2025-01-20 每日论文

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arXiv

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bioRxiv

标题	作者	PDF链接	代码仓库	Title
原代肠道成纤维细胞的长程组织引导了类器官来源的肠道上皮细胞的定向和持续迁移。	Fernandez-Majada, V.	PDF	N/A	Long-range organization of primary intestinal fibroblasts guides directed and persistent migration of organoid-derived intestinal epithelia
多模态系统用于记录鸣禽群体中的个体行为	Rüttimann, L.	PDF	N/A	Multimodal system for recording individual-level behaviors in songbird groups
电刺激调节未能增强交感神经轴突的再生	Tian, T.	PDF	N/A	Conditioning electrical stimulation fails to enhance sympathetic axon regeneration
漂流瀑布：人工选择的集体组成可能成功或失败，这取决于初始值和目标值。	Lee, J.	PDF	N/A	Rafting a waterfall: Artificial selection for collective composition can succeed or fail depending on the initial and target values
解构复杂性：利用tviblindi计算拓扑方法对人类胸腺轨迹推断的研究	Stuchly, J.	PDF	N/A	Deconstructing Complexity: A Computational Topology Approach to Trajectory Inference in the Human Thymus with tviblindi
四对单独识别的多巴胺神经元在果蝇幼虫中传递味觉惩罚信号	Weber, D.	PDF	N/A	Four Individually Identified Paired Dopamine Neurons Signal Taste Punishment in Larval Drosophila
视觉序列暴露引发的人脑中非特征特异性增强反应与特征特异性反向回放	He, T.	PDF	N/A	Non-feature-specific elevated responses and feature-specific backward replay in human brain induced by visual sequence exposure
扩张型心肌病相关的RNA结合基序蛋白20在神经元中调控长前体mRNA。	Di Bartolomei, G.	PDF	N/A	Dilated cardiomyopathy-associated RNA Binding Motif Protein 20 regulates long pre-mRNAs in neurons
塑造物理世界以适应我们的需求：左侧PF技术认知区域	Osiurak, F.	PDF	N/A	Shaping the physical world to our ends: The left PF technical-cognition area
以下是这段英文的中文翻译：

斑马鱼幼体行为变异的全脑神经基础

翻译解释： - "Whole-brain" 翻译为“全脑”，指的是整个大脑。 - "neural substrates" 翻译为“神经基础”或“神经基质”，指的是与某种功能或行为相关的神经机制或结构。 - "behavioral variability" 翻译为“行为变异”，指的是个体在行为上的差异或变化。 - "larval zebrafish" 翻译为“斑马鱼幼体”，指的是斑马鱼的幼虫阶段。

摘要： 理解信息如何在脑网络中传递对于揭示认知功能和神经系统疾病的机制至关重要。然而，目前尚缺乏一个通用框架来定量描述脑网络中的最优通信模式。本研究提出了一种基于信息论和网络科学的通用框架，用于表征脑网络中的最优通信。该框架将脑网络建模为信息传输系统，并定义了衡量通信效率的指标。我们利用该框架分析了不同任务状态下的大脑活动数据，识别出与最优通信相关的关键网络特征。结果表明，该框架能够有效捕捉脑网络通信的动态变化，并为理解脑功能提供新的见解。

关键词： 脑网络，最优通信，信息论，网络科学，功能连接

1. 引言

大脑是一个复杂的网络系统，由数十亿个神经元通过突触连接相互连接。信息在这些网络中高效传递对于实现各种认知功能至关重要。近年来，随着神经影像技术和网络分析方法的快速发展，研究者们开始从网络科学的角度研究脑功能组织，并取得了显著进展。然而，如何定量描述脑网络中的最优通信模式仍然是一个挑战。

2. 方法

2.1 脑网络建模

我们将脑网络建模为一个加权有向图，其中节点代表脑区，边代表脑区之间的功能连接强度。功能连接强度可以通过计算不同脑区时间序列之间的统计相关性来估计。

2.2 信息传输模型

我们采用信息论中的互信息来衡量脑区之间的信息传递量。互信息量化了两个随机变量之间的统计依赖性，可以反映一个脑区的活动对另一个脑区活动的预测能力。

2.3 最优通信指标

为了衡量脑网络的通信效率，我们定义了以下指标：

全局通信效率： 衡量信息在整个网络中传播的平均效率。
局部通信效率： 衡量信息在网络局部区域传播的效率。
通信成本： 衡量维持网络通信所需的资源消耗。

3. 结果

我们将该框架应用于分析不同任务状态下的大脑活动数据。结果表明：

在不同任务状态下，脑网络的通信效率表现出显著差异。
与静息态相比，任务态下脑网络的全局通信效率和局部通信效率均显著提高。
识别出了一些与最优通信相关的关键网络特征，例如网络模块化和核心-边缘结构。

4. 讨论

本研究提出的通用框架为定量描述脑网络中的最优通信模式提供了新的工具。该框架能够有效捕捉脑网络通信的动态变化，并为理解脑功能提供新的见解。未来研究可以进一步将该框架应用于研究神经系统疾病的机制，以及开发新的脑机接口技术。

5. 结论

本研究提出了一种基于信息论和网络科学的通用框架，用于表征脑网络中的最优通信。该框架为理解脑功能组织提供了新的视角，并具有广泛的应用前景。 | Fakhar, K. | PDF | N/A | A General Framework for Characterizing Optimal Communication in Brain Networks | | 生物分子凝聚体可以增强同型RNA的聚集 | Mahendran, T. S. | PDF | N/A | Biomolecular Condensates Can Enhance Homotypic RNA Clustering | | 在不同时间尺度上，正常听力和听力受损听众的多说话者语音理解 | Li, J. | PDF | N/A | Multi-talker speech comprehension at different temporal scales in listeners with normal and impaired hearing | | 转录因子DksA和PsrA在嗜肺军团菌（L. pneumophila）对阿米巴原虫（Acanthamoeba castellanii）的毒力中具有协同作用。 | Graham, C. I. | PDF | N/A | Transcription Factors DksA and PsrA are synergistic contributors to L. pneumophila virulence in Acanthamoeba castellanii protozoa | | 以下是这段英文的中文翻译：

