BioRxiv 2025-01-14 Papers
| 标题 | 作者 | PDF链接 | 代码仓库 | Title |
|---|---|---|---|---|
| 小细胞肺癌亚型分析利用血浆中的游离核小体 | Fialkoff, G. | N/A | Subtyping of Small Cell Lung Cancer using plasma cell-free nucleosomes | |
| 不确定性、相关性和学习之间的相互作用影响了听觉分类。 | Sheth, J. | N/A | The interplay of uncertainty, relevance and learning influences auditory categorization | |
| 骨膜骨骼干细胞在受伤后可以迁移到骨髓中并支持造血功能。 | Marchand, T. | N/A | Periosteal skeletal stem cells can migrate into the bone marrow and support hematopoiesis after injury | |
| BNST信号和BNST CRF在恐惧处理中的性别差异：对不可预测威胁在持续恐惧中的影响 | Hon, O. J. | N/A | Sex Differences in BNST Signaling and BNST CRF in Fear Processing: Implications for Unpredictable Threat in Sustained Fear | |
| 生命之树中转录错误率的狭窄范围 | Li, W. | N/A | A Narrow Range of Transcript-error Rates Across the Tree of Life | |
| 挪威云杉（Picea abies）的高辐射敏感性是由于其在保护、修复和应激反应方面的动员不如耐辐射的拟南芥（Arabidopsis thaliana）全面所致。 | Bhattacharjee, P. | N/A | High radiosensitivity in Norway spruce (Picea abies) is rendered by less comprehensive mobilisation of protection, repair and stress responses compared to the radiotolerant Arabidopsis thaliana | |
| 大豆初生细胞壁纤维素合酶的结构、功能与组装 | Ho, R. | N/A | Structure, function and assembly of soybean primary cell wall cellulose synthases | |
| 对有无静水压力条件下上皮类器官中腔体成核和融合的通用比较 | Lu, L. | N/A | Generic comparison of lumen nucleation and fusion in epithelial organoids with and without hydrostatic pressure | |
| 大肠杆菌在失去营养后的最初几个小时内，通过显著重塑其蛋白质组来为饥饿做准备。 | Gervais, T. | N/A | E. coli prepares for starvation by dramatically remodeling its proteome in the first hours after loss of nutrients | |
| 基于生物物理学的蛋白质语言模型用于蛋白质工程 | Gelman, S. | N/A | Biophysics-based protein language models for protein engineering | |
| 基于微管的成核作用导致植物皮层阵列对细胞几何形状具有高度敏感性。 | Saltini, M. | N/A | Microtubule-based nucleation results in a large sensitivity to cell geometry of the plant cortical array | |
| 遗传多样性对跨营养级的生态系统功能的影响与物种多样性相当，但方向相反。 | Fargeot, L. | N/A | Genetic diversity affects ecosystem functions across trophic levels as much as species diversity, but in an opposite direction | |
| 在没有六亚基ORC的情况下，原代肝细胞中的DNA复制 | Przanowska, R. K. | N/A | DNA replication in primary hepatocytes without the six-subunit ORC | |
| 可分离的记忆调节机制在不同时间尺度上促进恐惧遗忘 | Ni, Y. | N/A | Dissociable memory modulation mechanisms facilitate fear amnesia at different timescales | |
| 人类脂肪基质细胞在3D培养系统中向肌腱表型分化，并具有适应性的粘弹性特性。 | Horde, M. | N/A | Human adipose stromal cells differentiate towards a tendon phenotype with adapted visco-elastic properties in a 3D-culture system | |
| 增强肿瘤浸润T细胞的专属能量来源 | Miller, M. L. | N/A | Enhancing tumor-infiltrating T cells with an exclusive fuel source | |
| 季节性及空间变化对热带太平洋河口至开阔海域浮游植物群落的影响 | Tucker, S. J. | N/A | Seasonal and spatial transitions in phytoplankton assemblages spanning estuarine to open ocean waters of the tropical Pacific | |
| 超高剂量口服ω3二十二碳六烯酸（DHA）或二十碳五烯酸（EPA）在MYCN驱动的神经母细胞瘤模型中阻断肿瘤发生 | Patel, V. | N/A | Ultra-high dose oral ω3 docosahexaenoic acid (DHA) or eicosapentaenoic acid (EPA) block tumorigenesis in a MYCN-driven neuroblastoma model | |
| 在强烈波动的环境中，顺序代谢策略的适应优势源于群落相互作用。 | Wang, Z. | N/A | Fitness advantage of sequential metabolic strategies emerges from community interactions in strongly fluctuating environments | |
| 季节性及比较证据显示哺乳动物大脑大小可塑性中的适应性基因表达 | Thomas, W. R. | N/A | Seasonal and comparative evidence of adaptive gene expression in mammalian brain size plasticity | |
| 发育和年龄相关的突触消除是由胶质细胞中的Croquemort介导的。 | Jay, T. R. | N/A | Developmental and age-related synapse elimination is mediated by glial Croquemort | |
| 细菌性阴道病驱动的宫颈阴道免疫变化，扩展了增加HIV易感性的免疫学假说。 | MacLean, F. | N/A | Bacterial vaginosis-driven changes in cervicovaginal immunity that expand the immunological hypothesis for increased HIV susceptibility | |
| LCSKPOA：通过扩展的lcsk++实现高效且准确的骨架生成，从而支持带状半全局部分序列比对 | Weerakoon, M. | N/A | LCSKPOA: Enabling banded semi-global partial order alignments via efficient and accurate backbone generation through extended lcsk++ | |
| 在海马记忆任务中，海马下托和CA1位置细胞中任务需求相关放电模式的差异性再激活 | Seol, J.-M. | N/A | Differential Reactivation of Task-Demand-Associated Firing Patterns in Subicular and CA1 Place Cells during a Hippocampal Memory Task | |
| 环境背景塑造了丘脑中的空间和时间视觉处理。 | Peelman, K. | N/A | Environmental context sculpts spatial and temporal visual processing in thalamus | |
| MyVivarium：一款基于云端的实验动物群体管理应用程序，具备实时环境感知功能。 | Vidva, R. | N/A | MyVivarium: A cloud-based lab animal colony management application with realtime ambient sensing | |
| 以下是这段英文的中文翻译： |
弧菌属生物膜基质簇和蛋白质的综合基因组与进化分析
这个标题描述了一项研究，旨在对弧菌属（Vibrio genus）中与生物膜基质相关的基因簇和蛋白质进行全面分析，涵盖基因组学和进化生物学的研究方法。 | Yang, Y. | PDF | N/A | Comprehensive Genomic and Evolutionary Analysis of Biofilm Matrix Clusters and Proteins in the Vibrio Genus | | 在PLEKHM2 mRNA解码过程中，程序化的核糖体移码生成了一种持续活跃的介导物，该介导物依赖于驱动蛋白-1（kinesin-1）进行溶酶体运输。 | Loughran, G. | PDF | N/A | Programmed ribosomal frameshifting during PLEKHM2 mRNA decoding generates a constitutively active mediator of kinesin-1-dependent lysosome transport | | 结合剂和单体的价态决定了染色质塌缩和再膨胀的程度。 | Guha, S. | PDF | N/A | Binder and monomer valencies determine the extent of collapse and reswelling of chromatin | | 细胞类型特异性表达FOXP3所需的顺式调控元件和转录因子调控网络 | Umhoefer, J. M. | PDF | N/A | Cis-Regulatory Element and Transcription Factor Circuitry Required for Cell-Type Specific Expression of FOXP3 | | 三碘甲状腺原氨酸和黄芩素对Klotho的双向上调作用：缓解老年BALB/c小鼠的慢性肾脏疾病及其相关并发症 | Mohanty, S. K. | PDF | N/A | Bidirectional Upregulation of Klotho by Triiodothyronine and Baicalein: Mitigating Chronic Kidney Disease and Associated Complications in Aged BALB/c Mice | | 通过眼跳采样进行时空证据积累以实现物体识别 | Zheng, Z. | PDF | N/A | Spatiotemporal evidence accumulation through saccadic sampling for object recognition | | ATG9囊泡是细胞内纳米囊泡的一个亚型。 | Fesenko, M. | PDF | N/A | ATG9 vesicles are a subtype of intracellular nanovesicle | | Na+/K+-ATPase的电生成特性对高度活跃的放电细胞中的计算提出了挑战。 | Weerdmeester, L. | PDF | N/A | The electrogenicity of the Na+/K+-ATPase poses challenges for computation in highly active spiking cells | | 第六层皮质丘脑神经元通过皮质-皮质和皮质-丘脑-皮质通路诱导高频伽马振荡。 | Russo, S. | PDF | N/A | Layer 6 corticothalamic neurons induce high gamma oscillations through cortico-cortical and cortico-thalamo-cortical pathways | | 解码难以理解的声音：低信噪比下的神经语音追踪 | He, X. | PDF | N/A | Decoding the Unintelligible: Neural Speech Tracking in Low Signal-to-Noise Ratios | | 保守的基因组成和独特的系统发育历史是Triturus平衡致死系统背后的“bloopergene”特征。 | de Visser, M. C. | PDF | N/A | Conserved gene content and unique phylogenetic history characterize the 'bloopergene' underlying Triturus' balanced lethal system | | 分泌型Clever-1调节T细胞反应并影响癌症免疫治疗效果 | Prince, S. | PDF | N/A | Secreted Clever-1 Modulates T Cell Responses and Impacts Cancer Immunotherapy Efficacy | | 解码非模式生物的功能相互作用组与PHILHARMONIC | Sledzieski, S. | PDF | N/A | Decoding the Functional Interactome of Non-Model Organisms with PHILHARMONIC | | 西澳大利亚城市灌木丛火灾后兰花的成败：与其他特性深度融合的响应连续体 | Brundrett, M. C. | PDF | N/A | Orchid losers and winners after fire in West Australian urban bushland: A response continuum deeply integrated with other traits | | 将“Benchmarking unsupervised methods for inferring TCR specificity”翻译成中文是：
“用于推断TCR特异性的无监督方法的基准测试”
其中： - Benchmarking 意为“基准测试”或“性能评估” - unsupervised methods 意为“无监督方法” - inferring 意为“推断” - TCR specificity 意为“TCR特异性”（TCR指T细胞受体）
整句话的意思是评估或比较无监督学习方法在推断T细胞受体（TCR）特异性方面的性能。 | Jouannet, C. | PDF | N/A | Benchmarking unsupervised methods for inferring TCR specificity | | 小脑性伸手共济失调对运动学和动力学需求的敏感性 | Oh, K. | PDF | N/A | Sensitivity of Cerebellar Reaching Ataxia to Kinematic and Dynamic Demands | | DNA复制叉速度在皮质神经发生中起到节奏调节器的作用 | Wang, J. | PDF | N/A | DNA replication fork speed Acts as a Pacer in Cortical Neurogenesis | | 负责语言产生的布洛卡区受到肺功能的调节。 | Cao, S. | PDF | N/A | Broca's area responsible for speech production is regulated by lung functions | | 跑步鞋堆叠高度在不同跑步速度下对跑步风格和稳定性的影响 | Kettner, C. | PDF | N/A | The effects of running shoe stack height on running style and stability during level running at different running speeds | | 测试大黄蜂中的峰终法则：当最终奖励令人失望时，缺乏对更高奖励序列的偏好 | Armand, M. | PDF | N/A | Testing the peak-end rule in bumblebees: lack of preference for a higher-reward sequence when the final reward is disappointing | | 识别基孔肯雅病毒nsP2 ATP酶抑制剂 | Navarro, H. | PDF | N/A | Identification of Inhibitors of Chikungunya virus nsP2 ATPase | | 自闭症相关蛋白在纤毛处的汇聚 | Kostyanovskaya, E. | PDF | N/A | Convergence of autism proteins at the cilium | | Pol II降解独立于转录丧失激活细胞死亡。 | Harper, N. W. | PDF | N/A | Pol II degradation activates cell death independently from the loss of transcription | | 数据驱动的突触分类揭示了谷氨酸受体多样性的逻辑 | Micheva, K. D. | PDF | N/A | Data-driven synapse classification reveals a logic of glutamate receptor diversity | | 单个神经元的多样性支持视觉皮层通路中区域功能的专门化 | Feyerabend, M. | PDF | N/A | Single neuron diversity supports area functional specialization along the visual cortical pathways | | 撤回：生物学黎明时期的结构酶学、系统发育学、分化与符号反身性 | Carter, C. W. | PDF | N/A | WITHDRAWN: Structural Enzymology, Phylogenetics, Differentiation, and Symbolic Reflexivity at the Dawn of Biology | | 收集、检测和处理纵向光照数据中的非佩戴间隔 | Guidolin, C. | PDF | N/A | Collecting, detecting and handling non-wear intervals in longitudinal light exposure data | | 齿状回为高效的空间导航提供了灵活性。 | Soldi, N. | PDF | N/A | The dentate gyrus provides flexibility for efficient spatial navigation | | 跟随机器人的引导：在运动学习人机交互任务中通过脑电图预测人类和机器人运动 | Chatterjee, T. | PDF | N/A | Following the Robot's Lead: Predicting Human and Robot Movement from EEG in a Motor Learning HRI Task | | 对蓖麻蚕（学名：Samia ricini）的基因组组装进行了重大更新。 | Lee, J. | PDF | N/A | A major update of the genome assembly of Eri silkmoth, Samia ricini. | | grepq：一个用 Rust 编写的应用程序，能够通过将序列与一组正则表达式进行匹配来快速过滤 FASTQ 文件。 | Crosbie, N. D. | PDF | N/A | grepq: A Rust application that quickly filters FASTQ files by matching sequences to a set of regular expressions | | VZV gE通过Midnolin-蛋白酶体途径促进STING降解，从而抑制cGAS-STING信号通路 | Chen, L. | PDF | N/A | VZV gE Promotes STING Degradation via Midnolin-Proteasome Pathway to Inhibit cGAS-STING Signaling | | 漱口水暴露后唾液微生物组龋齿潜力的个体间差异 | Mermans, F. | PDF | N/A | Interindividual differences in caries potential of the salivary microbiome after mouthwash exposure | | 氯霉素诱导的枯草芽孢杆菌暂时表现出对多种抗生素的耐药性，包括糖肽类抗生素腐草霉素和博莱霉素。 | LaBonte, S. A. | PDF | N/A | Chloramphenicol-mobilized Bacillus subtilis transiently expresses resistance to multiple antibiotics, including the glycopeptides phleomycin and bleomycin | | 一套预组装的、基于pET28b的Golden Gate载体，用于高效的蛋白质工程和表达。 | Gaur, D. | PDF | N/A | A suite of pre-assembled, pET28b-based Golden Gate vectors for efficient protein engineering and expression | | 两种运输途径用于基于胎球蛋白A的矿物质复合物在成骨基质矿化中的作用 | Schaart, J. M. | PDF | N/A | Two Transport Routes for Fetuin-A-based Mineral Complexes in Osteogenic Matrix Mineralization | | 以下是这段英文的中文翻译：
水疱性口炎病毒糖蛋白G的单独结构及其与中和抗体复合物的结构
翻译解释： 1. "Structures of" 翻译为 "结构" 2. "vesicular stomatitis virus" 翻译为 "水疱性口炎病毒" 3. "glycoprotein G" 翻译为 "糖蛋白G" 4. "alone" 翻译为 "单独" 5. "in complex with" 翻译为 "与...复合物" 6. "a neutralizing antibody" 翻译为 "中和抗体"
这个翻译描述了水疱性口炎病毒糖蛋白G的两种结构：一种是单独的糖蛋白G结构，另一种是糖蛋白G与中和抗体形成的复合物结构。这种结构研究对于理解病毒与抗体的相互作用机制以及开发相关疫苗和治疗方法具有重要意义。 | Minoves, M. | PDF | N/A | Structures of vesicular stomatitis virus glycoprotein G alone and in complex with a neutralizing antibody | | 一个血管化的肝脏微生理系统捕捉了肝脏胰岛素抵抗和单核细胞浸润的关键特征 | Tevonian, E. N. | PDF | N/A | A Vascularized Liver Microphysiological System Captures Key Features of Hepatic Insulin Resistance and Monocyte Infiltration | | 通过下一代测序增强的新型免疫VNAR库挖掘，开发出FAP靶向治疗诊断学 | Gunaratne, G. | PDF | N/A | Development of FAP-targeted theranostics discovered by next-generation sequencing-augmented mining of a novel immunized VNAR library | | 生活作为一个函数：为什么Transformer架构难以获得基因组级别的基础能力 | Hassan, H. A. | PDF | N/A | Life as a Function: Why Transformer Architectures Struggle to Gain Genome-Level Foundational Capabilities | | 在艰难梭菌（Clostridioides difficile）中，类似LolA的蛋白质GerS通过链交换促进了细菌酰胺酶的全osteric激活。 | Bouchier, J. M. | PDF | N/A | Strand-swapping in the LolA-like protein GerS promotes the allosteric activation of a bacterial amidase in Clostridioides difficile | | 在豚鼠胎儿生长受限模型中，通过重复胎盘纳米颗粒介导的IGF1治疗对胎盘营养转运和信号传导的影响 | Davenport, B. | PDF | N/A | Placental Nutrient Transport and Signaling in a Guinea Pig Model of Fetal Growth Restriction with Repeated Placental Nanoparticle-mediated IGF1 Treatment | | RNA聚合酶II的CTD（C末端结构域）上的组合磷酸化选择性地控制蛋白质编码mRNA的转录和输出。 | Panina, S. B. | PDF | N/A | Combinatorial phosphorylation on CTD of RNA polymerase II selectively controls transcription and export of protein-coding mRNAs | | 基于组学的人类肝脏研究揭示了肥胖中MASLD进展的GTP酶驱动机制 | Zhao, Q. | PDF | N/A | Omics-based insights into human liver reveal GTPase-driven mechanisms of MASLD progression in obesity | | RBM20变异在扩张型和非致密化心肌病的患者特异性干细胞模型中诱导出不同的钙处理和代谢表型。 | Rebs, S. | PDF | N/A | RBM20-variants induce distinct calcium handling and metabolic phenotypes in patient-specific stem cell models of dilated and non-compaction cardiomyopathy | | 以下是将这段英文翻译成中文的结果：
