BioRxiv 2025-01-22 Papers

标题	作者	PDF链接	代码仓库	Title
视觉变化检测中起始优势的事件相关电位研究	Van Pelt, J.	PDF	N/A	An Event-Related Potential Study of Onset Primacy in Visual Change Detection
通过将成纤维细胞纳入杜氏肌营养不良症（Duchenne Muscular Dystrophy, DMD）的MYOrganoids模型中，研究发现疾病恶化现象，揭示了微抗肌萎缩蛋白（microdystrophin）治疗效果的局限性。	Palmieri, L.	PDF	N/A	Disease exacerbation by fibroblast inclusion in Duchenne Muscular Dystrophy MYOrganoids reveals limitations of microdystrophin therapeutic efficacy
使用尺寸排阻色谱法和密度梯度超速离心从小体积血浆中分离小细胞外囊泡：一项比较研究	Kong, F.	PDF	N/A	Isolating Small Extracellular Vesicles from Small Volumes of Blood Plasma using size exclusion chromatography and density gradient ultracentrifugation: A Comparative Study
荧光生成、亚单周转监测涉及NAD(P)H的酶反应为微滴中生物催化剂的定向超高通量进化提供了一个通用平台。	Penner, M.	PDF	N/A	Fluorogenic, sub-single-turnover monitoring of enzymatic reactions involving NAD(P)H provides a generalised platform for directed ultrahigh throughput evolution of biocatalysts in microdroplets
人的声音与全身的运动相协调。	Pouw, W.	PDF	N/A	The human voice aligns with whole-body kinetics
针对持续FGF23-ERK信号通路的基因治疗可减轻肾脏炎症	Salas-Bastos, A.	PDF	N/A	Gene therapy targeting sustained FGF23-ERK signaling alleviates kidney inflammation
细菌中一般应激反应启动的通用机制	Baral, R.	PDF	N/A	A General Mechanism for Initiating the General Stress Response in Bacteria
微生物群落结构受到与噬菌体抗性相关的宿主密度增加的影响。	Castledine, M.	PDF	N/A	Microbial community structure is affected by phage-resistance associated increases in host density
EPHA4信号传导失调与异常运动及特发性脊柱侧凸的发展相关联	Wang, L.	PDF	N/A	EPHA4 signaling dysregulation links abnormal locomotion and the development of idiopathic scoliosis
序列组成和保守性预测转座因子的表型相关性	Cerruti, Y.	PDF	N/A	Sequence composition and conservation predict the phenotypic relevance of transposable elements
升高的锥体细胞放电通过COX-2衍生的前列腺素E2信号传导协调小动脉血管收缩。	Le Gac, B.	PDF	N/A	Elevated pyramidal cell firing orchestrates arteriolar vasoconstriction through COX-2-derived prostaglandin E2 signaling
一段时期性的巨大基因组重排爆发与非海洋环节动物的起源	Vargas-Chavez, C.	PDF	N/A	An episodic burst of massive genomic rearrangements and the origin of non-marine annelids
对高表达甲状腺球蛋白基因的延迟共转录剪接进行显微镜分析	Ullrich, S.	PDF	N/A	Microscopy analysis of delayed co-transcriptional splicing in highly expressed thyroglobulin gene
健康与肥胖小鼠肝脏中饥饿响应代谢网络的结构稳健性与时间脆弱性	Morita, K.	PDF	N/A	Structural robustness and temporal vulnerability of the starvation-responsive metabolic network in liver of healthy and obese mice
使用微生物酶混合物进行多糖定量	Pontrelli, S.	PDF	N/A	Polysaccharide quantification using microbial enzyme cocktails
一种快速且高效的基因敲除方法应用于领鞭毛虫Salpingoeca rosetta，揭示了领鞭毛虫多细胞发育的遗传机制。	Combredet, C.	PDF	N/A	A fast and robust gene knockout method for Salpingoeca rosetta clarifies the genetics of choanoflagellate multicellular development
PA28γ通过C1QBP提升线粒体功能，从而促进肿瘤的恶性进展。	Wang, J.	PDF	N/A	PA28γ promotes the malignant progression of tumor by elevating mitochondrial function via C1QBP
一种新的醌类生物合成途径揭示了有氧代谢的进化	Elling, F. J.	PDF	N/A	A novel quinone biosynthetic pathway illuminates the evolution of aerobic metabolism
在东亚亚热带地区，三种鼠耳蝠（Myotis）的觅食生态位划分及毛足鼠耳蝠（Myotis pilosus）对海洋鱼类的摄食研究	Wei, X.	PDF	N/A	Foraging niche partitioning of three Myotis bat species and marine fish consumption by Myotis pilosus in a subtropical East Asian region
细胞几何形状、微管偏转和方向依赖性动态不稳定性在皮层阵列组织中的冲突作用	Tian, T. Y. Y.	PDF	N/A	Conflicting roles of cell geometry, microtubule deflection and orientation-dependent dynamic instability in cortical array organization
黑水虻的控制性和一夫多妻制交配：利用定量遗传设计推进育种计划	Jensen, K.	PDF	N/A	Controlled and polygynous mating in the black soldier fly: advancing breeding programs utilizing quantitative genetic designs
加拉帕戈斯群岛Scalesia适应性辐射中的基因组稳定性：尽管存在杂交和生态位转变，转座因子仍持续积累	Cerca, J.	PDF	N/A	Genomic stability in the Galapagos Scalesia adaptive radiation: Consistent transposable element accumulation despite hybridization and ecological niche shifts
以下是这段英文的中文翻译：

“关于Jyvaskylavirus的基因组和结构见解，这是首个从芬兰分离出的巨型病毒”

翻译说明： - “Genomic and structural insights” 翻译为 “基因组和结构见解” - “Jyvaskylavirus” 是病毒名称，保留原文 - “the first giant virus isolated from Finland” 翻译为 “首个从芬兰分离出的巨型病毒”