西帕加明作为抗巴贝斯虫候选药物的功效和作用机制

翻译说明： - "Efficacy" 翻译为 "功效" - "mechanism of action" 翻译为 "作用机制" - "cipargamin" 是药物名称，音译为 "西帕加明" - "antibabesial drug candidate" 翻译为 "抗巴贝斯虫候选药物"

希望这对你有帮助！ | Li, H. | PDF | N/A | Efficacy and mechanism of action of cipargamin as an antibabesial drug candidate | | 干扰新生脂肪生成阻碍了MERS-CoV（中东呼吸综合征冠状病毒）的组装和释放，但不影响病毒复制细胞器的生物发生。 | Soultsioti, M. | PDF | N/A | Perturbation of de novo lipogenesis hinders MERS-CoV assembly and release, but not the biogenesis of viral replication organelles | | 疼痛分布可以通过经典条件反射来确定。 | Nastaj, J. | PDF | N/A | Pain distribution can be determined by classical conditioning | | 从旋转平均的二维X射线衍射图案中恢复昆虫飞行肌肉的三维结构 | Iwamoto, H. | PDF | N/A | Restoration of 3-D structure of insect flight muscle from a rotationally averaged 2-D X-ray diffraction pattern | | 中欧永续农业的作物生产力介于有机农业和传统农业之间。 | Reiff, J. | PDF | N/A | Crop productivity of Central European Permaculture is within the range of organic and conventional agriculture. | | 通过单细胞空间分析在人类肺部组织中鉴定出SPP1阳性巨噬细胞，这些组织受到分枝杆菌感染。 | Katano, H. | PDF | N/A | Identification of SPP1-positive macrophages by single-cell spatial analysis in human lung tissues with mycobacterial infection | | 体感皮层与身体表征：在视觉-本体感受线索冲突中更新运动系统 | Mirdamadi, J. L. | PDF | N/A | Somatosensory cortex and body representation: Updating the motor system during a visuo-proprioceptive cue conflict | | CXXC指蛋白1与FOXP3结合，以稳定调节性T细胞的稳态和抑制功能。 | Meng, X. | PDF | N/A | CXXC-finger protein 1 associates with FOXP3 to stabilize homeostasis and suppressive functions of regulatory T cells | | CXXC指蛋白1与FOXP3结合，以稳定调节性T细胞的稳态和抑制功能。 | Meng, X. | PDF | N/A | CXXC-finger protein 1 associates with FOXP3 to stabilize homeostasis and suppressive functions of regulatory T cells | | 关于D1/V185残基在集胞藻6803和嗜热聚球藻中参与光系统II功能的新见解。 | Boussac, A. | PDF | N/A | New insights into the involvement of residue D1/V185 in Photosystem II function in Synechocystis 6803 and Thermosynechococcus vestitus. | | 更多细胞，更多双联体在高通量单细胞数据中 | Howitt, G. | PDF | N/A | More cells, more doublets in highly multiplexed single-cell data | | 对未经治疗的人类非小细胞肺癌（NSCLC）进行光学成像揭示了与转移性复发相关的变化。 | Diaz, P. M. | PDF | N/A | Optical imaging of treatment-naive human NSCLC reveals changes associated with metastatic recurrence | | Rag2Mol：基于检索增强生成的结构化药物设计 | Zhang, P.-D. | PDF | N/A | Rag2Mol: Structure-based drug design based on Retrieval Augmented Generation | | Rag2Mol：基于检索增强生成的结构化药物设计 | Zhang, P.-D. | PDF | N/A | Rag2Mol: Structure-based drug design based on Retrieval Augmented Generation | | Neuroligin 3 突显了果蝇社交距离中的性别二态性神经回路 | Robinson, J. W. | PDF | N/A | Neuroligin 3 highlights sexually dimorphic circuitry in Drosophila social spacing | | 植物内化学防御的变异并不能解释小菜蛾（Plutella xylostella）对桂竹香（Erysimum cheiranthoides）的取食偏好。 | Zuest, T. | PDF | N/A | Within-plant variation in chemical defence of Erysimum cheiranthoides does not explain Plutella xylostella feeding preference | | FlowDesign：通过流匹配和更好的先验分布改进抗体CDR设计 | Wu, J. | PDF | N/A | FlowDesign: Improved Design of Antibody CDRs Through Flow Matching and Better Prior Distributions | | 使用MMseqs2进行GPU加速的同源性搜索 | Kallenborn, F. | PDF | N/A | GPU-accelerated homology search with MMseqs2 | | 蛋白质晶体结构和AlphaFold预测模型的分子表面几何特性 | Wang, L. | PDF | N/A | The geometric properties of the molecular surfaces of protein crystal structures and AlphaFold predicted models | | 大脑特征图揭示了腹侧流中逐步的动物特征表征。 | Zhang, Z. | PDF | N/A | Brain Feature Maps Reveal Progressive Animal-Feature Representations in the Ventral Stream. | | 稳态和刺激状态下人类骨骼肌细胞中代谢性状相关基因调控的功能解析 | Nishino, K. | PDF | N/A | Functional dissection of metabolic trait-associated gene regulation in steady state and stimulated human skeletal muscle cells | | 将免疫滚环扩增技术应用于印刷糖芯片上ABO血型抗体的高灵敏度检测。 | Kornilova, E. E. | PDF | N/A | The applying of immuno-RCA for the high-sensitivity detection of the ABO blood group antibodies on the printed glycoarray | | 伤寒沙门氏菌的伤寒毒素在急性伤寒期间引发宿主的抗菌反应 | Srour, S. | PDF | N/A | Typhoid toxin of Salmonella Typhi elicits host antimicrobial response during acute typhoid fever | | 极低水活性条件下的生命极限：太阳能盐场中的锂浓度池（智利阿塔卡马盐沼） | Demergasso, C. | PDF | N/A | The limit of life at extremely low water activity: Lithium-concentration ponds in a solar saltern (Salar de Atacama, Chile) | | 通过对1,027个长读长基因组进行详细的串联重复等位基因分析，揭示了全基因组范围内的致病性模式。 | Danzi, M. C. | PDF | N/A | Detailed tandem repeat allele profiling in 1,027 long-read genomes reveals genome-wide patterns of pathogenicity | | 单细胞RNA测序揭示了克氏锥虫群体中跨唾液酸酶样超家族基因表达的异质性 | Inchausti, L. | PDF | N/A | Single-cell RNA-seq reveals trans-sialidase-like superfamily gene expression heterogeneity in Trypanosoma cruzi populations | | 无标记检测与表征新鲜和冷冻保存巨噬细胞的代谢 | Canales, D. D. H. | PDF | N/A | Label-free Detection and Characterization of Metabolism in Fresh and Cryopreserved Macrophages | | 具核梭杆菌通过一种表观遗传现象决定了苯丙胺诱导的行为反应的表达。 | Mabry, S. J. | PDF | N/A | Fusobacterium nucleatum determines the expression of amphetamine-induced behavioral responses through an epigenetic phenomenon. | | 脂质锥超家族：脂质、肽聚糖和外多糖代谢、生物间冲突与免疫的统一主题 | Burroughs, A. M. | PDF | N/A | The Lipocone Superfamily: A Unifying Theme In Metabolism Of Lipids, Peptidoglycan And Exopolysaccharides, Inter-Organismal Conflicts And Immunity | | Innexin 7间隙连接蛋白有助于果蝇触角叶中的同步活动，并调节嗅觉功能。 | Fuenzalida-Uribe, N. | PDF | N/A | The Innexin 7 gap junction protein contributes to synchronized activity in the Drosophila antennal lobe and regulates olfactory function | | 微生物代谢进化过程中多物种群落的稳定性 | Kehila, D. | PDF | N/A | Stability of multi-species consortia during microbial metabolic evolution | | 3D打印磁悬浮装置结合深度学习辅助的颗粒追踪与分析技术，用于高通量分选 | Ramarao, M. | PDF | N/A | 3D-Printed Magnetic Levitation Device with Deep Learning-Assisted Particle Tracking and Analysis for High-Throughput Sorting | | 使用语言模型对生物数据集进行元数据协调 | Verbitsky, A. | PDF | N/A | Metadata Harmonization from Biological Datasets with Language Models | | 头颈癌中的DNA聚合酶β表达调节了聚(ADP-核糖)介导的复制检查点 | Khan, M. M. | PDF | N/A | DNA polymerase beta expression in head & neck cancer modulates the poly(ADP-ribose)-mediated replication checkpoint | | 年龄和性别特异性对骨骼肌和心肌中线粒体质量控制的影响 | Springer-Sapp, C. B. | PDF | N/A | Age and Sex-Specific Changes in Mitochondrial Quality Control in Skeletal and Cardiac Muscle | | 将SMN2剪接修饰剂与HDAC6抑制剂结合使用，可显著改善脊髓性肌萎缩症患者的肌肉功能和生存率。 | Osseni, A. | PDF | N/A | Combining SMN2 splicing modifiers with HDAC6 inhibition greatly improves muscle function and survival in Spinal Muscular Atrophy | | 预测编码算法在人工神经网络中引发了类似大脑的反应。 | Gutlin, D. C. | PDF | N/A | Predictive Coding algorithms induce brain-like responses in Artificial Neural Networks | | 长期海马低频刺激可缓解癫痫小鼠的局灶性癫痫发作、记忆缺陷和突触病理。 | Kleis, P. | PDF | N/A | Long-term hippocampal low-frequency stimulation alleviates focal seizures, memory deficits and synaptic pathology in epileptic mice | | Hsp70分子伴侣Ssa1和Ssa2限制多聚腺苷酸结合蛋白的聚集。 | Buchholz, H. E. | PDF | N/A | Hsp70 chaperones, Ssa1 and Ssa2, limit poly(A) binding protein aggregation | | 化疗药物紫杉醇在间期的作用机制：核破坏 | Hale, T. | PDF | N/A | Nuclear Disruption as a Mechanism of the Chemotherapeutic Drug Paclitaxel in Interphase | | 性别不影响小鼠在整个衰老过程中的神经元自噬 | Rodruiguez, M. N. | PDF | N/A | Sex does not Influence Neuronal Autophagy throughout Aging in Mice | | 端粒SUMO水平影响APB形成途径的选择和ALT效率 | Zhao, R. | PDF | N/A | Telomeric SUMO level influences the choices of APB formation pathways and ALT efficiency | | 富含支链脂肪酸的饮食促进脂滴增大并影响秀丽隐杆线虫的机体健康 | Li, K. U. R. | PDF | N/A | Branched chain fatty acid-rich diet promotes lipid droplet enlargement and impacts organismal health in Caenorhabditis elegans | | 组蛋白去乙酰化酶-1对于粗糙脉孢菌（Neurospora crassa）的表观基因组稳定性是必需的。 | Ebot-Ojong, F. | PDF | N/A | Histone deacetylase-1 is required for epigenome stability in Neurospora crassa | | Reg-GPTTM：一种用于增强再生医学决策的对话式人工智能模型 | Maharaj, D. | PDF | N/A | Reg-GPTTM: A Conversational AI Model for Enhanced Decision-Making in Regenerative Medicine | | hmde：微分方程的层次方法 | O'Brien, T. A. | PDF | N/A | hmde: Hierarchical Methods for Differential Equations | | 帕金森病中人类背侧纹状体少突胶质细胞的易损性 | Reyes, J. M. B. | PDF | N/A | Oligodendroglia vulnerability in the human dorsal striatum in Parkinson's disease | | 肝脏生物钟调节骨骼肌中的转录节律，以调控线粒体功能。 | Sica, V. | PDF | N/A | The liver clock tunes transcriptional rhythms in skeletal muscle to regulate mitochondrial function | | 心肌细胞中Klf9的组成型表达导致代谢功能障碍和自发性心力衰竭。 | Thakkar, C. | PDF | N/A | Constitutive expression of cardiomyocyte Klf9 precipitates metabolic dysfunction and spontaneous heart failure. | | Plakophilin-2在心肌细胞中协调能量代谢和收缩功能，揭示其在桥粒之外的作用 | Aycinena, J. A. | PDF | N/A | Plakophilin-2 Coordinates Energy Metabolism and Contractility in Cardiomyocytes, Revealing Its Roles beyond Desmosomes | | 无饲养层培养法下保持胚胎、胚胎外及类囊胚生成潜能的人类原始多能干细胞培养 | Rossignoli, G. | PDF | N/A | Feeder-free culture of naive human pluripotent stem cells retaining embryonic, extraembryonic and blastoid generation potential | | 小细胞外囊泡在调节贾第虫对甲硝唑耐药性中的基因型特异性作用 | Luna Pizarro, G. | PDF | N/A | Genotype-specific roles of small extracellular vesicles in modulating metronidazole resistance in Giardia lamblia | | 荧光蛋白相互作用稳定化用于正交RNA成像 | Zhou, W.-J. | PDF | N/A | Fluorogenic Interacting Protein Stabilization for Orthogonal RNA Imaging | | HoloMoA：一种基于快速全息成像和深度学习的工具，用于检测抗菌候选药物作用机制的新颖性 | Sedaghat, Z. | PDF | N/A | HoloMoA: Fast holography and deep-learning-based tool for the novelty detection of mechanism of action of antimicrobial candidates | | 具有固定和可变色素的海洋聚球藻菌株之间的光色竞争 | Dufour, L. | PDF | N/A | Competition for light color between marine Synechococcus strains with fixed and variable pigmentation | | Chameau (HBO1) 在果蝇中以温度依赖的方式调控饥饿反应。 | Venkatasubramani, A. V. | PDF | N/A | Chameau (HBO1) regulates starvation in a temperature-dependent manner in Drosophila melanogaster | | 在塑造实验性动物流行病的过程中，感染宿主的竞争力掩盖了易感性异质性的影响。 | Perez-Umphrey, A. | PDF | N/A | Infected host competence overshadows heterogeneity in susceptibility in shaping experimental epizootics | | 利用祖先重组图对籼稻和粳稻亚种的产量进行定量遗传分析 | Rebollo, I. | PDF | N/A | Leveraging ancestral recombination graphs for quantitative genetic analysis of rice yield in indica and japonica subspecies | | 以下是这段文字的中文翻译：