一种通过重写γ-珠蛋白启动子并重新激活胎儿血红蛋白来治疗镰状细胞病的精准编辑策略。
翻译说明： 1. "prime editing" 翻译为“精准编辑”，这是一种新型的基因编辑技术。 2. "γ-globin promoters" 翻译为“γ-珠蛋白启动子”，γ-珠蛋白是胎儿血红蛋白的组成部分。 3. "reactivate fetal hemoglobin" 翻译为“重新激活胎儿血红蛋白”，这是治疗镰状细胞病的一种潜在方法。 4. "sickle cell disease" 翻译为“镰状细胞病”，这是一种遗传性血液疾病。
这个翻译准确地传达了原文的科学内容和技术目标。 | Chalumeau, A. | PDF | N/A | A prime editing strategy to rewrite the γ-globin promoters and reactivate fetal hemoglobin for sickle cell disease | | miR-379-3p通过调控嘧啶能受体、线粒体应激和干扰素反应来对抗癌症恶病质。 | Borja-Gonzalez, M. | PDF | N/A | miR-379-3p counteracts cancer cachexia through regulation of pyrimidinergic receptor, mitochondrial stress and interferon response. | | 雄性鸭子的求偶鸣叫：鸣管气囊的频谱组成与共振 | Mishkind, D. | PDF | N/A | Courtship vocalizations in male ducks: spectral composition and resonance of the syringeal bulla | | GPR15LG与CXCR4结合，并协同调节CXCL12诱导的细胞信号传导和迁移。 | Albers, D. | PDF | N/A | GPR15LG binds CXCR4 and synergistically modulates CXCL12-induced cell signaling and migration | | 稀疏交互作用建模能够在生物银行规模的研究中快速检测全基因组上位性。 | Stamp, J. | PDF | N/A | Sparse modeling of interactions enables fast detection of genome-wide epistasis in biobank-scale studies | | 通过对驱动复杂小眼症的调控变异的研究，深入探讨FOXE3转录网络及其疾病机制 | Plaisancie, J. | PDF | N/A | Insights into the FOXE3 Transcriptional Network and Disease Mechanisms from the Investigation of a Regulatory Variant Driving Complex Microphthalmia | | 显微镜节点：使用Blender进行多功能3D显微镜可视化 | Gros, O. | PDF | N/A | Microscopy Nodes: versatile 3D microscopy visualization with Blender | | 开发ERAF-AI：人工智能早期研究评估框架 | Falvo, D. | PDF | N/A | Developing ERAF-AI: An Early-stage ResearchAssessment Framework for Artificial Intelligence | | 分泌的福氏耐格里阿米巴小RNA作为原发性阿米巴脑膜脑炎诊断的生物标志物 | Russell, A. C. | PDF | N/A | Secreted small RNAs of Naegleria fowleri as biomarkers for diagnosis of primary amoebic meningoencephalitis | | 整合显式可靠性以做出最优选择：可信度对决策和元决策的影响 | Ota, K. | PDF | N/A | Integrating explicit reliability for optimal choices: effect of trustworthiness on decisions and metadecisions | | FGFR1抑制可防止与胶质母细胞瘤治疗抵抗相关的代谢适应 | Duran, R. V. | PDF | N/A | FGFR1 inhibition prevents metabolic adaptation associated with therapy resistance in glioblastoma | | DUSP12通过调节ZPR9促进细胞周期进程并保护细胞免受细胞死亡。 | Abdusamad, M. | PDF | N/A | DUSP12 promotes cell cycle progression and protects cells from cell death by regulating ZPR9 | | 弱且可调的黏附-离合器机制驱动快速细胞迁移和胶质母细胞瘤运动 | Baba, K. | PDF | N/A | Weak and tunable adhesion-clutch drives rapid cell migration and glioblastoma motility | | 弱且可调的黏附-离合器机制驱动快速细胞迁移和胶质母细胞瘤运动 | Baba, K. | PDF | N/A | Weak and tunable adhesion-clutch drives rapid cell migration and glioblastoma motility | | 有丝分裂驱动蛋白HSET的功能调控通过纤毛内运输蛋白实现。 | Guesdon, A. | PDF | N/A | Functional regulation of the mitotic kinesin HSET by Intraflagellar Transport proteins. | | 利用多尺度建模方法对α-突触核蛋白液态凝聚体和纤维状聚集体的肽抑制剂进行理性设计 | Ekambaram, S. | PDF | N/A | Rationale design of peptide inhibitors for α-Synuclein liquid condensates and fibrillar aggregates using multiscale modelling approach | | 突触中几何形状对蛋白质迁移的影响 | Dannenberg, S. | PDF | N/A | Geometry effects on protein mobility in a synapse | | 在急性环境挑战下斑马鱼尾部神经分泌系统中激素基因表达的变化 | Bichon, B. | PDF | N/A | Hormonal gene expression changes in the zebrafish caudal neurosecretory system under acute environmental challenges | | 效应器触发的处理体形成通过内质网应激反应和自噬在细菌感染时减弱宿主翻译 | Gonzalez-Fuente, M. | PDF | N/A | Effector-triggered processing body formation attenuates host translation via ER stress responses and autophagy upon bacterial infection | | 蕨类植物Ceratopteris richardii的U6启动子及表达Cas9内切酶的植株作为高效基因组编辑工具 | Schulz, R. | PDF | N/A | Ceratopteris richardii U6 promoters and plants expressing Cas9 endonuclease as tools for efficient genome editing in a fern | | 金盏花（Calendula officinalis）中抗炎三萜类化合物的生物合成与生物活性 | Golubova, D. | PDF | N/A | Biosynthesis and Bioactivity of Anti-Inflammatory Triterpenoids in Calendula officinalis (pot marigold) | | 四倍体马铃薯品种Desiree的单倍型解析基因组组装 | Godec, T. | PDF | N/A | Haplotype-resolved genome assembly of the tetraploid potato cultivar Desiree | | 形成冬季菌根的细根内生菌 | Sentoku, T. | PDF | N/A | Fine root endophytes forming winter mycorrhiza | | 对秀丽隐杆线虫（Caenorhabditis elegans）神经元网络的符号基序分析揭示了正前馈和负反馈环路的存在。 | Szilagyi, G. S. | PDF | N/A | Signed motif analysis of the Caenorhabditis elegans neuronal network reveals positive feedforward and negative feedback loops | | 将这段翻译成中文为：感觉运动皮层中功能性ALS病理的个体化表型分析 | Kalyani, A. | PDF | N/A | Individualized Phenotyping of Functional ALS Pathology in Sensorimotor Cortex | | 《人类大脑形态相关的血浆代谢标志物图谱》 | van der Meer, D. | PDF | N/A | Atlas of plasma metabolic markers linked to human brain morphology | | 白细胞介素-34和单核吞噬细胞对碎片的清除驱动斑马鱼视网膜色素上皮的再生 | Leach, L. L. | PDF | N/A | Interleukin-34 and debris clearance by mononuclear phagocytes drive retinal pigment epithelium regeneration in zebrafish | | 在嗜热四膜虫中，一种与溶酶体相关细胞器（LRO）生物发生所需的V-ATPase复合物，在LRO成熟过程中会解离。 | Pradhan, A. | PDF | N/A | A V-ATPase complex, required for biogenesis of a lysosome-related organelle (LRO) in Tetrahymena thermophila, disassembles during LRO maturation | | 沉默子元件中的遗传变异影响人类血细胞特征 | Tan, M. | PDF | N/A | Genetic variants within silencer elements contribute to human blood cell traits | | 氯仿从老化细胞和果蝇DJ-1突变体中释放 | Issitt, T. | PDF | N/A | Chloroform release from ageing cells and Drosophila DJ-1 mutants | | 使用机器学习模型评估微小RNA的遗传调控因子 | Cihan, M. | PDF | N/A | Evaluating Genetic Regulators of MicroRNAs Using Machine Learning Models | | 评估四种ECM相关基因在结直肠癌复发和转移中的预后价值 | Avcıoglu, B. S. D. | PDF | N/A | Evaluation of the Prognostic Value of Four ECM-Associated Genes in Recurrence and Metastasis of Colorectal Cancer | | 在蕨类植物Ceratopteris richardii中过量表达MADS-box基因CRM3会影响孢子体的发育。 | Schulz, R. | PDF | N/A | Overexpression of the MADS-box gene CRM3 in the fern Ceratopteris richardii affects sporophyte development | | 为六倍体甘薯及其二倍体野生近缘种构建参考质量的NLRome | Parada-Rojas, C. H. | PDF | N/A | A reference-quality NLRome for the hexaploid sweetpotato and diploid wild relatives | | 较低的慢波睡眠和快速眼动睡眠与阿尔茨海默病易感区域的脑萎缩有关。 | Cho, G. | PDF | N/A | Lower slow wave sleep and rapid eye-movement sleep are associated with brain atrophy of AD-vulnerable regions | | 变暖和降雨量增加会降低熊蜂蜂王的健康状况 | Archer, C. R. | PDF | N/A | WARMING AND INCREASED RAINFALL REDUCE BUMBLEBEE QUEEN FITNESS | | 利用抗体库数据和机器学习进行抗体亲和力工程 | Erlach, L. | PDF | N/A | Antibody affinity engineering using antibody repertoire data and machine learning | | easyEWAS：一个灵活且用户友好的R包，用于全表观基因组关联研究 | Wang, Y. | PDF | N/A | easyEWAS: a flexible and user-friendly R package for Epigenome-Wide Association Study | | RNA测序揭示了调控TNFα刺激下牙髓干细胞向成牙本质细胞样分化的关键因素 | Irfan, M. | PDF | N/A | RNA sequencing reveals key factors modulating TNFa-stimulated odontoblast-like differentiation of dental pulp stem cells | | 冷冻电镜捕捉到了LIS1激活动力蛋白的早期中间步骤 | Nguyen, K. H. V. | PDF | N/A | Cryo-EM captures early intermediate steps in dynein activation by LIS1 | | 通过冷冻电镜和分子动力学模拟揭示的血管紧张素-I转换酶的二聚化和动态特性 | Tang, W.-J. | PDF | N/A | Dimerization and dynamics of angiotensin-I converting enzyme revealed by cryoEM and MD simulations | | 通过冷冻电镜和分子动力学模拟揭示的血管紧张素-I转换酶的二聚化及动态特性 | mancl, j. M. | PDF | N/A | Dimerization and dynamics of angiotensin-I converting enzyme revealed by cryoEM and MD simulations | | 蛋白质的稳定性由单一位点的偏好决定，而不是成对协方差。 | Sternke, M. | PDF | N/A | Protein stability is determined by single-site bias rather than pairwise covariance | | 开源3D荧光显微镜主动样本稳定技术 | Patil, S. | PDF | N/A | Open-Source 3D Active Sample Stabilization for Fluorescence Microscopy | | 基于图像的纳米级三维主动样品稳定技术用于光学显微镜 | Vorlaufer, J. | PDF | N/A | Image-based 3D active sample stabilization on the nanometer scale for optical microscopy | | 药物诱导的核CTSL（nCTSL）在癌症DNA损伤反应中的作用及其治疗意义 | Thirusangu, P. | PDF | N/A | Role of drug induced nuclear CTSL (nCTSL) in DNA damage response in cancer- therapeutic implications | | 在大西洋鲑鱼循环水养殖系统废水中培养的三角褐指藻（Phaeodactylum tricornutum）的生物量生产、磷利用效率和脂肪酸组成 | Borg-Stoveland, S. | PDF | N/A | Biomass Production, Phosphorus Use Efficiency, and Fatty Acid Composition in Phaeodactylum tricornutum Cultivated in Wastewater from an Atlantic Salmon Recirculating Aquaculture System | | 一种具有集成DNA自我复制和膜生物合成的合成细胞 | Restrepo Sierra, A. M. | PDF | N/A | A synthetic cell with integrated DNA self-replication and membrane biosynthesis | | 缺氧诱导因子2α在肠道蠕虫感染期间促进保护性Th2细胞反应 | Labuda, J. C. | PDF | N/A | Hypoxia-inducible factor 2α promotes protective Th2 cell responses during intestinal helminth infection | | 通过全息加热显微镜实现的时空温度控制揭示了细胞的热敏钙信号传导机制。 | Oyama, K. | PDF | N/A | Spatiotemporal temperature control by holographic heating microscopy unveils cellular thermosensitive calcium signaling | | 将1400万种虚拟异喹啉类化合物与μ和κ阿片受体进行对接，揭示了具有减少戒断效应的双重拮抗剂-反向激动剂。 | Vigneron, S. F. | PDF | N/A | Docking 14 million virtual isoquinuclidines against the mu and kappa opioid receptors reveals dual antagonists-inverse agonists with reduced withdrawal effects | | BicD和MAP7通过互补机制协作激活同源二聚体果蝇驱动蛋白-1（kinesin-1）。 | Ali, M. Y. | PDF | N/A | BicD and MAP7 collaborate to activate homodimeric Drosophila kinesin-1 by complementary mechanisms | | 整合技术用于细胞外颗粒分离和单颗粒多参数表征，以追踪从组织到生物流体的癌症生物标志物 | Nguyen, K. T. | PDF | N/A | Integrated Techniques for Extracellular Particle Separation and Single-Particle Multiparametric Characterization to Track Cancer Biomarkers from Tissue to Biofluids | | 一种新型小鼠尾部模型用于不同剂量局部照射后辐射性皮肤损伤的研究 | Wang, T. | PDF | N/A | A novel murine tail model for radiation-induced skin injury following localized irradiation at varying doses | | 突变的p.H222P A型核纤层蛋白在患者来源的心肌细胞和扩张型心肌病小鼠模型中均驱动Loxl2介导的细胞外基质重塑 | Kervella, M. | PDF | N/A | The Mutated p.H222P A-type Lamins Drive Loxl2-Mediated Extracellular Matrix Remodeling in Both Patient-Derived Cardiomyocytes and Mouse Models of Dilated Cardiomyopathy | | “自然价值视角”量表：一个经过验证的量表，用于从变革的角度衡量未来自然的多元价值视角。 | Buijs, A. | PDF | N/A | The "value perspectives of nature" scale: A validated scale to measure plural value perspectives of future nature from a transformative angle. | | 混合的正负反馈回路驱动多样的单细胞基因表达动态 | Loman, T. E. | PDF | N/A | Mixed positive and negative feedback loops drive diverse single-cell gene expression dynamics | | 中性蛋白质进化中的固守性与偶然性及上位效应 | Schmelkin, L. | PDF | N/A | Entrenchment and contingency in neutral protein evolution with epistasis | | 长读长低通测序用于高分辨率性状定位 | Lee, K. C. | PDF | N/A | Long-Read Low-Pass Sequencing for High-Resolution Trait Mapping | | 实时彩色血流映射超声微机器人 | Dillinger, C. | PDF | N/A | Real-time Color Flow Mapping of Ultrasound Microrobots | | 多核非血红素铁依赖氧化酶：其底物、伴侣蛋白及生物合成基因簇的概览 | Antoine, R. | PDF | N/A | Multinuclear non-heme iron dependent oxidative enzymes: Landscape of their substrates, partner proteins and biosynthetic gene clusters | | Cleanet：基于蛋白质表达模式的细胞计数数据中稳健的双峰检测 | Ionita, M. | PDF | N/A | Cleanet: robust doublet detection in cytometry data based on protein expression patterns | | 通过捕捉键微调材料特性 | Rabbi, M. F. | PDF | N/A | Fine-Tuning of Material Properties via Catch Bonds | | MYCN mRNA中的非编码RNA元件是致癌作用的强效自主驱动因素。 | Powers, J. | PDF | N/A | Noncoding RNA elements within MYCN mRNA are potent autonomous drivers of oncogenesis. | | 细胞外基质驱动鸟苷酸的产生，并保护胰腺癌细胞免受奥沙利铂诱导的DNA损伤。 | Efthymiou, G. | PDF | N/A | The extracellular matrix drives guanylate production and protects pancreatic cancer cells from oxaliplatin-induced DNA damage. | | 在TP53野生型和突变型癌细胞中，使用DRx-098D靶向破坏MDM2同源二聚体和异源二聚体 | Cooke, S. F. | PDF | N/A | Targeting MDM2 homodimer and heterodimer disruption with DRx-098D in TP53 wild-type and mutant cancer cells | | 长期培养的患者来源卵巢癌类器官高度模拟了原始肿瘤及其临床反应。 | Thorel, L. | PDF | N/A | Long-term patient-derived ovarian cancer organoids closely recapitulate tumor of origin and clinical response | | ATP敏感的P2X5亚型：跨物种功能的重新评估 | Yang, X.-N. | PDF | N/A | ATP-sensitive isoforms of P2X5: A reevaluation of its function across species | | 分泌型氧化还原传感器roGFP2-Orp1揭示了植物质外体中的氧化动态。 | Ingelfinger, J. | PDF | N/A | The secreted redox sensor roGFP2-Orp1 reveals oxidative dynamics in the plant apoplast | | TrueSpot：一种用于量化荧光成像中信号点（puncta）的强大自动化工具 | Hospelhorn, B. G. | PDF | N/A | TrueSpot: A robust automated tool for quantifying signal puncta in fluorescent imaging | | 优化dsRNA序列以用于害虫控制和研究中的RNA干扰技术，利用dsRIP网络平台 | Cedden, D. | PDF | N/A | Optimizing dsRNA sequences for RNAi in pest control and research with the dsRIP Web-Platform | | CD2表达与人类T细胞中的干性相关因子和耗竭相关因子共同调控。 | Demetriou, P. | PDF | N/A | CD2 expression is co-regulated with stemness- and exhaustion-associated factors in human T cells | | 白细胞介素10在鸟类中控制着耐受性、病原体清除和免疫病理学之间的平衡。 | Meunier, D. | PDF | N/A | Interleukin 10 controls the balance between tolerance, pathogen elimination and immunopathology in birds. | | 组织驻留的骨骼肌巨噬细胞促进正常衰老中病毒性肺炎引起的肌肉减少症的恢复。 | Runyan, C. E. | PDF | N/A | Tissue-resident skeletal muscle macrophages promote recovery from viral pneumonia-induced sarcopenia in normal aging. | | 抗生素耐药性大肠杆菌在沃勒溪（Waller Creek）中很常见，这是一条长期受到粪便细菌污染的城区水道。 | Olivera Perez, L. | PDF | N/A | Antibiotic Resistant E. Coli are Common in Waller Creek, an Urban Waterway Chronically Contaminated with Fecal Bacteria | | 在进行基于特征的植物-传粉者相互作用预测时，物候更替是一个重要因素。 | Cantwell-Jones, A. R. | PDF | N/A | Phenological turnover matters when making trait-based predictions of plant-pollinator interactions | | 海拔和小气候温度对地中海山脉蝴蝶-花卉相互作用网络的影响 | Alamo, M. | PDF | N/A | Effects of elevation and microclimatic temperatures on butterfly-flower interaction networks in a Mediterranean mountain range | | 一张新的南满混合森林地图有助于估算其保护区域的面积。 | Dzizyurova, V. | PDF | N/A | A new map of South Manchurian mixed forests facilitates the estimation of their area for conservation purposes | | 较大的幼体海七鳃鳗（Petromyzon marinus）在暴露于杀七鳃鳗剂3-三氟甲基-4-硝基苯酚时，具有更长的存活时间。 | Nalesnik, A. M. | PDF | N/A | Larger larval sea lamprey (Petromyzon marinus) have longer survival times when exposed to the lampricide 3-trifluoromethyl-4-nitrophenol | | 对扁形动物毒素进化及其在陆地化过程中的作用进行蛋白质组学与转录组学联合研究 | Garcia-Vernet, R. | PDF | N/A | A proteo-transcriptomic investigation of toxin evolution in planarians and their role in flatworm terrestrialization | | 飞翅的宏观进化沿着发育路径中阻力最小的方向进行。 | Rohner, P. T. | PDF | N/A | Macroevolution of fly wings proceeds along developmental lines of least resistance | | 对真菌界中支撑转座子防御系统的遗传因素进行系统性筛选 | Badet, T. | PDF | N/A | A systematic screen for genetic factors underpinning transposon defense systems across the fungal kingdom | | 遗传变异在塑造衰老果蝇对饮食的表型反应中的作用 | Bak, N. K. | PDF | N/A | The Role of Genetic Variation in Shaping Phenotypic Responses to Diet in Aging Drosophila melanogaster | | 一种基于谱系的方法，用于揭示混合群体中特定祖先的结构 | Tang, J. | PDF | N/A | A genealogy-based approach for revealing ancestry-specific structures in admixed populations | | 一个鼠类结构变异数据库使得自发性鼠类淋巴瘤的遗传结构得以被表征 | Ren, W. | PDF | N/A | A Murine Database of Structural Variants Enables the Genetic Architecture of a Spontaneous Murine Lymphoma to be Characterized | | 生理相关的口腔微生物-宿主相互作用共培养模型 | Pang, Z. | PDF | N/A | Physiologically Relevant Coculture Model for Oral Microbial-Host Interactions | | 对用于骨骼再生的体外工程化但无细胞的人类组织移植物进行临床前验证 | Garcia Garcia, A. | PDF | N/A | Pre-clinical validation of in vitro engineered but cell-free human tissue grafts for skeletal regeneration | | 使用SHAPES评估生成模型对蛋白质结构的覆盖情况 | Lu, T. | PDF | N/A | Assessing Generative Model Coverage of Protein Structures with SHAPES | | 实时同步监测细菌培养物中的多种分析物 | Fink, M. M. | PDF | N/A | Real-time simultaneous monitoring of multiple analytes in bacterial cultures | | 高通量黏液微流变学用于表型分析和疾病建模 | Ling, F. | PDF | N/A | High-throughput Mucus Microrheology for Phenotyping and Disease Modeling | | 全球栖息地中病毒组编码的人类益生基因与致病基因的共存 | Qian, M. | PDF | N/A | Coexistence of Virome-Encoded Human Probiotic Genes and Pathogenic Genes in Global Habitats | | CellUntangler：利用深度生成模型分离单细胞数据中的不同生物信号 | Chen, S. | PDF | N/A | CellUntangler: separating distinct biological signals in single-cell data with deep generative models | | CryoNeRF：使用神经辐射场重建同质和异质的冷冻电镜结构 | Qu, H. | PDF | N/A | CryoNeRF: reconstruction of homogeneous and heterogeneous cryo-EM structures using neural radiance field | | Rosace-AA：通过氨基酸替换和位置特异性洞察增强深度突变扫描数据的解释 | Rao, J. | PDF | N/A | Rosace-AA: Enhancing Interpretation of Deep Mutational Scanning Data with Amino Acid Substitution and Position-Specific Insights | | scValue：基于价值的大规模单细胞转录组数据子采样 | Huang, L. | PDF | N/A | scValue: value-based subsampling of large-scale single-cell transcriptomic data | | 低复杂度连接器作为DNAJB分子伴侣中分子内和分子间相互作用的驱动因素 | Hobbs, B. | PDF | N/A | A low-complexity linker as a driver of intra- and intermolecular interactions in DNAJB chaperones | | 通过可变结合模式，广泛的全氟烷基物质（PFAS）能够与脂肪酸结合蛋白4（FABP4）结合。 | Birchfield, A. S. | PDF | N/A | Broad PFAS binding with fatty acid binding protein 4 is enabled by variable binding modes. | | 光诱导的果蝇隐花色素构象转换及其磁敏感性 | Chandler, S. A. | PDF | N/A | Light-induced conformational switching and magnetic sensitivity of Drosophila cryptochrome | | 具有Wnt1调节活性的抗癌合成芳基磺酰胺类药物 | Gutti, M. | PDF | N/A | Anticancer synthetic arylsulfonamides with Wnt1-modulating activity | | 由微外显子跳跃定义的神经元细胞粘附分子（NRCAM）变体是高级别胶质瘤中一种重要的、抗原性独特且可靶向的表面蛋白质形式。 | Sehgal, P. | PDF | N/A | Neuronal cell adhesion molecule (NRCAM) variant defined by microexon skipping is an essential, antigenically distinct, and targetable surface proteoform in high-grade glioma | | 通过有效靶向PI3K激酶，绕过Nrf2过度激活的头颈癌对顺铂的耐药性 | Sandulache, V. C. | PDF | N/A | Bypassing cisplatin resistance in Nrf2 hyperactivated head and neck cancer through effective PI3Kinase targeting | | 高效能新型多装甲IL13Rα2 CAR-T细胞颠覆了胶质母细胞瘤的免疫抑制微环境 | Mangolini, M. | PDF | N/A | Highly potent novel multi-armoured IL13Rα2 CAR-T subverts the immunosuppressive microenvironment of Glioblastoma | | 抑制谷氨酰胺代谢通过重塑巨噬细胞免疫微环境抑制肿瘤进展 | Li, T. | PDF | N/A | Inhibition of Glutamine Metabolism Suppresses Tumor Progression through Remodeling of the Macrophage Immune Microenvironment | | 反复出现的致癌性ZC3H18突变稳定了内源性逆转录病毒RNA | Tanu, T. | PDF | N/A | Recurrent oncogenic ZC3H18 mutations stabilize endogenous retroviral RNA | | 小分子促进内源性脂滴积累驱动溶酶体自噬 | Vechalapu, S. K. | PDF | N/A | Small molecule promoters of endogenous lipid droplet accumulation drive lysophagy | | 全球板块模型的选择会影响纬度生物多样性梯度重建的结果。 | Jones, L. A. | PDF | N/A | Global plate model choice impacts reconstructions of the latitudinal biodiversity gradient | | 以下是这段文字的中文翻译：