这段文字描述了对Jyvaskylavirus病毒的研究，重点是其基因组和结构特征，并强调这是第一个在芬兰发现的巨型病毒。 | de Freitas Almeida, G. M. | PDF | N/A | Genomic and structural insights into Jyvaskylavirus, the first giant virus isolated from Finland | | 主肺动脉的本构神经网络：探索未知 | Vervenne, T. | PDF | N/A | Constitutive neural networks for main pulmonary arteries: Discovering the undiscovered | | 阿利效应、产卵不同步性以及常见大规模产卵珊瑚中的混合繁殖模式 | Ricardo, G. F. | PDF | N/A | Allee effects, spawning asynchrony, and mixed reproductive modes in a common mass spawning coral | | 将生物分割数据集公平地（FAIRly）存储 | Ho, E. M. L. | PDF | N/A | Depositing biological segmentation datasets FAIRly | | 量化DIA-MS数据集中之前未被量化的约75-95%的肽段 | Saxena, G. | PDF | N/A | Quantifying the ~75-95% of Peptides in DIA-MS Datasets that were not Previously Quantified | | DUX4诱导的HSATII RNA积累驱动蛋白质聚集，影响RNA加工途径。 | Arends, T. | PDF | N/A | DUX4-induced HSATII RNA accumulation drives protein aggregation impacting RNA processing pathways. | | 一种用于预测蛋白质内在无序区域相互作用的深度学习方法 | Majila, K. | PDF | N/A | A deep learning method for predicting interactions for intrinsically disordered regions of proteins | | I2SIM：通过图像干扰和空间频谱优化提升高保真各向同性超分辨率 | He, E. | PDF | N/A | I2SIM: Boosting High-Fidelity Isotropic Super-Resolution with Image Interference and Spatial-Spectrum Optimization | | Nde1促进Lis1与全长自抑制状态的人源Dynein-1结合 | Yang, J. | PDF | N/A | Nde1 Promotes Lis1 Binding to Full-Length Autoinhibited Human Dynein-1 | | 在盲人视网膜中利用超敏感人类TRPV1通道进行红外光检测的工程研究 | Chevalier, M. | PDF | N/A | Engineering Infrared Light Detection in Blind Human Retina Using Ultrasensitive Human TRPV1 Channels | | 日本树蛙（Dryophytes japonicus）蝌蚪对多种蜻蜓若虫的捕食者诱导尾部颜色变化 | Noda, A. | PDF | N/A | Predator-Induced Tail Coloration Toward Diverse Dragonfly Nymphs in Tadpoles of the Japanese Tree Frog (Dryophytes japonicus) | | D类β-内酰胺酶中的标准化残基编号和二级结构命名法 | Stasyuk, A. | PDF | N/A | Standardized Residue Numbering and Secondary Structure Nomenclature in the Class D β-Lactamases | | 人乳寡糖通过梭菌属物种的代谢抑制炎症和病原体生长 | Chapman, J. A. | PDF | N/A | Human milk oligosaccharide metabolism by Clostridium species suppresses inflammation and pathogen growth | | 一种便捷的宏基因组学策略能够更好地表征无脊椎动物批量样本。 | Callens, M. | PDF | N/A | An accessible metagenomic strategy allows for better characterization of invertebrate bulk samples | | 全基因组分析揭示了突变表型在结核分枝杆菌耐药性出现中的作用 | Zein-Eddine, R. | PDF | N/A | Genome wide analyses reveal the role of mutator phenotypes in the emergence of drug resistance in Mycobacterium tuberculosis | | 基因组测序、分子标记开发及重要经济脆弱树种无忧树（Saraca asoca (Roxb.) W.J de Wilde）的遗传多样性评估 | P, M. | PDF | N/A | Genome Sequencing, Molecular Marker Development and Genetic Diversity Assessment of Economically Important Vulnerable Tree Species Saraca asoca (Roxb.) W.J de Wilde | | AI.zymes - 一个用于进化酶设计的模块化平台 | Merlicek, L. P. | PDF | N/A | AI.zymes - A modular platform for evolutionary enzyme design | | 以下是这段文字的中文翻译：

微泡空化在治疗诊断超声介导的血脑屏障开放和基因递送中的表征

一种用于双光子荧光显微镜分割的自监督深度学习流程

翻译说明： 1. "self-supervised" 翻译为 "自监督"，这是深度学习中的一种训练方式 2. "deep learning pipeline" 翻译为 "深度学习流程"，指一系列的处理步骤 3. "segmentation" 翻译为 "分割"，这是图像处理中的常用术语 4. "two-photon fluorescence microscopy" 翻译为 "双光子荧光显微镜"，这是一种先进的显微成像技术

这个标题描述了一种用于处理双光子荧光显微镜图像的自监督深度学习系统，主要用于图像分割任务。 | Ntiri, E. E. | PDF | N/A | A self-supervised deep learning pipeline for segmentation in two-photon fluorescence microscopy | | 自闭症相关基因Tbr1的缺失会破坏社会情感行为期间前额叶集合体的预测和编码功能。 | Turner, M. | PDF | N/A | Loss of the autism associated gene Tbr1 disrupts prediction and encoding by prefrontal ensembles during socioemotional behaviors | | 术中人类微电极记录的参数化：将动作电位形态与脑解剖结构联系起来 | Baker, M. R. | PDF | N/A | Parameterization of intraoperative human microelectroderecordings: Linking action potential morphology to brainanatomy | | 火花随距离减弱：不同经颅电刺激技术下电场分布对全局运动感知的影响 | Pavan, A. | PDF | N/A | Sparks fade with distance: The effect of electric field distribution on global motion perception using different tES techniques | | 神经网络爆发对功能连接性的影响 | Ramstad, O. H. | PDF | N/A | Influence of neural network bursts on functional connectivity | | 大麻素对中央杏仁核群体动态在威胁调查期间的调节作用 | Yasmin, F. | PDF | N/A | Cannabinoid Modulation of Central Amygdala Population Dynamics During Threat Investigation | | 多纤毛动态转导Shh信号以调节脉络丛功能 | He, L. | PDF | N/A | Multicilia dynamically transduce Shh signaling to regulate choroid plexus functions | | 在羽虱多样化的过程中，独立且重复地获得了内共生细菌。 | Soto-Patino, J. | PDF | N/A | Independent and repeated acquisition of endosymbiotic bacteria across the diversification of feather lice | | 关于拟南芥种质在蚜虫选择压力下可遗传变化的证据较弱 | Schmid, M. W. | PDF | N/A | Weak evidence for heritable changes in response to selection by aphids in Arabidopsis accessions | | 自闭症相关基因与邻近长链非编码RNA在关键基因调控网络上的汇聚 | Andersen, R. | PDF | N/A | Autism-Associated Genes and Neighboring lncRNAs Converge on Key Gene Regulatory Networks | | 比较评估重建人类病毒基因组的计算方法 | Sousa, M. J. P. | PDF | N/A | Comparative evaluation of computational methods for reconstruction of human viral genomes | | 混合生成模型：桥接机器学习与生物物理学，拓展RNA功能多样性 | Opuu, V. | PDF | N/A | Hybrid Generative Model: Bridging Machine Learning and Biophysics to Expand RNA Functional Diversity | | PI3K调控TAZ/YAP和mTORC1信号轴，这些信号轴可以被协同靶向。 | Garcia, K. C. | PDF | N/A | PI3K regulates TAZ/YAP and mTORC1 axes that can be synergistically targeted | | 阿尔茨海默病中突触小泡蛋白2A在细胞外囊泡和大脑中的水平降低——与Aβ、tau蛋白和突触素的关系 | Nussbaumer, J. | PDF | N/A | Reduced levels of synaptic vesicle protein 2A in the extracellular vesicles and brain of Alzheimer's disease- associations with Aβ, tau and synaptophysin | | 测量空间排序的强度 | Goel, N. | PDF | N/A | Measuring the Strength of Spatial Sorting | | 在性别特定的3D生物打印肺动脉外膜模型中，女性成纤维细胞的激活是由雌激素介导的。 | Mueller, M. C. | PDF | N/A | Female fibroblast activation is estrogen-mediated in sex-specific 3D-bioprinted pulmonary artery adventitia models | | 膜波动与脂质曲率之间的耦合导致线粒体膜中心磷脂的瞬时局部富集。 | Lee, C. T. | PDF | N/A | Coupling between membrane undulations and lipid curvature leads to transient local enrichment of cardiolipin in mitochondrial membranes | | 染色质凝聚体的多尺度结构合理化相分离及材料特性 | Zhou, H. | PDF | N/A | Multi-scale structure of chromatin condensates rationalizes phase separation and material properties | | 了解ProQ蛋白的RNA伴侣活性 | Singh, S. | PDF | N/A | Understanding RNA Chaperone Activity of ProQ Protein | | 一项以领域为中心的系统方法揭示了与干旱胁迫下高粱生长和发育相关的mRNA共价修饰。 | Yu, L. | PDF | N/A | A field-focused systems approach reveals mRNA covalent modifications linked to sorghum growth and development under drought stress | | 叶片渗透势的样本量是否会影响其与棉花产量的关系？ | Dong, X. | PDF | N/A | Does sample size of leaf osmotic potential affect its relationship with cotton yield? | | 微生理系统体外/体内转化操作条件的合理设计系统生物学框架 | Cadavid, J. L. | PDF | N/A | Systems biology framework for rational design of operational conditions for in vitro / in vivo translation of microphysiological systems | | 加权基因共表达网络分析揭示了长期感染约翰病的德西牛中的关键基因和长链非编码RNA | Sahu, A. | PDF | N/A | Weighted gene co-expression network analysis reveals key genes and lncRNAs in desi cattle chronically infected with Johne's disease | | 脑池造瘘术有助于清除创伤性脑损伤患者脑脊液中的代谢废物。 | He, W. | PDF | N/A | Cisternostomy facilitates clearance of metabolic waste from cerebrospinal fluid in patients with traumatic brain injury | | Scg2驱动皮质脊髓回路与脊髓前运动中间神经元的重组，以促进中风后运动功能的恢复。 | Sato, T. | PDF | N/A | Scg2 drives reorganization of the corticospinal circuit with spinal premotor interneurons to recover motor function after stroke | | 在大鼠中，导水管周围灰质中的Fos表达与心理社会压力诱导的可卡因寻求行为相关，而腹内侧下丘脑中的Fos表达则与此无关。 | Hinds, N. M. | PDF | N/A | Fos expression in the periaqueductal gray, but not the ventromedial hypothalamus, is correlated with psychosocial stress-induced cocaine-seeking behavior in rats | | 以下是这段文字的中文翻译：