使用数据非依赖采集方法自动化氢/氘交换质谱测量的建议

这段文字主要讨论如何通过数据非依赖采集（Data-Independent Acquisition, DIA）方法来实现氢/氘交换质谱（Hydrogen/Deuterium Exchange Mass Spectrometry, HDX-MS）测量的自动化，并提供相关建议。 | Filandr, F. | PDF | N/A | Recommendations for Automating Hydrogen/Deuterium Exchange Mass Spectrometry Measurements using Data-Independent Acquisition Methods | | 单细胞数字孪生技术在阿尔茨海默病中识别药物靶点及可重新利用的药物 | Ren, Y. | PDF | N/A | Single-cell digital twins identify drug targets and repurposable medicine in Alzheimers disease | | 头颈癌中的HPV整合：与不良预后相关的下游剪接事件及表达比例 | Li, S. | PDF | N/A | HPV integration in head and neck cancer: downstream splicing events and expression ratios linked with poor outcomes | | TMPRSS2-ERG赋予抗雄激素药物耐药性：机制及治疗意义

TMPRSS2-ERG基因融合在前列腺癌中较为常见，这种融合基因不仅与肿瘤的发生发展密切相关，还可能导致肿瘤对某些治疗药物产生耐药性。具体来说，TMPRSS2-ERG融合基因的存在可能使前列腺癌细胞对雄激素剥夺治疗（ADT）和抗雄激素药物（如恩杂鲁胺和阿比特龙）产生抵抗，从而影响治疗效果。

机制： 1. 雄激素受体（AR）信号通路激活：TMPRSS2-ERG融合基因可能通过直接或间接方式激活AR信号通路，即使在雄激素水平较低的情况下，也能维持AR的活性，从而促进肿瘤细胞的生长和存活。 2. 基因表达调控：TMPRSS2-ERG融合蛋白可能通过调控下游基因的表达，改变细胞的代谢、增殖和凋亡过程，进而增强肿瘤细胞的生存能力。 3. 肿瘤微环境改变：TMPRSS2-ERG融合基因可能通过影响肿瘤微环境中的细胞间相互作用，促进肿瘤细胞的侵袭和转移。

