BioRxiv 2025-01-29 Papers
| 标题 | 作者 | PDF链接 | 代码仓库 | Title |
|---|---|---|---|---|
| 用于单细胞ATAC-seq数据分析的共识峰定义的通用参考 | Meng, Q. | N/A | A generic reference defined by consensus peaks for scATAC-seq data analysis | |
| 强大的遗传分化但有限的生态位分割：由异时性生殖隔离形成的同域物种对 | Irvine, M. | N/A | Strong genetic differentiation but limited niche partitioning in a sympatric species pair separated by an allochronic reproductive barrier | |
| 在解剖追踪数据中自监督分割和表征纤维束 | Sundaresan, V. | N/A | Self-supervised segmentation and characterization of fiber bundles in anatomic tracing data | |
| 通过BRCA2减数分裂结构域缺失揭示的紧张DNA系链模型下的染色体配对 | Koornneef, L. | N/A | Chromosome Pairing Through Tensed DNA Tethers Model Revealed by BRCA2 Meiotic Domain Deletion | |
| 跨模态泛化的皮层回路 | Guyoton, M. | N/A | Cortical circuits for cross-modal generalization | |
| 锌缺乏期间受损的KAT7依赖性组蛋白H3K14乙酰化的病理生理学意义 | Fujisawa, T. | N/A | Pathophysiological Significance of Impaired KAT7-Dependent Histone H3K14 Acetylation During Zinc Deficiency | |
| Bioinfo-Bench：一个用于评估LLM生物信息学技能的简单基准测试框架 | Chen, Q. | N/A | Bioinfo-Bench: A Simple Benchmark Framework for LLM Bioinformatics Skills Evaluation | |
| 视觉皮层中的曲率形成：我们如何进行采样？ | Nisar, I. | N/A | Curvature formation in the visual cortex: How do we sample? | |
| 使用快速共分化平台从人类诱导多能干细胞生成可移植且具有生物反应性的结肠组织。 | Dalleywater, W. | N/A | Generation of transplantable and biologically responsive colonic tissue from human induced pluripotent stem cells using a rapid co-differentiation platform. | |
| 来自成年雌性大鼠的嗅鞘细胞是一种混合型胶质细胞，能够促进神经修复。 | Phelps, P. E. | N/A | Olfactory ensheathing cells from adult female rats are hybrid glia that promote neural repair | |
| 干扰物在视觉工作记忆中引发空间特定的神经偏向 | Raya, D. V. | N/A | Distractors induce space-specific neural biases in visual working memory | |
| 细胞器组学：AI驱动的深度细胞器表型分析揭示人类神经元中新的ALS机制 | Krispin, S. | N/A | Organellomics: AI-driven deep organellar phenotyping reveals novel ALS mechanisms in human neurons | |
| 视叶神经元中终端选择子组合的建立 | Simon, F. | N/A | Establishment of terminal selector combinations in optic lobe neurons | |
| 皮质群体编码的关键在于细胞生理学的精细调节。 | Revah, O. | N/A | Cortical population coding critically depends on fine-tuning of cell physiology | |
| 多重、多模态的分泌蛋白质变异效应映射 | Popp, N. A. | N/A | Multiplex, multimodal mapping of variant effects in secreted proteins | |
| 将功能连接性锚定到个体沟回形态的研究，在儿童推理能力的研究中提供了新的见解。 | Hakkinen, S. | N/A | Anchoring functional connectivity to individual sulcal morphology yields insights in a pediatric study of reasoning | |
| 疟原虫（Plasmodium falciparum）的SUN结构域蛋白对于正常的核分裂和DNA修复至关重要。 | Kandelis-Shalev, S. | N/A | SUN-domain proteins of the malaria parasite Plasmodium falciparum are essential for proper nuclear division and DNA repair | |
| 沙眼衣原体的T3SS结构和效应基因在不同的表型细胞形式中表达。 | Grieshaber, N. | N/A | The T3SS structural and effector genes of Chlamydia trachomatis are expressed in distinct phenotypic cell forms. | |
| 同步思维促进学习：师生互动预示学期内学业进步 | Xu, X. | N/A | Syncing Minds for Learning: Student-Teacher Interaction Forecasts Academic Improvements Over Semesters | |
| 帕金森病中的抑郁与多巴胺无反应性相关，表现为在基于努力的决策过程中奖励敏感性降低。 | Costello, H. | N/A | Depression in Parkinson's disease is associated with dopamine unresponsive reduced reward sensitivity during effort-based decision making | |
| 巨噬细胞上的磷脂酰丝氨酸结合受体CD300f介导宿主对致病性和非致病性立克次体的入侵。 | Voss, O. H. | N/A | Phosphatidylserine-binding receptor, CD300f, on macrophages mediates host invasion of pathogenic and non-pathogenic rickettsiae. | |
| AARS2通过微调PKM2介导的代谢改善心肌缺血 | Zhang, Z. | N/A | AARS2 ameliorates myocardial ischemia via fine-tuning PKM2-mediated metabolism | |
| 6-OHDA帕金森病小鼠模型表现出感觉行为缺陷 | Linen, S. R. | N/A | The 6-OHDA Parkinson's Disease Mouse Model Shows Deficits in Sensory Behavior | |
| 早期生命阶段鲑鱼暴露于6PPD-醌的外源代谢组 | Ankley, P. J. | N/A | Xenometabolome of Early-Life Stage Salmonids Exposed to 6PPD-Quinone | |
| 从具身化虚拟角色的视角出发调节了替代性疼痛和愉悦的时间动态：一项结合沉浸式虚拟现实和脑电图的研究 | Nicolardi, V. | N/A | Taking the perspective of an embodied avatar modulates the temporal dynamics of vicarious pain and pleasure: a combined Immersive Virtual Reality and EEG study | |
| 染色体X剂量调节遗传多样性小鼠胚胎干细胞中非整倍体的发展 | Stanton, A. | N/A | Chromosome X Dosage Modulates Development of Aneuploidy in Genetically Diverse Mouse Embryonic Stem Cells | |
| 左半球卒中患者自然动作表现的认知神经心理学和神经解剖学预测因素：一项回顾性分析 | Thibault, S. | N/A | Cognitive neuropsychological and neuroanatomic predictors of naturalistic action performance in left hemisphere stroke: a retrospective analysis | |
| HIV共受体相关基因（CCR5和CXCR4）启动子甲基化：原创研究 | Esman, A. | N/A | HIV Coreceptors Related Genes (CCR5 and CXCR4) Promoter Methylation: Original Research | |
| SAMA：一款具有正确性保证的序列组装工具 | Salmela, L. | N/A | SAMA: a contig assembler with correctness guarantee | |
| 使用lr-kallisto进行长读长测序转录组定量 | Loving, R. K. | N/A | Long-read sequencing transcriptome quantification with lr-kallisto | |
| 解析人类MLH1蛋白稳定性及其相互作用的突变效应 | Larsen-Ledet, S. | N/A | Disentangling the mutational effects on protein stability and interaction of human MLH1 | |