从皮层兴奋性神经元中去除Miro1后引发的焦虑相关行为

翻译说明： - "Anxiety-associated behaviors" 翻译为 "焦虑相关行为" - "following ablation of" 翻译为 "去除...后引发的" 或 "切除...后导致的" - "Miro1" 是一个基因名称，通常不翻译 - "cortical excitatory neurons" 翻译为 "皮层兴奋性神经元"

半翅目昆虫生物钟和光输入途径基因的进化

翻译说明： - "Evolution" 翻译为“进化” - "circadian clock" 翻译为“生物钟” - "light-input pathway genes" 翻译为“光输入途径基因” - "Hemiptera" 翻译为“半翅目”（昆虫纲的一个目，包括蝉、蚜虫等）

粗糙脉孢菌细胞壁重塑同种异体识别检查点等位基因特异性所需区域的鉴定

翻译说明： - "Identification" 译为 "鉴定" - "regions required for" 译为 "所需区域" - "allelic specificity" 译为 "等位基因特异性" - "cell wall remodeling" 译为 "细胞壁重塑" - "allorecognition checkpoint" 译为 "同种异体识别检查点" - "Neurospora crassa" 译为 "粗糙脉孢菌"

对来自高温泻湖的新型耐热广盐性单细胞海洋蓝藻 Cyanobacterium sp. DS4 的比较基因组分析

翻译说明： 1. "Comparative genomic analysis" 翻译为“比较基因组分析”。 2. "novel heat-tolerant and euryhaline strain" 翻译为“新型耐热广盐性菌株”。 3. "unicellular marine cyanobacterium" 翻译为“单细胞海洋蓝藻”。 4. "high-temperature lagoon" 翻译为“高温泻湖”。

小鼠单细胞长读长剪接图谱（Ouro-Seq）

如果需要进一步解释或调整，请告诉我！ | An, H. | PDF | N/A | Mouse Single-Cell Long-Read Splicing Atlas by Ouro-Seq | | 单条哺乳动物染色质纤维上普遍存在且程序化的核小体扭曲模式 | Yang, M. G. | PDF | N/A | Pervasive and programmed nucleosome distortion patterns on single mammalian chromatin fibers | | 调节老年人CD8+ T细胞衰老的表观遗传机制 | Turano, P. S. | PDF | N/A | Epigenetic mechanisms regulating CD8+ T cell senescence in aging humans | | 低水平污染混淆了群体基因组分析。 | Ward, A. | PDF | N/A | Low level contamination confounds population genomic analysis | | 基于质谱的蛋白质组学中复杂肽形通用谱图注释器 | Schulte, D. | PDF | N/A | A universal spectrum annotator for complex peptidoforms in mass spectrometry-based proteomics | | 标题：Phyla：迈向系统发育推断的基础模型

在生物信息学领域，系统发育推断（Phylogenetic Inference）是研究物种间进化关系的重要方法。近年来，随着人工智能技术的快速发展，研究人员开始探索如何利用深度学习等先进技术来构建更高效、更准确的系统发育推断模型。本文将介绍一个名为“Phyla”的项目，该项目旨在开发一个基础模型（Foundation Model），以支持更广泛、更深入的系统发育研究。

1. 背景与动机

系统发育推断是通过分析物种的遗传数据（如DNA序列）来构建进化树（Phylogenetic Tree）的过程。传统的系统发育方法通常依赖于最大似然法（Maximum Likelihood）或贝叶斯推断（Bayesian Inference），这些方法在处理大规模数据集时往往计算复杂度高，且难以捕捉复杂的进化模式。

随着基因组数据的爆炸式增长，传统的系统发育方法面临着巨大的挑战。因此，开发一种能够高效处理大规模数据、并能够自动学习进化模式的系统发育推断模型变得尤为重要。

2. Phyla项目的目标

Phyla项目的核心目标是构建一个基础模型，该模型能够作为系统发育推断的通用框架，适用于各种不同类型的生物数据和进化场景。具体来说，Phyla项目旨在实现以下几个目标：

高效性：通过深度学习技术，显著提高系统发育推断的计算效率，使其能够处理大规模基因组数据。
准确性：利用深度学习的强大表达能力，捕捉复杂的进化模式，提高推断结果的准确性。
通用性：开发一个通用的基础模型，能够适应不同的生物数据类型（如DNA、RNA、蛋白质序列）和不同的进化场景（如物种分化、基因家族进化等）。