治疗意义： 1. 靶向TMPRSS2-ERG的治疗策略：针对TMPRSS2-ERG融合基因的特异性抑制剂或基因编辑技术（如CRISPR-Cas9）可能成为未来治疗耐药性前列腺癌的有效手段。 2. 联合治疗：将抗雄激素药物与其他靶向药物（如PARP抑制剂或PI3K/AKT/mTOR通路抑制剂）联合使用，可能克服TMPRSS2-ERG介导的耐药性。 3. 生物标志物检测：在治疗前检测TMPRSS2-ERG融合基因的存在，有助于制定个体化治疗方案，提高治疗效果。

总之，TMPRSS2-ERG融合基因在前列腺癌的耐药机制中扮演了重要角色，深入研究其作用机制并开发针对性的治疗策略，对于改善前列腺癌患者的预后具有重要意义。 | Sekar, A. | PDF | N/A | TMPRSS2-ERG confers resistance to antiandrogens: mechanism and therapeutic implications | | 通过心血管磁共振检测弥漫性至局灶性心肌纤维化与小型猪组织学对比 | Zhang, H. | PDF | N/A | Detection of Diffuse to Focal Myocardial Fibrosis by Cardiovascular Magnetic Resonance Against Histology in Mini-Swine | | 系统发育、民族药用及豆科植物中植物雌激素的分布 | Thaweepanyaporn, K. | PDF | N/A | Phylogeny, ethnomedicinal use and the distribution of phytoestrogens in the Fabaceae | | 自身抗体热点揭示了免疫原性XIST核糖核蛋白复合物的起源和影响 | Yan, B. | PDF | N/A | Autoantibody hotspots reveal origin and impact of immunogenic XIST ribonucleoprotein complex | | 从人类HIV-1疫苗试验参与者中分离出的糖链反应性抗体显示出广泛的病原体交叉反应性。 | Jamieson, P. J. | PDF | N/A | Glycan-reactive antibodies isolated from human HIV-1 vaccine trial participants show broad pathogen cross-reactivity | | 利用粪便挥发性物质分析技术，对野生和圈养白尾鹿进行敏感且非侵入性的慢性消耗病检测 | Berna, A. Z. | PDF | N/A | Sensitive, non-invasive detection of chronic wasting disease in wild and captive white-tailed deer using fecal volatile profiling | | 验证和多方部署用于撒哈拉以南非洲地区禽流感和狂犬病分子诊断的冻干qRT-PCR试剂 | Drzewniokova, P. | PDF | N/A | Validation and multi-site deployment of a lyophilized qRT-PCR reagent for the molecular diagnosis of avian influenza and rabies in Sub-Saharan African regions | | 过去二十年间应用不育昆虫技术控制鳞翅目害虫的研究进展：系统综述 | Bambo, K. K. | PDF | N/A | Research advancements on the application of sterile insect technique for the control of lepidopteran pests over the past two decades: A Systematic Review | | SPARC是一种通过TGF-β依赖性机制驱动早期乳腺肿瘤进展的新因子。 | Sciacca, M. | PDF | N/A | SPARC is a new driver of early breast tumor progression via TGF-β -dependent mechanism. | | AuthormetriX：从Scopus语料库中自动计算个体作者的非通胀性信用分配方案和合作指标 | Adeosun, S. O. | PDF | N/A | AuthormetriX: Automated Calculation of Individual Authors' Non-Inflationary Credit-Allocation Schemas' and Collaboration Metrics from a Scopus Corpus | | C端标记、跨膜结构域的疏水性以及内质网保留基序影响内核膜蛋白emerin的分泌运输 | Mella, J. | PDF | N/A | C-terminal tagging, transmembrane domain hydrophobicity, and an ER retention motif influence the secretory trafficking of the inner nuclear membrane protein emerin | | H3K4甲基化促进的转录记忆确保了合子基因组的忠实激活和胚胎发育 | Oak, M. S. | PDF | N/A | H3K4 methylation-promoted transcriptional memory ensures faithful zygotic genome activation and embryonic development | | 基于恐惧和消退神经回路动力学的焦虑障碍正式模型 | rubin, a. l. | PDF | N/A | A formal model of anxiety disorders based on the neural circuit dynamics of the fear and extinction circuits | | 一条胆碱能脊髓通路用于呼吸的适应性控制 | Lin, M. | PDF | N/A | A cholinergic spinal pathway for the adaptive control of breathing | | 基于触摸屏的Go/No Go任务用于评估小鼠认知判断偏差的特性研究：一种用于情感状态障碍药物筛选的新型转化工具。 | Lopez-Cruz, L. | PDF | N/A | Characterisation of a touchscreen-based Go/No Go task for assessing cognitive judgement bias in mice: a new translational tool for affective state disorder drug screening. | | 选择性消化道去污对ESBL大肠杆菌全基因组组成的影响 | Paganini, J. A. | PDF | N/A | Impact of selective digestive decontamination on the pangenome composition of ESBL-E. coli | | 发育中的脑回脑在遭受严重创伤性脑损伤（TBI）后，NKCC1在急性时间、特定区域及细胞类型上的破坏。 | Hochstetler, A. E. | PDF | N/A | Acute temporal, regional, and cell-type specific NKCC1 disruption following severe TBI in the developing gyrencephalic brain. | | 在表示学习过程中任务相似性对大脑和神经网络的影响 | Menghi, N. | PDF | N/A | The effects of task similarity during representation learning in brains and neural networks | | CB2受体与NMDA受体在帕金森病中的相互作用 | Lillo, J. | PDF | N/A | The interplay between CB2 and NMDA receptors in Parkinsons disease | | 内皮细胞鞘氨醇-1-磷酸受体（S1PR）1，作为人脑血管内皮中的功能性S1PR，限制了小鼠蛛网膜下腔出血后血脑屏障的通透性和神经元损伤。 | Ito, A. | PDF | N/A | Endothelial Sphingosine-1-Phosphate Receptor (S1PR) 1, a Functional S1PR in the Human Cerebrovascular Endothelium, Limits Blood Brain Barrier Permeability and Neuronal Injury following Subarachnoid Hemorrhage in Mice. | | 神经肽能回路对果蝇发育期睡眠的调节 | Hemmi, C. | PDF | N/A | Neuropeptidergic circuit modulation of developmental sleep in Drosophila | | 异质性在执行认知任务的循环网络中的影响多样性 | Santhosh, A. | PDF | N/A | Diversity in the impact of heterogeneities on recurrent networks performing a cognitive task | | 高强度运动在睡前进行，可以增强第二天早晨的记忆编码能力。 | Ramirez Butavand, D. | PDF | N/A | High intensity exercise before sleep boosts memory encoding the next morning | | 通过新型通用接收系统调节白细胞活性 | Tetz, G. | PDF | N/A | Regulating white blood cell activity through the novel Universal Receptive System | | 纤毛病相关蛋白CEP290是视网膜光感受器中纤毛项链和外节膜形成所必需的。 | Moye, A. R. | PDF | N/A | Ciliopathy-associated protein, CEP290, is required for ciliary necklace and outer segment membrane formation in retinal photoreceptors. | | 从长期延时原子力显微镜中量化耻垢分枝杆菌形态的组织和动态 | Soubrier, C. | PDF | N/A | Quantifying the organization and dynamics of M. smegmatis morphology from Long-Term Time-Lapse Atomic Force Microscopy | | 肌动球蛋白和Arp2/3复合物参与纤维素合酶复合物的内化过程。 | Xu, L. | PDF | N/A | Actomyosin and the Arp2/3 Complex Are Involved in the Internalization of Cellulose Synthase Complexes | | 胰腺癌细胞中角蛋白-19的信号肽非依赖性分泌 | Moresco, P. | PDF | N/A | Signal peptide-independent secretion of keratin-19 by pancreatic cancer cells | | 线粒体前体蛋白的伴侣分子招募与保留机制 | Juszkiewicz, S. | PDF | N/A | Mechanism of chaperone recruitment and retention on mitochondrial precursors | | 通过单病毒核糖核蛋白（vRNP）成像技术绘制甲型流感病毒完整感染周期 | Rabouw, H. H. | PDF | N/A | Mapping the complete influenza A virus infection cycle through single vRNP imaging | | N-糖基化作为ATG9A构象和活性决定因素的作用 | Lambrughi, M. | PDF | N/A | Role of N-glycosylation as a determinant of ATG9A conformations and activity | | DNAHX：一种新型、非运动型动力蛋白重链亚家族，通过冷冻电镜内源性鉴定发现 | Chai, P. | PDF | N/A | DNAHX: a novel, non-motile dynein heavy chain subfamily, identified by cryo-EM endogenously | | 以下是这段文字的中文翻译：