| 评估Pseudovibrio海洋细菌中基因表达载体的效果 | Dai, Y. | N/A | Evaluation of vectors for gene expression in Pseudovibrio marine bacteria | |
| 时间创造空间：在编码时间连续感觉经验的网络中，位置场的出现 | Wang, Z. | N/A | Time Makes Space: Emergence of Place Fields in Networks Encoding Temporally Continuous Sensory Experiences | |
| 未能解决炎症问题会导致杜氏肌营养不良症小鼠模型中出现幼年期心脏损伤 | Novak, J. S. | N/A | Failure to resolve inflammation contributes to juvenile onset cardiac damage in a mouse model of Duchenne Muscular Dystrophy | |
| SP140-RESIST通路调控干扰素mRNA的稳定性及抗病毒免疫反应 | Witt, K. C. | N/A | The SP140-RESIST pathway regulates interferon mRNA stability and antiviral immunity | |
| 信心评级数据的信心-噪声信心提升（CNCB）模型 | Mamassian, P. | N/A | The Confidence-Noise Confidence-Boost (CNCB) model of confidence rating data | |
| 视觉诱发活动及猕猴下丘中听觉反应的变异性调制 | Schmehl, M. N. | N/A | Visually-evoked activity and variable modulation of auditory responses in the macaque inferior colliculus | |
| 动力蛋白（kinesin）的两个马达结构域的动力学调控协调了其沿微管的步进运动。 | Niitani, Y. | N/A | Kinetic regulation of kinesin's two motor domains coordinates its stepping along microtubules | |
| AlphaFold3 对抗体和纳米抗体对接学到了什么，还有哪些问题尚未解决？ | Hitawala, F. N. | N/A | What has AlphaFold3 learned about antibody and nanobody docking, and what remains unsolved? | |
| 复杂空间种群结构对崎岖适应度景观中早期和长期适应的影响 | Servajean, R. | N/A | Impact of complex spatial population structure on early and long-term adaptation in rugged fitness landscapes | |
| 记忆编码的预测性影响：研究振荡和N400事件相关电位成分 | Jano, S. L. | N/A | Predictive influences on memory encoding: investigating oscillations and the N400 event-related potential component | |
| 使用工程化受体对合成mRNA进行细胞外配体响应的翻译调控 | Nakanishi, H. | N/A | Extracellular ligand-responsive translational regulation of synthetic mRNAs using engineered receptors | |
| 首次完整昆虫眼睛的三维重建与形态功能映射 | Makarova, A. A. | N/A | The first complete 3D reconstruction and morphofunctional mapping of an insect eye | |
| 防止BMP4前结构域磷酸化的突变会损害同源二聚体的蛋白水解成熟，从而导致小鼠死亡。 | Kim, H.-s. | N/A | Mutations that prevent phosphorylation of the BMP4 prodomain impair proteolytic maturation of homodimers leading to lethality in mice | |
| CLCFM3：一种用于高精度植物三维建模的先进摄影测量算法 | Hayashi, A. | N/A | CLCFM3: An advanced photogrammetry algorithm for high-precision plant 3D modeling | |
| 解码不同细胞和疾病状态下基因表达的序列决定因素 | Lal, A. | N/A | Decoding sequence determinants of gene expression in diverse cellular and disease states | |
| 表观遗传轨迹预测ACPA阳性个体临床类风湿性关节炎的发展：针对免疫反应预防类风湿性关节炎（TIP-RA） |
这段翻译的中文意思是：通过研究表观遗传变化的过程，可以预测抗环瓜氨酸肽抗体（ACPA）阳性的个体是否会发展为临床类风湿性关节炎。TIP-RA项目旨在通过调节免疫反应来预防类风湿性关节炎的发生。 | Prideaux, E. B. | PDF | N/A | Epigenetic trajectory predicts development of clinical rheumatoid arthritis in ACPA+ individuals: Targeting Immune Responses for Prevention of Rheumatoid Arthritis (TIP-RA) | | S100a4+肺泡巨噬细胞通过促进由脂肪酸代谢调控的血管生成功能，加速癌前非典型腺瘤样增生的进展。 | Huang, H. | PDF | N/A | S100a4+ alveolar macrophages accelerate the progression of precancerous atypical adenomatous hyperplasia by promoting the angiogenic function regulated by fatty acid metabolism | | 以下是这段英文的中文翻译：
"甘蓝属物种在适应高温发芽方面的未探索多样性"
翻译说明： - "unexplored diversity" 译为 "未探索的多样性"，表示尚未被充分研究或发现的多样性。 - "adaptation of germination to high temperatures" 译为 "适应高温发芽"，指植物在高温条件下发芽的适应性。 - "Brassica species" 译为 "甘蓝属物种"，Brassica 是植物学中的甘蓝属，包括许多重要的农作物，如白菜、油菜、芥菜等。
希望这个翻译对你有帮助！ | Tiret, M. | PDF | N/A | An unexplored diversity for adaptation of germination to high temperatures in Brassica species | | TFE3融合蛋白在易位性肾细胞癌中驱动氧化代谢、铁死亡抗性和总体RNA合成。 | Helleux, A. | PDF | N/A | TFE3 fusion proteins drive oxidative metabolism, ferroptosis resistance and general RNA synthesis in translocation renal cell carcinoma | | LYCEUM：学习在低覆盖度古代基因组上调用拷贝数变异 | Yilmaz, M. A. | PDF | N/A | LYCEUM: Learning to call copy number variants on low coverage ancient genomes | | SenSeqNet：一种基于深度学习的蛋白质序列细胞衰老检测框架 | Jiang, H. | PDF | N/A | SenSeqNet: A Deep Learning Framework for Cellular Senescence Detection from Protein Sequences | | 从超弦到索引：利用掩码Burrows-Wheeler变换（MBWT）为无约束k-mer集合构建的空间高效索引 | Sladky, O. | PDF | N/A | FroM Superstring to Indexing: a space-efficient index for unconstrained k-mer sets using the Masked Burrows-Wheeler Transform (MBWT) | | SAM转甲基化途径和腺苷回收为ATP对于系统调节和免疫反应至关重要。 | Nedbalova, P. | PDF | N/A | SAM transmethylation pathway and adenosine recycling to ATP are essential for systemic regulation and immune response | | 在妊娠首三个月期间人类心脏图谱的多模态精细化 | De Bono, C. | PDF | N/A | Multi-modal refinement of the human heart atlas during the first gestational trimester | | 研究设计和生物银行规模数据集中有害罕见变异的抽样 | Steiner, M. C. | PDF | N/A | Study design and the sampling of deleterious rare variants in biobank-scale datasets | | 易增加芬太尼摄入量的行为和遗传标记。 | Keady, J. | PDF | N/A | Behavioral and genetic markers of susceptibility to escalate fentanyl intake. | | 基于联合单细胞基础模型和图学习的基因调控连接预测 | Kommu, S. | PDF | N/A | Prediction of Gene Regulatory Connections with Joint Single-Cell Foundation Models and Graph-Based Learning | | 一种双特异性T细胞接合抗体在实验性同源和基因工程胶质母细胞瘤模型中显示出强大的活性、特异性及肿瘤微环境重塑能力 | Zannikou, M. Z. | PDF | N/A | A Bi-Specific T Cell-Engaging Antibody Shows Potent Activity, Specificity, and Tumor Microenvironment Remodeling in Experimental Syngeneic and Genetically Engineered Models of GBM | | 双相情感障碍和精神分裂症风险基因AKAP11编码一种自噬受体，该受体将PKA激酶网络稳态的调节与突触传递耦合起来。 | Lee, Y.-K. | PDF | N/A | Bipolar and schizophrenia risk gene AKAP11 encodes an autophagy receptor coupling the regulation of PKA kinase network homeostasis to synaptic transmission | | 在阿尔茨海默病神经病理学发病时，对人类内嗅皮层进行细胞类型特异性分析 | Rodriguez-Rodriguez, P. | PDF | N/A | Cell-type specific profiling of human entorhinal cortex at the onset of Alzheimer's disease neuropathology | | 在雄性大鼠的昼夜节律松果体中寻找小胶质细胞的节律模式 | Freites, C. L. | PDF | N/A | Seeking rhythmic patterns in microglial cells within the circadian pineal gland from male rats | | 连接地球与太空：部署于国际空间站的灵活且具韧性的联邦学习框架 | Casaletto, J. A. | PDF | N/A | Bridging Earth and Space: A Flexible and Resilient Federated Learning Framework Deployed on the International Space Station | | BRCA1-BARD1复合物BRCT重复序列识别磷酸化RNAPII C端域的不同机制：来自结构和功能分析的见解
在这段翻译中，我尽量保持了原文的专业性和准确性，同时确保中文表达的流畅性。以下是翻译的要点解释：
- Distinct Mechanisms of Recognition 翻译为“不同机制”，强调了识别过程的多样性。
- Phosphorylated RNAPII C-Terminal Domain 翻译为“磷酸化RNAPII C端域”，保留了专业术语的准确性。
- BRCT Repeats 翻译为“BRCT重复序列”，这是生物学中常见的术语，直接翻译即可。
- BRCA1-BARD1 Complex 翻译为“BRCA1-BARD1复合物”，同样保留了专业术语的准确性。
- Insights from Structural and Functional Analyses 翻译为“来自结构和功能分析的见解”，强调了分析方法的多样性和结果的深入性。
希望这个翻译能够满足您的需求。如果有任何进一步的修改或调整，请随时告知。 | Klapstova, V. | PDF | N/A | Distinct Mechanisms of Recognition of Phosphorylated RNAPII C-Terminal Domain by BRCT Repeats of the BRCA1-BARD1 Complex: Insights from Structural and Functional Analyses | | 癫痫发作前高连接状态的出现：多患者验证、生理相关性及网络建模 | Medina Leandro, B. N. | PDF | N/A | Emergence of high-connectivity states before epileptic seizures: Multi-patient validation, physiological correlates, and network modeling | | A-TWAS：一种整合多种贝叶斯先验的聚合转录组范围关联研究模型 | Liang, Y. | PDF | N/A | A-TWAS: An aggregated transcriptome-wide association study model incorporating multiple Bayesian priors | | 腺苷上的RNA修饰共同调控巨噬细胞功能 | Griesche, V. | PDF | N/A | RNA modifications on Adenosine co-Regulate Macrophage Function | | 缺乏IFITM3的小鼠中SARS-CoV-2变体的加速适应保留了独特的趋向性和致病性 | Denz, P. J. | PDF | N/A | Accelerated Adaptation of SARS-CoV-2 Variants in Mice Lacking IFITM3 Preserves Distinct Tropism and Pathogenesis | | 将转录组数据与代谢模型整合，揭示了巴氏甲烷八叠球菌（Methanosarcina barkeri）的电子传递机制。 | Tang, W. | PDF | N/A | Integrating transcriptomic data with metabolic model unravels the electron transfer mechanisms of Methanosarcina barkeri | | 微调机械约束可解耦小鼠伪胚胎中的模式形成与基因表达 | Pineau, J. | PDF | N/A | Fine-tuning mechanical constraints uncouple patterning and gene expression in murine pseudo-embryos | | 受体变构促进胚胎发育过程中特定情境下的Sonic Hedgehog信号传导 | Ansari, S. S. | PDF | N/A | Receptor Allostery Promotes Context-Specific Sonic Hedgehog Signaling During Embryonic Development | | 细胞与基质之间的相互作用调节了禽类原始生殖细胞的未分化状态和自我更新能力。 | Ichikawa, K. | PDF | N/A | A cell-matrix interaction regulates the undifferentiated state and self-renewal capacity of avian primordial germ cells | | 在阿尔茨海默病模型小鼠的早期阶段中，食欲素神经的参与及食欲素受体拮抗剂的预防作用 | Hada, K. | PDF | N/A | Involvement of orexin nerves in early stage of Alzheimer's disease model mice and preventive effect of orexin receptor antagonists | | 家蟋蟀（Acheta domesticus）中的竞争互动传奇：直接与间接效应视角
这段文字描述了一项关于家蟋蟀之间竞争互动的研究，从直接效应和间接效应的角度进行了探讨。 | Sekhar, M. A. | PDF | N/A | A saga of agonistic interactions in house crickets (Acheta domesticus): A direct and indirect effects perspective | | 通过矩阵化和特征选择对动物行为进行张量分析 | Wang, B. | PDF | N/A | Tensor analysis of animal behavior by matricization and feature selection | | 乞食成本而非食物获取导致斑胸草雀育雏数量对生长的影响 | Tangili, M. | PDF | N/A | Begging costs rather than food received cause brood size effect on growth in zebra finches | | 雌性利用多种线索来评估竞争，以做出产卵决策。 | Sharma, M. | PDF | N/A | Females use multiple cues to assess competition for egg-laying decisions | | 以下是这段英文的中文翻译：
对化学和温度刺激的感官辨别在无体腔动物Symsagittifera roscoffensis中的研究
希望这对你有帮助！如果需要进一步调整或补充，请告诉我。 | Komarov, N. | PDF | N/A | Sensory discrimination of chemical and temperature stimuli in the acoel Symsagittifera roscoffensis | | 斑马鱼早期发育温度依赖性数据集 | Miller, A. | PDF | N/A | Dataset on Temperature Dependency of Zebrafish Early Development | | 猕猴（Macaca mulatta）大脑皮层结构中的莱维飞行模式 | Tozzi, A. | PDF | N/A | Levy Flight Patterns in the Cortical Architecture of Macaca mulatta | | 耳蜗植入者在空间听觉中的耳间时间差和耳间水平差的相互作用 | Buchholz, S. | PDF | N/A | Interactions of Interaural Time and Level Differences in Spatial Hearing with Cochlear Implants | | ADHD风险基因ADGRL3在人类神经发育过程中的表达谱及其遗传变异的影响 | McNeill, R. V. | PDF | N/A | Expression profile of the ADHD risk gene ADGRL3 during human neurodevelopment and the effects of genetic variation | | 一种模块化架构，用于在新颖的感觉运动任务中通过逐次试验学习冗余肌肉活动模式 | Rebelo Dal'Bello, L. | PDF | N/A | A modular architecture for trial-by-trial learning of redundant muscle activity patterns in novel sensorimotor tasks | | 1型或2型糖尿病患者Meynert基底核的神经病理学变化。 | Jiang, W. | PDF | N/A | Neuropathological changes in the nucleus basalis of Meynert in people with type 1 or type 2 diabetes mellitus. | | 前扣带皮层在复杂联想学习中的作用：监测动作状态与动作内容 | Huang, W. | PDF | N/A | Anterior cingulate cortex in complex associative learning: monitoring action state and action content | | 药物诱导与非药理学觉醒：相似还是不同的状态？TRAP2转基因小鼠的全脑分析 | Maciel, R. | PDF | N/A | Drug-induced versus non-pharmacological wakefulness: similar or different states? A whole brain analysis in TRAP2 transgenic mice | | 上肢配对关联刺激前、期间及后的脑电图反应 | Shikauchi, Y. | PDF | N/A | Electroencephalographic responses before, during, and after upper limb paired associative stimulation | | 多孔模型再现了血脑屏障紧密连接链的渗透特性，包括野生型和突变型claudin-5的特征。 | Berselli, A. | PDF | N/A | A multi-pore model of the blood-brain barrier tight junction strands recapitulates the permeability features of wild-type and mutant claudin-5 | | 局部嗅觉神经刺激会在大鼠嗅球中引发斑块状的柱状激活。 | Jahan, I. | PDF | N/A | Local olfactory nerve stimulation triggers patchy activation of columns across rat olfactory bulb | | 章鱼垂直叶的细胞和突触组织 | Bidel, F. | PDF | N/A | Cellular and synaptic organization of the Octopus vertical lobe | | 识别表达M4毒蕈碱型乙酰胆碱受体的星形胶质细胞，这些细胞在小鼠朊病毒病中调节运动功能和生存 | Tejeda, G. S. | PDF | N/A | Identification of M4 muscarinic acetylcholine receptor expressing astrocytes that regulate locomotion and survival in murine prion disease | | WormSNAP：一款用于快速、准确且无偏地检测秀丽隐杆线虫中荧光斑点的软件 | Tiroumalechetty, A. | PDF | N/A | WormSNAP: A software for fast, accurate, and unbiased detection of fluorescent puncta in C. elegans | | 关于检索状态启动的反应性解释的证据 | Han, S. | PDF | N/A | Evidence for a reactionary account of retrieval state initiation | | 组织生长控制的负反馈数学模型 | Kazmierczak, B. | PDF | N/A | Mathematical modelling of tissue growth control by a negative feedback | | 通过对美国国际旅行者肠道细菌的测序，洞察全球抗生素耐药性动态 | Sridhar, S. | PDF | N/A | Insights into global antimicrobial resistance dynamics through the sequencing of enteric bacteria from U.S. international travelers | | 合成粘蛋白作为糖类定义的益生元 | Alty, J. W. | PDF | N/A | Synthetic Mucins as Glycan-Defined Prebiotics | | FastCCC：一种用于单细胞转录组学研究中的可扩展、稳健且基于参考的细胞间通讯分析的无排列框架 | Hou, S. | PDF | N/A | FastCCC: A permutation-free framework for scalable, robust, and reference-based cell-cell communication analysis in single cell transcriptomics studies | | 过量的过氧化物酶体周围Ca2+会损害β细胞脂毒性中的自噬降解功能。 | Nguyen, H. T. | PDF | N/A | Perilysosomal Ca2+ overload impairs autophagic degradation in β-cell lipotoxicity | | 改进原代培养星形胶质细胞的转染方法以观察细胞骨架结构 | IKOMA, C. | PDF | N/A | Improved transfection methods of primary cultured astrocytes for observation of cytoskeletal structures | | 与系统性硬化症中纤维化性肺病相关的CD57+细胞毒性CD8 T细胞亚群 | Sasaki, T. | PDF | N/A | A CD57+ cytotoxic CD8 T cell subset associated with fibrotic lung disease in systemic sclerosis | | 代谢适应以特定亚群的方式重编程CD4 T细胞，在伴有和不伴有脓毒症的人类危重疾病中 | Stier, M. T. | PDF | N/A | Metabolic Adaptations Rewire CD4 T Cells in a Subset-Specific Manner in Human Critical Illness with and without Sepsis | | 非常规启动的1型滤泡辅助T细胞是黏膜病毒感染后长期存活的IgA浆细胞发育所必需的 | Haniuda, K. | PDF | N/A | Unconventionally primed type 1 follicular helper T cells are required for long-lived IgA plasma cell development following mucosal viral infection | | 在昆虫细胞中表达的库蠓过敏原能够诱导患有昆虫叮咬过敏症的马的外周血白细胞释放硫肽白三烯。 | Jonsdottir, S. | PDF | N/A | Culicoides allergens expressed in insect cells induce sulfidoleukotriene release in peripheral blood leukocytes from horses affected with insect bite hypersensitivity | | RIG-I刺激增强原代人CD8 T细胞的效应功能和增殖能力 | Mohamed, A. A. | PDF | N/A | RIG-I Stimulation Enhances Effector Function and Proliferation of Primary Human CD8 T Cells | | 在端粒酶阴性的细胞中，最短的端粒在达到一个临界长度时会触发复制性衰老，同时也会加剧基因组的不稳定性。 | Berardi, P. | PDF | N/A | The shortest telomere in telomerase-negative cells triggers replicative senescence at a critical threshold length and also fuels genomic instability | | 驱动蛋白-8/Kip3 需要 β-微管蛋白尾部来发挥解聚酶活性。 | Alemany, K. | PDF | N/A | Kinesin-8/Kip3 requires β-tubulin tail for depolymerase activity | | 通过整合组学分析和两阶段贝叶斯优化实现可持续水产养殖的数据驱动饲料优化 | Terayama, K. | PDF | N/A | Data-Driven Feed Optimization for Sustainable Aquaculture through Integrated Omics Analysis and Two-stage Bayesian optimization | | 评估一项快速评估功能，以协助华盛顿州对普通渡鸦（Corvus corax）的监测和管理 | Brussee, B. | PDF | N/A | Evaluation of a Rapid Assessment Function to aid monitoring and management of Common Ravens (Corvus corax) in Washington state | | Xist RNA依赖性和非依赖性机制调节B淋巴细胞中动态X染色体失活 | Toothacre, N. E. | PDF | N/A | Xist RNA Dependent and Independent Mechanisms Regulate Dynamic X Chromosome Inactivation in B Lymphocytes | | dnaSORA - 一种用于DNA点云的统一扩散变换器 | Njie, e. G. | PDF | N/A | dnaSORA - A Unified Diffusion Transformer for DNA point clouds | | 灯刷染色体的三维基因组学凸显了活跃转录在染色质组织中的作用 | Lagunov, T. | PDF | N/A | The 3D genomics of lampbrush chromosomes highlights the role of active transcription in chromatin organization | | PICRUSt2-MPGA：PICRUSt2功能预测参考数据库的更新 | Wright, R. J. | PDF | N/A | PICRUSt2-MPGA: an update to the reference database used for functional prediction within PICRUSt2 | | 变构效应在SARS-CoV-2刺突蛋白中连接了hACE2结合、泛变种中和和螺旋延伸。 | Colyer, A. | PDF | N/A | Allostery links hACE2 binding, pan-variant neutralisation and helical extension in the SARS-CoV-2 Spike protein | | 人类α5β3 GABAA受体激活与增强的结构基础 | Cowgill, J. | PDF | N/A | Structural basis for activation and potentiation in a human α5β3 GABAA receptor | | 缺氧通过HIF-1α的激活调节人肺动脉外膜成纤维细胞的表型。 | Philip, J. L. | PDF | N/A | Hypoxia modulates human pulmonary arterial adventitial fibroblast phenotype through HIF-1α activation | | mRNA脂质纳米颗粒结合纳米纤维-水凝胶复合材料为癌症免疫治疗创建了一个局部免疫刺激微环境 | Zhu, Y. | PDF | N/A | mRNA lipid nanoparticle-incorporated nanofiber-hydrogel composite generates a local immunostimulatory niche for cancer immunotherapy | | 微流控共培养技术在骨关节炎研究中模拟人类关节炎症的应用 | Mirazi, H. | PDF | N/A | Microfluidic Co-Culture for Modeling Human Joint Inflammation in Osteoarthritis Research | | DeepSynBa：具有完整剂量-反应谱的可操作药物组合预测 | Kuru, H. I. | PDF | N/A | DeepSynBa: Actionable Drug Combination Prediction with Complete Dose-Response Profiles | | Zmap：一种将单细胞映射到空间数据的智能区域分配方法 | Cai, Q. | PDF | N/A | Zmap: an intelligent region-allocation method to map single-cell into spatial data | | 系统性识别胶质母细胞瘤中环境依赖性基因必需性：GBM-CoDE平台 | Foster, M. T. | PDF | N/A | Systematic identification of context-dependent gene essentiality in Glioblastoma: The GBM-CoDE platform | | JRSeek：人工智能与病毒中的果冻卷折叠分类相遇 | Sanchez, J. E. | PDF | N/A | JRSeek: Artificial Intelligence Meets Jelly Roll Fold Classification in Viruses | | 将定向进化与机器学习相结合，实现精确的基因型到表型预测 | Howard, A. J. | PDF | N/A | Combining Directed Evolution with Machine Learning Enables Accurate Genotype-to-Phenotype Predictions | | 小鼠体内视网膜电图的生物物理基础：四层电流源密度模型 | Peinado Allina, G. | PDF | N/A | Biophysical Basis of the in vivo Electroretinogram of the Mouse: 4-Shell Current Source Density Model | | 准确表征KRAS与效应蛋白复合物的变构能量景观、结合热点和长程通讯：采用微秒级分子动力学、结合能量深度突变扫描和变构网络建模的综合方法 | Xiao, S. | PDF | N/A | Accurate Characterization of the Allosteric Energy Landscapes, Binding Hotspots and Long-Range Communications for KRAS Complexes with Effector Proteins : Integrative Approach Using Microsecond Molecular Dynamics, Deep Mutational Scanning of Binding Energetics and Allosteric Network Modeling | | CRISPR-Cas9变体的保真度动力学机制 | Hecht, A. D. | PDF | N/A | Kinetic mechanism for fidelity of CRISPR-Cas9 variants | | 肿瘤细胞MHC II类分子的缺失导致BRAF突变的间变性甲状腺癌对MAPK抑制剂不敏感 | Tiedje, V. | PDF | N/A | Loss of tumor cell MHC Class II drives insensitivity of BRAF-mutant anaplastic thyroid cancers to MAPK inhibitors | | 一种由特定YAP1亚型YAP1-2α与TAZ异源二聚化激活的超增强子赋予了癌症干细胞特性和耐药性。 | Ooki, T. | PDF | N/A | A super-enhancer actuated by heterodimerization of a specific YAP1 isoform, YAP1-2α, with TAZ endows cancer stemness and drug resistance | | 由特定YAP1亚型YAP1-2α与TAZ异源二聚化驱动的超级增强子赋予癌症干细胞特性和耐药性。 | Ooki, T. | PDF | N/A | A super-enhancer actuated by heterodimerization of a specific YAP1 isoform, YAP1-2α, with TAZ endows cancer stemness and drug resistance | | 基因型对水分亏缺的响应：通过减少玉米细胞壁中的对香豆酸和皮层木质化提高其消化率 | Lopez-Malvar, A. | PDF | N/A | Genotype-Dependent Response to Water Deficit: Increases in Maize Cell Wall Digestibility Occurs Through Reducing Both p-Coumaric Acid and Lignification of the Rind | | 将“The genus Boechera as a model for apomixis research”翻译成中文是：
“Boechera属作为无融合生殖研究的模型” | Mandakova, T. | PDF | N/A | The genus Boechera as a model for apomixis research | | 使用树搜索设计生化电路 | Bhamidipati, P. S. | PDF | N/A | Designing biochemical circuits with tree search | | 物理防御的军备竞赛：马卡兰加蚁植物的钩状毛状体能够杀死灰蝶科毛虫，但有一种专门化的毛虫拥有反防御机制。 | Chowdhury, R. | PDF | N/A | Arms race of physical defences: Hooked trichomes of Macaranga ant-plants kill lycaenid caterpillars, but one specialist has a counter-defence | | 解码行为中非人类灵长类动物小脑细胞外记录中神经元身份的策略 | Herzfeld, D. J. | PDF | N/A | Strategies to decipher neuron identity from extracellular recordings in the cerebellum of behaving non-human primates | | 药物治疗改变了神经微生理系统中信息处理的表现 | Watmuff, B. | PDF | N/A | Drug treatment alters performance in a neural microphysiological system of information processing | | 线粒体功能障碍是严重酒精相关性肝炎患者单核细胞免疫缺陷的基础。 | Middleton, P. K. | PDF | N/A | Mitochondrial dysfunction underlies monocyte immune deficiency in patients with severe alcohol-related hepatitis | | 系统性红斑狼疮（SLE）患者及小鼠狼疮模型中Tph与Tfh细胞之间的克隆关系 | Sasaki, T. | PDF | N/A | Clonal relationships between Tph and Tfh cells in patients with SLE and in murine lupus | | 工程化分枝杆菌及其相关分枝杆菌噬菌体在土壤微观环境中的存活与扩散研究
