BioRxiv 2025-01-08 Papers
| 标题 | 作者 | PDF链接 | 代码仓库 | Title |
|---|---|---|---|---|
| microRNA-19b调控鸟类前脑的增殖与模式形成 | Mishra, A. | N/A | microRNA-19b regulates proliferation & patterning in the avian forebrain | |
| 通过对适应性效应全分布的分析来检测驯化信号 | Castellano, D. | N/A | Detection of Domestication Signals through the Analysis of the FullDistribution of Fitness Effects | |
| 视听提示必须具有可预测性，并与胜利配对，以驱动风险选择。 | Hathaway, B. A. | N/A | Audiovisual cues must be predictable and win-paired to drive risky choice | |
| 从体内脉冲序列重建电路连接性：基于深度域自适应匹配的方法 | Sheng, K. | N/A | Reconstructing Circuit Connectivity from in vivo Spike Trains Using Deep Domain-Adaptive Matching | |
| mimicINT：一种用于推断微生物-宿主蛋白质相互作用的工作流程 | Choteau, S. A. | N/A | mimicINT: a workflow for microbe-host protein interaction inference | |
| 经验回放促进了网格细胞多尺度六边形模式的快速形成。 | Zhang, B. | N/A | Experience replay facilitates the rapid formation of multi-scale hexagonal patterns of grid cells | |
| 使用人类诱导多能干细胞（iPSC）群体筛选药物反应的变异性 | Platani, M. | N/A | Screening for variable drug responses using human iPSC cohorts | |
| 除了毒牙之外：Uloboridae蜘蛛虽然失去了毒液，但并未失去其毒性。 | Peng, X. | N/A | Beyond venomous fangs: Uloboridae spiders have lost their venom but not their toxicity | |
| 电影揭示了婴儿视觉皮层的精细组织结构。 | Ellis, C. T. | N/A | Movies reveal the fine-grained organization of infant visual cortex | |
| 工程细菌启动并控制一种溶瘤病毒 | Singer, Z. S. | N/A | Engineered bacteria launch and control an oncolytic virus | |
| 撤回：HER2细胞定位、细胞间接触和细胞密度调节HER2阳性乳腺癌中的癌细胞可塑性 | Sameri, S. | N/A | WITHDRAWN: HER2 Cellular Localization, Cell-Cell Contacts, and Cell Density Regulate Cancer Cell Plasticity in HER2+ Breast Cancer | |
| 小鼠梨状皮层和内嗅皮层中气味与位置信息的差异编码 | Mena, W. | N/A | Differential encoding of odor and place in mouse piriform and entorhinal cortex | |
| 皮层感觉老化具有层次特异性 | Liu, P. | N/A | Cortical sensory aging is layer-specific | |
| 本地树木覆盖率预测热带乡村景观中蚊子物种丰富度和疾病媒介的存在 | Farner, J. E. | N/A | Local tree cover predicts mosquito species richness and disease vector presence in a tropical countryside landscape | |
| 脑类器官中的原序列模拟了内在脑状态 | van der Molen, T. | N/A | Protosequences in brain organoids model intrinsic brain states | |
| 物种界定分析表明，来自地中海东北部沿海地区的Terpios gelatinosus（海绵动物门，普通海绵纲）存在隐存种现象。 | Ozturk, E. | N/A | Species delimitation analysis indicates cryptic speciation for Terpios gelatinosus (Porifera, Demospongiae) from coastal regions of the northeastern Mediterranean Sea | |
| MagIC-Cryo-EM: 在磁性珠粒上对异质样品中稀缺大分子进行结构测定 | Arimura, Y. | N/A | MagIC-Cryo-EM: Structural determination on magnetic beads for scarce macromolecules in heterogeneous samples | |
| 将圆形变为方形或结合条纹：真核生物中棋盘图案的多样性与形成 | Galipot, P. | N/A | Changing rounds into squares or combining stripes: Diversity and formation of checkerboard patterns in Eukaryotes | |
| 通过深度学习探索从头设计的双功能抗菌肽库 | Dong, R. | N/A | Exploring the repository of de novo designed bifunctional antimicrobial peptides through deep learning | |
| CapP介导了机会性人类病原体蜡样芽孢杆菌（Bacillus cereus）中生物膜特异性菌毛的结构形成。 | Alvarez-Mena, A. | N/A | CapP mediates the structural formation of biofilm-specific pili in the opportunistic human pathogen Bacillus cereus | |
| 爱丁堡大学生物科学家开放数据实践的兴起 | Deeb, H. | N/A | The Rise of Open Data Practices Among Bioscientists at the University of Edinburgh | |
| ATG6与NPR1相互作用通过增加其核积累和稳定性，增强了拟南芥对Pst DC3000/avrRps4的抗性。 | Zhang, B. | N/A | ATG6 interacting with NPR1 increases Arabidopsis thaliana resistance to Pst DC3000/avrRps4 by increasing its nuclear accumulation and stability | |
| NFIB影响小鼠GABA能神经元成熟过程中祖细胞的能力 | Bright, A. R. | N/A | NFIB influences progenitor competence in maturation of GABAergic neurons in mice | |
| 循环中的线粒体生物能量学作为肝脏生物能量学的指纹：如何监测遗传性MASLD | Paolini, E. | N/A | Circulating mitochondrial bioenergetics as fingerprint of the hepatic one: how to monitor genetic MASLD | |
| 大流行性大肠杆菌克隆的基本繁殖数差异显著，且可与大流行性流感病毒相媲美。 | Ojala, F. A. | N/A | Basic reproduction number for pandemic Escherichia coli clones varies markedly and can be comparable to pandemic influenza viruses | |
| 钙膜蛋白/C16orf74中的一个新基序决定了钙调磷酸酶介导的多聚体去磷酸化作用。 | Bradburn, D. A. | N/A | A novel motif in calcimembrin/C16orf74 dictates multimeric dephosphorylation by calcineurin | |
| Peptonizer2000：为宏蛋白质组学带来信心 | Holstein, T. | N/A | The Peptonizer2000: bringing confidence to metaproteomics | |
| 磷酸二酯酶1A与YTHDF2发生物理相互作用，并加强了非小细胞肺癌的进展。 | Zhang, C. | N/A | Phosphodiesterase 1A physically interacts with YTHDF2 and reinforces the progression of non-small cell lung cancer | |
| 磷酸二酯酶1A与YTHDF2发生物理相互作用，并加强非小细胞肺癌的进展。 | Zhang, C. | N/A | Phosphodiesterase 1A physically interacts with YTHDF2 and reinforces the progression of non-small cell lung cancer | |
| 大分子凝聚不太可能缓冲细胞内渗透压。 | Kay, A. R. | N/A | Macromolecular condensation is unlikely to buffer intracellular osmolality | |
| 蛋白激酶A调控的中心体肌动蛋白池设定了T细胞极化的阈值。 | Randriamampita, C. | N/A | A protein kinase A-regulated centrosomal actin pool sets the threshold for T cell polarization | |
| 无细胞表达和SMA共聚物封装功能性受体酪氨酸激酶疾病变体FGFR3-TACC3 | Snow, A. J. D. | N/A | Cell-free expression and SMA copolymer encapsulation of a functional receptor tyrosine kinase disease variant, FGFR3-TACC3 | |
| 一种可复制且可推广的基于神经影像学的个体疼痛敏感性指标 | Zhang, L.-B. | N/A | A replicable and generalizable neuroimaging-based indicator of pain sensitivity across individuals | |
| 巴罗萨谷地区葡萄园蒸散发组分、作物系数及水分生产力的区域动态变化 | Phogat, V. | N/A | Regional dynamics in the evapotranspiration components, crop coefficients and water productivity of vineyards in the Barossa Valley | |
