BioRxiv 2025-01-23 Papers
| 标题 | 作者 | PDF链接 | 代码仓库 | Title |
|---|---|---|---|---|
| 一种基于反义寡核苷酸的策略，用于改善22q11.2缺失综合征中的认知功能障碍 | Thakur, P. | N/A | An antisense oligonucleotide-based strategy to ameliorate cognitive dysfunction in the 22q11.2 Deletion Syndrome | |
| 一种在中枢神经系统全细胞膜片钳记录中可靠测量微型自发突触后电位/电流的新方法 | Dervinis, M. | N/A | A novel method for reliably measuring miniature and spontaneous postsynaptic potentials/currents in whole-cell patch clamp recordings in the central nervous system | |
| 即使不是最优的，新奇感也能驱动人类的探索。 | Modirshanechi, A. | N/A | Even if suboptimal, novelty drives human exploration | |
| 以下是这段英文的中文翻译： |
在胚胎肌肉收缩开始时对肌腱成纤维细胞的转录组分析揭示了新的力响应基因
这个翻译保留了原文的科学性和准确性，同时使其更符合中文的表达习惯。 | Nayak, P. | PDF | N/A | Transcriptome profiling of tendon fibroblasts at the onset of embryonic muscle contraction reveals novel force-responsive genes | | Kiwa是一种嵌入细菌膜的防御超级复合体，它通过噬菌体诱导的膜变化而被激活。 | Zhang, Z. | PDF | N/A | Kiwa is a bacterial membrane-embedded defence supercomplex activated by phage-induced membrane changes | | Treacle形成类似液体的相凝聚物的能力对于核仁纤维中心的组装、高效的rRNA转录和加工以及rRNA基因修复至关重要。 | Velichko, A. K. | PDF | N/A | Treacle's ability to form liquid-like phase condensates is essential for nucleolar fibrillar center assembly, efficient rRNA transcription and processing, and rRNA gene repair | | 神经表征动态揭示了认知任务学习的计算原理 | Mill, R. D. | PDF | N/A | Neural representation dynamics reveal computational principles of cognitive task learning | | 猕猴内侧后顶叶皮层中时间顺序记忆的神经特征 | Zuo, S. | PDF | N/A | Neural signatures for temporal order memory in the macaque medial posterior parietal cortex | | 通过单细胞表达分析对肠嗜铬细胞进行分层 | Song, Y. | PDF | N/A | Stratification of enterochromaffin cells by single-cell expression analysis | | 利用基因表达中的波动来检测基因之间的因果关系 | Joly-Smith, E. | PDF | N/A | Exploiting fluctuations in gene expression to detect causal interactions between genes | | 依赖关系下的赢家诅咒：利用卷积密度修正经验贝叶斯 | Hawinkel, S. | PDF | N/A | The winner's curse under dependence: repairing empirical Bayes using convoluted densities | | 敲除细胞周期依赖性激酶8和19会导致细胞周期素C的耗竭，并抑制小鼠的精子发生和雄性生育能力。 | Bruter, A. V. | PDF | N/A | Knockout of cyclin dependent kinases 8 and 19 leads to depletion of cyclin C and suppresses spermatogenesis and male fertility in mice | | 空间频率表示预测了下颞叶皮层中的类别编码 | Toosi, R. | PDF | N/A | The Spatial Frequency Representation Predicts Category Coding in the Inferior Temporal Cortex | | 高氧诱导的骨髓来源的原代间充质基质细胞染色质结构改变 | Monroe, L. | PDF | N/A | Hyperoxia Induced Alteration of Chromatin Structure in Bone Marrow Derived Primary Mesenchymal Stromal Cells | | 辣椒素作为一种新型的NRF2激动剂，通过直接破坏KEAP1-NRF2相互作用，抑制乙醇诱导的胃黏膜氧化损伤。 | Gao, X. | PDF | N/A | Capsaicin acts as a novel NRF2 agonist to suppress ethanol induced gastric mucosa oxidative damage by directly disrupting the KEAP1-NRF2 interaction | | 大规模并行尖峰记录中超同步伪迹的检测与去除 | Oberste-Frielinghaus, J. | PDF | N/A | Detection and Removal of Hyper-synchronous Artifacts in Massively Parallel Spike Recordings | | 在贝叶斯推断过程中，随着信念精度的增加，神经变异性会压缩。 | Skowron, A. | PDF | N/A | Neural variability compresses with increasing belief precision during Bayesian inference | | 蜘蛛基因组对半水生和水生生活的适应性 | Fan, Z. | PDF | N/A | Genomic adaptations to semi-aquatic and aquatic life in spiders | | 跨物种和发育过程中海马体和新皮质之间由阿片介导的抑制性调节存在差异 | Caccavano, A. P. | PDF | N/A | Divergent opioid-mediated suppression of inhibition between hippocampus and neocortex across species and development | | 对比胚胎来源和出生后来源的脑内常驻巨噬细胞在维持睡眠-觉醒神经回路中的贡献 | Seifinejad, A. | PDF | N/A | Contrasting contribution of embryo- and postnatally-derived brain-resident macrophages in sustaining sleep-wake circuitry | | 细胞内乳酸动态揭示了果蝇谷氨酸能神经元的代谢多样性 | Price, M. S. | PDF | N/A | Intracellular Lactate Dynamics Reveal the Metabolic Diversity of Drosophila Glutamatergic Neurons | | 评估生化领域模型分布外表现的新框架 | Fernandez-Diaz, R. | PDF | N/A | A new framework for evaluating model out-of-distribution for the biochemical domain | | 在代谢组学中弥合极性：串联质谱之间的跨电离模式化学相似性预测 | de Jonge, N. F. | PDF | N/A | Bridging polarities in metabolomics: Cross-ionization mode chemical similarity prediction between tandem mass spectra | | 轴突膜刚度和破裂的分子动力学研究 | Majdolhosseini, M. | PDF | N/A | Molecular dynamics study of stiffness and rupture of axonal membranes | | 大规模基因组测序研究中的高效存储与回归计算 | Rivas, M. A. | PDF | N/A | Efficient storage and regression computation for population-scale genome sequencing studies | | 原肠胚预标记的后侧增强子通过与TGF-β信号通路的相互作用启动后侧组织发育 | Chen, Y. | PDF | N/A | Gastrula-premarked posterior enhancer primes posterior tissue development through cross-talk with TGF-β signaling pathway | | 沙眼衣原体的T3SS结构基因和效应基因在不同的表型细胞形式中表达。 | Grieshaber, N. | PDF | N/A | The T3SS structural and effector genes of Chlamydia trachomatis are expressed in distinct phenotypic cell forms. | | 一种来自细菌的非典型多胺拮抗动物线粒体功能 | Nauta, K. M. | PDF | N/A | A noncanonical polyamine from bacteria antagonizes animal mitochondrial function | | 高通量筛选近红外催产素纳米传感器，实现在小鼠和草原田鼠中的催产素成像 | Adams, J. | PDF | N/A | High-throughput evolution of near-infrared oxytocin nanosensors enables oxytocin imaging in mice and prairie voles | | Shiba：一种跨平台系统识别差异RNA剪接的多功能计算方法 | Kubota, N. | PDF | N/A | Shiba: A versatile computational method for systematic identification of differential RNA splicing across platforms | | ERH促进早期胚胎分化并在体细胞中的隐性多能性H3K9me3景观上覆盖H3K9me3异染色质 | Katznelson, A. | PDF | N/A | ERH Enables Early Embryonic Differentiation and Overlays H3K9me3 Heterochromatin on a Cryptic Pluripotency H3K9me3 Landscape in Somatic Cells | | 代谢组学分析及新型三维培养系统在软骨细胞机械转导研究中的应用与表征