3. 技术路线

Phyla项目的技术路线主要包括以下几个步骤：

数据预处理：对输入的生物数据进行预处理，包括序列比对、特征提取等步骤，以便为深度学习模型提供高质量的输入数据。
模型设计：设计一个深度神经网络模型，该模型能够自动学习序列之间的进化关系，并生成相应的系统发育树。模型可能包括卷积神经网络（CNN）、循环神经网络（RNN）或Transformer等架构。
训练与优化：利用大规模的系统发育数据集对模型进行训练，并通过优化算法（如梯度下降法）不断调整模型参数，以提高推断的准确性。
模型评估：在多个标准数据集上对模型进行评估，比较其与传统系统发育方法的性能差异，确保模型在实际应用中的有效性。

4. 预期成果

Phyla项目的预期成果包括：

开源模型：将开发的基础模型开源，供全球研究人员使用和进一步改进。
工具包：提供一个用户友好的工具包，使生物学家能够轻松地使用该模型进行系统发育推断。
应用案例：通过多个实际案例展示该模型在不同生物数据上的应用效果，推动系统发育研究的发展。

5. 结论

Phyla项目代表了系统发育推断领域的一次重要尝试，通过引入深度学习技术，有望显著提升系统发育推断的效率和准确性。随着项目的不断推进，我们期待Phyla能够成为系统发育研究中的一项重要工具，为理解生物进化提供新的视角和方法。

一种简单且可扩展的Marchantia polymorpha（地钱）切段转化方法

翻译说明： 1. "A Simple and Scalable" 翻译为 "一种简单且可扩展的"，描述了该方法的特点。 2. "Chopped-Thallus Transformation Method" 翻译为 "切段转化方法"，其中 "Chopped-Thallus" 指的是将地钱的叶状体切碎后进行转化。 3. "Marchantia polymorpha" 是植物学名，通常翻译为 "地钱" 或 "多形地钱"。

