BioRxiv 2025-01-26 Papers

标题	作者	PDF链接	代码仓库	Title
钠耦合二羧酸转运蛋白中的电梯机制动力学	Kinz-Thompson, C. D.	PDF	N/A	Elevator mechanism dynamics in a sodium-coupled dicarboxylate transporter
新生树突分支由局部爆发的Spire依赖性肌动蛋白聚合启动。	Hatton, D.	PDF	N/A	Nascent dendrite branches initiated by a localized burst of Spire-dependent actin polymerization.
直接检测活性生物聚合物网络中不同长度尺度上的变形模式	Stam, S.	PDF	N/A	Direct detection of deformation modes on varying length scales in active biopolymer networks
细胞自主性极化通过平面细胞极性信号通路实现	Weiner, A. T.	PDF	N/A	Cell autonomous polarization by the planar cell polarity signaling pathway
非肌肉肌球蛋白II调控果蝇突触前肌动蛋白组装及神经元机械生物学	Ermanoska, B.	PDF	N/A	Non-muscle myosin II regulates presynaptic actin assemblies and neuronal mechanobiology in Drosophila
在S期进入时，通过蛋白酶体依赖的方式从染色质中移除Orc6，以防止MCM重新加载和四倍体的发生。	Hayashi-Takanaka, Y.	PDF	N/A	Proteasome-dependent Orc6 removal from chromatin upon S-phase entry safeguards against MCM reloading and tetraploidy
这位兄弟绝缘体具有不同的绝缘和远程配对特性的子元素。	Fujioka, M.	PDF	N/A	The homie insulator has sub-elements with different insulating and long-range pairing properties
以下是将“A theory of brain-computer interface learning via low-dimensional control”翻译成中文的结果：

“通过低维控制实现脑机接口学习的理论”

人体Glp1r A316T变体的体内功能分析和结构表征

翻译解释： - "In vivo" 指的是在活体内进行的实验或研究。 - "functional profiling" 指的是对功能的分析或描述。 - "structural characterisation" 指的是对结构的表征或描述。 - "human Glp1r A316T variant" 指的是人体中Glp1r基因的A316T变体。

希望这个翻译对你有帮助！ | El Eid, L. | PDF | N/A | In vivo functional profiling and structural characterisation of the human Glp1r A316T variant | | 高通量突触分析揭示了果蝇大脑中细胞类型特定的空间配置 | Wu, H. | PDF | N/A | High-throughput synapse profiling reveals cell-type-specific spatial configurations in the fly brain | | 章鱼胺信号协调单个果蝇蘑菇体神经元内突触前机制的空间模式。 | Wu, H. | PDF | N/A | Octopamine signals coordinate the spatial pattern of presynaptic machineries within individual Drosophila mushroom body neurons | | MDL-001：一种口服、安全且耐受性良好的广谱病毒聚合酶抑制剂 | Woods, V. | PDF | N/A | MDL-001: An Oral, Safe, and Well-Tolerated Broad-Spectrum Inhibitor of Viral Polymerases | | 定制女性卫生洗液，含有来自乳酸菌属的后生元，用于治疗尿路感染（UTI）。 | Nair, V. G. | PDF | N/A | Customized feminine hygiene wash containing postbiotics from Lactobacillus spp. to treat Urinary Tract Infections (UTI) | | 调和时间与预测误差理论在联想学习中的关系 | Hamou, N. | PDF | N/A | Reconciling time and prediction error theories of associative learning | | TIME-CoExpress：利用单细胞转录组学数据对动态基因共表达模式进行时间轨迹建模 | Yang, S. | PDF | N/A | TIME-CoExpress: Temporal Trajectory Modeling of Dynamic Gene Co-expression Patterns Using Single-Cell Transcriptomics Data | | 端到端学习用于皮质神经假体视觉的安全刺激参数 | Kücükoglu, B. | PDF | N/A | End-to-end Learning of Safe Stimulation Parameters for Cortical Neuroprosthetic Vision | | 低频超声波介导的血脑屏障开放使得脂质纳米颗粒RNA能够无创地递送至胶质母细胞瘤。 | Elbaz, M. | PDF | N/A | Low-frequency ultrasound-mediated blood-brain barrier opening enables non-invasive lipid nanoparticle RNA delivery to glioblastoma | | 在不平衡研究中，针对多个协方差估计量的基因集富集线性组合检验的稳定性与性能 | Khademioureh, S. | PDF | N/A | Stability and Performance of Linear Combination Tests of Gene Set Enrichment for Multiple Covariance Estimators in Unbalanced Studies | | PBCV-1中衣壳蛋白变体的局部微环境 | Guo, W. | PDF | N/A | Local Microenvironments of capsomer variants in the PBCV-1 | | 靶向磷脂酰丝氨酸（PS）的嵌合干扰素（IFN）融合蛋白在抗肿瘤应用中的作用 | Gadiyar, V. | PDF | N/A | Phosphatidylserine (PS)-targeting chimeric Interferon (IFN) fusion proteins for anti-tumor applications | | 在三维球体培养过程中，随时间变化的染色质成熟提高了非小细胞肺癌的临床前建模效果。 | Darracq, A. | PDF | N/A | Time-dependent chromatin maturation during 3D spheroid culture improves preclinical modeling of non-small cell lung cancer | | γδ T细胞是儿童神经母细胞瘤中主要的抗肿瘤T细胞。 | Castenmiller, S. M. | PDF | N/A | γδ T cells are the prime anti-tumoral T cells in pediatric neuroblastoma | | 在不同条件和季节下无家可归者的睡眠情况 | Rice, A. | PDF | N/A | Sleep in People Experiencing Homelessness Under Different Conditions and Seasons | | 比较蛋白质组学揭示了番茄在有益和病原微生物相互作用中的不同生物标志物、蛋白质网络和防御反应 | Singh, D. P. | PDF | N/A | Comparative proteomics uncovers distinct biomarkers, protein networks and defense responses in tomato during beneficial and pathogenic microbial interactions | | BubR1和Mad2调控果蝇滞育期成虫中肠的重塑 | Adachi, Y. | PDF | N/A | BubR1 and Mad2 regulate adult midgut remodeling in Drosophila diapause | | DNA折纸技术引导的胶体纳米光子材料与硅光子学的集成 | Luo, X. | PDF | N/A | DNA origami directed integration of colloidal nanophotonic materials with silicon photonics | | E2F1通过细胞和病毒转录网络抑制EBV裂解再激活 | Biswas, J. | PDF | N/A | E2F1 Suppresses EBV Lytic Reactivation through Cellular and Viral Transcriptional Networks | | 以下是这段文字的中文翻译：