裸盖菇素对大鼠的年龄和发情周期依赖性影响
翻译说明： - "Age-dependent" 翻译为 "年龄依赖性"，表示效果随年龄变化。 - "estrous-dependent" 翻译为 "发情周期依赖性"，表示效果与大鼠的发情周期有关。 - "psilocybin" 是裸盖菇素，一种具有精神活性的化合物。 - "rats" 翻译为 "大鼠"，是常用的实验动物。
整句话的意思是研究裸盖菇素对大鼠的影响如何随年龄和发情周期的变化而变化。 | Zylko, A. L. | PDF | N/A | Age- and estrous-dependent effects of psilocybin in rats | | 探索Kv1.3和MAPK14在有机粉尘暴露后介导小胶质细胞氧化应激和神经炎症中的作用 | Massey, N. | PDF | N/A | Exploring the Role of Kv1.3 and MAPK14 in Mediating Microglial Oxidative Stress and Neuroinflammation Following Organic Dust Exposure | | 赤霉素促进Nolana mollis和Heliotropium pycnophyllum种子的萌发 | van den Brink, L. | PDF | N/A | Gibberellin enhances germination of Nolana mollis and Heliotropium pycnophyllum seeds | | 冬季变暖，春季变迁：耐寒性动态预测跨大陆尺度上的芽破期及相关低温威胁 | Campos-Arguedas, F. | PDF | N/A | Warming winters, changing springs: cold hardiness dynamics predict budbreak and associated low temperature threats on an intercontinental scale | | 不稳定的花青素着色在Streptocarpus sect. Saintpaulia（非洲紫罗兰）中是由于单个MYB基因的变异选择性所致。 | Kurata, D. | PDF | N/A | Unstable anthocyanin pigmentation in Streptocarpus sect. Saintpaulia (African violet) is due to variant selectivity of a single MYB gene | | 分开、分离与融合：产酸梭菌-隆达梭菌共生转录程序导致种间细胞融合 | Willis, N. B. | PDF | N/A | Separate, Separated and Together: the Transcriptional Program of the Clostridium acetobutylicum- Clostridium ljungdahlii syntrophy leading to interspecies cell fusion | | 朗格汉斯细胞驱动Tfh和B细胞反应，不依赖经典的细胞因子信号 | Bouteau, A. | PDF | N/A | Langerhans Cells Drive Tfh and B Cell Responses Independent of Canonical Cytokine Signals | | 通过重新调控小鼠胰腺导管腺癌中的免疫抑制性中性粒细胞来改进立体定向体部放射治疗（SBRT） | Murphy, J. D. | PDF | N/A | Improving SBRT by re-wiring immunosuppressive neutrophils in murine pancreatic ductal adenocarcinoma | | 局部递送SBRT和IL-12至小鼠PDAC肿瘤可调节造血功能 | Vrooman, T. G. | PDF | N/A | Local delivery of SBRT and IL-12 to Murine PDAC Tumors Modulates Hematopoiesis | | 多唾液酸化是免疫激活的一个普遍特征。 | Makhsous, S. | PDF | N/A | Polysialylation is a general feature of immune activation | | 通过系统免疫学方法生成T细胞受体、细胞因子和细胞库滑液图谱，以定义关节炎疾病之间的共性和差异。 | Ha, M. K. | PDF | N/A | Generation of a T cell receptor, cytokine and cell repertoire synovial fluid atlas to define commonalities and dissimilarities between arthritic diseases through systems immunology approaches | | RNA解旋酶DDX1通过促进tRNA连接酶活性来调节生发中心选择和亲和力成熟。 | Kimber, R. | PDF | N/A | RNA helicase DDX1 regulates germinal centre selection and affinity maturation by promoting tRNA ligase activity | | 利用环境DNA追踪河流昆虫群落的物候 | Cereghetti, E. | PDF | N/A | Tracking the phenology of riverine insect communities using environmental DNA | | 以下是这段英文的中文翻译：
"陆地节肢动物在扩散、生活史和热生态位方面表现出一致的相关性。"
翻译解释： - "Consistent covariation" 翻译为 "一致的相关性" - "dispersal" 翻译为 "扩散" - "life history" 翻译为 "生活史" - "thermal niches" 翻译为 "热生态位" - "across terrestrial arthropods" 翻译为 "在陆地节肢动物中"
整句话的意思是，在陆地节肢动物中，扩散能力、生活史特征和热生态位之间存在一致的相关性。 | Logghe, G. | PDF | N/A | Consistent covariation of dispersal, life history and thermal niches across terrestrial arthropods | | 城市化如何影响蜗牛（Cornu aspersum）的壳表型、行为及寄生虫感染率？ | Dahirel, M. | PDF | N/A | How does urbanization shape shell phenotype, behaviour and parasite prevalence in the snail Cornu aspersum? | | 野火灰对海洋浮游植物培养物的光合作用及生长的影响 | Van Houtan, K. S. | PDF | N/A | Wildfire ash impacts to photosynthesis and growth of marine phytoplankton cultures | | 为什么在比较表型组和基因组预测模型时，准确性指标存在不足 | Wang, F. | PDF | N/A | Why Accuracy Metrics Fall Short in Comparing Phenomic and Genomic Prediction Models | | 肌成纤维细胞在肺纤维化的血管化微生理模型中减少血管生成和血管新生 | Cambria, E. | PDF | N/A | Myofibroblasts reduce angiogenesis and vasculogenesis in a vascularized microphysiological model of lung fibrosis | | 精准mRNA纳米医学用于ARDS和动脉粥样硬化的靶向血管治疗 | Zhou, Z. | PDF | N/A | Precision mRNA Nanomedicine for Targeted Vascular Therapies in ARDS and Atherosclerosis | | 通过使用合成的干细胞肽前药对肠道共生菌进行原位修饰，实现皮质类固醇的局部递送。 | Baryakova, T. | PDF | N/A | Localized delivery of corticosteroids via in situ modification of gut commensals using a synthetic stem peptide prodrug | | 通过反应核心的成对结构相似性改进水解酶的功能分类 | Ferdous, S. | PDF | N/A | Improved Functional Classification of Hydrolases through Pairwise Structural Similarity of Reaction Cores | | CocycleHunter：基于同调的单细胞RNA测序数据中的环状基因集富集与遗传相位估计。 | Maggs, K. | PDF | N/A | CocycleHunter: cohomology-based circular gene setenrichment and genetic phase estimation in single-cell RNA-seq data. | | Oncodrive3D：快速准确地检测正选择下的体细胞突变结构簇 | Pellegrini, S. | PDF | N/A | Oncodrive3D: Fast and accurate detection of structural clusters of somatic mutations under positive selection | | 探索维生素D及其类似物作为一种可能的治疗干预手段，针对神经退行性疾病（如帕金森病）中的炎症介质。 | Pal, R. | PDF | N/A | Exploring vitamin D and its analogues as a possible therapeutic intervention in targeting inflammatory mediators in neurodegenerative disorders like Parkinsons disease | | 《数据库穿越时空与医学：VGL离子通道跨膜氨基酸的序列、结构及临床汇编与比较》
这个标题的中文翻译尽量保持了原文的专业性和准确性，同时确保语言流畅。标题中的关键术语如“Database”（数据库）、“Permeating through Time, Space, and Medicine”（穿越时空与医学）、“sequence, structure, and clinical compilation and comparison”（序列、结构及临床汇编与比较）以及“transmembrane amino acids in VGL ion channels”（VGL离子通道跨膜氨基酸）都得到了恰当的翻译。 | Yeh, F. | PDF | N/A | Database Permeating through Time, Space, and Medicine: A sequence, structure, and clinical compilation and comparison of transmembrane amino acids in VGL ion channels | | MISO：微流控蛋白质分离技术使得从单个细胞群体中确定单颗粒冷冻电镜结构成为可能。 | Eluru, G. | PDF | N/A | MISO: Microfluidic protein isolation enables single particle cryo-EM structure determination from a single cell colony | | ANGPTL6变异导致小鼠脑血管功能障碍并增加颅内动脉瘤的易感性 | Baron-Menguy, C. | PDF | N/A | ANGPTL6 variant induces cerebral vascular dysfunction and predisposes to intracranial aneurysm in mice | | 以下是这段英文的中文翻译：
为蚤蝇（Megaselia abdita）提供的基因组资源：一种用于果蝇比较发育研究的模式生物
翻译说明： - "Genomic Resources" 翻译为“基因组资源”，指的是与基因组相关的数据、工具或信息。 - "Scuttle Fly" 是“蚤蝇”的英文名称，属于双翅目昆虫。 - "Megaselia abdita" 是蚤蝇的学名，通常直接保留拉丁名。 - "Model Organism" 翻译为“模式生物”，指在科学研究中被广泛使用的代表性生物。 - "Comparative Developmental Studies" 翻译为“比较发育研究”，指通过比较不同物种的发育过程来研究其异同。 - "Flies" 翻译为“果蝇”或“蝇类”，这里泛指双翅目昆虫。