| 入侵物种甘蔗蟾蜍（Rhinella marina）归巢行为的神经与感官基础 | Shaykevich, D. A. | N/A | Neural and sensory basis of homing behavior in the invasive cane toad, Rhinella marina | |
| P-body因子在白色念珠菌丝状生长和应激反应中的作用 | Tosiano, M. A. | N/A | Roles of P-body factors in Candida albicans filamentation and stress response | |
| 同步θ网络表征成功的记忆检索 | Rao, A. M. | N/A | Synchronous theta networks characterize successful memory retrieval | |
| 蛋白质稳态调节抗生素耐药细菌中的基因剂量进化 | Jena, C. | N/A | Proteostasis modulates gene dosage evolution in antibiotic-resistant bacteria | |
| ComBat-met：调整DNA甲基化数据中的批次效应 | Wang, J. | N/A | ComBat-met: Adjusting Batch Effects in DNA Methylation Data | |
| 单分子脂质生物传感器减轻内源性效应蛋白的抑制 | Holmes, V. | N/A | Single molecule Lipid Biosensors Mitigate Inhibition of Endogenous Effector Proteins | |
| Colora：一个用于完整染色体级别从头基因组组装的Snakemake工作流程 | Obinu, L. | N/A | Colora: A Snakemake Workflow for Complete Chromosome-scale De Novo Genome Assembly | |
| Maf家族bZIP转录因子NRL在视网膜光感受器中与RNA结合蛋白和R环相互作用 | Corso Diaz, X. | N/A | Maf-family bZIP transcription factor NRL interacts with RNA-binding proteins and R-loops in retinal photoreceptors | |
| 基于生物学信息的皮质模型预测光遗传学扰动 | Sourmpis, C. | N/A | Biologically informed cortical models predict optogenetic perturbations | |
| 自上而下的反馈至关重要：类脑连接模式对视听整合的功能影响 | Tugsbayar, M. | N/A | Top-down feedback matters: Functional impact of brainlike connectivity motifs on audiovisual integration | |
| 撤回：遮荫对加勒比海柳珊瑚（Briareum asbestinum）行为生态学的影响，研究地点为美国佛罗里达群岛 | Draud, S. L. | N/A | WITHDRAWN: Influence of Shading on the Behavioral Ecology of a Caribbean Alcyonacean Octocoral, Briareum asbestinum, in the Florida Keys, United States | |
| 以下是这段文字的中文翻译： |
计算视角下C肽流动性驱动的小型前胰岛素变构行为研究
这个标题描述了一项研究，旨在通过计算手段揭示C肽（C Peptide）的流动性如何影响小型前胰岛素（Mini Proinsulin）的变构行为。变构行为是指蛋白质在结合特定分子或发生结构变化时，其功能或活性发生改变的现象。C肽是前胰岛素分子的一部分，其流动性可能对前胰岛素的整体结构和功能有重要影响。 | AYAN, E. | PDF | N/A | Computational Insights into the Allosteric Behavior of Mini Proinsulin Driven by C Peptide Mobility | | 多基因载体的模块化克隆用于杆状病毒系统和酵母 | Lai, Z. | PDF | N/A | Modular cloning of multigene vectors for the baculovirus system and yeast | | 扭转诱导的创伤性视神经病变（TITON）：一种生理相关的创伤性视神经病变动物模型 | Ryan, A. K. | PDF | N/A | Torsion-Induced Traumatic Optic Neuropathy (TITON): A Physiologically Relevant Animal Model of Traumatic Optic Neuropathy | | 朊病毒的传播受到一个层次化网络的控制，该网络涉及核内的Tfap2c和hnRNP K因子以及细胞质中的mTORC1复合物。 | Sellitto, S. | PDF | N/A | Prion propagation is controlled by a hierarchical network involving the nuclear Tfap2c and hnRNP K factors and the cytosolic mTORC1 complex | | 效应器选择先于运动规范：来自运动规划中重复效应的证据 | Seegelke, C. | PDF | N/A | Effector selection precedes movement specification: evidence from repetition effects in motor planning | | RDAforest: 识别多基因适应的环境驱动因素。 | Matz, M. V. | PDF | N/A | RDAforest: identifying environmental drivers of polygenic adaptation. | | 单核细胞展开蛋白反应分析（SNUPR）：一种揭示多发性骨髓瘤中硼替佐米耐药机制的新方法 | Arguello, R. J. | PDF | N/A | Single-Nuclei Analysis of the Unfolded Protein Response (SNUPR): A Novel Method revealing bortezomib resistance mechanisms in Multiple Myeloma | | 一种新的离散几何方法用于利用化学交联进行蛋白质的综合对接 | Zhang, Y. | PDF | N/A | A new discrete-geometry approach for integrative docking of proteins using chemical crosslinks | | 宿主基因型塑造了硬粒小麦根部的真菌群落 | TRINQUIER, M. | PDF | N/A | Host genotype shapes root mycobiota in durum wheat | | 一个保留内源性UTR的高通量蛋白质标记工具包，用于研究动质体中的基因调控。 | Carbajo, C. G. | PDF | N/A | A high-throughput protein tagging toolkit that retains endogenous UTRs for studying gene regulation in Kinetoplastids. | | 反事实扩散模型用于病理学中人工智能模型的机制解释性 | Zigutyte, L. | PDF | N/A | Counterfactual Diffusion Models for Mechanistic Explainability of Artificial Intelligence Models in Pathology | | 4-甲基吡唑介导的细胞色素P450 2E1抑制保护肾上皮细胞免受顺铂毒性，但对膀胱癌细胞无保护作用 | Akakpo, J. Y. | PDF | N/A | 4-Methylpyrazole-mediated inhibition of Cytochrome P450 2E1 protects renal epithelial cells, but not bladder cancer cells, from cisplatin toxicity | | 人类骨骼肌在重复的抗阻训练后，既具有可逆的蛋白质组特征，也保留了蛋白质组记忆。 | Hulmi, J. J. | PDF | N/A | Human skeletal muscle possesses both reversible proteomic signatures and a retained proteomic memory after repeated resistance training | | 使用U-Net集成进行密集细胞和细胞器的分割 | Fulton, S. | PDF | N/A | Densely Populated Cell and Organelles Segmentation with U-Net Ensembles | | 同时抑制COX-1和COX-2不足以引发与长期使用非甾体抗炎药（NSAID）相关的肠病。 | Barekat, K. | PDF | N/A | Concomitant suppression of COX-1 and COX-2 is insufficient to induce enteropathy associated with chronic NSAID use | | GABRA1移码变异损害GABAA受体的蛋白质稳态 | Williams, M. P. | PDF | N/A | GABRA1 frameshift variants impair GABAA receptor proteostasis | | HIV-1蛋白编码序列存在于相关细菌中。 | Pelaez-Prestel, H. F. | PDF | N/A | HIV-1 protein coding sequences are present in relevant bacteria | | 人类CFTR开放状态的结构与氯离子传导特性 | Zeng, Z. W. | PDF | N/A | Structure and Cl- Conductance Properties of the Open State of Human CFTR | | 大脑反应的持续时间各不相同——建模策略与挑战 | Skukies, R. S. | PDF | N/A | Brain responses vary in duration - modeling strategies and challenges | | FaDAM3 和 FaDAM4 是调控栽培草莓季节性二态性的候选基因。 | David, S. | PDF | N/A | FaDAM3 and FaDAM4 are candidate genes for the regulation of seasonal dimorphism in cultivated strawberry | | 患者来源的三阴性乳腺癌异种移植模型实现了解构和化疗反应的预测 | Lei, J. T. | PDF | N/A | Patient-Derived Xenografts of Triple-Negative Breast Cancer Enable Deconvolution and Prediction of Chemotherapy Responses | | 能量变化预测冈比亚按蚊的死亡率 | Zeferino, T. G. | PDF | N/A | Energetic shifts predict the mortality of Anopheles gambiae | | 关于巴西东部拉戈阿圣塔地区中全新世时期一种小型食果蝙蝠的说明 | Chahud, A. | PDF | N/A | NOTE ON A SMALL FRUIT-EATING BAT FROM THE MIDDLE HOLOCENE OF LAGOA SANTA, EASTERN BRAZIL | | 有机磷酸酯的计算机毒性评估：一项关于其与人血清白蛋白（HSA）相互作用的密度泛函理论（DFT）和分子对接研究 | Singh, T. | PDF | N/A | In Silico Toxicity Assessment of Organophosphates: A DFT and Molecular Docking Study on Their Interaction with Human Serum Albumin (HSA) | | ChromBPNet：基于偏差分解、基础分辨率的深度学习模型揭示染色质可及性中的顺式调控序列语法、转录因子足迹和调控变异 | Pampari, A. | PDF | N/A | ChromBPNet: bias factorized, base-resolution deep learning models of chromatin accessibility reveal cis-regulatory sequence syntax, transcription factor footprints and regulatory variants | | LPS诱导的脓毒症以区域和警觉状态特异性的方式破坏大脑活动。 | Leemburg, S. | PDF | N/A | LPS-induced sepsis disrupts brain activity in a region- and vigilance-state specific manner | | 基因组-热力学相位同步：麦克斯韦妖般的细胞命运转变调控 | Tsuchiya, M. | PDF | N/A | Genomic-Thermodynamic Phase Synchronization: Maxwell's Demon-Like Regulation of Cell Fate Transition | | 肥胖中血管生成信号的综合分析：毛细血管特征与VEGF结合动力学 | Lee, Y. | PDF | N/A | Integrative analysis of angiogenic signaling in obesity: capillary features and VEGF binding kinetics | | 成年小鼠视觉皮层中移植的中间神经元在新的眼优势可塑性时期的整合 | Rakela, B. | PDF | N/A | Integration of Transplanted Interneurons Over a New Period of Ocular Dominance Plasticity in Adult Mouse Visual Cortex | | 钙离子动态调节发育节奏，从而产生进化上不同的轴突束长度 | Lindhout, F. W. | PDF | N/A | Calcium dynamics tune developmental tempo to generate evolutionarily divergent axon tract lengths | | CLCNet：一种用于植物基因组预测的对比学习与染色体感知网络 | Huang, J. | PDF | N/A | CLCNet: a contrastive learning and chromosome-aware network for genomic prediction in plants | | 最优异步布尔网络模型推断 | Karlebach, G. | PDF | N/A | Optimal Inference of Asynchronous Boolean Network Models | | 甲烷菌与短链脂肪酸的微生物产量变化及人体可代谢能量的改变有关。 | Dirks, B. | PDF | N/A | Methanogens are associated with altered microbial production of short-chain fatty acids and human-host metabolizable energy | | 脑引导的卷积神经网络揭示了场景处理中的任务特定表征 | Hansen, B. C. | PDF | N/A | Brain-Guided Convolutional Neural Networks Reveal Task-Specific Representations in Scene Processing | | 内源性大麻素通过逆向增益控制促进短暂的奖励参与。 | Marcus, D. J. | PDF | N/A | Endocannabinoids facilitate transitory reward engagement through retrograde gain control | | WormID-Benchmark：在神经元分辨率下提取秀丽隐杆线虫的全脑神经动力学 | Adhinarta, J. | PDF | N/A | WormID-Benchmark: Extracting Whole-Brain Neural Dynamics of C. elegans At the Neuron Resolution | | Elp3的缺失会损害脑室管膜细胞的成熟速度 | Tielens, S. | PDF | N/A | Loss of Elp3 impairs the maturation tempo of brain ependymal cells | | 在风险情境下的直觉性感觉运动决策会考虑牛顿物理学。 | Tatai, F. | PDF | N/A | Intuitive sensorimotor decisions under risk take Newtonian physics into account | | 同源感觉和异源感觉的去习惯化在果蝇中涉及不同的神经回路。 | Charonitakis, A. | PDF | N/A | Homosensory and heterosensory dishabituation engage distinct circuits in Drosophila | | 深度学习在癌症基因组生物标志物发现中的应用 | Unger, M. | PDF | N/A | Deep Learning for Biomarker Discovery in Cancer Genomes | | 从外侧内嗅皮层投射到基底外侧杏仁核的神经元介导了偶然气味-味觉关联的编码。 | Gonzalez-Parra, J. A. | PDF | N/A | Projecting neurons from lateral entorhinal cortex to basolateral amygdala mediate the encoding of incidental odor-taste associations | | 较高的上表皮气孔密度与春小麦较低的谷物产量相关。 | Samantara, K. | PDF | N/A | Higher adaxial stomatal density is associated with lower grain yield in spring wheat | | 钙触发的质外体活性氧爆发平衡重力和机械信号以导航土壤 | Kulich, I. | PDF | N/A | Calcium-triggered apoplastic ROS bursts balance gravity and mechanical signals to navigate soil | | 《睾丸酮丛毛单胞菌TA441在类固醇降解中去除C17丙酰基残基所需的脱氢酶、水合酶和醛缩酶的鉴定：(ChsE1-ChsE2)2和(ChsH1-ChsH2MaoC)2-(Ltp2-ChsH2DUF35)2复合物的结构与功能解析》
本研究聚焦于睾丸酮丛毛单胞菌TA441在类固醇降解过程中，对C17位丙酰基残基的去除机制。研究团队通过系统性的实验与分析，成功鉴定出参与该生物转化过程的关键酶类，包括脱氢酶、水合酶和醛缩酶。这些酶在类固醇分子侧链的修饰与断裂中扮演着不可或缺的角色，确保了降解途径的高效进行。
研究进一步深入探讨了这些酶在空间结构上的组织方式及其功能协同机制。特别是，研究揭示了两种重要的酶复合物：(ChsE1-ChsE2)2和(ChsH1-ChsH2MaoC)2-(Ltp2-ChsH2DUF35)2。这些复合物通过特定的蛋白质-蛋白质相互作用形成稳定的多酶组装体，不仅优化了底物的传递与转化效率，还可能通过变构效应调节各组成酶的活性，以适应不同的代谢需求。
通过对这些复合物的高分辨率结构解析，研究团队获得了关于其催化机制、底物识别及产物释放的详细分子信息。这些发现不仅深化了我们对睾丸酮丛毛单胞菌TA441类固醇降解途径的理解，也为设计新型生物催化剂或开发针对相关代谢疾病的治疗策略提供了宝贵的理论依据。 | Horinouchi, M. | PDF | N/A | Identification of Dehydrogenase, Hydratase, and Aldolase Required for C17 Propionyl Residue Removal in Steroid Degradation by Comamonas testosteroni TA441: Structural and Functional Insights into the (ChsE1-ChsE2)2 and (ChsH1-ChsH2MaoC)2-(Ltp2-ChsH2DUF35)2 Complexes | | 丰富且活跃的产乙酸菌增强了蓝碳生态系统的二氧化碳吸收能力。 | Rodriguez Martinez, K. | PDF | N/A | Abundant and active acetogens enhance the carbon dioxide sink of Blue Carbon ecosystems | | 与佛罗里达西南部卡伦藻（Karenia brevis）有害藻华相关的多样化单链RNA病毒 | Lim, S. J. | PDF | N/A | Diverse ssRNA viruses associated with Karenia brevis harmful algal blooms in Southwest Florida | | 粪肠球菌MBBL3展现出良好的益生潜力及对牛乳腺炎相关大肠杆菌和肺炎克雷伯菌的抗菌效果 | Siddique, N. | PDF | N/A | Enterococcus faecium MBBL3 Exhibits Promising Probiotic Potential and Antimicrobial Efficacy Against Bovine Mastitis-Associated Escherichia coli and Klebsiella pneumoniae | | 优化合成性囊性纤维化痰液培养基以促进非典型流感嗜血杆菌的生长 | Do Carmo Silva, P. | PDF | N/A | Optimising synthetic cystic fibrosis sputum media for growth of non-typeable Haemophilus influenzae | | 长期耕作制度对细菌碳同化结构的影响 | Schaedel, M. | PDF | N/A | Long-term tillage regime structures bacterial carbon assimilation | | 文化支持的SAR116支系的生态生理学展示了代谢和空间生态位的分配 | Coelho, J. T. | PDF | N/A | Culture-supported ecophysiology of the SAR116 clade demonstrates metabolic and spatial niche partitioning | | 针对组蛋白乙酰化以克服寄生虫阴道毛滴虫（Trichomonas vaginalis）的耐药性 | Seifert-Gorzycki, J. | PDF | N/A | Targeting histone acetylation to overcome drug resistance in the parasite Trichomonas vaginalis | | 分离感染人畜共患病原体猪链球菌的噬菌体揭示了新的结构和基因组特征 | Osei, E. K. | PDF | N/A | Isolation of phages infecting the zoonotic pathogen Streptococcus suis reveals novel structural and genomic characteristics | | 大肠杆菌Rac原噬菌体的KilR是一种细菌细胞形态的双重形态发生抑制剂。 | Govindarajan, S. | PDF | N/A | KilR of E. coli Rac prophage is a dual morphogenetic inhibitor of bacterial cell shape | | 通过宿主来源的读数标准化对哺乳动物肠道中绝对细菌生物量进行宏基因组学估计。 | Tang, G. | PDF | N/A | Metagenomic estimation of absolute bacterial biomass in the mammalian gut through host-derived read normalization. | | 代谢标记揭示了分枝杆菌表面相关的脂蛋白 | Parkin, L. A. | PDF | N/A | Metabolic tagging reveals surface-associated lipoproteins in mycobacteria | | 全球生物群落中微生物基因组和宏基因组完成反硝化作用的替代途径分布 | Pold, G. | PDF | N/A | Distribution of alternative routes for completing denitrification in microbial genomes and metagenomes of global biomes | | 评估用毒力抑制剂处理的铜绿假单胞菌中外排泵表达与运动表型之间的联系 | Lembke, H. | PDF | N/A | Evaluating the Link Between Efflux Pump Expression and Motility Phenotypes in Pseudomonas aeruginosa Treated with Virulence Inhibitors | | 保守的Dsup和HMGN核小体结合基序识别核小体的结构基础 | Alegrio-Louro, J. | PDF | N/A | Structural basis of nucleosome recognition by the conserved Dsup and HMGN nucleosome-binding motif | | 多能性因子提高小鼠胚胎干细胞中晚期DNA复制起始点的启动效率 | Rodriguez-Carballo, E. | PDF | N/A | Pluripotency factors enhance the firing efficiency of late DNA replication origins in mouse embryonic stem cells | | 核苷酸水平上的RNA N6-甲基腺苷（m6A）修饰图谱绘制及疟疾病原体恶性疟原虫mRNA 3'末端加工过程中全局多聚腺苷酸化事件的综合分析 | Catacalos-Goad, C. | PDF | N/A | Nucleotide-resolution Mapping of RNA N6-Methyladenosine (m6A) modifications and comprehensive analysis of global polyadenylation events in mRNA 3' end processing in malaria pathogen Plasmodium falciparum | | 以下是这段英文的中文翻译：
结构洞察癫痫相关配体-受体复合物LGI1-ADAM22的异源六聚体组装
翻译说明：
- "Structural insights" 翻译为“结构洞察”，表示对结构的深入理解。
- "heterohexameric assembly" 指由不同亚基组成的六聚体结构，翻译为“异源六聚体组装”。
- "epilepsy-related" 表示与癫痫相关，翻译为“癫痫相关的”。
- "ligand-receptor complex" 指配体与受体形成的复合物，翻译为“配体-受体复合物”。
- "LGI1-ADAM22" 是具体的蛋白质名称，保留原文不翻译。
希望这个翻译对你有帮助！ | Yamaguchi, T. | PDF | N/A | Structural insights into heterohexameric assembly of epilepsy-related ligand-receptor complex LGI1-ADAM22 | | 通过计算机模拟方法对第七因子激活蛋白酶（FSAP）进行结构与功能分析及其在昆虫细胞中的表达。 | Kandanur, S. P. | PDF | N/A | Structure-function analysis of Factor Seven Activating Protease (FSAP) by in-silico methods and its expression in insect cells. | | TRIM21-NUP98 界面能够容纳结构多样的分子胶降解剂。 | Han, T. | PDF | N/A | TRIM21-NUP98 interface accommodates structurally diverse molecular glue degraders | | TRIM21-NUP98 界面能够容纳结构多样的分子胶降解剂。 | Cheng, Y. | PDF | N/A | TRIM21-NUP98 interface accommodates structurally diverse molecular glue degraders | | 锌指蛋白POGZ与Polycomb抑制复合物1结合，在神经元分化过程中调节骨形态发生蛋白信号传导。 | Chavez, J. | PDF | N/A | The zinc-finger protein POGZ associates with Polycomb repressive complex 1 to regulate bone morphogenetic protein signaling during neuronal differentiation | | AAVone：一种经济高效的单质粒解决方案，用于高效生产AAV并减少DNA杂质 | Yang, R. | PDF | N/A | AAVone: A Cost-Effective, Single-Plasmid Solution for Efficient AAV Production with Reduced DNA Impurities | | AAVone：一种经济高效的单质粒解决方案，用于高效生产AAV并减少DNA杂质 | Yang, R. | PDF | N/A | AAVone: A Cost-Effective, Single-Plasmid Solution for Efficient AAV Production with Reduced DNA Impurities | | 快速灵活的微消化器消化过程 | Zheng, A. | PDF | N/A | Fast and flexible minimizer digestion with digest | | 以下是这段英文的中文翻译：
单分子分析PARP1与G-四链体的相互作用
希望这对你有帮助！如果有其他问题，欢迎继续提问。 | Gaur, P. | PDF | N/A | Single-molecule analysis of PARP1-G-quadruplex interaction | | 将干旱条件下的差异表达与耐旱物种特有的基因家族扩展相结合，预测了十字花科物种中适应干旱的候选基因。 | Uebermuth-Feldhaus, C. | PDF | N/A | Integration of differential expression under drought with gene family expansion unique to drought tolerant species predicts candidate genes for drought adaptation in Brassicaceae species. | | 鞭毛的流动诱导弯曲控制细菌表面行为 | Palalay, J.-J. S. | PDF | N/A | Flow-induced bending of flagella controls bacterial surface behavior | | 温带盐沼有孔虫Haynesina sp.对海岸酸化的形态响应 | Powers, C. | PDF | N/A | Morphological responses of a temperate salt marsh foraminifer, Haynesina sp., to coastal acidification | | 脂肪细胞中的醛固酮在阻塞性睡眠呼吸暂停中的作用 | Dong, Y. | PDF | N/A | Adipocyte Aldosterone in Obstructive Sleep Apnea | | 聚合酶Eta招募FANCD2至常见脆弱位点以维持基因组稳定性 | Niljikar, M. | PDF | N/A | Polymerase Eta Recruits FANCD2 to Common Fragile Sites to Maintain Genome Stability | | 比较CRISPRi筛选揭示人类干细胞对mRNA翻译耦合质量控制机制的依赖性 | Rodschinka, G. | PDF | N/A | Comparative CRISPRi screens reveal a human stem cell dependence on mRNA translation-coupled quality control | | 细胞死亡引发的免疫反应和凝血功能障碍促进了果蝇中的恶病质。 | Singh, A. | PDF | N/A | Cell-death induced immune response and coagulopathy promote cachexia in Drosophila | | CSDE1在黑色素瘤中调控miR-20a-5p/TMBIM6轴 | Ramakrishna, S. | PDF | N/A | CSDE1 regulates miR-20a-5p/ TMBIM6 axis in melanoma | | ANGPTL3与PCSK9结合，共同调节细胞内脂质稳态。 | Bini, S. | PDF | N/A | ANGPTL3 binds to PCSK9 to coordinately regulate intracellular lipid homeostasis. | | 工程化构建具有复杂多羽状肌纤维结构的3D骨骼肌组织 | Stang, M. A. | PDF | N/A | Engineering 3D Skeletal Muscle Tissue with Complex Multipennate Myofiber Architectures | | 特异性蛋白1对于脊髓运动轴突中ephrin介导的肢体轨迹至关重要。 | Liao, P. | PDF | N/A | Specificity Protein 1 is essential for the limb trajectory of ephrin-mediated spinal motor axons | | 光遗传学控制蛋白激酶C-ε活性揭示其时空分辨率的固有信号特性 | Ong, Q. | PDF | N/A | Optogenetic control of Protein Kinase C-epsilon activity reveals its intrinsic signaling properties with spatiotemporal resolution | | OTULIN通过诱导经典Wnt信号通路阻止角质形成细胞死亡和皮肤炎症 | Lecomte, K. | PDF | N/A | Canonical Wnt induction by OTULIN prevents keratinocyte death and skin inflammation | | 一项化学基因组筛选鉴定了酿酒酵母中磷脂酰胆碱生物合成的甲基化依赖性新生途径的新遗传互作因子。 | Maliva, A. M. | PDF | N/A | A chemical genomic screen identifies novel genetic interactors of the methylation-dependent de novo pathway of phosphatidylcholine biosynthesis in Saccharomyces cerevisiae. | | 评估从遗传谱系追踪数据推断单细胞系统发育和种群动态的准确性 | Pilarski, J. | PDF | N/A | Assessing the inference of single-cell phylogenies and population dynamics from genetic lineage tracing data | | 大规模单细胞测序项目的完整性评估 | Miihkinen, M. | PDF | N/A | Completeness estimation of large-scale single-cell sequencing projects | | Cullin-RING连接酶BioE3揭示了分子胶诱导的新底物和内源性Cereblon泛素组的重编程 | Merino-Cacho, L. | PDF | N/A | Cullin-RING ligase BioE3 reveals molecular-glue-induced neosubstrates and rewiring of the endogenous Cereblon ubiquitome | | 铁死亡和衰老中的氧化还原稳态：fard-1和dhs-25在秀丽隐杆线虫中的因果作用 | Pensotti, R. | PDF | N/A | Redox homeostasis in ferroptosis and aging: a causal role for fard-1 and dhs-25 in Caenorhabditis elegans | | 视网膜色素上皮中ER:黑色素体膜接触位点的鉴定。 | Eden, E. R. | PDF | N/A | Identification of ER:melanosome membrane contact sites in the retinal pigment epithelium. | | CellPhePy：一个用于从显微镜延时视频中自动进行细胞表型分析的CellPhe工具包的Python实现。 | Wiggins, L. | PDF | N/A | CellPhePy: a Python implementation of the CellPhe toolkit for automated cell phenotyping from microscopy time-lapse videos | | SDS-22通过稳定PP1催化亚基GSP-1/-2，在线虫胚胎的极性建立过程中发挥重要作用。 | Gotta, M. | PDF | N/A | SDS-22 stabilizes the PP1 catalytic subunits GSP-1/-2 contributing to polarity establishment in C. elegans embryos | | 用尿石素A缓解促炎性SASP和DAMP：一种新型的衰老调节策略
（注：SASP指的是衰老相关分泌表型，DAMP指的是损伤相关分子模式，尿石素A是一种天然化合物，具有抗炎和抗衰老的潜力。） | Barkovskaya, A. | PDF | N/A | Mitigating Proinflammatory SASP and DAMP with Urolithin A: A Novel Senomorphic Strategy | | β1整合素-FAK-Piezo1信号轴驱动原位硬化介导的细胞外基质重塑和三维乳腺上皮的侵袭 | Sakthivel, K. | PDF | N/A | β1 Integrin-FAK-Piezo1 signalling axis drives in-situ stiffening mediated ECM remodelling and invasion of 3D breast epithelium | | 趋化因子在血管生成过程中诱导从非定向迁移向定向迁移的相变。 | Gui, N. | PDF | N/A | Chemokine induces phase transition from non-directional to directional migration during angiogenesis | | MLC1在诱导多能干细胞（iPSCs）中的改变会导致星形胶质细胞谱系中出现类似疾病的细胞空泡化表型。 | Sharma, S. | PDF | N/A | MLC1 alteration in iPSCs give rise to disease-like cellular vacuolation phenotype in the astrocyte lineage | | 损伤后由毛细血管形态发生基因2控制的肠道干细胞更新 | Bracq, L. | PDF | N/A | Intestinal stem cell renewal controlled by capillary morphogenesis gene 2 following injury | | 揭示CISD2/NAF-1 44-67抗癌活性的分子机制 | Rowland, L. | PDF | N/A | Unraveling the molecular mechanism underlying the anticancer activity of CISD2/NAF-144-67 | | 马鲁拉提取物对人宫颈癌细胞系的抗增殖活性、植物化学、网络药理学、分子对接及基因表达分析 | Lagu, I. J. | PDF | N/A | Antiproliferative Activity, Phytochemistry, Network Pharmacology, Molecular Docking and Gene Expression Analysis of Maerua edulis Extracts against Human Cervical Cancer Cell Line | | 趋同的基因组和分子特征预测透明细胞肾细胞癌的异时性转移风险 | Naeini, M. M. | PDF | N/A | Convergent genomic and molecular features predict risk of metachronous metastasis in clear cell renal cell carcinoma | | 癌症相关成纤维细胞在胰腺导管腺癌细胞中驱动上皮间质转化和经典向基底样转变，并伴随IL-8表达的丧失。 | Guinn, S. | PDF | N/A | Cancer associated fibroblasts drive epithelial to mesenchymal transition and classical to basal change in pancreatic ductal adenocarcinoma cells with loss of IL-8 expression | | 米托蒽醌通过结合在DBD-LBD界面抑制并下调ERα。 | Wang, H. | PDF | N/A | Mitoxantrone inhibits and downregulates ERα through binding at the DBD-LBD interface | | 雄激素受体抑制在BRCA突变和同源重组修复缺陷之外的前列腺癌模型中扩展了PARP抑制剂的活性。 | Illuzzi, G. | PDF | N/A | Androgen receptor inhibition extends PARP inhibitor activity in prostate cancer models beyond BRCA mutations and defects in homologous recombination repair. | | 双核糖体分析揭示了肿瘤微环境中癌细胞和基质细胞的代谢限制。 | Aviles Huerta, D. | PDF | N/A | Dual Ribosome Profiling reveals metabolic limitations of cancer and stromal cells in thetumor microenvironment | | TGFBR2高表达的间充质胶质瘤干细胞模拟调节性T细胞，抑制CD4+和CD8+ T细胞功能。 | Johnson, A. L. | PDF | N/A | TGFBR2-High mesenchymal glioma stem cells phenocopy regulatory T cells to suppress CD4+ and CD8+ T cell function | | 多能干细胞衍生的自然杀伤（NK）祖细胞疗法可预防肿瘤发生并根除微小残留病灶 | Wang, Z. | PDF | N/A | Pluripotent stem cell-derived NK progenitor cell therapy prevents tumour occurrence and eradicates minimal residual disease | | 使用积分投影模型（IPMs）和重复LiDAR建模森林动态 | Rosen, A. | PDF | N/A | Modelling forest dynamics using integral projection models (IPMs) and repeat LiDAR | | 斜坡序列可能解释了在配对免疫球蛋白样2型受体α（PILRA）中与阿尔茨海默病相关的同义变异。 | Miller, J. B. | PDF | N/A | Ramp sequence may explain synonymous variant association with Alzheimer's disease in the Paired Immunoglobulin-like Type 2 Receptor Alpha (PILRA) | | 提升MALDI质谱成像性能：低温热蒸发技术用于可控基质沉积及图像质量优化 | Mahamdi, T. | PDF | N/A | Improving MALDI Mass Spectrometry Imaging Performance: Low-Temperature Thermal Evaporation for Controlled Matrix Deposition and Improved Image Quality | | 混合超分子-共价生物树脂在光基体积生物打印结构中促进细胞迁移和自组装 | Falandt, M. | PDF | N/A | Hybrid supramolecular-covalent bioresin promotes cell migration and self-assembly in light-based volumetric bioprinted constructs | | 简单的控制方法超越了最先进的深度学习算法，揭示了基础模型在预测基因扰动方面的有效性。 | Wong, D. R. | PDF | N/A | Simple controls exceed best deep learning algorithms and reveal foundation model effectiveness for predicting genetic perturbations | | 简单的控制方法超越了最佳深度学习算法，揭示了基础模型在预测基因扰动方面的有效性。 | Wong, D. R. | PDF | N/A | Simple controls exceed best deep learning algorithms and reveal foundation model effectiveness for predicting genetic perturbations | | 组蛋白甲基转移酶PRDM9促进胶质母细胞瘤中药物耐受性持久细胞的存活 | Joun, G. L. | PDF | N/A | Histone methyltransferase PRDM9 promotes survival of drug-tolerant persister cells in glioblastoma | | DNA甲基化影响基因表达但不影响大肠杆菌的全局染色质结构 | Morgan, W. J. | PDF | N/A | DNA methylation affects gene expression but not global chromatin structure in Escherichia coli | | 跟随机器人的引领：在运动学习人机交互任务中通过脑电图预测人类和机器人运动 | Chatterjee, T. | PDF | N/A | Following the Robot's Lead: Predicting Human and Robot Movement from EEG in a Motor Learning HRI Task | | 行为和神经声音分类：来自自然和合成声音的洞见 | Ogg, M. | PDF | N/A | Behavioral and neural sound classification: Insights from natural and synthetic sounds | | RhCMV扩展了CCR5记忆T细胞，并促进SIV在肠道黏膜中的病毒库建立。 | Perdios, C. | PDF | N/A | RhCMV Expands CCR5 Memory T Cells and promotes SIV reservoir seeding in the Gut Mucosa | | Wnt信号通路驱动炎症性关节炎中的基质炎症 | Mueller, A. A. | PDF | N/A | Wnt signaling drives stromal inflammation in inflammatory arthritis | | 通过连续活体显微镜观察，揭示了脾脏中自身反应性生发中心的时间动态变化。 | Pohl, L. | PDF | N/A | Serial intravital microscopy reveals temporal dynamics of autoreactive germinal centers in the spleen | | 母体免疫激活会在后代中留下调节性T细胞缺陷，这种缺陷会导致类似自闭症的表型。 | Ellul, P. | PDF | N/A | Maternal immune activation imprints a regulatory T cell deficiency in offspring that drives an autism-like phenotype | | 缺氧介导的组织特异性间充质干细胞分子相互作用驱动急性移植物抗宿主病中的代谢重编程和免疫调节 | Mendiratta, M. | PDF | N/A | Hypoxia-Mediated Molecular Interactions of Tissue-Specific Mesenchymal Stem Cells Drive Metabolic Reprogramming and Immunomodulation in Acute Graft-versus-Host Disease | | 蚂蚁-植物互惠关系在低纬度地区更强吗？以印度次大陆的蓖麻植物为例的研究 | Nathan, P. | PDF | N/A | Are ant-plant mutualisms stronger at lower latitudes? A case study using the castor plant in the Indian subcontinent | | 利用人工智能最大化基于自然的解决方案，以协调全球生物多样性、气候和水资源目标。 | Alejo, C. | PDF | N/A | Maximizing Nature-based Solutions using Artificial Intelligence to align global biodiversity, climate, and water targets. | | CENdetectHOR：一款用于中心粒分析和HOR检测的综合工具 | Daponte, A. | PDF | N/A | CENdetectHOR: a comprehensive tool for CENtromere profiling and HOR detection | | 改进的突触动力学伴随着拟南芥自交四倍体的减数分裂稳定性 | Gonzalo, A. | PDF | N/A | Improved synapsis dynamics accompany meiotic stability in Arabidopsis arenosa autotetraploids | | DNA数据（基因组草图和环境DNA条形码）与化学数据相结合，展示了其在追溯分析与牛群致命中毒相关的饲料来源方面的实用性。 | Cook, D. | PDF | N/A | DNA data (genome skims and metabarcodes) paired with chemical data demonstrate utility for retrospective analysis of forage linked to fatal poisoning of cattle | | 使用RESCUE模拟纵向单细胞RNA测序数据 | Wynn, E. A. | PDF | N/A | Simulating Longitudinal Single-cell RNA Sequencing Data with RESCUE | | HD2Net：一种用于荧光显微镜中同时去噪和去像差的深度学习框架 | Hou, X. | PDF | N/A | HD2Net: A Deep Learning Framework for Simultaneous Denoising and Deaberration in Fluorescence Microscopy | | 以下是这段英文的中文翻译：
针对结核分枝杆菌β-内酰胺酶BlaC的天然化合物的分子对接、验证、动态模拟和药代动力学预测
翻译说明： - Molecular docking：分子对接 - validation：验证 - dynamic simulation：动态模拟 - pharmacokinetic prediction：药代动力学预测 - natural compounds：天然化合物 - Mycobacterium tuberculosis：结核分枝杆菌 - Beta-lactamase BlaC：β-内酰胺酶BlaC
希望这对你有帮助！ | Sreekumar, S. | PDF | N/A | Molecular docking, validation, dynamic simulation and pharmacokinetic prediction of natural compounds against Mycobacterium tuberculosis Beta-lactamase BlaC | | LncPTPred：基于交联免疫沉淀（CLIP-Seq）数据预测长链非编码RNA与蛋白质相互作用 | Das, G. | PDF | N/A | LncPTPred: Predicting lncRNA-Protein Interaction based on Crosslinking and Immunoprecipitation (CLIP-Seq) Data | | DNALONGBENCH：用于长距离DNA预测任务的基准测试套件 | Cheng, W. | PDF | N/A | DNALONGBENCH: A Benchmark Suite for Long-Range DNA Prediction Tasks | | QUICHE揭示了在三阴性乳腺癌中抗肿瘤反应的结构定义。 | Ranek, J. S. | PDF | N/A | QUICHE reveals structural definitions of anti-tumor responses in triple negative breast cancer | | 将生物信号网络的Petri网模型转换为影响图 | Gamache-Poirier, S. | PDF | N/A | Transformation of Petri net models of biological signaling networks into influence graphs | | 微调分子力学力场以符合实验自由能测量 | Rufa, D. | PDF | N/A | Fine-tuning molecular mechanics force fields to experimental free energy measurements | | 拟南芥代谢的特征时间尺度及其强制表型效应 | Santoro, G. | PDF | N/A | The Characteristic Timescales of the Arabidopsis thaliana Metabolism and the Phenotypic Effects of Forcing Them | | 低磁场以钟形响应刺激心脏线粒体生物能量学：可能通过自由基对机制 | Sheu, S.-S. | PDF | N/A | Low Magnetic Fields Stimulate Cardiac Mitochondrial Bioenergetics with a Bell-Shaped Response: Possibly Via a Radical Pair Mechanism | | 生长激素过量通过增加糖化应激驱动肝脏衰老 | Singh, P. | PDF | N/A | Growth Hormone Excess Drives Liver Aging via increased Glycation stress | | DTPPI：利用加权药物-蛋白质网络预测药物相互作用 | Szydlik, S. | PDF | N/A | DTPPI: predicting drug interactions using a weighted drug-protein network | | 优化疫苗诱导的免疫疗法在黑色素瘤中的疗效 | Chamseddine, I. | PDF | N/A | Optimizing the Efficacy of Vaccine-Induced Immunotherapy in Melanomas | | 了解低密度种群中的检测概率，以指导淡水贻贝的最佳环境DNA（eDNA）采样 | Rodgers, T. W. | PDF | N/A | Understanding detection probability in a low-density population to inform optimal eDNA sampling for freshwater mussels | | 体外模拟急性脑损伤环境。 | Maria Arzate, D. | PDF | N/A | Modeling the acutely injured brain environment in vitro. | | 模拟体外急性损伤的脑环境。 | Maria Arzate, D. | PDF | N/A | Modeling the acutely injured brain environment in vitro. | | 使用基于人工智能的软件对非骨质疏松和骨质疏松小鼠骨折血肿和骨髓中的免疫细胞亚型进行无偏倚的鉴别。 | Fischer, V. | PDF | N/A | Using artificial intelligence-based software for an unbiased discrimination of immune cell subtypes in the fracture hematoma and bone marrow of non-osteoporotic and osteoporotic mice | | σ调节因子FecR的裂解级联反应协调了TonB依赖的信号转导 | Yokoyama, T. | PDF | N/A | Cleavage cascade of the sigma regulator FecR orchestrates TonB-dependent signal transduction | | 以下是这段英文的中文翻译：