这段翻译将英文标题“Metabolomic Profiling and Characterization of a Novel 3D Culture System for Studying Chondrocyte Mechanotransduction”转化为中文，同时保持了原文的专业性和准确性。翻译后的标题清晰地表达了研究的两个主要方面：一是代谢组学分析，二是新型三维培养系统的应用与表征，特别是在软骨细胞机械转导研究中的应用。 | Brahmachary, P. | PDF | N/A | Metabolomic Profiling and Characterization of a Novel 3D Culture System for Studying Chondrocyte Mechanotransduction | | 共生条件下兼性共生珊瑚中细胞类型特异性免疫调节 | Valadez-Ingersoll, M. | PDF | N/A | Cell type-specific immune regulation under symbiosis in a facultatively symbiotic coral | | GTSE1通过cyclin D1-CDK4/6的稳定化促进细胞增殖：与癌症预后的相关性 | Garcia-Vazquez, N. | PDF | N/A | Stabilization of GTSE1 by cyclin D1-CDK4/6 promotes cell proliferation: relevance in cancer prognosis | | 新型量子分析方法揭示了不同大小皮质锥体神经元之间平均兴奋性突触电量的保守性。 | Dervinis, M. | PDF | N/A | Novel quantal analysis method reveals conservation of average excitatory synaptic charge across cortical pyramidal neurons of different sizes | | 重编程细胞的分化成功在体内具有异质性，并受到体细胞身份记忆的调控 | Zikmund, T. | PDF | N/A | Differentiation Success of Reprogrammed Cells is Heterogenous In Vivo and Modulated by Somatic Cell Identity Memory | | 新颖的口头指令会招募具有时间可变信息维度的抽象神经模式 | Pena, P. | PDF | N/A | Novel verbal instructions recruit abstract neural patterns of time-variable information dimensionality | | 禽类特异性沙门氏菌向地方性流行转变的过程中，伴随着局部抗性组和移动组的相互作用。 | Jia, C. | PDF | N/A | Avian-specific Salmonella transition to endemicity is accompanied by localized resistome and mobilome interaction | | 对合作繁殖鸟类中影响出生扩散的决定因素进行路径分析 | Borger, M. J. | PDF | N/A | A path analysis disentangling determinants of natal dispersal in a cooperatively breeding bird | | 人类腹侧颞叶皮层的白质连接从出生起就由细胞结构、离心率和类别选择性组织起来。 | Kubota, E. | PDF | N/A | White matter connections of human ventral temporal cortex are organized by cytoarchitecture, eccentricity, and category-selectivity from birth | | 来自韩国杜霍组（中新世）的新金枪鱼标本（Auxis属） | Suh, D. | PDF | N/A | A new tuna specimen (Genus Auxis) from the Duho Formation (Miocene) of South Korea | | 聚焦超声增强模型治疗药物向脑海绵状血管瘤的输送和渗透 | Fisher, D. G. | PDF | N/A | Focused Ultrasound Augments the Delivery and Penetration of Model Therapeutics into Cerebral Cavernous Malformations | | 自组织的噬菌体与宿主菌群共存 | Yadav, A. | PDF | N/A | Self-organized coexistence of phage and a population of host colonies | | 胰岛初级纤毛中轴丝动力蛋白的超微结构扩展显微镜研究 | Dong, X. | PDF | N/A | Ultrastructure expansion microscopy of axonemal dynein in islet primary cilia | | 以下是这段英文的中文翻译：
"在Sideroxydans lithotrophicus ES-1中，通过MtoAB孔蛋白-多血红素细胞色素复合物进行的微生物磁铁矿氧化"