这个标题描述了一种用于地钱遗传转化的新方法，该方法简单易行且适用于大规模操作。 | Batth, R. | PDF | N/A | A Simple and Scalable Chopped-Thallus Transformation Method for Marchantia polymorpha | | 解码调控小麦花序发育的细胞转录调控网络 | Liu, X. | PDF | N/A | Decoding cellular transcriptional regulatory networks governing wheat inflorescence development | | CYP722A1驱动的卡拉克通酸16-羟基化调控拟南芥的花期转换 | Kuno, M. | PDF | N/A | CYP722A1-driven 16-hydroxylation of carlactonoic acid regulates the floral transition in Arabidopsis | | 埃及蝗虫（Anacridium aegyptium）行走过程中的非线性运动模式：详细案例研究 | Tozzi, A. | PDF | N/A | Nonlinear locomotion patterns in the Egyptian Locust (Anacridium aegyptium) during walking: a detailed case study | | 致癌应激是一种由未折叠蛋白反应驱动的新型免疫原性信号，并被中性粒细胞检测到。 | Debiesse, A. | PDF | N/A | Oncogenic Stress is a Novel Immunogenic Signal Driven by the Unfolded Protein Response and Detected by Neutrophils | | 通过分组简化物种相互作用矩阵：影响和响应的最佳分组不同 | Brown, C. R. P. | PDF | N/A | Simplifying species interaction matrices by grouping: optimal groupings differ between effects and responses | | 酮体β-羟基丁酸不会延长寿命，但在食物受限的水蚤中上调了繁殖力，并具有跨代效应。 | C. Pearson, A. C. | PDF | N/A | Ketone body b-Hydroxybutyrate does not extend lifespan, but upregulates fecundity in food-limited Daphnia, with a transgenerational effect | | 多功能弯曲磁铁光束线配备毛细管光学元件，用于组织切片中金属的X射线荧光研究 | Roter, B. | PDF | N/A | Multifunctional bending magnet beamline with a capillary optic for X-ray fluorescence studies of metals in tissue sections | | 一种明亮的合成近红外荧光素增强了使用萤火虫荧光素酶进行深层组织生物发光成像的能力。 | Saito-Moriya, R. | PDF | N/A | A bright synthetic near-infrared luciferin enhances the capabilities of deep-tissue bioluminescence imaging using firefly luciferases | | 当邻居发挥作用时：对影响癌症驱动突变效应的蛋白质相互作用的系统级分析 | Vital, M. F. | PDF | N/A | When neighbours play a role: a systems-level analysis of protein interactions conditioning cancer driver mutation effects | | SCAN-ACT：通过单细胞转录组学发现适应性T细胞疗法的靶点 | Testa, S. | PDF | N/A | SCAN-ACT: Adoptive T Cell Therapy Target Discovery Through Single-Cell Transcriptomics | | 免疫细胞线粒体表型在线粒体疾病中基本保持不变，并不反映疾病的严重程度。 | Liu, C. C. | PDF | N/A | Immune cell mitochondrial phenotypes are largely preserved in mitochondrial diseases and do not reflect disease severity | | 物种引入对相互作用的食果鸟类和肉质果植物性状多样性的影响取决于本地性状多样性 | Nowak, L. | PDF | N/A | Impacts of species introductions on the trait diversity of interacting avian frugivores and fleshy-fruited plants depend on native trait diversity | | 从二倍体到多倍体转变过程中超级基因的命运 | Mora Carrera, E. | PDF | N/A | Fate of a supergene in the shift from diploidy to polyploidy | | 丙酮酸及相关能量代谢物调节对青光眼高遗传风险的抵抗力 | Li, K. | PDF | N/A | Pyruvate and Related Energetic Metabolites Modulate Resilience Against High Genetic Risk for Glaucoma | | GETgene-AI：一个用于优先考虑可操作癌症药物靶点的框架 | Gu, A. | PDF | N/A | GETgene-AI: A Framework for Prioritizing Actionable Cancer Drug Targets | | 补充游离酸β-羟基丁酸并不能像生酮饮食那样改善雄性小鼠中由硫酸葡聚糖钠诱导的结肠炎。 | Toivio, L. | PDF | N/A | Free acid β-hydroxybutyrate supplementation does not ameliorate dextran sodium sulfate-induced colitis similar to ketogenic diet in male mice | | 抑制EZH2通过调节滑膜和巨噬细胞炎症、轴突导向以及破骨细胞生成，缓解实验性小鼠模型中的骨关节炎和疼痛 | Brochard, S. | PDF | N/A | Inhibiting EZH2 Alleviates Osteoarthritis and Pain in an Experimental Murine Model Through Modulating Synovial and Macrophage Inflammation, Axon Guidance, and Osteoclastogenesis | | 从横截面数据中表征正在进行的大脑老化 | Smith, S. M. | PDF | N/A | Characterising ongoing brain aging from cross-sectional data | | “元分析一路到底：神经影像元分析概览” | Oudyk, K. M. | PDF | N/A | Meta all the way down: An overview of neuroimaging meta-analyses | | 多模态神经影像学揭示了新发帕金森病患者中左旋多巴诱导的运动障碍的独特特征 | Shukla, S. | PDF | N/A | Multimodal Neuroimaging Reveals Distinct Characteristics of Levodopa-Induced Dyskinesias in de novo Parkinsons Disease Patients | | 代谢酶GYS1在细胞核内与NONO/p54nrb结合，以时空调节糖原生成和肌原性分化。 | Peng, S. | PDF | N/A | The metabolic enzyme GYS1 condenses with NONO/p54nrb in the nucleus to spatiotemporally regulate glycogenesis and myogenic differentiation | | 一种利用D-半乳糖诱导间充质干细胞衰老趋势的方法 | Ji, X. | PDF | N/A | A method for inducing a senescence trend in mesenchymal stem cells using D-galactose | | 病毒感染显著降低昆虫的适应性：一项元分析 | Cesar, C. S. | PDF | N/A | Virus infection significantly decreases insect fitness: a meta-analysis | | 遥测验证背甲微化学：互补工具重建濒危大西洋鲟鱼种群的迁徙生活史 | Ingram, E. C. | PDF | N/A | Telemetry-validation of dorsal scute microchemistry: complementary tools reconstruct the migratory life-history of an endangered population of Atlantic Sturgeon | | 通过对家短尾负鼠（Monodelphis domestica）的毒液抗性进行表征，我们获得了关于哺乳动物血液生理学的新见解。 | Holding, M. L. | PDF | N/A | Characterizing venom resistance in Monodelphis domestica yields new insights into mammalian blood physiology | | 《新热带地区闭鞘姜科的修订：六十年分类学奋斗的成果》 | Maas, P. J. M. | PDF | N/A | A revision of the Neotropical Costaceae: results from sixty years of taxonomic struggle | | 迈向使用快速且内存高效算法进行全基因组多基因评分推断 | Zabad, S. | PDF | N/A | Towards whole-genome inference of polygenic scores with fast and memory-efficient algorithms | | 利用片段化纵向数据估算育种田中果树的生长曲线：以柑橘杂交幼苗为例 | Kimura, S. | PDF | N/A | Estimating fruit tree growth curves in breeding field using fragmented longitudinal data: An application to citrus hybrid seedlings | | 针对可溶性和多通道膜蛋白的表位特异性抗体的从头设计，具有高特异性、可开发性和功能性 | Nabla Bio, | PDF | N/A | De novo design of epitope-specific antibodies against soluble and multipass membrane proteins with high specificity, developability, and function | | 肿瘤发生中无偏倚共现突变景观 | Li, Y. | PDF | N/A | Unbiased co-occurring mutational landscapes in tumorigenesis | | 解锁精准诊断：整合代谢组学与先进机器学习技术的多模态框架 | Shahnazari, P. | PDF | N/A | Unlocking Precision Diagnostics: A Multimodal Framework Integrating Metabolomics with Advanced Machine Learning Techniques | | 成纤维细胞密度是药物诱发心律失常的风险因素 | Hirose, K. | PDF | N/A | Fibroblast Density is a Risk Factor for Drug-induced Arrhythmias | | 对多切片空间分辨转录组数据分析的聚类方法进行全面比较 | Xiong, C. | PDF | N/A | A comprehensive comparison on clustering methods for multi-slide spatially resolved transcriptomics data analysis | | 使用pyCERR和癌症基因组云进行医学图像分析的人工智能应用 | Apte, A. | PDF | N/A | Artificial Intelligence Apps for Medical Image Analysis using pyCERR and Cancer Genomics Cloud | | RAS-PI3K通路在CAFs中塑造肿瘤ECM的物理化学特性并抑制肿瘤进展 | Cuesta, C. | PDF | N/A | RAS-PI3K Pathway in CAFs Shapes Physicochemical Properties of Tumor ECM and restrains Tumor progression | | 通过新型GATA1/TAL1/鞘磷脂合成酶1（SGMS1）转录轴调控细胞周期。对反白血病策略的启示。 | Raza, Y. | PDF | N/A | Regulation of cell cycle by the novel GATA1/TAL1/Sphingomyelin Synthase 1 (SGMS1) transcriptional axis. Implications for anti-leukemic strategies. | | 基于DNA甲基化的细胞类型去卷积揭示了脑肿瘤微环境中的独特细胞组成 | Liu, F. | PDF | N/A | DNA Methylation-Based Cell Type Deconvolution Reveals the Distinct Cell Composition in Brain Tumor Microenvironment | | 非人灵长类中枢神经系统组织和生物流体中反义寡核苷酸的定量通过拼接-连接PCR检测 | Jepp, T. B. C. | PDF | N/A | Antisense Oligonucleotide Quantification via Splint-Ligation PCR Assay in Non-Human Primate Central Nervous System Tissues and Biofluids | | 表皮细胞动力学通过调控OsZHD1和OsZHD2调节水稻叶枕关节形态发生和叶片角度形成 | Xu, Y. | PDF | N/A | Epidermal Cell Dynamics Regulates Rice Lamina Joint Morphogenesis and Leaf Angle Formation through OsZHD1 and OsZHD2 Regulation | | 光诱导植物中的光敏色素B（Phytochrome B）发生SUMO化修饰，进而招募免疫调节因子NPR1进入核凝聚体中，从而调控植物的免疫反应。 | Ghosh, S. | PDF | N/A | Light induces Phytochrome B SUMOylation to recruit the immune regulator NPR1 in nuclear condensates to control immunity in plants | | 以下是这段英文的中文翻译：

栽培草莓季节性开花基因型中花启动早期步骤的分子机制

翻译说明： - "Molecular mechanisms" 翻译为“分子机制”。 - "underlying" 表示“基础的”或“内在的”，这里翻译为“的”。 - "early steps" 翻译为“早期步骤”。 - "floral initiation" 翻译为“花启动”或“花形成”。 - "seasonal flowering genotypes" 翻译为“季节性开花基因型”。 - "cultivated strawberry" 翻译为“栽培草莓”。