人类T细胞受体对恶性疟原虫环子孢子蛋白（CSP）的克隆性、特异性及HLA限制性
翻译说明： - Clonality：克隆性，指T细胞受体的克隆扩增特性。 - specificity：特异性，指T细胞受体对特定抗原的识别能力。 - HLA restriction：HLA限制性，指T细胞受体识别抗原时需要与特定的人类白细胞抗原（HLA）分子结合。 - Plasmodium falciparum CSP：恶性疟原虫环子孢子蛋白（CSP），是疟疾疫苗研究中的重要抗原。
希望这段翻译对你有帮助！ | van Dijk, H. | PDF | N/A | Clonality, specificity, and HLA restriction of human T cell receptors against Plasmodium falciparum CSP | | 通过CRAMP1在组蛋白位点体内对组蛋白H1表达的独特调控 | Bodner, J. | PDF | N/A | Distinct Control of histone H1 expression within the Histone Locus body by CRAMP1 | | 急性和慢性主动脉综合征中的血浆无细胞DNA。 | Weerakkody, R. A. | PDF | N/A | Plasma Cell-Free DNA in Acute and Chronic Aortic Syndromes. | | 生物医学文献中句子的表征与自动分类：以基因表达和蛋白激酶活性的生物数据管理为例 | Raciti, D. | PDF | N/A | Characterization and automated classification of sentences in the biomedical literature: a case study for biocuration of gene expression and protein kinase activity | | PyPE_RESP：一个用于简化和标准化RESP电荷推导的工具 | Lapsien, M. | PDF | N/A | PyPE_RESP: A tool to facilitate and standardize derivation of RESP charges | | 血清和血浆中的鞘脂作为蒽环类药物诱导心脏毒性的生物标志物 | Mohammed, S. | PDF | N/A | SERUM AND PLASMA SPHINGOLIPIDS AS BIOMARKERS OFANTHRACYCLINE-INDUCED CARDIOTOXICITY | | Maturase K与一种新功能化的分支酶形成质体剪接复合体。 | Liang, Y. | PDF | N/A | Maturase K forms a plastidial splicing complex with a neofunctionalized branching enzyme | | 马铃薯晚疫病防治：使用植物源产品与减少铜制剂的应用 | Musa, T. | PDF | N/A | Potato Late Blight Control with a Botanical Product and Reduced Copper Applications | | 一个应用于黑暗诱导叶片衰老的植物生理学家庭实验室，由大学生和科学教师共同参与 | Soumen, S. | PDF | N/A | An at-home Plant Physiology laboratory applied to dark-induced leaf senescence by college students and science teachers | | 揭示生物医学问题中机器学习SHAP特征交互隐藏可解释性模式的单图可视化 | Furger, F. | PDF | N/A | A Single-Graph Visualization to Reveal Hidden Explainability Patterns of SHAP Feature Interactions in Machine Learning for Biomedical Issues | | 2-脱氧-D-葡萄糖化学交换敏感自旋锁定MRI在大鼠中风后脑葡萄糖代谢中的应用 | Boehm-Sturm, P. | PDF | N/A | 2-Deoxy-D-glucose chemical exchange-sensitive spin-lock MRI of cerebral glucose metabolism after stroke in the rat | | 眼动指标是脑盲症中视觉意识感知和神经处理的一个标志。 | Kronemer, S. I. | PDF | N/A | Eye metrics are a marker of visual conscious awareness and neural processing in cerebral blindness | | 随着年龄增长，幼稚T细胞与记忆T细胞比例的逆转：与自身免疫的潜在联系及终身感染史的作用 | Montgomery, R. M. | PDF | N/A | The Inversion of Naive-to-Memory T Cell Ratios With Age: Potential Links to Autoimmunity and the Role of Lifetime Infection History | | 在西班牙鉴定和表征新型蝙蝠冠状病毒 | Soriano-Tordera, C. | PDF | N/A | Identification and characterization of novel bat coronaviruses in Spain | | RNase III切割信号跨越剪接位点分布，强制对共宿主的snoRNA进行顺序处理。 | Migeot, V. | PDF | N/A | RNase III cleavage signals spread across splice junctions enforce sequential processing of co-hosted snoRNAs. | | 单核多组学ATAC和RNA测序揭示了黑腹果蝇胚胎热塑性的分子基础 | O'Leary, T. S. | PDF | N/A | Single-nuclei multiome ATAC and RNA sequencing reveals the molecular basis of thermal plasticity in Drosophila melanogaster embryos | | 在极端洪水和季节性变化条件下，曼氏血吸虫中间宿主——扁卷螺（Biomphalaria）的生态位稳定性 | Iacovidou, M. A. | PDF | N/A | Ecological niche stability of Biomphalaria intermediate hosts for Schistosoma mansoni under extreme flooding and seasonal change | | 海草-海绵共生体中的硝化作用 | Berlinghof, J. | PDF | N/A | Nitrification in a seagrass-sponge association | | 肠道宏病毒组揭示了非人类灵长类动物携带的潜在人畜共患病原体和环境RNA病毒 | Yan, Y. | PDF | N/A | Gut meta-virome reveals potential zoonotic pathogens and environmental RNA viruses carried by non-human primates | | 通过系统发育基因组学解析陆生涡虫的进化历史 | Benitez-Alvarez, L. | PDF | N/A | Disentangling the evolutionary history of terrestrial planarians through phylogenomics | | 花粉形态学、深度学习、系统发育学与罗汉松属环境适应性进化 | Adaime, M.-E. | PDF | N/A | Pollen morphology, deep learning, phylogenetics, and the evolution of environmental adaptations in Podocarpus | | 全基因组病毒新生RNA测序揭示单核苷酸精度的聚合酶暂停景观 | Zhu, Z. | PDF | N/A | Genome-wide Viral Nascent RNA Sequencing Unveils Polymerase Pausing Landscape at Single-nucleotide Precision | | 在Y-STR参考数据库中查找痕迹档案供体及其父系亲属的概率 | Olsen, T. O. S. | PDF | N/A | Probabilities of finding trace profile donors and their paternal relatives in Y-STR reference databases | | 合理设计与优化一种强效的IDO1蛋白降解靶向嵌合体（PROTAC） | Monsen, P. J. | PDF | N/A | Rational Design and Optimization of a Potent IDO1 Proteolysis Targeting Chimera (PROTAC) | | 一个渐进性人类肝脏胰岛素抵抗的微生理模型 | Hellen, D. J. | PDF | N/A | A Microphysiological Model of Progressive Human Hepatic Insulin Resistance | | 通过基础模型衍生的潜在空间似然优化提高功能性蛋白质生成 | Guan, C. | PDF | N/A | Improving functional protein generation via foundation model-derived latent space likelihood optimization | | SARS-CoV-2的突变率在不同位点之间存在高度变异性，并受到序列背景、基因组区域和RNA结构的影响。 | Haddox, H. K. | PDF | N/A | The mutation rate of SARS-CoV-2 is highly variable between sites and is influenced by sequence context, genomic region, and RNA structure | | RNA G-四链体通过多种途径从类似线圈的集合体中形成 | Pokorna, P. | PDF | N/A | RNA G-Quadruplex Emerges from a Coil-Like Ensemble via Multiple Pathways | | 植物组织中镝的无损检测与定量分析 | Hernandez-Pagan, E. | PDF | N/A | Nondestructive Detection and Quantification of Dysprosium in Plant Tissues | | 噪声性听力损失增强了耳蜗外侧传出神经中依赖钙离子的自发性爆发活动。 | Hong, H. | PDF | N/A | Noise-induced hearing loss enhances Ca2+-dependent spontaneous bursting activity in lateralcochlear efferents | | 瑞士和马来西亚的生理相关光照和光照行为 | Biller, A. | PDF | N/A | Physiologically-relevant light exposure and light behaviour in Switzerland and Malaysia | | 驱动抓挠屈肌和伸肌交替的脊髓前运动网络 | Yao, M. | PDF | N/A | The spinal premotor network driving scratching flexor and extensor alternation | | 单细胞测序揭示裸盖菇素诱导小鼠内侧前额叶皮层持续性的细胞类型特异性可塑性 | Zhou, D. | PDF | N/A | Single-cell sequencing reveals psilocybin induces sustained cell-type specific plasticity in mouse medial prefrontal cortex | | 这段文字可以翻译为：