解释： - Microbial magnetite oxidation：微生物磁铁矿氧化，指的是微生物通过代谢过程氧化磁铁矿（Fe₃O₄）。 - MtoAB porin-multiheme cytochrome complex：MtoAB孔蛋白-多血红素细胞色素复合物，是一种蛋白质复合物，参与电子传递和氧化还原反应。 - Sideroxydans lithotrophicus ES-1：一种化能自养细菌，能够利用铁作为能量来源。
整句话描述了在Sideroxydans lithotrophicus ES-1这种细菌中，通过MtoAB孔蛋白-多血红素细胞色素复合物实现磁铁矿氧化的过程。 | Keffer, J. L. | PDF | N/A | Microbial magnetite oxidation via MtoAB porin-multiheme cytochrome complex in Sideroxydans lithotrophicus ES-1 | | 加速融合依赖的内体逃逸提高了递送酶货物的活性 | Vazquez Maldonado, A. L. | PDF | N/A | Hastened fusion-dependent endosomal escape improves activity of delivered enzyme cargo | | 后顶叶皮层调节前额叶皮层的神经时间尺度和刺激驱动的注意力调制 | Soyuhos, O. | PDF | N/A | Posterior parietal cortex regulates neural timescales and stimulus-driven attentional modulation in the prefrontal cortex | | 解析温度梯度下对杨树（Populus fremontii）叶片反射率的遗传性和可塑性影响 | Seeley, M. M. | PDF | N/A | Disentangling heritability and plasticity effects on Populus fremontii leaf reflectance across a temperature gradient | | 肝脏线粒体能量代谢降低会损害胃预负荷和禁食后的食物摄入调节 | Ponte, M. E. | PDF | N/A | Reduced Liver Mitochondrial Energy Metabolism Impairs Food Intake Regulation Following Gastric Preloads and Fasting | | 通过结合逆折叠和蛋白质语言模型进行线性规划播种的抗体库设计 | Hayes, C. F. | PDF | N/A | Antibody Library Design by Seeding Linear Programming with Inverse Folding and Protein Language Models | | 空间蛋白质组学通过并行累积-串行碎裂支持的MALDI MS/MS成像：首次窥见多重和空间肽段鉴定
这段文字描述了一种先进的蛋白质组学技术，即通过MALDI（基质辅助激光解吸/电离）质谱成像技术，结合并行累积和串行碎裂的方法，首次实现了对多重肽段的空间分布进行鉴定。这种技术能够提供蛋白质在生物样本中的空间分布信息，对于理解蛋白质的功能和相互作用具有重要意义。 | Li, M. J. | PDF | N/A | Spatial Proteomics By Parallel Accumulation-Serial Fragmentation Supported MALDI MS/MS Imaging: A First Glance Into Multiplexed and Spatial Peptide Identification | | SARS-CoV-2 BA.2.86变异株及其子代谱系刺突蛋白中对赖氨酸的偏好性增加，而非精氨酸 | Bozic, A. | PDF | N/A | Increased preference for lysine over arginine in spike proteins of SARS-CoV-2 BA.2.86 variant and its daughter lineages | | CTCF的耗竭在细胞分化过程中使增强子介导的基因激活与染色质中心的形成脱钩。 | Karpinska, M. A. | PDF | N/A | CTCF depletion decouples enhancer-mediated gene activation from chromatin hub formation during cellular differentiation | | 大脑特征图谱揭示了腹侧流中逐步发展的动物特征表征。 | Zhang, Z. | PDF | N/A | Brain Feature Maps Reveal Progressive Animal-Feature Representations in the Ventral Stream. | | 细胞竞争赋予播散性肿瘤细胞锚定可塑性 | Huh, H. D. | PDF | N/A | Cell competition confers anchorage plasticity of disseminated tumor cells | | 人类诱导多能干细胞（iPSCs）中12号染色体三体性激增的起源 | Narozna, M. | PDF | N/A | Origin of Chromosome 12 Trisomy Surge in Human Induced Pluripotent Stem Cells (iPSCs) | | 胆碱能波对视网膜神经节细胞的转录组有一定的影响。 | Somaiya, R. D. | PDF | N/A | Cholinergic waves have a modest influence on the transcriptome of retinal ganglion cells | | 去修饰工具：一种用于筛选古蛋白质组学中修饰引起的替代肽分类的工具 | Evans, M. | PDF | N/A | The Demodifier: a tool for screening modification-induced alternate peptide taxonomy in palaeoproteomics | | 与Heliconiini（一种蝴蝶）多次向群居幼虫行为转变相关的趋同分子进化 | Cicconardi, F. | PDF | N/A | Convergent molecular evolution associated with repeated transitions to gregarious larval behaviour in Heliconiini | | 三者的力量：动力蛋白激活蛋白（Dynactin）在负载下与三个动力蛋白（dynein）结合，以产生更大的力量 | Rao, L. | PDF | N/A | The Power of Three: Dynactin associates with three dyneins under load for greater force production | | 将这段文字翻译成中文如下：
原子层面的机器学习在糖生物学中的应用：蛋白质-聚糖相互作用及跨手性识别
这个标题描述了一个研究领域，主要利用原子层面的机器学习技术来研究糖生物学中的两个关键问题：蛋白质与聚糖之间的相互作用，以及跨手性识别机制。 | Carpenter, E. J. | PDF | N/A | Atom-level Machine Learning of Protein-glycan Interactions and Cross-chiral Recognition in Glycobiology | | 共享神经网络用于高度喜爱和不喜爱的音乐 | Ripolles, P. | PDF | N/A | A Shared Neural Network for Highly Liked and Disliked Music | | 自动检测体积在体成像数据中荧光标记的突触 | Chen, Z. | PDF | N/A | Automatic detection of fluorescently labeled synapses in volumetric in vivo imaging data | | STExplorer：探索空间组学数据的微观地理 | Zormpas, E. | PDF | N/A | STExplorer: Navigating the Micro-Geography of Spatial Omics Data | | 通过时钟基因之间的相位差异推断癌症中的昼夜节律紊乱 | Zhang, Z. | PDF | N/A | Inferring circadian rhythm disruptions in cancer using phase differences between clock genes | | 肿瘤免疫模拟是乳腺癌中的一种普遍现象，而上皮细胞中的CD69能够促进肿瘤的早期进展。 | Berens, E. B. | PDF | N/A | Neoplastic immune mimicry is a generalizable phenomenon in breast cancer and epithelial CD69 enables early tumor progression | | 免疫细胞线粒体表型在大多数线粒体疾病中基本保持不变，且不反映疾病的严重程度。 | Liu, C. C. | PDF | N/A | Immune cell mitochondrial phenotypes are largely preserved in mitochondrial diseases and do not reflect disease severity | | 选择由不同细胞外基质分子驱动的白血病前期造血干细胞 | Jassinskaja, M. | PDF | N/A | Selection of pre-leukemic hematopoietic stem cells driven by distinct extracellular matrix molecules | | araCNA：利用长距离序列模型进行体细胞拷贝数分析 | Visscher, E. | PDF | N/A | araCNA: Somatic copy number profiling using long-range sequence models | | 上皮生长因子样-7（EGFL7）对造血干细胞（HSC）增殖的调控 | Kulkarni, R. | PDF | N/A | Regulation of hematopoietic stem cell (HSC) proliferation by Epithelial Growth Factor Like-7 (EGFL7) | | 以下是这段英文的中文翻译：
退出多能性过程中增强子-启动子相互作用的纳米尺度动态
翻译说明： - Nanoscale Dynamics 翻译为“纳米尺度动态”，指的是在纳米级别上的动态变化或行为。 - Enhancer-Promoter Interactions 翻译为“增强子-启动子相互作用”，指的是基因调控中增强子与启动子之间的相互作用。 - during Exit from Pluripotency 翻译为“退出多能性过程中”，指的是细胞从多能性状态（如干细胞）向分化状态转变的过程。