希望这个翻译对你有帮助！如果需要进一步调整或解释，请告诉我。 | Ziegler, F. M. R. | PDF | N/A | Molecular mechanisms underlying the early steps of floral initiation in seasonal flowering genotypes of cultivated strawberry | | Rubisco在整个生命树中都是缓慢的。 | de Pins, B. | PDF | N/A | Rubisco is slow across the tree of life | | 基因编辑的低免疫原性人原代胆管细胞类器官的免疫和突变特征 | Petrus-Reurer, S. | PDF | N/A | Immune and Mutational Profile of Gene-Edited Low-Immunogenic Human Primary Cholangiocyte Organoids | | CAR T细胞工程影响抗原非依赖性激活和共抑制 | Stuecheli, S. | PDF | N/A | CAR T cell engineering impacts antigen-independent activation and co-inhibition | | Scube2通过招募高密度脂蛋白（HDL）受体到质膜上，启动Dispatched和ADAM10介导的Shh（Sonic Hedgehog）释放。 | Puschmann, J. | PDF | N/A | Scube2 primes Dispatched and ADAM10-mediated Shh release by recruiting HDL acceptors to the plasma membrane | | 含Valosin蛋白是淀粉样前体蛋白细胞外囊泡中的货物 | Lue, Y. | PDF | N/A | Valosin-containing Protein is Cargo in Amyloid Precursor Protein Extracellular Vesicles | | 选择由不同细胞外基质分子驱动的白血病前期造血干细胞 | Jassinskaja, M. | PDF | N/A | Selection of pre-leukemic hematopoietic stem cells driven by distinct extracellular matrix molecules | | LIN28介导的基因调控环路同步器官发生过程中的发育转变 | Thevarajan, I. | PDF | N/A | LIN28-mediated gene regulatory loops synchronize developmental transitions throughout organogenesis | | 人类生长的二元细胞生物学 II 从胎儿各部分大小计算人类胎儿的大小 | Gu, Z. | PDF | N/A | The Binary Cellular Biology of Human Growth II Calculating the Size of the Human Fetus from the Size of its Parts | | 早期人类大脑发育中专一性tRNA表达的鉴定 | Bagi, A. L. | PDF | N/A | Identification of Specialized tRNA Expression in Early Human Brain Development | | 在肝脏发育过程中，通过胶原蛋白I进行的机械信号传导调节胆管细胞的定向分化和小管形成。 | Thelwall, I. G. | PDF | N/A | Mechanical signalling through collagen I regulates cholangiocyte specification and tubulogenesis during liver development | | 2019-2022年法国北部狍子（Capreolus capreolus）中针对伯氏疏螺旋体和蜱传脑炎病毒的血清学空间分布模式 | Metras, R. | PDF | N/A | Spatial pattern of serology against Borrelia and tick-borne encephalitis virus in roe deer (Capreolus capreolus), Northern France, 2019-2022 | | 与阿拉伯按蚊相比，疟疾媒介非洲按蚊的延迟交配和交配行为 | Hape, E. E. | PDF | N/A | Delayed copulation and mating in the malaria vector Anopheles funestus compared to Anopheles arabiensis | | 以下是这段英文的中文翻译：

"微孢子虫系统发育中基因组结构和表观遗传修饰的变异"

翻译解释： - "Variation" 翻译为 "变异" - "genome architecture" 翻译为 "基因组结构" - "epigenetic modification" 翻译为 "表观遗传修饰" - "across the microsporidia phylogeny" 翻译为 "微孢子虫系统发育中"

注：上述翻译基于提供的信息，假设“Distinct Genetic Populations and Resistance Backgrounds”指的是对法氏按蚊在坦桑尼亚地区不同遗传种群及其抗药性背景的研究。如果上下文有更具体的指向，翻译可相应调整。 | Odero, J. O. | PDF | N/A | Distinct Genetic Populations and Resistance Backgrounds of the Malaria Vector Anopheles funestus in Tanzania | | 大量分离分析揭示了与科罗拉多马铃薯甲虫对吡虫啉抗性相关的基因组区域。 | Edison, A. | PDF | N/A | Bulk segregant analysis reveals genomic regions associated with imidacloprid resistance in the Colorado potato beetle | | 在为期两年的新生儿和儿童血流感染调查中，马拉色菌（Malassezia furfur）分离株的遗传多样性有限，这证实了在深部感染中存在对一种特定IGS1基因型的偏好。 | Theelen, B. | PDF | N/A | Limited genetic diversity among Malassezia furfur isolates during two one-year neonatal and pediatric bloodstream infection surveys confirms preference for one specific IGS1 genotype in deep-seated infections | | DNA呼吸对转录因子物理相互作用的贡献 | Butt, W. A. | PDF | N/A | Contribution of DNA breathing to physical interactions with transcription factors | | 鉴定两种难以捉摸的人类核糖核酸酶MRP特异性蛋白成分 | Che, R. | PDF | N/A | Identification of Two Elusive Human Ribonuclease MRP-Specific Protein Components | | 使用语言模型预测CRISPR碱基编辑器在组织特异性转录组中RNA脱靶风险 | Nakamae, K. | PDF | N/A | Risk Prediction of RNA Off-Targets of CRISPR Base Editors in Tissue-Specific Transcriptomes Using Language Models | | 识别驱动细胞分化的转录因子 | Martini, P. | PDF | N/A | Identifying transcription factors driving cell differentiation | | PDP-Miner：一种人工智能/机器学习工具，用于在数千个细菌基因组中检测具有解聚酶结构域的噬菌体尾部蛋白 | Gauthier, J. | PDF | N/A | PDP-Miner: an AI/ML tool to detect prophage tail proteins with depolymerase domains across thousands of bacterial genomes | | 对留尼汪岛CHIKGene队列中慢性基孔肯雅热的转录组分析揭示了感染后10多年基因表达的变化 | Gerardin, P. | PDF | N/A | Transcriptomic analysis of chronic chikungunya in the Reunionese CHIKGene cohort uncovers a shift in gene expression more than 10 years after infection | | 利用深度学习驱动的优化和分子模拟挖掘内源性肽组中的肽结合物 | Hartman, E. | PDF | N/A | Mining the endogenous peptidome for peptide binders with deep learning-driven optimization and molecular simulations | | 大规模人群研究中的人类微生物组研究的全面质量控制流程 | Li, R. | PDF | N/A | A comprehensive quality control pipeline in human microbiome research for large population studies | | 整合多层工作流程用于翻译后修饰的定量分析 | Devesa, C. A. | PDF | N/A | Integrative multi-layer workflow for quantitative analysis of post-translational modifications | | SGLT2抑制剂的脱靶效应预测：一种揭示结构机制的综合生物信息学方法 | Yang, H.-J. | PDF | N/A | Off-target prediction of SGLT2 inhibitors: an integrative bioinformatics approach to uncover structural mechanisms | | 在中枢和周围神经系统肿瘤中，PLK1与EYA家族抑制剂之间存在强大的合成致死效应。 | Nelson, C. B. | PDF | N/A | Potent synthetic lethality between PLK1 and EYA-family inhibitors in tumours of the central and peripheral nervous system | | araCNA：利用长程序列模型进行体细胞拷贝数分析 | Visscher, E. | PDF | N/A | araCNA: Somatic copy number profiling using long-range sequence models | | 外骨膜素第17外显子跳跃增强了局部AAV-微肌营养不良蛋白给药在杜氏肌营养不良纤维化模型中的疗效 | Trundle, J. | PDF | N/A | Periostin exon 17 skipping enhances the efficacy of local AAV-microdystrophin administration in a fibrotic model of Duchenne muscular dystrophy | | 《骨间膜智能特性基础的弹性蛋白与胶原蛋白分布》