希望这段翻译对您有帮助！ | Tenger-Trolander, A. | PDF | N/A | Genomic Resources for the Scuttle Fly Megaselia abdita: A Model Organism for Comparative Developmental Studies in Flies | | 生物噪声的群体遗传学 | Weinreich, D. M. | PDF | N/A | The Population Genetics of Biological Noise | | 线粒体基因组的结构与拟南芥的地理分布有关。 | Xian, W. | PDF | N/A | The structure of mitochondrial genomes is associated with geography in Arabidopsis thaliana | | 使用模块化育种程序模拟器（MoBPS）优化玉米快速循环育种方案 | Pook, T. | PDF | N/A | Optimization of a maize rapid cycle breeding scheme using the Modular Breeding Program Simulator (MoBPS) | | 一个经过微调的ProtGPT2（Transformer模型），用于预测更具毒性的SARS-CoV-2变体，并通过生物物理方法理解其毒性。 | Paul D, S. | PDF | N/A | A Fine-tuned ProtGPT2 (transformer model) for Predicting more Virulent SARS-CoV-2 variants and understanding its virulence by biophysical methods. | | 单光子单粒子追踪 | Xu, L. W. Q. | PDF | N/A | Single-Photon Single-Particle Tracking | | MDL-001：一种口服、安全且耐受性良好的广谱病毒聚合酶抑制剂 | Woods, V. | PDF | N/A | MDL-001: An Oral, Safe, and Well-Tolerated Broad-Spectrum Inhibitor of Viral Polymerases | | 通过靶向基因组随机化解析人类超级增强子的分辨率 | Koeppel, J. | PDF | N/A | Resolution of a human super-enhancer by targeted genome randomisation | | 在噬菌体诱导过程中，Cro2和CI2与OR操作子结合在控制溶原稳定性中的作用 | Pang, Y. | PDF | N/A | Roles of Cro2 and CI2 binding to OR operators in controlling lysogeny stability during prophage induction | | 损伤信号优先激活杀伤性CD8+/-调节性T细胞以保护受损组织 | Josyula, A. | PDF | N/A | Damage signals preferentially activate killer CD8+/- regulatory T cells to protect injured tissue | | 未接种疫苗的HLA-A2+患者中与COVID-19严重程度相关的不同CD8+ T细胞类型 | Masuda, K. | PDF | N/A | Distinct CD8+ T-cell types Associated with COVID-19 Severity in Unvaccinated HLA-A2+ Patients | | 系统发育上遥远但共居：立陶宛松林中扁枝石松、欧洲赤松和欧洲越橘细根的真菌群落 | Kuprina, K. | PDF | N/A | Phylogenetically distant but cohabiting: Fungal communities of fine roots in Diphasiastrum complanatum, Pinus sylvestris, and Vaccinium myrtillus in a Lithuanian pine forest | | 气候和区域植物丰富度驱动蝴蝶幼虫的饮食特化 | Gross, C. P. | PDF | N/A | Climate and regional plant richness drive diet specialization in butterfly caterpillars | | 超补偿等位基因能够挽救多种有害的基因替换，并缓冲突变的影响。 | Jiang, W. | PDF | N/A | Super-compensator alleles rescue diverse deleterious substitutions and buffer the effects of mutations | | 并非所有分支都平等：系统发育多样性分析中的分支长度评估。 | Miranda-Esquivel, D. R. | PDF | N/A | Not all branches are equal: Branch Length Evaluation for Phylogenetic Diversity analysis. | | 将FAcD从二聚体转化为活性单体的从头设计策略 | Chen, K.-W. | PDF | N/A | A De Novo Design Strategy to Convert FAcD from Dimer to Active Monomer | | ARGfore: 一种利用时间序列宏基因组数据集预测抗生素抗性基因丰度的多变量框架 | Choi, J. M. | PDF | N/A | ARGfore: A multivariate framework for forecasting antibiotic resistance gene abundances using time-series metagenomic datasets | | 以下是这段英文的中文翻译：
淀粉样纤维组装的结构基础：由主细胞信号调节因子人类受体相互作用蛋白激酶1介导
这个标题描述了一项研究，旨在揭示人类受体相互作用蛋白激酶1（RIPK1）在淀粉样纤维组装中的结构机制。RIPK1是一种关键的细胞信号调节因子，参与多种细胞过程，包括炎症和细胞死亡。淀粉样纤维是一种与多种神经退行性疾病（如阿尔茨海默病）相关的蛋白质聚集体。研究其组装机制对于理解疾病的发生和开发潜在治疗方法具有重要意义。 | Polonio, P. | PDF | N/A | Structural Basis for the Assembly of Amyloid Fibrils by the Master Cell-Signaling Regulator Human Receptor-Interacting Protein Kinase 1 | | 肝脏淋巴功能障碍作为纤维化和肝硬化进展的驱动因素 | Jeong, J. | PDF | N/A | Liver Lymphatic Dysfunction as a Driver of Fibrosis and Cirrhosis Progression | | 在线GPCR药物发现资源 | Caroli, J. | PDF | N/A | An online GPCR drug discovery resource | | 在大鼠适应运动训练前后，骨骼肌线粒体中均含有核编码的RNA种类。 | Silver, J. L. | PDF | N/A | Skeletal muscle mitochondria contain nuclear-encoded RNA species prior to and following adaptation to exercise training in rats | | 过度表达TEMPRANILLO样蛋白促进杨树的内休眠解除 | Gomez-Soto, D. | PDF | N/A | OVEREXPRESSION OF TEMPRANILLO-LIKE PROTEINS PROMOTES ENDORMANCY RELEASE IN POPLAR | | 关于“Candidatus Accumulibacter”双底物生长的代谢影响 | Paez-Watson, T. | PDF | N/A | Metabolic implications for dual substrate growth in "Candidatus Accumulibacter" | | 一项整合系统生物学的方法确立了精氨酸生物合成作为白色念珠菌在宿主感染期间的代谢弱点。 | Chakraborty, S. | PDF | N/A | An integrated systems biology approach establishes arginine biosynthesis as a metabolic weakness in Candida albicans during host infection | | 一种在SPR生物传感器芯片上生产数千种单链抗体变体的方法，用于测量目标结合动力学并深入表征抗体结合位点。 | Cook, R. L. | PDF | N/A | An approach to produce thousands of single-chain antibody variants on a SPR biosensor chip for measuring target binding kinetics and for deep characterization of antibody paratopes | | 在CASPR2抗体脑炎中，宽松的中枢耐受性加上缺陷的外周检查点使得致病性记忆B细胞得以存在。 | Sun, B. | PDF | N/A | Permissive central tolerance plus defective peripheral checkpoints licence pathogenic memory B cells in CASPR2-antibody encephalitis | | 在CASPR2抗体脑炎中，宽松的中枢耐受加上有缺陷的外周检查点使得致病性记忆B细胞得以存在。 | Sun, B. | PDF | N/A | Permissive central tolerance plus defective peripheral checkpoints licence pathogenic memory B cells in CASPR2-antibody encephalitis | | 生成具有生成性变压器的T细胞受体同源表位序列 | Ma, M. | PDF | N/A | Generating cognate epitope sequences of T-cell receptors with a generative transformer | | 极端高多样性条形码HIV文库使得单细胞多组学分析病毒表达和命运决定成为可能。 | Zhang, T.-h. | PDF | N/A | Extreme high-diversity barcoded HIV library enables single cell multi-omics analysis of viral expression and fate determination | | 构建机械生物学图谱：在五种原代人类细胞类型中对2418种激酶抑制剂进行高通量收缩性筛选，揭示了相关细胞类型之间的选择性差异反应 | Shpak, A. | PDF | N/A | Building an atlas of mechanobiology: high-throughput contractility screen of 2418 kinase inhibitors in five primary human cell types reveals selective divergent responses among related cell types | | 单壁碳纳米管探针用于直接在无细胞表达反应中表征蛋白酶 | Hejazi, S. | PDF | N/A | Single-Walled Carbon Nanotube Probes for Protease Characterization Directly in Cell-Free Expression Reactions | | RNA3DClust：基于聚类方法的RNA三维结构分割 | Le, Q. K. | PDF | N/A | RNA3DClust: segmentation of RNA three-dimensional structures using a clustering-based approach | | COSIME：协作式多视图集成与可扩展及可解释的模型解释器 | Choi, J. J. | PDF | N/A | COSIME: Cooperative multi-view integration and Scalable and Interpretable Model Explainer | | 梅尔基奥尔：一种混合型曼巴-Transformer RNA碱基识别器