临床和遗传因素对多形性胶质母细胞瘤生存期的影响：一项回顾性分析

翻译说明： 1. "Clinical and Genetic Determinants" 翻译为“临床和遗传因素”。 2. "Glioblastoma Multiforme" 是多形性胶质母细胞瘤的英文名称，直接保留专业术语。 3. "Survival" 翻译为“生存期”。 4. "Retrospective Analysis" 翻译为“回顾性分析”。

这段翻译将英文标题“Unmasking Epstein-Barr Role in Gastric Carcinogenesis: A Gene Expression Approach to Virus-Positive Tumors”转化为中文，同时保持了原文的专业性和准确性。翻译中，“Unmasking”译为“揭示”，表达了研究的探索性质；“Epstein-Barr”即“爱泼斯坦-巴尔病毒”，是医学领域的专有名词；“Gastric Carcinogenesis”译为“胃癌发生”，直接对应了医学领域的术语；“A Gene Expression Approach”译为“基于基因表达的研究方法”，明确了研究的核心手段；“Virus-Positive Tumors”则译为“病毒阳性肿瘤”，直接对应了医学领域的术语。整体翻译流畅，符合中文表达习惯，同时保持了原文的专业性和准确性。 | Santos da Silva, V. C. | PDF | N/A | Unmasking Epstein-Barr Role in Gastric Carcinogenesis: A Gene Expression Approach to Virus-Positive Tumors | | TGR5介导的胆管细胞中的Ca2+信号传导 | Chen, X. | PDF | N/A | TGR5-mediated Ca2+ signaling in cholangiocytes | | 当黄素二铁蛋白（Flavodiiron protein）在被子植物烟草（Nicotiana tabacum）中表达时，其活性会胜过循环电子传递。 | Rizzetto, N. | PDF | N/A | Flavodiiron protein activity outcompetes cyclic electron transport when expressed in angiosperm Nicotiana tabacum | | 生物医学知识图谱嵌入中链接预测的数据泄露基准测试 | BRIERE, G. | PDF | N/A | Benchmarking Data Leakage on Link Prediction in Biomedical Knowledge Graph Embeddings | | 表皮抗肿瘤祖细胞需要通过SOX2驱动的发育重编程来驱动肿瘤发生。 | Centeno, P. P. | PDF | N/A | Epidermal tumour-resistant progenitors require SOX2-driven developmental reprogramming to drive tumorigenesis | | ASK1过表达通过FGF21保护免受高脂饮食诱导的体重增加 | Goergen, A. | PDF | N/A | ASK1 overexpression protects from HFD-induced body weight gain via FGF21 | | 单细胞和空间转录组学揭示了一种自然模型中慢性肉芽肿病的发病机制 | Yu, H. | PDF | N/A | Single-cell and spatial transcriptomics reveal the pathogenesis of chronic granulomatous disease in a natural model | | 热带森林演替过程中的分层现象通过功能独特的树冠层增强了传粉者的多样性。 | Diniz, U. M. | PDF | N/A | Stratification along tropical forest succession enhances pollinator diversity via functionally unique canopies | | 入侵者的营养位置及其直接和间接关系对本地食物网的影响 | Moreh, A. | PDF | N/A | Invaders' trophic position and their direct and indirect relationship influence on resident food webs | | 来自大群体样本的系谱中突变数量的中心极限定理 | Fu, Y.-X. | PDF | N/A | The central limit theorem for the number of mutations in the genealogy of a sample from a large population | | 全面突变表征钙感应蛋白STIM1的EF手结构揭示了对其结构和功能至关重要的残基 | Kamath, N. D. | PDF | N/A | Comprehensive mutational characterization of the calcium-sensing STIM1 EF-hand reveals residues essential for structure and function | | 鸣禽的种系限制染色体与常规染色体相比具有不同的着丝粒。 | Ridl, J. | PDF | N/A | Germline-restricted chromosome of songbirds has different centromere compared to regular chromosomes | | 非洲裔美国人肝细胞中的MeQTL定位揭示了DNA甲基化和基因表达的共享遗传调控因子 | Carver, K. M. | PDF | N/A | MeQTL Mapping in African American Hepatocytes Reveals Shared Genetic Regulators of DNA Methylation and Gene Expression | | 生物工程可见聚合物网片用于增强泌尿妇科健康 | Houshyar, S. | PDF | N/A | Bioengineered visible polymeric mesh to enhance urogynaecological health | | BioMaster：用于自动化生物信息学分析工作流程的多代理系统 | Su, H. | PDF | N/A | BioMaster: Multi-agent System for Automated Bioinformatics Analysis Workflow | | 人类基因组书：单词、句子和段落 | Wang, L. | PDF | N/A | Human Genome Book:Words,Sentences and Paragraphs | | 揭示巴西登革热血清型3的传播：3III_B.3.2谱系多次引入的证据 | Pereira, J. S. | PDF | N/A | Unraveling Dengue Serotype 3 Transmission in Brazil: Evidence for Multiple Introductions of the 3III_B.3.2 Lineage | | 集成对接用于内在无序蛋白质 | Dhar, A. | PDF | N/A | Ensemble docking for intrinsically disordered proteins | | 高剂量DFMO改变神经母细胞瘤中的蛋白质翻译 | Franson, A. T. | PDF | N/A | High-dose DFMO alters protein translation in neuroblastoma | | 烟草细胞质膜中PIN-FORMED生长素外排载体的纳米域分布和功能由其与细胞壁的相互作用所决定。 | Stelate, A. | PDF | N/A | Nanodomain distribution and function of PIN-FORMED auxin efflux carriers in the plasma membrane of tobacco cells are defined by their interactions with the cell wall | | 季节性变化及利用无人机热成像正射影像图估算韩国有蹄类动物种群和识别物种的挑战 | Kim, J. | PDF | N/A | Seasonal Variations and Challenges in Estimating Populations and Identifying Species of Korean Ungulates Using Drone-Derived Thermal Orthomosaic Maps | | 肠道分段丝状菌通过重编程肺泡巨噬细胞保护小鼠免受流感感染后的致命性细菌性肺炎。 | Ngo, V. L. | PDF | N/A | Reprogramming of alveolar macrophages by intestinal segmented filamentous bacteria protects mice from lethal bacterial pneumoniae following influenza infection | | 无需抽血的多生物标志物采样与检测可穿戴光子设备 | Lin, Z.-T. | PDF | N/A | Wearable Photonic Device for Multiple Biomarker Sampling and Detection Without Blood Draws | | 特征驱动的全组织成像，具备亚细胞分辨率 | Lin, J. | PDF | N/A | Feature-Driven Whole-Tissue Imaging with Subcellular Resolution | | 使用微内窥镜上的传感器进行多重光学记录，实现多种神经调节信号的同时实时追踪。 | Kalugin, P. N. | PDF | N/A | Simultaneous, real-time tracking of many neuromodulatory signals with Multiplexed Optical Recording of Sensors on a micro-Endoscope | | 纹状体细胞类型特异性的稳定性和重组是代理和习惯的基础 | Malvaez, M. | PDF | N/A | Striatal cell-type specific stability and reorganization underlying agency and habit | | 联合中枢与外周神经刺激改善大鼠前肢模型中混合性外周神经损伤的功能恢复 | Eftekari, S. C. | PDF | N/A | Combined Central and Peripheral Nerve Stimulation Improves Functional Recovery of Mixed Peripheral Nerve Injury in a Rat Forelimb Model | | 通过冷大气等离子体增强免疫细胞激活：通过分子动力学破坏PD-1/PD-L1/PD-L2免疫检查点 | Rasulbek, M. | PDF | N/A | Enhancing Immune Cell Activation through Cold Atmospheric Plasma: Disruption of PD-1/PD-L1/PD-L2 Immune Checkpoints via Molecular Dynamics | | 通过番茄MAGIC群体鉴定热胁迫条件下生殖成功的QTL | Lin, Y.