为“分化调节因子” - "Valproic Acid" 译为“丙戊酸” - "Medulloblastoma" 译为“髓母细胞瘤” - "Neurospheres" 译为“神经球”
希望这段翻译对你有帮助！如果有其他问题，请随时告诉我。 | Freire, N. H. | PDF | N/A | Modulation of Stemness and Differentiation Regulators by Valproic Acid in Medulloblastoma Neurospheres | | 以下是将这段英文翻译成中文的结果：
一个计算设计的多样化且具有选择性的过氧化酶面板，用于萜烯的氧官能化。
翻译解释： - "computationally designed" 翻译为“计算设计的”，表示通过计算方法进行设计。 - "panel" 翻译为“面板”或“一组”，在这里指的是一个集合或系列。 - "diverse and selective" 翻译为“多样化且具有选择性的”，描述了这些过氧化酶的特性。 - "peroxygenases" 翻译为“过氧化酶”，是一种酶类。 - "terpene oxyfunctionalization" 翻译为“萜烯的氧官能化”，指的是在萜烯分子中引入氧原子的化学反应。
整体翻译保持了原文的科学性和准确性，同时使中文表达流畅易懂。 | Munch, J. | PDF | N/A | A computationally designed panel of diverse and selective peroxygenases for terpene oxyfunctionalization | | UBR-1 缺陷导致秀丽隐杆线虫对伊维菌素产生抗性。 | Li, Y. | PDF | N/A | UBR-1 deficiency leads to ivermectin resistance in C. elegans | | 人类腹侧颞叶皮层功能偏侧化的个体差异：局部竞争与长程耦合 | Blauch, N. M. | PDF | N/A | Individual variation in the functional lateralization of human ventral temporal cortex: Local competition and long-range coupling | | 探索基因组编辑信息的管道，利用大型语言模型和基因组编辑元数据库 | Suzuki, T. | PDF | N/A | Pipeline to explore information on genome editing using large language models and genome editing meta-database | | BrainACTIV：利用基于扩散的图像处理技术识别驱动皮层选择性的视觉语义属性 | Garcia Cerdas, D. | PDF | N/A | BrainACTIV: Identifying visuo-semantic properties driving cortical selectivity using diffusion-based image manipulation | | 通过多重邻近标记进行染色质结构映射 | Delamarre, A. | PDF | N/A | Chromatin architecture mapping by multiplex proximity tagging | | 哺乳动物大脑发育与进化中的双重计算系统 | Imam, N. | PDF | N/A | Dual Computational Systems in the Development and Evolution of Mammalian Brains | | Rac1抑制可预防转甲状腺素蛋白淀粉样多发性神经病中的轴突细胞骨架功能障碍 | Magalhaes, J. | PDF | N/A | Rac1 inhibition prevents axonal cytoskeleton dysfunction in Transthyretin Amyloid Polyneuropathy | | 在体内通过光调节激酶对内源性标记蛋白的调控 | vigano, a. m. | PDF | N/A | In vivo regulation of an endogenously-tagged protein by a light-regulated kinase | | 高分辨率成像与三维RPE（视网膜色素上皮）片层结构的解析 | Donaldson, K. J. | PDF | N/A | High resolution imaging and interpretation of three-dimensional RPE sheet structure | | 快速模拟同源片段 | Temple, S. D. | PDF | N/A | Fast simulation of identity-by-descent segments | | 利用全基因组、线粒体DNA和单倍型块来解析复杂的人口历史：以广泛混合的北极鱼类为例 | Dallaire, X. | PDF | N/A | Leveraging whole genomes, mitochondrial DNA, and haploblocks to decipher complex demographic histories: an example from a broadly admixed arctic fish | | 秀丽隐杆线虫早期胚胎中新蛋白质翻译的景观与调控 | Shukla, Y. | PDF | N/A | Landscape and regulation of new protein translation in the early C. elegans embryo | | ABHD2活性对于孕酮对人类精子的非基因组作用不是必需的。 | Arnolds, O. | PDF | N/A | ABHD2 activity is not required for the non-genomic action of progesterone on human sperm | | 早期抗生素和益生菌治疗对极低出生体重早产儿肠道微生物组和耐药组的影响 | Kiu, R. | PDF | N/A | Impact of early life antibiotic and probiotic treatment on gut microbiome and resistome of very-low-birth-weight preterm infants | | 一种用于预测蛋白质内在无序区域相互作用的深度学习方法 | Majila, K. | PDF | N/A | A deep learning method for predicting interactions for intrinsically disordered regions of proteins | | HapCNV：低输入DNA测序数据中CNV检测的综合框架 | Yu, X. | PDF | N/A | HapCNV: A Comprehensive Framework for CNV Detection in Low-input DNA Sequencing Data | | 为细胞基因扰动的计算机模拟基准测试人工智能模型 | Li, C. | PDF | N/A | Benchmarking AI Models for In Silico Gene Perturbation of Cells | | 在实验室中展示软X射线断层扫描技术，用于结合X射线和光学显微镜的低温生物成像研究。 | O'Connor, S. | PDF | N/A | Demonstrating Soft X-Ray Tomography in the lab for correlative cryogenic biological imaging using X-rays and light microscopy | | 以下是这段文字的中文翻译：
在裸鳃类动物Caloria militaris中，对钵水母类水螅体的捕食及选择性刺丝囊的摄取动态
翻译解释： - Predation on scyphozoan polyps：对钵水母类水螅体的捕食。钵水母类（Scyphozoa）是水母的一个类群，水螅体是其生活史中的一个阶段。 - selective nematocyst incorporation dynamics：选择性刺丝囊的摄取动态。刺丝囊（nematocyst）是刺胞动物（如水母）特有的细胞器，用于捕食和防御。 - aeolid：裸鳃类动物，是一类海蛞蝓。 - Caloria militaris：一种裸鳃类动物的学名。
希望这个翻译对你有帮助！ | Dror, H. | PDF | N/A | Predation on scyphozoan polyps and selective nematocyst incorporation dynamics in the aeolid, Caloria militaris | | 病毒准种推断：个体样本比较分析方法 | Gregori, J. | PDF | N/A | Inference with Viral Quasispecies. Methods for Individual Samples Comparative Analysis. | | 状态依赖性对棘状投射神经元的调节控制帕金森病小鼠模型中左旋多巴诱导的运动障碍 | Zhai, S. | PDF | N/A | State-dependent modulation of spiny projection neurons controls levodopa-induced dyskinesia in a mouse model of Parkinson's disease | | 使用实验和模型评估浮游植物-细菌相互作用的四种潜在机制 | Weissberg, O. | PDF | N/A | Four Potential Mechanisms Underlying Phytoplankton-Bacteria Interactions Assessed Using Experiments and Models | | 一种改进的快速且灵敏的长片段扩增方法，用于基于纳米孔技术的呼吸道合胞病毒（RSV）全基因组测序 | Dong, X. | PDF | N/A | An improved rapid and sensitive long amplicon method for nanopore-based RSV whole genome sequencing | | 应对不确定性：奖励位置的变化引发海马体空间表征的重组 | Tessereau, C. | PDF | N/A | Navigating uncertainty: reward location variability induces reorganization of hippocampal spatial representations | | 基因组缺失和重复对人类大脑皮层认知能力的镜像效应 | Kumar, K. | PDF | N/A | Mirror effect of genomic deletions and duplications on cognitive ability across the human cerebral cortex | | 杏仁核GABA神经元：压力与繁殖的守门人 | Yu, J. | PDF | N/A | Amygdala GABA Neurons: Gatekeepers of Stress and Reproduction | | 麻醉成年雄性大鼠蓝斑去甲肾上腺素能神经元的昼夜节律调制 | Rae, R. J. | PDF | N/A | Diurnal Modulation of Locus Coeruleus Noradrenergic Neurons in Anesthetized Adult Male Rats | | 转录对持续氧化应激的反应需要G蛋白偶联受体信号通路的胆碱能激活 | Biswas, K. | PDF | N/A | Transcriptional responses to prolonged oxidative stress require cholinergic activation of G-protein-coupled receptor signaling | | 内源性大麻素通过逆向增益控制促进短暂的奖赏参与。 | Marcus, D. J. | PDF | N/A | Endocannabinoids facilitate transitory reward engagement through retrograde gain control | | 基于注意力机制的条件去噪扩散概率模型用于特定个体脑网络合成 | Ajith, M. | PDF | N/A | Conditional Denoising Diffusion Probabilistic Models with Attention for Subject-Specific Brain Network Synthesis | | WormID-Benchmark：在神经元分辨率下提取秀丽隐杆线虫的全脑神经动力学 | Adhinarta, J. | PDF | N/A | WormID-Benchmark: Extracting Whole-Brain Neural Dynamics of C. elegans At the Neuron Resolution | | WormID-基准测试：以神经元分辨率提取秀丽隐杆线虫的全脑神经动力学 | Adhinarta, J. | PDF | N/A | WormID-Benchmark: Extracting Whole-Brain Neural Dynamics of C. elegans At the Neuron Resolution | | 背侧海马体介导小鼠的光-音感觉预条件化任务 | Pinho, J. S. | PDF | N/A | Dorsal hippocampus mediates light-tone sensory preconditioning task in mice | | VIP中间神经元驱动的抑制性回路中的NMDA依赖性共塑性 | Jablonska, J. | PDF | N/A | NMDA-dependent coplasticity in VIP interneuron-driven inhibitory circuits | | 非常规短潜伏期听觉通路直接激活深层皮质 | Garcia, M. M. | PDF | N/A | Noncanonical Short-Latency Auditory Pathway Directly Activates Deep Cortical Layers | | ## 绘制早期大脑发育图谱：新生儿皮层连接转变的解剖学基础
摘要： 新生儿的大脑在出生后经历了快速而显著的发育，其中皮层连接的建立和重塑是至关重要的过程。本研究旨在通过先进的神经影像技术，绘制新生儿早期大脑发育的解剖学图谱，重点关注皮层连接的动态变化。我们将探讨不同脑区之间连接模式的转变，以及这些转变与早期认知和行为发展的关系。通过揭示新生儿大脑皮层连接的解剖学基础，本研究将为理解早期大脑发育的机制提供新的见解，并为早期干预和神经发育障碍的诊断提供潜在的生物标志物。
关键词： 新生儿，大脑发育，皮层连接，神经影像，解剖学，认知发展
正文：
新生期是人类大脑发育最快速、最关键的阶段之一。在此期间，大脑经历了显著的生长和重塑，为未来的认知、情感和行为发展奠定了基础。其中，皮层连接的建立和重塑是新生儿大脑发育的核心过程。
1. 新生儿大脑发育的解剖学基础
新生儿的大脑在出生时已经具备了基本的结构，但各个脑区之间的连接尚未完全建立。随着大脑的发育，神经元之间的突触连接迅速增加，并经历一个“修剪”过程，最终形成高效的神经网络。
2. 皮层连接的动态变化
近年来，随着功能磁共振成像（fMRI）和扩散张量成像（DTI）等神经影像技术的发展，研究人员能够非侵入性地观察新生儿大脑的发育过程。这些技术揭示了新生儿皮层连接的动态变化，包括：
- 连接强度的变化： 某些脑区之间的连接在出生后会逐渐增强，而另一些连接则会减弱。
- 连接模式的变化： 新生儿大脑的连接模式从局部连接为主逐渐转变为长距离连接为主。
- 网络拓扑结构的变化： 新生儿大脑的网络拓扑结构从随机网络逐渐转变为小世界网络，最终形成类似于成人的高效网络结构。
3. 皮层连接与早期发展
研究表明，新生儿皮层连接的动态变化与早期认知和行为发展密切相关。例如，语言相关脑区之间的连接强度与语言能力的发展呈正相关，而注意相关脑区之间的连接模式与注意力的发展密切相关。
4. 未来方向
未来的研究需要进一步探索以下方面：
- 皮层连接变化的分子机制： 研究基因表达、突触可塑性等因素如何影响皮层连接的动态变化。
- 皮层连接与早期经验的交互作用： 研究早期经验如何塑造皮层连接的发育轨迹。
- 皮层连接作为神经发育障碍的生物标志物： 研究皮层连接异常是否可以作为自闭症、注意力缺陷多动障碍等神经发育障碍的早期诊断指标。
结论：
绘制新生儿早期大脑发育的解剖学图谱，对于理解早期大脑发育的机制、预测个体发展轨迹以及开发早期干预策略具有重要意义。随着神经影像技术和数据分析方法的不断进步，我们有望在未来更深入地揭示新生儿大脑发育的奥秘。 | Li, D. | PDF | N/A | Mapping Early Brain Maturation: Anatomical Substrates of Cortical Connectivity Shifts in Neonates | | 在具有阿尔茨海默病相关病理的人类活检组织中，早期淀粉样蛋白脊柱反应和锥体神经元突触传递受损 | Dougalis, A. | PDF | N/A | Early amyloid spine response and impaired synaptic transmission of pyramidal neurons in human biopsies with Alzheimer's Disease-related pathology | | 果蝇Toll-2控制同源域的形成和折叠时间 | Alpar, L. | PDF | N/A | Drosophila Toll-2 controls homeotic domain formation and timing of folding | | 体内受体酪氨酸激酶活性测量揭示了发育梯度的反馈调节 | Ho, E. K. | PDF | N/A | In vivo measurements of receptor tyrosine kinase activity reveal feedback regulation of a developmental gradient | | 在运动过程中，注意线索效应会发生逆转。 | Djebbara, Z. | PDF | N/A | Attentional cueing effects are reversed during locomotion | | 纹状体内递送针对突变HTT基因的锌指蛋白可消除zQ175DN亨廷顿病小鼠的脂质表型 | Iwanowicz, A. | PDF | N/A | Intrastriatal delivery of a zinc finger protein targeting the mutant HTT gene obviates lipid phenotypes in zQ175DN HD mice | | 动态转录组重塑揭示人类神经祖细胞在视网膜色素变性模型中保护视力的机制 | Shahin, S. | PDF | N/A | Dynamic Transcriptomic Remodeling in Human Neural Progenitor Cells Reveals Mechanisms for Vision Preservation in Retinitis Pigmentosa Model | | 使用TCGA RNA-seq数据对老年肉瘤患者进行转录组分析 | Nagarajan, V. | PDF | N/A | Transcriptomic Profiling of Old Age Sarcoma Patients using TCGA RNA-seq data | | 使用单分子定位显微镜技术在小鼠大脑中识别低拷贝突触甘氨酸受体 | Camuso, S. | PDF | N/A | Identification of low copy synaptic glycine receptors in the mouse brain using single molecule localisation microscopy | | 压力、表观遗传重塑与FKBP51：通往慢性疼痛易感性的路径 | Morgan, O. B. | PDF | N/A | Stress, Epigenetic Remodeling and FKBP51: Pathways to Chronic Pain Vulnerability | | 使用脑磁图追踪40赫兹不可见光谱闪烁的传播 | Henney, M. A. | PDF | N/A | Using magnetoencephalography to track the propagation of 40 Hz invisible spectral flicker | | Elp3的缺失会损害脑室管膜细胞的成熟速度 | Tielens, S. | PDF | N/A | Loss of Elp3 impairs the maturation tempo of brain ependymal cells | | 在枕颞皮层中对生物力学上（不）可能的人类运动的神经编码 | Marrazzo, G. | PDF | N/A | Neural encoding of biomechanically (im)possible human movements in occipitotemporal cortex | | 在风险情境下，直觉性的感觉运动决策会考虑到牛顿物理学。 | Tatai, F. | PDF | N/A | Intuitive sensorimotor decisions under risk take Newtonian physics into account | | 人类睡眠纺锤波追踪实验性兴奋的脑回路 | Thom, J. L. | PDF | N/A | Human sleep spindles track experimentally excited brain circuits | | 同感觉和异感觉去习惯化在果蝇中涉及不同的神经回路。 | Charonitakis, A. | PDF | N/A | Homosensory and heterosensory dishabituation engage distinct circuits in Drosophila | | 一项温度敏感突变体筛选揭示了嗜热古菌中翻译应激诱导的细胞周期调控 | Foo, S. | PDF | N/A | A temperature sensitive mutant screen reveals translational stress-induced cell cycle regulation in a thermophilic archaeon | | 坏死性小肠结肠炎导致Wnt2b基因敲除小鼠回肠杯状细胞损失增加 | Adegboye, C. | PDF | N/A | Necrotizing enterocolitis causes increased ileal goblet cell loss in Wnt2b KO mice | | 揭示幽门螺杆菌的质粒组：一个未被探索的潜在致病性来源 | Mendoza-Guido, B. | PDF | N/A | Unraveling the plasmidome of Helicobacter pylori: an unexplored source of potential pathogenicity | | 嵌合肽（GEP44）在饮食诱导的肥胖大鼠中减少体重、能量摄入和能量消耗 | Goldberg, M. E. | PDF | N/A | The Chimeric Peptide (GEP44) Reduces Body Weight, Energy Intake, and Energy Expenditure in Diet-Induced Obese Rats | | 病毒模拟揭示在选择压力下宿主内系统动力学迁移率估计存在高估偏差 | Ochsner, N. | PDF | N/A | Viral Simulation Reveals Overestimation Bias in Within-Host Phylodynamic Migration Rate Estimates Under Selection | | 蜂王缺失揭示了隐秘的工蜂影响力，并分散了熊蜂的社会网络结构。 | Ruttenberg, D. M. | PDF | N/A | Queen loss unmasks cryptic worker influence and decentralizes the bumble bee social network | | protPheMut：一种用于人类错义变异中癌症和神经发育障碍分类的可解释机器学习工具 | Wang, J. | PDF | N/A | protPheMut: An Interpretable Machine Learning Tool for Classification of Cancer and Neurodevelopmental Disorders in Human Missense Variants | | 对短串联重复序列变异的多癌症分析揭示了共享的基因调控机制 | Xia, F. | PDF | N/A | Multicancer analyses of short tandem repeat variations reveal shared gene regulatory mechanisms | | 狂犬病病毒G蛋白mRNA与肌肉靶向脂质纳米颗粒配方在小鼠中的免疫原性研究 | LI, Q. | PDF | N/A | Immunogenicity of Rabies Virus G-Protein mRNA Formulated with Muscle Targeting Lipid Nanoparticles in Mice | | Armadillo重复仅蛋白对植物CNGC通道的功能至关重要 | Kulich, I. | PDF | N/A | Armadillo Repeat Only Proteins Are Crucial for the Function of Plant CNGC Channels | | 确定苋菜（Amaranthus powellii）对MCPA抗性的机制 | Aicklen, I. | PDF | N/A | Determination of the mechanisms of MCPA resistance in Amaranthus powellii | | 局部引发的行波生成了全局可观测的行波。 | Petras, K. | PDF | N/A | Locally induced traveling waves generate globally observable traveling waves | | MRP8-Cre驱动小鼠中的脱靶基因组效应使其在体重增加和代谢研究中的应用变得复杂。 | Soltani, F. | PDF | N/A | Off-target genomic effects in MRP8-Cre driver mice complicate its use in weight gain and metabolic studies | | 甲烷氧化细菌Methylomicrobium album BG8大量释放S层单位及相关蛋白。 | Hermary, M. K. | PDF | N/A | Prolific release of S-layer units and associated proteins by the methanotrophic bacterium Methylomicrobium album BG8 | | 腺病毒性角膜炎中的病毒和细胞特异性HMGB1分泌及上皮下浸润形成 | Saha, A. | PDF | N/A | Virus and Cell Specific HMGB1 Secretion and Subepithelial Infiltrate Formation in Adenovirus Keratitis | | 基于邻近性的蛋白质组学揭示Git1作为Smoothened信号传导的调控因子 | Ge, X. | PDF | N/A | Proximity based proteomics reveals Git1 as a regulator of Smoothened signaling | | 追踪北海大西洋鳕鱼40年间的稳定性变化 | Tao, H.-H. | PDF | N/A | Tracking changes in stability of North Sea Atlantic cod in 40 years | | 欧洲芦苇莺宿主基因组适应杜鹃巢寄生的特征 | Smith, W. J. | PDF | N/A | Signatures of genomic adaptation to Cuckoo brood parasitism in Reed Warbler hosts across Europe | | strata：一种推断性染色体和其他超基因进化层次的新工作流程 | Rougemont, Q. | PDF | N/A | EASYstrata: a new workflow to infer evolutionary strata along sex chromosomes and other supergenes | | 在1,027个长读长基因组中进行的详细串联重复等位基因分析揭示了全基因组范围内的致病性模式 | Danzi, M. C. | PDF | N/A | Detailed tandem repeat allele profiling in 1,027 long-read genomes reveals genome-wide patterns of pathogenicity | | PROTAC分子介导的SpCas9蛋白降解以实现精确基因组编辑 | Sun, S. | PDF | N/A | PROTAC molecule-mediated SpCas9 protein degradation for precise genome editing | | 发现蛋白质中的表达调控残基 | Jiang, F. | PDF | N/A | Discovery of Expression-Governing Residues in Proteins | | 基因组学中序列-功能可解释深度学习模型的综合基准与指南 | Sun, C. | PDF | N/A | A comprehensive benchmark and guide for sequence-function interpretable deep learning models in genomics | | 深度学习在癌症基因组生物标志物发现中的应用 | Unger, M. | PDF | N/A | Deep Learning for Biomarker Discovery in Cancer Genomes | | 量化微生物组中的宏基因组菌株关联——以Anpan为例 | Ghazi, A. R. | PDF | N/A | Quantifying Metagenomic Strain Associations fromMicrobiomes with Anpan | | Ralstonia solanacearum（青枯病菌）的效应蛋白RipAV靶向植物的U-box蛋白，并诱导BIK1通过蛋白酶体途径降解。 | Rufian, J. S. | PDF | N/A | The Ralstonia solanacearum effector RipAV targets Plant U-box proteins and induces proteasomal-dependent degradation of BIK1 | | 变异效应取决于多基因背景：实验、临床和进化的意义 | Chapel, M. E. | PDF | N/A | Variant effects depend on polygenic background: experimental, clinical, and evolutionary implications | | 《二穗短柄草根系结构和解剖对硝酸盐和铵盐适应的调控分析》 | Rouina, H. | PDF | N/A | Regulatory Analysis of Root Architectural and Anatomical Adaptation to Nitrate and Ammonium in Brachypodium distachyon | | 光和叶绿体氧化还原状态调节了烟草叶片感染丁香假单胞菌（Pseudomonas syringae pv tabaci）的进程。 | Arce, R. C. | PDF | N/A | Light and chloroplast redox state modulate the progression of tobacco leaf infection by Pseudomonas syringae pv tabaci | | 伏隔核多巴胺编码了食欲性巴甫洛夫条件反射中的痕迹期。 | Wanat, M. | PDF | N/A | Nucleus accumbens dopamine encodes the trace period during appetitive Pavlovian conditioning | | 人类皮层动力学反映了局部几何结构和网络拓扑结构的梯度贡献。 | Royer, J. | PDF | N/A | Human cortical dynamics reflect graded contributions of local geometry and network topography | | 应激激活的中脑岛至BNST通路调节雌性小鼠戒断诱导的负性情感易感性 | Williams, B. M. | PDF | N/A | A stress-activated mid-insula to BNST pathway regulates susceptibility to abstinence-induced negative affect in female mice | | 从外侧内嗅皮层投射到基底外侧杏仁核的神经元介导了偶然气味-味觉关联的编码。 | Gonzlez-Parra, J. A. | PDF | N/A | Projecting neurons from lateral entorhinal cortex to basolateral amygdala mediate the encoding of incidental odor-taste associations | | Fis1 是皮层锥体神经元树突线粒体网络发育所必需的。 | Strucinska, K. | PDF | N/A | Fis1 is required for the development of the dendritic mitochondrial network in pyramidal cortical neurons | | 在300种人类细胞和组织中，选择性剪接呈现出稀疏分布的特点，并且与细胞身份密切相关。 | Liang, A. | PDF | N/A | Alternative splicing in 300 human cells and tissues is sparsely distributed and strongly associated with cell identity |