本研究探讨了经过基因工程改造的分枝杆菌（Mycobacterium smegmatis）及其相伴的分枝杆菌噬菌体在模拟土壤微观环境中的存活能力与扩散特性。研究旨在评估这些微生物在自然环境中的持久性及其对土壤生态系统可能产生的影响。通过一系列控制实验，我们观察了工程化分枝杆菌在不同土壤条件下的生长动态，以及噬菌体如何影响其宿主的存活与分布。研究结果对于理解基因工程微生物在自然环境中的行为模式，以及评估其潜在生态风险具有重要意义。 | Fleeharty, M. S. | PDF | N/A | Survival and Spread of Engineered Mycobacterium smegmatis and Associated Mycobacteriophage in Soil Microcosms | | 靶向去泛素化酶（DUBs）和泛素途径调节剂以增强宿主对细菌感染的防御能力 | Santelices, J. | PDF | N/A | Targeting deubiquitinating enzymes (DUBs) and ubiquitin pathway modulators to enhance host defense against bacterial infections | | 组蛋白变体H2A.Z与EBNA1协同作用维持爱泼斯坦-巴尔病毒潜伏表观基因组 | Castro-Munoz, J. L. | PDF | N/A | Histone Variant H2A.Z Cooperates with EBNA1 to Maintain Epstein-Barr Virus Latent Epigenome | | 表皮干细胞来源的细胞外囊泡通过miR-200s/ZEBs轴诱导成纤维细胞间充质-表皮转化，从而缓解增生性瘢痕。 | Zhen, M. | PDF | N/A | Epidermal stem cell-derived extracellular vesicles induce fibroblasts mesenchymal-epidermal transition to alleviate hypertrophic scar via the miR-200s/ZEBs axis | | RNA促进突触素凝聚并调节局部翻译 | Rankovic, B. | PDF | N/A | RNA promotes synapsin coacervation and modulates local translation | | 源自血管生成相关miRNA修饰的间充质基质细胞的细胞外囊泡在缺血动物模型中的治疗能力 | Wada, Y. | PDF | N/A | Therapeutic ability of extracellular vesicles derived from angio-miRNA-modified mesenchymal stromal cells in ischemic animal models | | 耐力训练恢复了大鼠骨骼肌在休息和对急性运动反应中因老化而受损的溶酶体生物发生因子。 | Rajabi, H. | PDF | N/A | Endurance training restores ageing-impaired lysosomal biogenesis factors in rest and response to acute exercise in rat skeletal muscle | | 一项关于氧化磷酸化必需基因的最新清单揭示了家族性梅尼埃病的线粒体起源 | Harhai, M. | PDF | N/A | An updated inventory of genes essential for oxidative phosphorylation identifies a mitochondrial origin in familial Meniere disease | | 使用相关光镜和电镜技术可视化亚细胞器脂质分布 | Lennartz, H. M. | PDF | N/A | Visualizing sub-organellar lipid distribution using correlative light and electron microscopy | | 人类大脑类器官模型在自体环境中模拟了由星形胶质细胞支持的肿瘤浸润和迁移。 | Schickel, E. | PDF | N/A | Human cerebral organoids model tumor infiltration and migration supported by astrocytes in an autologous setting | | 水文连通性增强了亚马逊矿区池塘中的鱼类生物多样性：来自环境DNA（eDNA）和传统采样方法的见解 | Timana-Mendoza, C. | PDF | N/A | Hydrological Connectivity Enhances Fish Biodiversity in Amazonian Mining Ponds: Insights from eDNA and Traditional Sampling | | PhorEau：一种新的基于过程的模型，用于预测森林功能，从树木生态生理学到森林动态和生物地理学 | Postic, T. | PDF | N/A | PhorEau: a new process-based model to predict forest functioning, from tree ecophysiology to forest dynamics and biogeography | | 心跳般的动力学驱动甲烷单加氧酶中的氧活化 | Hwang, Y. | PDF | N/A | Heartbeat-like dynamics drives oxygen activation in methane monooxygenase | | 统计晶体学揭示了SARS-CoV-2主蛋白酶（Mpro）中的一种变构网络。 | Creon, A. | PDF | N/A | Statistical crystallography reveals an allosteric network in SARS-CoV-2 Mpro | | 基于3D打印模具的肠道芯片方法：一种经济高效且易于实施的方法 | Delannoy, E. | PDF | N/A | Gut-on-Chip Methodology Based on 3D-Printed Molds: A Cost-Effective and Accessible Approach | | 通过使用增长网络进行特征融合来改进基于可穿戴设备的癫痫发作预测 | Hasija, T. | PDF | N/A | Improving wearable-based seizure prediction by feature fusion using growing network | | multiHIVE：用于单细胞多组学整合的分层多模态深度生成模型 | Nanduri, A. | PDF | N/A | multiHIVE: Hierarchical Multimodal Deep Generative Model for Single-cell Multiomics Integration | | 利用神经网络模型进行药物再利用：以心脏肥大为案例研究 | Magnussosn, R. | PDF | N/A | Leveraging Neural Network Models for Drug Repurposing: A case study on Cardiac Hypertrophy | | 卫星烟草花叶病毒：利用高分辨率模拟揭示衣壳和核衣壳稳定性的环境驱动因素 | Blazhynska, M. | PDF | N/A | Satellite Tobacco Mosaic Virus: Revealing Environmental Drivers of Capsid and Nucleocapsid Stability using High-Resolution Simulations | | 捕捉任意几何形状组织表面上的向列序 | Eckert, J. | PDF | N/A | Capturing Nematic Order on Tissue Surfaces of Arbitrary Geometry | | 将以下内容翻译成中文：通过甲醇生物精炼工程化低pH耐受性Komagataella phaffii用于工业级衣康酸生产 | Wei, F. | PDF | N/A | Engineering low pH-tolerant Komagataella phaffii for industrial-ready itaconic acid production via methanol biorefinery | | 体内果蝇大脑的自发荧光寿命成像捕捉到与记忆形成相关的代谢变化 | Roussel, P. | PDF | N/A | In vivo autofluorescence lifetime imaging of the Drosophila brain captures metabolic shifts associated with memory formation | | 在模拟飞行中暴露于空间定向障碍错觉下的眼动模式 | Harel, M. | PDF | N/A | Eye movement patterns under exposure to spatial disorientation illusions during simulated flight | | δ-原钙粘蛋白在斑马鱼视顶盖中引导神经回路组装的通道化作用
翻译说明： 1. "Canalization" 译为 "通道化作用"，在生物学中通常指发育过程中基因或分子对特定发育路径的引导和稳定作用。 2. "circuit assembly" 译为 "神经回路组装"，指神经元之间形成特定连接的过程。 3. "δ-protocadherins" 译为 "δ-原钙粘蛋白"，是一类在神经系统中起重要作用的细胞粘附分子。 4. "zebrafish optic tectum" 译为 "斑马鱼视顶盖"，是斑马鱼大脑中处理视觉信息的重要区域。
这个标题描述了一项关于δ-原钙粘蛋白如何引导斑马鱼视顶盖中神经回路形成的研究。 | Biswas, S. | PDF | N/A | Canalization of circuit assembly by δ-protocadherins in the zebrafish optic tectum | | MK-801阻断NMDA受体后海马CA1神经元的电生理和网络动力学破坏 | Aba-Perez, P. | PDF | N/A | Electrophysiological and network dynamics disruption of hippocampal CA1 neurons after NMDAr blockade by MK-801 | | 长链非编码RNA Mir17hg和D43Rik控制巨噬细胞对弓形虫感染的反应 | Menard, K. L. | PDF | N/A | Long Noncoding RNA Mir17hg and D43Rik Control the Macrophage Response to Toxoplasma gondii Infection | | 解码成骨不全症的表型变异性：斑马鱼作为分子和超微结构洞察的模型。 | Debaenst, S. | PDF | N/A | Decoding Phenotypic Variability in Osteogenesis Imperfecta: Zebrafish as a Model for Molecular and Ultrastructural Insights. | | 网络理论预测生态系统在不同环境条件下的稳健性 | Agazzi, G. | PDF | N/A | Network theory predicts ecosystem robustness across environmental conditions | | 非本地植物的气候生态位保守性取决于引入历史和生物地理背景 | Rönnfeldt, A. | PDF | N/A | Climatic niche conservatism in non-native plants depends on introduction history and biogeographic context | | 远洋鱼类下颌形态多样但功能趋同 | Knapp, A. | PDF | N/A | Divergent morphologies with convergent performance in the mandible of pelagiarian fishes | | 以下是这段文字的中文翻译：