-P. | PDF | N/A | Identification of QTL for reproductive success under heat stress conditions through a tomato MAGIC population | | Soffritto：一种用于预测高分辨率复制时序的深度学习模型 | Bolzan, D. | PDF | N/A | Soffritto: a deep-learning model for predicting high-resolution replication timing | | ARTEMIS 结合了自编码器和薛定谔桥技术，用于从时间序列单细胞数据中预测基因表达、细胞群体和扰动的连续动态变化。 | Alatkar, S. A. | PDF | N/A | ARTEMIS integrates autoencoders and schrodinger bridges to predict continuous dynamics of gene expression, cell population and perturbation from time-series single-cell data | | Realfreq：用于纳米孔测序的实时碱基修饰分析 | Samarasinghe, S. | PDF | N/A | Realfreq: Real-time base modification analysis for nanopore sequencing | | 工程化的CRO-CD7 CAR-NK细胞源自多能干细胞，能够避免自相残杀，并有效抑制人类T细胞恶性肿瘤。 | Lin, Y. | PDF | N/A | Engineered CRO-CD7 CAR-NK cells derived from pluripotent stem cells avoid fratricide and efficiently suppress human T-cell malignancies | | 无序神经网络中的对称性与连续吸引子 | Clark, D. G. | PDF | N/A | Symmetries and continuous attractors in disordered neural circuits | | 在大鼠出生后第24天期间，皮层下产生的运动在睡眠和清醒状态下都会激活运动皮层。 | Reid, M. R. | PDF | N/A | Subcortically generated movements activate motor cortex during sleep and wake in rats through postnatal day 24 | | 溶血葡萄球菌是早产儿肠道中抗生素耐药基因的储存库。 | Lamberte, L. E. | PDF | N/A | Staphylococcus haemolyticus is a reservoir of antibiotic resistance genes in the preterm infant gut | | 通过细胞外囊泡或脂质纳米颗粒将mRNA靶向递送至心脏 | Nawaz, M. | PDF | N/A | Targeted delivery of mRNA to the heart via extracellular vesicles or lipid nanoparticles | | 双价适配体组装体针对B细胞标记物CD19和CD20的生化功能 | Cen, Y. N. | PDF | N/A | The biochemical function of bivalent aptamer assemblies against B-cell markers CD19 and CD20 | | 批量资源血管生成工具（BRAT），用于实现微血管网络的高内涵显微镜筛选。 | Krek, H. | PDF | N/A | The Batch-Resourcing Angiogenesis Tool (BRAT) to enable high-content microscopy screening of microvascular networks. | | 通过移植CFTR基因校正的气道干细胞，实现鼻窦上皮的持久重建。 | Bravo, D. T. | PDF | N/A | Durable reconstitution of sinonasal epithelium by transplant of CFTR gene corrected airway stem cells | | RegFormer：一个由基因调控层次驱动的单细胞基础模型 | Hu, L. | PDF | N/A | RegFormer: A Single-Cell Foundation Model Powered by Gene Regulatory Hierarchies | | RNAbpFlow: 基于碱基对增强的SE(3)-流匹配用于条件性RNA三维结构生成 | Tarafder, S. | PDF | N/A | RNAbpFlow: Base pair-augmented SE(3)-flow matching for conditional RNA 3D structure generation | | 以下是这段英文的中文翻译：

"SLC6转运蛋白家族中临床致病性的突变热点"

翻译解释： - "Mutation hot spots" 翻译为 "突变热点"，指的是在基因序列中容易发生突变的区域。 - "clinical pathogenicity" 翻译为 "临床致病性"，指的是突变对疾病发生和发展的影响。 - "across the SLC6 transporter family" 翻译为 "在SLC6转运蛋白家族中"，指的是研究范围涵盖整个SLC6转运蛋白家族。