希望这个翻译对你有帮助！ | Stumberger, G. | PDF | N/A | Nanoscale Dynamics of Enhancer-Promoter Interactions during Exit from Pluripotency | | 非洲爪蟾胚胎上皮细胞中的超细胞收缩性受细胞外核苷酸和嘌呤能G蛋白偶联受体P2Y2的调控。 | Joshi, S. D. | PDF | N/A | Supracellular contractility in Xenopus laevis embryonic epithelia regulated by extracellular nucleotides and the purinergic G-protein coupled receptor P2Y2. | | 非洲爪蟾胚胎上皮中的超细胞收缩性受细胞外核苷酸和嘌呤能G蛋白偶联受体P2Y2的调控。 | Joshi, S. D. | PDF | N/A | Supracellular contractility in Xenopus laevis embryonic epithelia regulated by extracellular nucleotides and the purinergic G-protein coupled receptor P2Y2. | | CD271分选用于改进肝细胞分离：从小鼠和人类肝脏中半自动同时制备实质细胞和非实质细胞 | Dropmann, A. | PDF | N/A | CD271 sorting for improved liver cell isolation: Semiautomated and simultaneous preparation of parenchymal and non-parenchymal cells from mouse and human livers | | 共生体特异性摄取是由刺胞动物幼虫中的整合素介导的。 | Jones, V. A. S. | PDF | N/A | Symbiont-specific uptake is mediated by integrins in cnidarian larvae | | GEI-17介导的GDI-1的SUMO化调控凋亡细胞的清除 | Xiao, H. | PDF | N/A | GEI-17-Mediated SUMOylation of GDI-1 Regulates Apoptotic Cell Clearance | | 高血糖通过PI3Kγ依赖的自噬缺陷加剧平滑肌泡沫细胞的形成 | Labrana, H. | PDF | N/A | Hyperglycemia worsens smooth muscle foam cell formation through PI3Kgamma-dependent defective autophagy | | iPSC衍生的肝细胞准确再现了α-1-抗胰蛋白酶缺乏症中的群体多样性，并提供了一个用于大规模药物疗效筛选研究的新型体外模型。 | Gil, C. | PDF | N/A | iPSC-derived hepatocytes accurately recapitulate population diversity in alpha-1-antitrypsin deficiency and offer a novel in vitro model for large-scale drug efficacy screening studies. | | 脂质饱和度的变化触发线粒体外膜的重塑 | Wong, S. | PDF | N/A | Alterations in Lipid Saturation Trigger Remodeling of the Outer Mitochondrial Membrane | | ND-13，一种源自DJ-1的肽，作为预防糖尿病肾病中NLRP3炎症小体活性的新型药理学方法。 | Caballero Herrero, M. J. | PDF | N/A | ND-13, a DJ-1 derived peptide, as a novel pharmacological approach in the prevention of NLRP3 inflammasome activity in Diabetic Nephropathy | | “多才多艺且精通多数：Carpobrotus类群在繁殖策略上未表现出权衡取舍。” | Canavan, S. | PDF | N/A | Jack of all trades and master of most: Carpobrotus taxa show no trade-off in reproductive strategies | | 挥发性抑制肽信号增强了植物间相互作用中的挥发性反应。 | Wang, L. | PDF | N/A | Volatile-suppressed peptide signaling enhances volatile responses in plant-plant interactions | | 在快速进展者中，两种CCR5嗜性HIV-1病毒对不同的记忆CD4亚群具有嗜性。 | Marichannegowda, M. | PDF | N/A | Distinct memory CD4 subset tropism of two CCR5-tropic HIV-1 in a rapid progressor | | 以下是这段英文的中文翻译：
"整个妊娠期间细胞滋养层细胞群体动态特征"
解释： - "Characterization" 意为“特征描述”或“特性分析”。 - "cytotrophoblast" 是“细胞滋养层”，指胎盘中的一种细胞类型。 - "cell population dynamics" 意为“细胞群体动态”或“细胞群体变化”。 - "throughout pregnancy" 指“整个妊娠期间”。
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线虫卵子激活所需的精卵蛋白伙伴关系
翻译说明： - "sperm-oocyte" 翻译为 "精卵"，指的是精子和卵子。 - "protein partnership" 翻译为 "蛋白伙伴关系"，指的是蛋白质之间的相互作用或合作。 - "egg activation" 翻译为 "卵子激活"，指的是卵子在受精后启动发育的过程。 - "Caenorhabditis elegans" 是模式生物秀丽隐杆线虫的学名，通常直接保留英文名称或简称为 "线虫"。
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