“原神经基因Neurog1和Neurog2在发育中的背根神经节中的功能等效性突出了神经发生时间对偏向体感前体命运的重要性。”
翻译说明： - Functional Equivalence：功能等效性，指两个基因在功能上具有相似或相同的作用。 - Proneural Genes：原神经基因，参与神经发育的基因。 - Neurog1 and Neurog2：两个具体的原神经基因名称。 - Developing Dorsal Root Ganglia：发育中的背根神经节，是感觉神经元的聚集区域。 - Timing of Neurogenesis：神经发生的时间，指神经元生成的时间点。 - Biasing Somatosensory Precursor Fates：偏向体感前体命运，指影响体感神经元前体细胞的发育方向。
整句话强调了Neurog1和Neurog2在背根神经节发育中的功能相似性，并指出神经发生的时间点对体感神经元前体细胞的命运决定具有重要影响。 | Desiderio, S. | PDF | N/A | Functional Equivalence of the Proneural Genes Neurog1 and Neurog2 in the Developing Dorsal Root Ganglia Highlights the Importance of Timing of Neurogenesis in Biasing Somatosensory Precursor Fates | | 谱系启动和细胞类型比例分配依赖于随机因素和确定性因素之间的相互作用。 | Salvidge, W. | PDF | N/A | Linage priming and cell type proportioning depends on the interplay between stochastic and deterministic factors | | Dmrt2在胚胎扣带皮层中调控神经元发育：揭示性别偏向的脆弱性
这段翻译将英文标题“Dmrt2 Orchestrates Neuronal Development in the Embryonic Cingulate Cortex: Unveiling Sex-Biased Vulnerabilities”转化为中文，保留了原文的科学性和专业性，同时确保了语言的流畅性和准确性。标题中的“Dmrt2”是一个基因名称，直接保留不变；“Orchestrates”翻译为“调控”，体现了该基因在神经元发育中的主导作用；“Embryonic Cingulate Cortex”翻译为“胚胎扣带皮层”，准确描述了研究发生的具体位置；“Unveiling”翻译为“揭示”，表达了研究的目的和意义；“Sex-Biased Vulnerabilities”翻译为“性别偏向的脆弱性”，强调了研究中发现的性别差异及其潜在影响。 | Serrano-Saiz, E. | PDF | N/A | Dmrt2 Orchestrates Neuronal Development in the Embryonic Cingulate Cortex: Unveiling Sex-Biased Vulnerabilities | | 缺氧诱导因子1α是果蝇幼虫糖酵解程序建立所必需的 | Heidarian, Y. | PDF | N/A | Hypoxia-inducible factor 1α is required to establish the larval glycolytic program in Drosophila melanogaster | | 区域性调控的肌动球蛋白组织影响心腔曲率形成过程中的心肌细胞形态变化 | Leerberg, D. M. | PDF | N/A | Regionalized regulation of actomyosin organization influences cardiomyocyte cell shape changes during chamber curvature formation | | 通过凝视相关消息暴露实现记忆植入：利用虚拟现实研究媒体影响 | Cho, H. J. | PDF | N/A | Memory Inception through Gaze-Contingent Message Exposure: Using Virtual Reality to Study Media Influence | | 在LPS暴露前，用zymosan预刺激精确切割的牛乳房切片显示出训练免疫的指标。 | Filor, V. | PDF | N/A | Pre-stimulation of Precision-Cut bovine udder slices with zymosan before LPS exposure indicates indicators for trained immunity | | 大气压毛细管等离子体射流非常适合为等离子体驱动的生物催化提供H2O2。 | Dirks, T. | PDF | N/A | The atmospheric pressure capillary plasma jet is well-suited to supply H2O2 for plasma-driven biocatalysis | | 细胞间信号传导与负反馈之间的相互作用在增强单细胞变异性的同时减少了群体噪声 | Ren, X. | PDF | N/A | The Interplay Between Cell-cell Signaling and Negative Feedback Reduces Population Noise While Enhancing Single-cell Variability | | 从鸟类中鉴定出一种双向性科尔米病毒 | Kishimoto, M. | PDF | N/A | Identification of an ambisense kolmiovirus from birds | | 微量金属的可用性控制了大肠杆菌中终端电子受体的利用。 | Ricciardelli, A. | PDF | N/A | Trace metals availability controls terminal electron acceptor utilization in Escherichia coli | | 人类巨细胞病毒的gH/gL/gO复合物与血小板衍生生长因子受体α（PDGFRα）结合后，会提供一个调控信号，激活融合蛋白gB，这一过程可以被中和抗体所阻断。 | Schultz, E. P. | PDF | N/A | Human cytomegalovirus gH/gL/gO binding to PDGFRα provides a regulatory signal activating the fusion protein gB that can be blocked by neutralizing antibodies. | | DefensePredictor: 一种用于发现新型原核生物免疫系统的机器学习模型 | DeWeirdt, P. C. | PDF | N/A | DefensePredictor: A Machine Learning Model to Discover Novel Prokaryotic Immune Systems | | 基因组分析：从墨西哥索诺拉州西北部传统米尔帕农业系统中分离的副地衣芽孢杆菌AA1 | Verdugo-Fuentes, A. A. | PDF | N/A | Genome Analysis of Bacillus paralicheniformis AA1 isolated from a conventional milpa farming system in the northwestern region of Sonora, Mexico | | ATF6通过诱导stomatin蛋白表达和改变胆固醇动态，使蜱虫能够感染病原体。 | Vosbigian, K. A. | PDF | N/A | ATF6 enables pathogen infection in ticks by inducing stomatin and altering cholesterol dynamics | | 细菌和宿主酶调节由莱姆病病原体的肽聚糖引发的炎症反应。 | McCausland, J. W. | PDF | N/A | Bacterial and host enzymes modulate the inflammatory response produced by the peptidoglycan of the Lyme disease agent | | SifA介导的沙门氏菌包含空泡重塑通过促进营养可及性防止细菌休眠 | Valenzuela, C. | PDF | N/A | SifA-mediated Remodeling of the Salmonella-Containing Vacuole Prevents Bacterial Dormancy by Promoting Nutrient Accessibility | | 蛋白质和基因组语言模型描绘了抗噬菌体防御的广阔图景。 | Mordret, E. | PDF | N/A | Protein and genomic language models chart a vast landscape of antiphage defenses | | 假帕林介导的铜绿假单胞菌锌摄取决定了特定的临床相关表型和感染结果 | Bosc, L. | PDF | N/A | Pseudopaline-mediated zinc uptake by Pseudomonas aeruginosa determines specific clinically relevant phenotypes and infection outcome | | 口腔鳞状细胞癌患者临床分离的核梭杆菌特征分析 | Lim, S. | PDF | N/A | Characterization of Clinical Fusobacterium nucleatum Isolates from Oral Squamous Cell Carcinoma Patients | | 母乳中的miRNA在哺乳期间对母亲和婴儿的感染做出反应。 | Alsaweed, M. | PDF | N/A | Human milk miRNAs respond to infections of the mother and infant during breastfeeding | | 爱尔兰常见库蠓（双翅目：蠓科）的分子特征研究 | Isiye, E. | PDF | N/A | Molecular characterisation of common Culicoides Biting Midges (Diptera: Ceratopogonidae) in Ireland |