主要生物特征性状和指数的土著绵羊母羊群体主成分分析及其与体重的相关性
这个标题描述了一项研究，该研究对土著绵羊母羊群体的主要生物特征性状和指数进行了主成分分析，并探讨了这些性状和指数与体重之间的关系。 | Weldegerima, T. M. | PDF | N/A | Principal Component Analysis of Major Biometric Traits and Indices of Indigenous Sheep Ewe Populations, and Relationships with their Body Weights | | 自分泌糖皮质激素信号在激素活性癌症中诱导抗原表达用于免疫治疗 | Schauer, M. P. | PDF | N/A | Autocrine glucocorticoid signaling in hormonally active cancer induces antigen expression for immunotherapy | | 使用大型语言模型从患者来源的癌症模型的科学文本中提取知识：算法开发与验证 | Yao, J. | PDF | N/A | Extracting knowledge from scientific texts on patient-derived cancer models using Large Language Models: algorithm development and validation | | 评估人类肝脏球状体作为抗BSL-3出血热病毒药物评价模型的有效性 | Chaput, S. | PDF | N/A | Assessing Human Liver Spheroids as a Model for Antiviral Drug Evaluation Against BSL-3 Haemorrhagic Fever viruses | | Boechera 还是非 Boechera？对误分类的亚洲物种 B. calcarea（十字花科）的基因组见解与分类学重新评估
这篇研究探讨了被误分类为 Boechera 属的亚洲物种 B. calcarea（十字花科）的分类学问题。通过基因组分析，研究者对其分类地位进行了重新评估，旨在确定其是否确实属于 Boechera 属，或是否应归入其他分类群。研究结果可能对该物种的系统发育关系和分类学归属提供新的见解。 | Mandakova, T. | PDF | N/A | Boechera or not? Genomic insights and taxonomic reassessment of the misclassified Asian species B. calcarea (Brassicaceae) | | 古代在表型产生中的偏见驱动了一个蛋白质家族的功能进化。 | Herrera-Alvarez, S. | PDF | N/A | Ancient biases in phenotype production drove the functional evolution of a protein family | | CPSF6促进HIV-1前整合复合体功能 | Chaudhuri, E. | PDF | N/A | CPSF6 Promotes HIV-1 Preintegration Complex Function | | 将酶定位到生物分子凝聚体中可以增加它们的积累，并有利于在烟草本氏烟（Nicotiana benthamiana）中工程化代谢途径的性能。 | Lindstrom Battle, A. L. | PDF | N/A | Localising enzymes to biomolecular condensates increases their accumulation and benefits engineered metabolic pathway performance in Nicotiana benthamiana | | 艰难梭菌主要毒素重塑肠道上皮，影响孢子对肠道组织的粘附/内化及其与肠道玻连蛋白的关联。 | Castro-Cordova, P. | PDF | N/A | Clostridioides difficile major toxins remodel the intestinal epithelia, affecting spore adherence/internalization into intestinal tissue and their association with gut vitronectin. | | 接种人类粪便的小鼠肠道内细菌遗传多样性均匀分布 | Wasney, M. | PDF | N/A | Uniform bacterial genetic diversity along the guts of mice inoculated with human stool | | 深度学习揭示了成人肠道微生物组中的功能原型，这些原型构成了个体间差异的基础，并混淆了疾病信号。 | Meawad, M. | PDF | N/A | Deep learning reveals functional archetypes in the adult human gut microbiome that underlie interindividual variability and confound disease signals | | 单域和多域抗噬菌体防御毒素的RelE/ParE超家族 | Gerdes, K. | PDF | N/A | Mono and Multidomain Anti-phage Defense Toxins of the RelE/ParE Superfamily | | 真菌Clonostachys rosea降解塑料的分子机制 | Gambarini, V. | PDF | N/A | Molecular mechanisms of plastic biodegradation by the fungus Clonostachys rosea | | 通过临床监测捕捉动态噬菌体-病原体共进化 | Mathur, Y. | PDF | N/A | Capturing dynamic phage-pathogen coevolution by clinical surveillance | | 致死性链球菌感染与淋巴结瓶颈扩大有关。 | Xia, L. | PDF | N/A | Lethal streptococcal infection is associated with widened lymph node bottlenecks | | 使用从分离的环境细菌中获得的新型逆转录子进行噬菌体防御和基因组编辑 | Nakamura, K. | PDF | N/A | Phage defense and genome editing using novel retrons sourced from isolated environmental bacteria | | 揭示并克服甲烷氧化菌中的氨毒性，以实现可持续生物制造和甲烷去除 | Zhang, H. | PDF | N/A | Unraveling and overcoming the ammonia toxicity in methanotrophs for sustainable biomanufacturing and methane removal | | 利用低温电子显微镜技术深入探究嗜鞭毛噬菌体7-7-1的结构及其初始宿主附着机制 | Noteborn, W. E. M. | PDF | N/A | Using cryogenic electron microscopy methods to gain insight into structure and initial host attachment of the flagellotropic bacteriophage 7-7-1 | | 代谢物的专性交叉喂养在土壤微生物群落中很常见。 | Yousif, G. | PDF | N/A | Obligate cross-feeding of metabolites is common in soil microbial communities | | Legumain切割对SET的构象和功能调控 | Horak, C. | PDF | N/A | Conformational and Functional Regulation of SET by Legumain Cleavage | | 阐明TNF-α介导的调控血脑屏障内皮细胞摄取Aβ42的分子机制 | Salian, V. | PDF | N/A | Elucidating Molecular Mechanisms Governing TNF-Alpha-Mediated Regulation of Amyloid Beta 42 Uptake in Blood-Brain Barrier Endothelial Cells | | 位于DNA拓扑异构酶2-α C端结构域中的富含赖氨酸区域充当多磷酸肌醇相互作用位点和核仁定位信号。 | Ardawatia, V. | PDF | N/A | Lysine-rich regions located in the C-terminal domain of DNA Topoisomerase 2-alpha act as polyphosphoinositide interaction sites and nucleolar localisation signals | | 多路复用映射蛋白质-蛋白质相互作用界面 | He, J. | PDF | N/A | Multiplex mapping of protein-protein interaction interfaces | | 含有丝绒结构域的转录因子VeA在构巢曲霉（Aspergillus nidulans）的营养生长过程中从细胞质穿梭到细胞核，并在那里停留以进行有性发育，但在进行无性发育时必须返回细胞质。 | Strohdiek, A. | PDF | N/A | The Aspergillus nidulans velvet domain containing transcription factor VeA is shuttled from cytoplasm into nucleus during vegetative growth and stays there for sexual development, but has to return into cytoplasm for asexual development | | 14-nt sgRNA引导的tRNase ZL对MALAT1 RNA的切割 | Takahashi, M. | PDF | N/A | Cleavage of MALAT1 RNA by 14-nt sgRNA-guided tRNase ZL | | 蛋白质序列编辑定义了SKN-1A/Nrf1和SKN-1C/Nrf2的不同和重叠功能。 | Jochim, B. E. | PDF | N/A | Protein sequence editing defines distinct and overlapping functions of SKN-1A/Nrf1 and SKN-1C/Nrf2. | | 从酵母到人类，septin原丝中的界面完整性由一个保守的精氨酸残基维持。 | Grupp, B. | PDF | N/A | Interface integrity in septin protofilaments is maintained by an arginine residue conserved from yeast to man. | | DMB标记用于荚膜多糖的检测和分析 | Rutschmann, C. | PDF | N/A | DMB labelling for detection and analysis of capsular polysaccharides | | 定制最小TIM桶结构以设计一种全新酶 | Beck, J. | PDF | N/A | Customizing the Structure of a Minimal TIM Barrel to Craft a De Novo Enzyme | | 睡眠剥夺后，慢波活动的增加在微觉醒后立即达到最高水平。 | Hauglund, N. L. | PDF | N/A | Increased slow wave activity in response to sleep deprivation is highest immediately after micro-arousals | | 早期的去甲肾上腺素激增沿着脑干通路驱动感觉诱发的觉醒。 | Matosevich, N. | PDF | N/A | An early surge of norepinephrine along brainstem pathways drives sensory-evoked awakening | | 铜绿假单胞菌的T3SS（III型分泌系统）能够促进其穿过原位上皮多层结构，这一过程不依赖于T3SS的针状结构。 | Jedel, E. | PDF | N/A | The Pseudomonas aeruginosa T3SS can contribute to traversal of an in situ epithelial multilayer independently of the T3SS needle | | 无眼蛛形纲动物中Pax6基因的表达暗示了其在蛛形纲头部发育中的祖先作用 | Joyce, I. | PDF | N/A | The Expression of Pax6 Genes in an Eyeless Arachnid Suggests Their Ancestral Role in Arachnid Head Development | | 雌激素相关受体在成年雌性果蝇中对于生殖干细胞维持是必需的 | Zike, A. B. | PDF | N/A | Estrogen-Related Receptor is Required in Adult Drosophila Females for Germline Stem Cell Maintenance | | 获取扩增序列标志着自私的小鼠t-单倍型的形成。 | Swanepoel, C. | PDF | N/A | Acquisition of ampliconic sequences marks a selfish mouse t-haplotype | | 过渡金属金属碳硼烷在三阴性乳腺癌细胞及脊椎动物癌症模型中展现出前所未有的细胞毒性 | Farras, P. | PDF | N/A | Unprecedented Cytotoxicity of Transition Metal Metallacarboranes on Triple Negative Breast Cancer Cells and a Vertebrate Cancer Model | | 翻译如下：
鉴定Orotidine 5'-单磷酸脱羧酶焓活化中的支架特异性能量转移网络
这段翻译的意思是：在研究Orotidine 5'-单磷酸脱羧酶（OMP脱羧酶）的焓活化过程中，识别出与该酶支架结构相关的特定能量转移网络。 | Dubey, P. | PDF | N/A | Identification of Scaffold Specific Energy Transfer Networks in the Enthalpic Activation of Orotidine 5'-Monophosphate Decarboxylase | | 以下是将这段英文翻译成中文的结果：
“针对来自炎症性早产儿肠道黏膜的肠杆菌科细菌的强效噬菌体联合体的表征”
翻译说明： - Characterization：表征，指对噬菌体联合体的特性进行研究或描述。 - virulent bacteriophage consortium：强效噬菌体联合体，指一组具有强感染能力的噬菌体。 - targeting Enterobacteriaceae：针对肠杆菌科细菌，肠杆菌科是一类常见的肠道细菌。 - inflamed preterm gut mucosa：炎症性早产儿肠道黏膜，指早产儿肠道黏膜发生炎症的情况。
希望翻译对您有帮助！ | Spiegelhauer, M. R. | PDF | N/A | Characterization of a virulent bacteriophage consortium targeting Enterobacteriaceae from inflamed preterm gut mucosa | | 血小板通过细胞外囊泡传递线粒体调节中性粒细胞的表型和功能 | Allan, H. E. | PDF | N/A | Platelet mitochondrial transfer via extracellular vesicles modulates neutrophil phenotype and function | | 单细胞转录组分析揭示了老年人类骨髓中一种新型的RAB13+内皮亚群和促纤维化间充质细胞。 | Cenzano, I. | PDF | N/A | Single-cell transcriptional profiling reveals a novel RAB13+ endothelial subpopulation and profibrotic mesenchymal cells in the aged human bone marrow | | 关于解旋酶RECQL5在转录调控中的结构洞察 | Ariza, A. J. F. | PDF | N/A | Structural insights into transcriptional regulation by the helicase RECQL5 | | 亲本起源效应对胚胎端粒延长的影响决定了端粒长度的遗传。 | Jeon, H.-J. | PDF | N/A | A parent-of-origin effect on embryonic telomere elongation determines telomere length inheritance | | WDR2调控孤儿驱动蛋白KIN-G以促进布氏锥虫中钩复合体和高尔基体的生物发生 | Zhou, Q. | PDF | N/A | WDR2 regulates the orphan kinesin KIN-G to promote hook complex and Golgi biogenesis in Trypanosoma brucei | | 心力衰竭患者线粒体、脂滴与肌浆网并列的超微结构分析 | Latchman, N. R. | PDF | N/A | Ultrastructure analysis of mitochondria, lipid droplet and sarcoplasmic reticulum apposition in human heart failure | | 促炎性细胞因子通过iNOS依赖的线粒体抑制介导胰腺β细胞对高尔基体形态的特异性改变。 | Blom, S. E. | PDF | N/A | Proinflammatory cytokines mediate pancreatic beta-cell specific alterations to Golgi morphology via iNOS-dependent mitochondrial inhibition | | 识别和治疗中枢神经系统外的CLN3疾病 | Ziolkowska, E. A. | PDF | N/A | Identifying and treating CLN3 disease outside the central nervous system | | APOE3和APOE4人类星形胶质细胞对嵌合小鼠中阿尔茨海默病关键特征的差异性影响 | Cruz-Sese, J. | PDF | N/A | Divergent Effects of APOE3 and APOE4 Human Astrocytes on Key Alzheimer's Disease Hallmarks in Chimeric Mice | | PP6磷酸酶和延伸子通过调控微管调节因子的水平，促进依赖于驱动蛋白5的纺锤体组装。 | Marin, L. | PDF | N/A | PP6 phosphatase and Elongator contribute to kinesin 5-dependent spindle assembly by controlling microtubule regulator levels | | 以下是这段英文的中文翻译：
"一种广泛分布的有蹄类动物迁徙行为的遗传性"
解释： - "heritability" 翻译为 "遗传性" - "migration behaviours" 翻译为 "迁徙行为" - "wide-ranging ungulate" 翻译为 "广泛分布的有蹄类动物"
这个短语描述的是关于某种有蹄类动物（如鹿、羚羊等）迁徙行为遗传特征的研究。 | Bonar, M. | PDF | N/A | The heritability of migration behaviours in a wide-ranging ungulate |