这段翻译为中文是：《骨间膜智能特性基础的弹性蛋白与胶原蛋白分布》。这个标题指的是一项研究或文章，探讨了在骨间膜（interosseous membrane）中弹性蛋白（elastin）和胶原蛋白（collagen）的分布情况，这些蛋白质的分布被认为是骨间膜具有某些“智能”或特殊功能特性的基础。 | Anastopolous, S. | PDF | N/A | The Distribution of Elastin and Collagen Underpinning the Smart Properties of the Interosseous Membrane | | 脂联素在热量限制期间对脂质、氨基酸和葡萄糖代谢产生性别依赖性的影响。 | Ikushima, Y. M. | PDF | N/A | Adiponectin exerts sex-dependent effects on lipid, amino acid, and glucose metabolism during caloric restriction | | Tobamovirus抗性基因Tm-1对番茄ToBRFV抗性控制的贡献 | Zinger, A. | PDF | N/A | Contribution of the Tobamovirus resistance gene Tm-1 to control of ToBRFV resistance in tomato | | 一个强大的平台，用于简化芳香族非天然氨基酸的生物合成和大肠杆菌中的遗传密码扩展。 | Zhang, J. | PDF | N/A | A robust platform streamlining aromatic noncanonical amino acid biosynthesis and genetic code expansion in E. coli | | 细胞图谱与表型的发育基础 | Lou, A. | PDF | N/A | Cell atlases and the Developmental Foundations of the Phenotype | | Mef2c通过调节对Ephrin排斥的敏感性来控制出生后胼胝体轴突的靶向 | Sudarsanam, S. | PDF | N/A | Mef2c Controls Postnatal Callosal Axon Targeting by Regulating Sensitivity to Ephrin Repulsion | | 感觉运动适应揭示了三维感知中的系统性偏差。 | Lim, C. | PDF | N/A | Sensorimotor adaptation reveals systematic biases in 3D perception. | | 大型动物癫痫模型平台：海马区颞叶癫痫的卡因酸猪模型 | Mivalt, F. | PDF | N/A | Large Animal Epilepsy Model Platform: Kainic Acid Porcine Model of Mesial Temporal Lobe Epilepsy | | CLASP1/2 调节自然杀伤细胞中免疫突触的成熟 | Pariani, A. P. | PDF | N/A | CLASP1/2 REGULATE IMMUNE SYNAPSE MATURATION IN NATURAL KILLER CELLS | | SLAMF6能够促进病毒特异性CD8+ T细胞高效附着、形成突触并杀死HIV-1感染的CD4+ T细胞。 | Monel, B. | PDF | N/A | SLAMF6 enables efficient attachment, synapse formation, and killing of HIV-1-infected CD4+ T cells by virus-specific CD8+ T cells | | 类风湿性关节炎免疫突触中的STAT3磷酸化 | Novak, H. | PDF | N/A | STAT3 phosphorylation in the rheumatoid arthritis immunological synapse | | SwiftMHC：一种用于MHC结合肽识别和3D建模的高速注意力网络 | Xue, L. C. | PDF | N/A | SwiftMHC: A High-Speed Attention Network for MHC-Bound Peptide Identification and 3D Modeling | | 坏死碎片的降解而非分解对于促进急性肝损伤后的恢复至关重要。 | Schuermans, S. | PDF | N/A | Degradation rather than disassembly of necrotic debris is essential to enhance recovery after acute liver injury | | 核苷酸切除修复内切酶XPF在动基体寄生虫布氏锥虫中的作用 | Gomez-Linan, C. | PDF | N/A | Role of the Nucleotide Excision Repair endonuclease XPF in the kinetoplastid parasite Trypanosoma brucei | | 硫代奎诺糖在小鼠和人类肠道微生物群中的降解方式不同，且不会被宿主代谢。 | Krasenbrink, J. | PDF | N/A | Sulfoquinovose is differently degraded by the mouse and human gut microbiota and not metabolized by the host | | I型分区相关蛋白通过转录激活和oriT区域结合增强接合转移 | Kishida, K. | PDF | N/A | Type I partition-related proteins enhance conjugative transfer through transcriptional activation and oriT region binding | | 细胞外聚合物降解塑造了微生物群落的多样性 | Pontrelli, S. | PDF | N/A | Extracellular polymeric substance degradation shapes microbial community diversity | | 西尼罗河病毒基因组中CpG和UpA二核苷酸增加对库蚊传播病毒及脊椎动物宿主发病机制的影响 | van Bree, J. | PDF | N/A | The effect of increased CpG and UpA dinucleotides in the West Nile virus genome on virus transmission by Culex mosquitoes and pathogenesis in a vertebrate host | | 在鲍曼不动杆菌中，针对抗菌肽TAT-RasGAP317-326的体外耐药性筛选可通过pmrAB基因的突变导致对多粘菌素的交叉耐药性。 | Ritz, E. | PDF | N/A | In vitro resistance selection in Acinetobacter baumannii against the antimicrobial peptide TAT-RasGAP317-326 can cause cross-resistance to polymyxins through mutations in pmrAB | | ca-circSCN8A通过LLPS引发的R-Loop促进HPASMCs的铁死亡 | Li, M. | PDF | N/A | ca-circSCN8A promotes HPASMCs ferroptosis via LLPS initiated R-Loop | | 全球范围内N端半胱氨酸依赖性降解机制的剖析 | Bekturova, A. | PDF | N/A | Global Profiling of N-terminal Cysteine-Dependent Degradation Mechanisms | | 灵长类特有的微小RNA-1202通过靶向APC2调控多巴胺能神经元的生成，并在中脑类器官中调节WNT/β-catenin信号通路。 | Long, X. | PDF | N/A | Primate-specific microRNA-1202 regulates dopaminergic neurogenesis by targeting APC2 and modulates WNT/β-catenin signaling pathway in midbrain organoid | | 以下是这段文字的中文翻译：

两种马达加斯加果蝠（杜氏果蝠 Eidolon dupreanum 和马达加斯加狐蝠 Rousettus madagascariensis）体外寄生虫负担的多样性和季节性研究。

翻译说明： 1. "Diversity and seasonality" 翻译为“多样性和季节性”。 2. "ectoparasite burden" 翻译为“体外寄生虫负担”，指寄生在宿主体表的寄生虫数量或影响。 3. "two species of Madagascar fruit bat" 翻译为“两种马达加斯加果蝠”，具体指后文提到的两种蝙蝠。 4. "Eidolon dupreanum" 和 "Rousettus madagascariensis" 分别是两种蝙蝠的学名，翻译时保留拉丁学名，同时补充中文名“杜氏果蝠”和“马达加斯加狐蝠”。