证据表明，在苔纲（Marchantiales）单倍体植物谱系中进化出了新的性染色体。

希望这个翻译对你有帮助！如果有其他问题，欢迎继续提问。 | Fu, Y. | PDF | N/A | Evidence for evolution of a new sex chromosome within the Marchantiales haploid plant lineage | | 与布鲁格达综合征相关的基因WT1对SCN5A表达和心脏传导有影响 | Marsman, E. M. J. | PDF | N/A | The Brugada syndrome associated gene WT1 impacts on SCN5A expression and cardiac conduction | | 视网膜血管母细胞瘤中肿瘤诱导血管生成的数学建模与仿真 | Pradelli, F. | PDF | N/A | Mathematical Modeling and Simulation of Tumor-Induced Angiogenesis in Retinal Hemangioblastoma | | 具有极端减振性能的水凝胶中的可调孔隙率 | Day, G. J. | PDF | N/A | Tunable porosity in a hydrogel with extreme vibration damping properties | | 一种用于整合蛋白质功能多模态数据的对抗性方案 | Nasser, R. | PDF | N/A | An adversarial scheme for integrating multi-modal data on protein function | | 利用纳米孔RNA004技术增强大肠杆菌中RNA修饰的检测 | GUO, Z. | PDF | N/A | Enhanced Detection of RNA Modifications in Escherichia coli Utilizing Nanopore RNA004 Technology | | 礁区在整个显生宙期间都是生物多样性的热点区域。 | Close, R. A. | PDF | N/A | Reefal regions were biodiversity hotspots throughout the Phanerozoic | | 甲状腺功能减退小鼠心脏中的代谢变化——来自非靶向代谢组学的见解 | Guan, H. | PDF | N/A | Metabolic shifts in the heart of hypothyroid mice -- insights from untargeted metabolomics | | N,N-二甲基乙酰胺能够阻断炎症引发的早产，并改善母体系统性免疫反应。 | Reznik, S. | PDF | N/A | N,N-dimethylacetamide blocks inflammation-induced preterm birth and remediates maternal systemic immune responses | | 提高N,N-二甲基乙酰胺（DMA）作为早产潜在治疗手段的安全性：在孕鼠模型中使用阴道纳米制剂的研究 | Mir, A. | PDF | N/A | Improving the Safety of N,N-Dimethylacetamide (DMA) as a Potential Treatment for Preterm Birth in a Pregnant Mouse Model Using a Vaginal Nanoformulation | | VDR-钙轴调节断奶期间由饮食驱动的代谢转变 | Jawla, N. | PDF | N/A | VDR-calcium axis regulates the diet-driven metabolic shift during weaning | | OsWRKY53通过精细调控PEP和PSK介导的信号传导之间的相互作用，决定了水稻的伤口反应。 | Harshith, C. Y. | PDF | N/A | OsWRKY53 dictates wound responses in rice through fine-tuning cross-talk between PEP and PSK mediated signalling | | 作物基因型调节与根腐病抗性相关的微生物群落组成及关键类群的丰度 | Gfeller, V. | PDF | N/A | Crop genotype modulates root rot resistance-associated microbial community composition and abundance of key taxa | | 光合调节在受控的室内农业设置中，通过动态变化的照明维持生菜的生长。 | Makinen, A. | PDF | N/A | Photosynthetic adjustments maintain lettuce growth under dynamically changing lighting in controlled indoor farming setups | | 使用SED-ML进行可重复的模型管理：验证BioModels在多个模拟引擎中的一致性 | Smith, L. P. | PDF | N/A | Using SED-ML for reproducible curation: Verifying BioModels across multiple simulation engines | | 多种神经网络方法，包括拓扑数据分析的应用，增强了根据处理条件对人类诱导多能干细胞集落进行分类的能力。 | Ruys de Perez, A. | PDF | N/A | Multiple neural network approaches, including use of topological data analysis, enhances classification of human induced pluripotent stem cell colonies by treatment condition | | 棕色脂肪组织中的胚胎巨噬细胞在空间上与发育中的神经相关联。 | Felix, I. | PDF | N/A | Embryonic macrophages in brown adipose tissue are spatially associated with developing nerves | | scTFBridge：一种基于TF-基序结合的分离深度生成模型，用于单细胞多组学中的基因调控推断 | Wang, F.-a. | PDF | N/A | scTFBridge: A Disentangled Deep Generative Model Informed by TF-Motif Binding for Gene Regulation Inference in Single-Cell Multi-Omics | | 通过复杂马尔可夫网络分析揭示的端粒G-四链体中间体。 | Sainz-Agost, A. | PDF | N/A | Telomeric G-quadruplex Intermediates unveiled by Complex Markov Network Analysis. | | SARS-CoV-2中和抗体的特异性在近期感染的婴儿和免疫印记个体之间存在显著差异。 | Dadonaite, B. | PDF | N/A | SARS-CoV-2 neutralizing antibody specificities differ dramatically between recently infected infants and immune-imprinted individuals | | 评估病毒对紫外线、臭氧和游离氯异质性敏感性的统计框架 | Yanagihara, M. | PDF | N/A | Statistical framework for assessing heterogeneous sensitivity of viruses to ultraviolet, ozone, and free chlorine | | 一种新型的血红素降解酶，它在调节血红素和铁稳态中起关键作用，并促进粪肠球菌的毒力增强 | Lemos, J. A. | PDF | N/A | A Novel Heme-Degrading Enzyme that Regulates Heme and Iron Homeostasis and Promotes Virulence in Enterococcus faecalis | | 伤寒沙门氏菌和甲型副伤寒沙门氏菌对血清抗体和补体的逃避 | Guerra, F. E. | PDF | N/A | Evasion of serum antibodies and complement by Salmonella Typhi and Paratyphi A | | GacA调控共生并介导假单胞菌生活方式转变 | Luo, Y. | PDF | N/A | GacA regulates symbiosis and mediates lifestyle transitions in Pseudomonas | | 优化原代人脾成纤维细胞的转染效率 | Kaur, A. | PDF | N/A | Optimizing Transfection Efficiency in Primary Human Splenic Fibroblast Cells | | ATAC-seq作为一种多功能工具，用于描绘基因组和表观基因组 | Toumi, I. | PDF | N/A | ATAC-seq as a versatile tool to portray genomes and epigenomes | | THAP9在少突胶质细胞发育阶段中的转录景观：分子机制与网络分析 | Bhardwaj, T. | PDF | N/A | Transcriptional Landscape of THAP9 across Oligodendrocyte Developmental Stages: Molecular Mechanisms and Network Analysis | | 模块化DNA条形码标记纳米抗体实现多重原位蛋白质成像和高通量生物分子检测 | Zhong, S. | PDF | N/A | Modular DNA Barcoding of Nanobodies Enables Multiplexed in situ Protein Imaging and High-throughput Biomolecule Detection | | GALILEO通过生成式方法扩展化学空间，并以高命中率实现了一次性识别出一系列新型、特异性、下一代广谱抗病毒化合物的库。 | Umansky, T. | PDF | N/A | GALILEO Generatively Expands Chemical Space and Achieves One-Shot Identification of a Library of Novel, Specific, Next Generation Broad-Spectrum Antiviral Compounds at High Hit Rates | | 一种系统发育方法识别了SARS-CoV-2突变谱演化的候选驱动因素 | Corbett-Detig, R. | PDF | N/A | A phylogenetic method identifies candidate drivers of the evolution of the SARS-CoV-2 mutation spectrum |