（注：这里的“Melchior”是一个专有名词，可能指代某个特定的项目或工具名称，因此直接音译为“梅尔基奥尔”。而“Hybrid Mamba-Transformer”则描述了该碱基识别器的技术特点，即结合了“Mamba”和“Transformer”两种技术，因此翻译为“混合型曼巴-Transformer”。最后，“RNA Basecaller”指的是用于RNA测序中识别碱基的工具，翻译为“RNA碱基识别器”。） | Litman, E. | PDF | N/A | Melchior: A Hybrid Mamba-Transformer RNA Basecaller | | 抑制EMT驱动因子PTK6可增强针对三阴性乳腺癌的抗肿瘤免疫反应 | Irie, H. | PDF | N/A | Inhibition of EMT driver PTK6 enhances anti-tumor immune responses against triple-negative breast cancer | | 同时靶向KRAS和CDK4可协同抑制胰腺癌细胞 | Paulsohn, M.-B. | PDF | N/A | Simultaneous Targeting of KRAS and CDK4 Synergistically Suppresses Pancreatic Cancer Cells | | 非经典途径激活PAR1诱导哺乳动物乳腺癌细胞自噬 | Saha, S. | PDF | N/A | Non-canonical activation of PAR1 induces autophagy in mammalian breast cancer cells | | 使用秀丽隐杆线虫评估发育神经毒理学相关的神经元结构和功能改变 | Huayta, J. | PDF | N/A | Assessment of developmental neurotoxicology-associated alterations in neuronal architecture and function using Caenorhabditis elegans | | 二酰基甘油激酶zeta调控B淋巴细胞中CD40介导的免疫突触形成、mTORC1信号传导及浆细胞命运 | Fernandez-Barrecheguren, A. | PDF | N/A | Diacylglycerol kinase zeta dictates CD40-mediated immune synapse formation, mTORC1 signaling and plasma cell fate in B lymphocytes | | 使用icCITE-seq技术对表面蛋白、细胞内蛋白和基因表达进行联合单细胞测量 | Chen, K. Y. | PDF | N/A | Joint single-cell measurements of surface proteins, intracellular proteins and gene expression with icCITE-seq | | 从顺序谱系追踪数据解析细胞系统发育的策略 | Mulberry, N. | PDF | N/A | Strategies for resolving cellular phylogenies from sequential lineage tracing data | | 高分辨率多尺度分析胚胎生殖细胞样细胞的衍生过程揭示了人类多能状态的转变 | Stucchi, S. | PDF | N/A | High resolution multi-scale profiling of embryonic germ cell-like cells derivation reveals pluripotent state transitions in humans | | 在不同前体决定因子的果蝇物种之间，染色质可及性水平的对称性破缺保守性 | Amiri, E. E. | PDF | N/A | Conservation of symmetry breaking at the level of chromatin accessibility between fly species with unrelated anterior determinants | | 在小鼠早期胚胎中，持续存在的TTC21B蛋白对于前脑神经祖细胞的正常增殖是必需的。 | Niewoehner, R. | PDF | N/A | Perdurant TTC21B protein in the early mouse embryo is required for proper forebrain neural progenitor proliferation. | | 区域内皮细胞异质性是小鼠肾脏血管发育的基础。 | Luo, P. M. | PDF | N/A | Zonal endothelial cell heterogeneity underlies murine renal vascular development. | | 以下是这段文字的中文翻译：
非洲爪蟾中肾转录组学的比较分析：肾单位发育阶段的保守性
翻译说明： - "Comparative analysis" 译为“比较分析”。 - "Xenopus" 是非洲爪蟾的学名，译为“非洲爪蟾”。 - "mesonephric" 指的是中肾，译为“中肾”。 - "transcriptomics" 是转录组学的意思，译为“转录组学”。 - "Conservation" 在这里指进化上的保守性，译为“保守性”。 - "developmental lineage" 译为“发育谱系”。 - "nephron stages" 译为“肾单位阶段”。
整段翻译为：非洲爪蟾中肾转录组学的比较分析：肾单位发育阶段的保守性 | Corkins, M. E. | PDF | N/A | Comparative analysis of Xenopus mesonephric transcriptomics: Conservation of the developmental lineage of nephron stages | | 自组织组装体揭示肠道神经系统在肠道稳态和再生中的动态 | Sari, I. | PDF | N/A | Self-Organizing Assembloids Reveal Enteric Nervous System Dynamics in Gut Homeostasis and Regeneration | | Keystone工程使微生物群落能够实现集体范围的扩展。 | Simsek, E. | PDF | N/A | Keystone engineering enables collective range expansion in microbial communities | | 以下是这段文字的中文翻译：
不同冠层覆盖水平下山毛榉林在农林牧管理下的土壤碳固存
翻译说明： - Soil Carbon Sequestration：土壤碳固存，指土壤中碳的储存过程。 - Nothofagus obliqua：南美山毛榉，一种常见的南半球树种。 - Canopy Cover Levels：冠层覆盖水平，指森林中树冠的覆盖程度。 - Silvopastoral Management：农林牧管理，一种结合林业、农业和牧业的可持续土地利用方式。
希望这段翻译对你有帮助！ | Ramos, C. | PDF | N/A | Soil Carbon Sequestration in Nothofagus obliqua Forests with Different Canopy Cover Levels under Silvopastoral Management | | 在细胞动力学的最优传输中去偏Sinkhorn散度 | Cooper, J. | PDF | N/A | Debiasing Sinkhorn divergence in optimal transport of cellular dynamics | | 来自人类肿瘤的细胞对组织依赖性的机械感知 | Parihar, K. | PDF | N/A | Tissue-dependent mechanosensing by cells derived from human tumors | | 从果蝇到人类：CEBPZ、NOC2L和NOC3L在rRNA加工和肿瘤发生中的保守作用 | Rambaldelli, G. | PDF | N/A | From Flies to Humans: Conserved Roles of CEBPZ, NOC2L, and NOC3L in rRNA Processing and Tumorigenesis | | SYNGAP1酶活性和结构功能的分离：内在兴奋性和癫痫易感性 | Brill, J. | PDF | N/A | Dissociation of SYNGAP1 Enzymatic and Structural Roles: Intrinsic Excitability and Seizure Susceptibility | | 在小鼠肾脏发育过程中，亨利袢的细降支起源于近端小管细胞。 | Chung, E. | PDF | N/A | The thin descending limb of the loop of Henle originates from proximal tubule cells during mouse kidney development | | ECM签名揭示结肠生态位中静息干细胞的多样性 | Hickey, S. E. | PDF | N/A | ECM Signatures Reveal Quiescent Stem Cell Diversity in the Colonic Niche | | 奥比拉赫马特（乌兹别克斯坦）的箭头，距今约8万年前。 | Plisson, H. | PDF | N/A | Arrow heads at Obi-Rakhmat (Uzbekistan) 80 ka ago | | 视觉空间计算因类别和流线而异，并在青春期持续发展。 | Yao, J. K. | PDF | N/A | Visuospatial computations vary by category and stream and continue to develop in adolescence | | 亲和行为调节稳态的发展并塑造马匹的生物行为轨迹。 | Valenchon, M. | PDF | N/A | Affiliative behaviours regulate allostasis development and shape biobehavioural trajectories in horse | | 橄榄小脑系统差异性地编码感觉事件对行为的影响。 | Scheer, I. | PDF | N/A | The olivocerebellar system differentially encodes the effect sensory events exert on behavior | | 前额叶皮层微刺激对工作记忆的鲁棒性 | Soldado-Magraner, J. | PDF | N/A | Robustness of working memory to prefrontal cortex microstimulation | | 默认模式子网络和多需求区域对人物、地点和时间转换的专门化反应 | Zhou, A. X. | PDF | N/A | Specialized response of default mode subnetworks and multiple-demand regions to transitions of person, place and time | | 精神病大脑中的时空复杂性 | Li, Q. | PDF | N/A | Spatiotemporal Complexity in the Psychotic Brain | | 模拟小鼠初级运动皮层中的自组织和自持续群体活动模式 | Doherty, D. W. | PDF | N/A | Self-organized and self-sustained ensemble activity patterns in simulation of mouse primary motor cortex | | KAT6A乙酰化通过AMPK相互作用驱动代谢适应，从而介导细胞生长和线粒体代谢。 | Keller, M. A. | PDF | N/A | KAT6A acetylation drives metabolic adaptation to mediate cellular growth and mitochondrial metabolism through AMPK interaction | | HINT1的核质转位调节细胞密度的成熟 | Zhang, X. | PDF | N/A | The nucleocytoplasmic translocation of HINT1 regulates the maturation of cell density | | 鉴定两种在艰难梭菌（Clostridioides difficile）中合成膜糖脂所需的糖基转移酶 | Zbylicki, B. R. | PDF | N/A | Identification of two glycosyltransferases required for synthesis of membrane glycolipids in Clostridioides difficile | | 翻译：表征毒力调节因子Rns的配体结合口袋，Rns是AraC/XylS家族转录因子的成员。 | Tolbert, J. D. | PDF | N/A | Characterization of the ligand binding pocket of the virulence regulator Rns, a Member of the AraC/XylS family of transcription factors | | 大规模并行液滴共培养的元条形码分析 | Tan, J. Y. | PDF | N/A | Massively parallel metabarcoding of droplet co-cultures |