希望这个翻译对你有帮助！ | Andrianiaina, A. F. | PDF | N/A | Diversity and seasonality of ectoparasite burden on two species of Madagascar fruit bat, Eidolon dupreanum and Rousettus madagascariensis | | 稀有真菌类群的空间周转率较低，主要由草地土壤中的随机过程主导。 | Zhang, B. | PDF | N/A | Lower spatial turnover of rare fungal taxa dominantly shaped by stochastic processes in grassland soils | | 在绘制濒危地中海僧海豹分布图时，社交媒体和新闻媒体的作用：数据获取的显著提升与持续存在的偏见 | Castro, A. | PDF | N/A | Social and news media in mapping the endangered Mediterranean Monk seal: exceptional data gains but persistent bias | | 法罗群岛巨型小鼠的群体基因组学：杂交、殖民化以及对识别选择基因组目标的新挑战 | Payseur, B. A. | PDF | N/A | Population Genomics of Giant Mice from the Faroe Islands: Hybridization, Colonization, and a Novel Challenge to Identifying Genomic Targets of Selection | | 球茎大麦（Hordeum bulbosum；禾本科）的区域解析系统地理学 | Blattner, F. R. | PDF | N/A | An area-resolved phylogeography of bulbous barley (Hordeum bulbosum; Poaceae) | | 生物信息学分析揭示了Trefoil因子3参与哮喘发病机制的分子机制 | He, F. | PDF | N/A | Bioinformatic analysis reveals the molecular mechanisms of Trefoil factor 3 involved in asthma pathogenesis | | 在陨石衍生的培养物中发现单链DNA：新型遗传元素的证据。 | Lopez Ramon y Cajal, C. | PDF | N/A | Discovery of single-stranded DNA in meteorite-derived cultures: evidence of novel genetic elements. | | 计算设计的干细胞表位模拟物能够引发广泛反应的抗体。 | Wehrle, S. | PDF | N/A | Computationally designed stem-epitope mimetics elicit broadly reactive antibodies | | 这段文字翻译成中文是：一种无半胱氨酸且超快速的分裂内含肽，通过理性设计从易聚集转变为在蛋白质反式剪接中高效。 | Humberg, C. | PDF | N/A | A Cysteine-Less and Ultra-Fast Split Intein Rationally Engineered from Being Aggregation-Prone to Highly Efficient in Protein trans-Splicing | | 通过非经典氨基酸诱变技术研究α-突触核蛋白中所有与疾病相关的赖氨酸乙酰化位点 | Shimogawa, M. | PDF | N/A | Investigation of All Disease-Relevant Lysine Acetylation Sites in α-Synuclein Enabled by Non-canonical Amino Acid Mutagenesis | | BRCA1-BARD1复合物BRCT重复序列识别磷酸化RNAPII C端结构域的不同机制：来自结构和功能分析的见解 | Klapstova, V. | PDF | N/A | Distinct Mechanisms of Recognition of Phosphorylated RNAPII C-Terminal Domain by BRCT Repeats of the BRCA1-BARD1 Complex: Insights from Structural and Functional Analyses | | 虚弱代谢组学生物标志物：一项关于雌性和雄性小鼠衰老的纵向研究 | Zhu, D. | PDF | N/A | Metabolomics biomarkers of frailty: a longitudinal study of aging female and male mice | | 通过计算方法从Cochlospermum物种中分离的生物活性化合物发现新型HMG-CoA还原酶抑制剂 | Olatoye, T. I. | PDF | N/A | Discovery of Novel Inhibitors of HMG-CoA Reductase using Bioactive Compounds isolated from Cochlospermum Species through Computational Methods | | 基于差异表达统计证据的基因排序贝叶斯框架 | Hoerbst, F. | PDF | N/A | A Bayesian framework for ranking genes based on their statistical evidence for differential expression | | RNA-seq基因融合检测工具的荟萃分析：在基准测试中的性能和变异性 | Ostrowska, I. | PDF | N/A | Meta-analysis of RNA-seq gene fusion detection tools: performance and variability across benchmarks | | 以下是将这段英文翻译成中文的结果：

全光学策略以最小化可逆切换荧光蛋白的光漂白

翻译解释： - All-Optical Strategies：全光学策略，指的是完全基于光学手段的方法或技术。 - Minimize：最小化，意味着减少或降低到最低程度。 - Photo-Bleaching：光漂白，指的是在光照条件下，荧光分子失去其荧光特性的现象。 - Reversibly Switchable Fluorescent Proteins：可逆切换荧光蛋白，指的是能够通过某种刺激（如光、化学物质等）在荧光和非荧光状态之间可逆切换的荧光蛋白。

热响应性动态变化在珊瑚Acropora cervicornis的选择性剪接中 | Stankiewicz, K. H. | PDF | N/A | Heat-responsive dynamic shifts in alternative splicing of the coral Acropora cervicornis | | 肺免疫细胞群体中的单细胞转录组特征揭示结节病的标志 | Moore, C. | PDF | N/A | Single Cell Transcriptome Signatures of Sarcoidosis in Lung Immune Cell Populations | | 真菌感染和治疗期间，Galleria mellonella 幼虫转录起始位点的全基因组定位 | Abugessaisa, I. | PDF | N/A | Genome-wide mapping of the Galleria mellonella larvae transcription start sites during fungal infection and treatment | | 冷冻电镜与分子动力学模拟揭示未成熟登革热病毒样颗粒的结构特征 | Palur, V. R. | PDF | N/A | Structural Insights into Immature Dengue Virus-Like Particles Revealed by Cryo-EM and Molecular Dynamics Simulations | | 在高膨胀压力下的大肠杆菌细胞壁的非线性连续介质描述 | Albarran, O. | PDF | N/A | Nonlinear continuum description of the E. coli cell wall under high turgor pressure | | 亚基旋转如何控制核糖体中tRNA的动态 | Byju, S. | PDF | N/A | How subunit rotation controls tRNA dynamics in the ribosome | | 多种正黄病毒在蚊子唾液中分泌sfRNA，通过抑制MDA5介导的早期干扰素反应来促进传播。 | Serrato-Pomar, I. | PDF | N/A | Multiple orthoflaviviruses secrete sfRNA in mosquito saliva to promote transmission by inhibiting MDA5-mediated early interferon response | | 组蛋白甲基转移酶DOT1L维持CD8 T细胞的身份并限制其细胞毒性潜能 | Malik, M. | PDF | N/A | Histone methyltransferase DOT1L maintains identity and restricts cytotoxic potential of CD8 T cells | | RNA结合蛋白RSRC2通过与长链非编码RNA C1QTNF1-AS1相互作用，促进有丝分裂的准确性。 | Georgieva, K. | PDF | N/A | The RNA-binding protein RSRC2 promotes mitotic fidelity by interacting with the lncRNA C1QTNF1-AS1 | | 染色体乘客复合体识别核小体的枢轴-系链模型 | Ruza, R. R. | PDF | N/A | A pivot-tether model for nucleosome recognition by the chromosomal passenger complex | | 抑制由Cullin-3适配蛋白SHKBP1介导的SQSTM1/p62寡聚化和Keap1隔离 | Luan, L. | PDF | N/A | Inhibition of SQSTM1/p62 oligomerization and Keap1 sequestration by the Cullin-3 adaptor SHKBP1 | | 工具使用的大脑表征与执行动作的身体部位和运动经验无关 | Martinez-Addiego, F. | PDF | N/A | Tool-use brain representations are independent of the acting body part and motor experience | | 转座子入侵灵长类基因组塑造了人类炎症增强子及炎症疾病易感性 | Ye, M. | PDF | N/A | Transposon invasion of primate genomes shaped human inflammatory enhancers and susceptibility to inflammatory diseases | | 贝叶斯数据驱动的动粒动力学建模：人类中期板的时空组织 | Koki, C. | PDF | N/A | Bayesian data driven modelling of kinetochore dynamics: space-time organisation of the human metaphase plate |