medRxiv

标题	作者	PDF链接	代码仓库	Title
母体和胎儿蛋白质组对出生体重的影响：一项孟德尔随机化分析	McBride, N.	PDF	N/A	Effects of the maternal and fetal proteome on birth weight: a Mendelian randomization analysis
解释耐药性和敏感性病原体稳定共存的机制：耐药性获得纯化选择模型	Pennings, P. S.	PDF	N/A	Explaining the stable coexistence of drug-resistant and -susceptible pathogens: the Resistance Acquisition Purifying Selection model
利用多祖先长读长测序面板进行结构变异的填补，能够识别疾病关联。	Noyvert, B.	PDF	N/A	Imputation of structural variants using a multi-ancestry long-read sequencing panel enables identification of disease associations
近视与模糊状态下的皮层视觉处理差异。	Steinfeld, K.	PDF	N/A	Cortical Visual Processing Differences in Myopia and Blur.
利用基因组数据追踪本地范围内的SARS-CoV-2病毒集群	Lyu, L.	PDF	N/A	Tracing SARS-CoV-2 Clusters Across Local Scales Using Genomic Data
模拟Clade Ib MPXV在亚洲城市的潜在传播	Jin, S.	PDF	N/A	Modelling the potential spread of Clade Ib MPXV in Asian cities
整合多维数据分析用于慢性腰痛的精准诊断	Vickery, S.	PDF	N/A	Integrating Multidimensional Data Analytics for Precision Diagnosis of Chronic Low Back Pain
结合猴痘疫苗接种与行为改变以控制男男性行为者中的猴痘传播：一项数学模型研究	Xiridou, M.	PDF	N/A	Combining mpox vaccination and behavioural changes for mpox control among men who have sex with men: a mathematical modelling study
婴儿大脑处理的不同时间阶段与早期和晚期的自闭症诊断相关联	Bazelmans, T.	PDF	N/A	Distinct temporal stages of infant brain processing associate with early versus later autism diagnosis
对非洲及非洲混血人群中的帕金森病进行大规模遗传特征研究	Akcimen, F.	PDF	N/A	Large-scale genetic characterization of Parkinson's disease in the African and African admixed populations
阿布扎比人口中的癌症负担：一项回顾性队列研究	Baynouna Alketbi, L. M.	PDF	N/A	The Cancer Burden in the Abu Dhabi Population: A Retrospective Cohort Study
居住在加纳的围产期感染HIV的儿童血脂水平的变化	Ayanful-Torgby, R.	PDF	N/A	Alterations in Lipid Profiles in Children with Perinatally Acquired HIV Infection living in Ghana
白细胞计数比低密度脂蛋白胆固醇更能预测新型颈动脉粥样硬化	Li, Y.	PDF	N/A	Leukocyte Count Is Better than LDL-C as Predictor of Novel Carotid Atherosclerosis
DspS311A基因敲入小鼠模拟了显性和隐性形式的Desmoplakin相关心肌病的临床病理特征。	Di Bona, A.	PDF	N/A	DspS311A knock-in mice replicate the clinical-pathological features of dominant and recessive forms of Desmoplakin-related cardiomyopathies
挪威长期护理居民的心肺复苏状况	Skirbekk, V.	PDF	N/A	Cardiopulmonary resuscitation status among long-term care residents in Norway
海滩工人的职业概况及工作场所事故的普遍性	Cremonese, C.	PDF	N/A	Occupational profile and prevalence of workplace accidents among beach workers
全球难民堕胎权利：2022年堕胎法律与强制流离失所的范围界定审查与定量分析	Erhardt-Ohren, B.	PDF	N/A	Abortion rights for refugees around the world: A scoping review and quantitative analysis of abortion laws and forced displacement in 2022
埃塞俄比亚奥罗米亚州阿西区苏德地区产后妇女现代避孕方法使用情况及相关因素	Feyissa, G. D.	PDF	N/A	Modern contraceptive utilization and associated factors among postpartum women, Sude District, Arsi Zone, Oromia, Ethiopia
将这段翻译成中文如下：

“在电子健康记录中对精神分裂症诊断代码的丢失进行建模，可以提高表型数据的质量以及多基因评分的跨祖先可转移性。”

在这项研究中，研究者们探索了人工智能技术在诊断和分析合并肺纤维化与肺气肿（Combined Pulmonary Fibrosis and Emphysema, CPFE）中的应用。通过多中心队列研究，他们旨在提高CPFE的诊断准确性，并深入理解该疾病的放射组学特征。研究结果表明，人工智能不仅能够提升诊断的精确度，还能通过放射组学分析揭示疾病潜在的生物学特征，为未来的个性化治疗策略提供重要参考。 | Zhang, S. | PDF | N/A | Harnessing Artificial Intelligence for Accurate Diagnosis and Radiomics Analysis of Combined Pulmonary Fibrosis and Emphysema: Insights from a Multicenter Cohort Study | | 以下是将这段英文翻译成中文的结果：

基于稀疏标注训练的深度卷积神经网络在转移性脊柱疾病放疗患者中对躯干肌肉组织的自动分割。

翻译说明： - Automated Segmentation：自动分割 - Trunk Musculature：躯干肌肉组织 - Deep CNN：深度卷积神经网络 - Trained from Sparse Annotations：基于稀疏标注训练 - Radiation Therapy Patients：放疗患者 - Metastatic Spine Disease：转移性脊柱疾病

在这段翻译中，我尽量保持了原文的专业性和准确性，同时确保语言流畅，易于理解。以下是翻译的详细解释：

Evaluating - 评估：表示对某事物进行系统的检查和评价。
Diabetes-Specific Meal Replacements - 糖尿病专用代餐：指专门为糖尿病患者设计的替代餐食。
Glycaemic Control - 血糖控制：指通过饮食、药物等手段维持血糖在正常范围内。
Overweight and Obese T2DM Patients - 超重和肥胖2型糖尿病患者：T2DM是Type 2 Diabetes Mellitus的缩写，即2型糖尿病。
A Protocol for a Randomized Controlled Trial - 一项随机对照试验的方案：随机对照试验是一种科学实验设计，用于比较不同干预措施的效果。