BioRxiv 2025-02-02 Papers
| 标题 | 作者 | PDF链接 | 代码仓库 | Title |
|---|---|---|---|---|
| 乳房的粗略心理地图以乳头为锚点。 | Long, K. | N/A | The coarse mental map of the breast is anchored on the nipple | |
| CoSMIC - 一种用于大规模、高分辨率微生物分析新生态位的混合方法 | Knafo, M. | N/A | CoSMIC - A hybrid approach for large-scale, high-resolution microbial profiling of novel niches | |
| 受精后转录启动在祖先LTR逆转录转座子中驱动ZDBF2的谱系特异性基因组印记 | Kobayashi, H. | N/A | Post-fertilization transcription initiation in an ancestral LTR retrotransposon drives lineage-specific genomic imprinting of ZDBF2 | |
| 在不影响遗传完整性和产仔数的情况下，培育出雌性后代偏多的工程小鼠 | Yosef, I. | N/A | Engineering mice for female-biased progeny without impacting genetic integrity and litter size | |
| 帕金森病相关的人脑DNA甲基化与DNA羟甲基化之间的转变 | Choza, J. I. | N/A | Parkinson's disease-associated shifts between DNA methylation and DNA hydroxymethylation in human brain | |
| EFMouse：一个用于模拟小鼠大脑中刺激诱发电场的Matlab工具箱 | Sanchez-Romero, R. | N/A | EFMouse: a Matlab toolbox to model stimulation-induced electric fields in the mouse brain | |
| 决策信心在顶叶皮层中的群体表征 | Zylberberg, A. | N/A | Population Representation of the Confidence in a Decision in the Parietal Cortex | |
| 神经成熟提供了表征的稳定性以及理解复杂概念的解决方案。 | Watanabe, H. | N/A | Neural Maturation Provides the Stability of Representation and the Solution for Understanding Complex Concepts | |
| GreedyMini：生成低密度DNA最小化器 | Golan, S. | N/A | GreedyMini: Generating low-density DNA minimizers | |
| 致癌基因诱导的衰老和衰老相关分泌表型（SASP）决定了palbociclib在PIK3CA突变结直肠癌中的疗效 | Cao, P. | N/A | Oncogene-induced senescence and senescence-associated secretory phenotype (SASP) determine the efficacy of palbociclib in PIK3CA mutated colorectal cancer | |
| 人类骨骼肌在反复进行阻力训练后，不仅具有可逆的蛋白质组特征，还保留了蛋白质组记忆。 | Hulmi, J. J. | N/A | Human skeletal muscle possesses both reversible proteomic signatures and a retained proteomic memory after repeated resistance training | |
| 系统生物学驱动的NF-κB和BCL2靶向治疗克服了弥漫性大B细胞淋巴瘤（DLBCL）中微环境介导的BH3模拟物耐药性。 | Vareli, A. | N/A | Systems biology-enabled targeting of NF-κB and BCL2 overcomes microenvironment-mediated BH3-mimetic resistance in DLBCL. | |
| 药理浓度的维生素C能够抑制髓过氧化物酶生成次氯酸，而氧化形式的维生素C则能够抑制关键巯基蛋白的功能以及Jurkat细胞的生长。 | Peskin, A. V. | N/A | Pharmacological concentrations of vitamin C inhibit hypochlorous acid generation by myeloperoxidase, and oxidized vitamin C inhibits critical thiol proteins and growth of Jurkat cells | |
| 用于晶体衍射数据质量评估的I/σI与{Rmerg, Rmeas, Rpim, CC1/2}的关系 | Fu, Z. | N/A | I/σI vs {Rmerg, Rmeas, Rpim, CC1/2} for Crystal Diffraction Data Quality Evaluation | |
| singIST：一种用于疾病模型与人类之间单细胞转录组学比较的综合方法 | Moruno-Cuenca, A. | N/A | singIST: an integrative method for comparative single-cell trancriptomics between disease models and humans | |
| 运动序列学习涉及更好地预测下一个动作以及优化运动轨迹。 | Kashefi, M. | N/A | Motor sequence learning involves better prediction of the next action andoptimization of movement trajectories | |
| grepq：一个用Rust编写的应用程序，能够通过将序列与一组正则表达式进行匹配来快速过滤FASTQ文件。 | Crosbie, N. D. | N/A | grepq: A Rust application that quickly filters FASTQ files by matching sequences to a set of regular expressions | |
| 多区域脑类器官：融合了大脑、内皮和中后脑成分的类器官 | Kshirsagar, A. | N/A | Multi-Region Brain Organoid: Fusion Organoid with Cerebral, Endothelial and Mid-Hindbrain Components | |
| 小脑浦肯野细胞条纹模式揭示了小鼠在正常衰老过程中细胞丢失的差异脆弱性和抵抗力。 | Donofrio, S. G. | N/A | Cerebellar Purkinje cell stripe patterns reveal a differential vulnerability and resistance to cell loss during normal aging in mice | |
| 多语言计算模型揭示了对21种语言的共享大脑反应 | de Varda, A. G. | N/A | Multilingual Computational Models Reveal Shared Brain Responses to 21 Languages | |
| 人口结构逆转了具有按比例缩放的出生率和死亡率的变异选择 | Wodarz, D. | N/A | Population structure reverses selection of variants with proportionally scaled birth and death rates | |
| 在多物种渔业中管理风险与权衡：营养控制和价格不对称的作用 | Villain, T. | N/A | Managing risks and trade-offs in multispecies fisheries: the role of trophic control and price asymmetry | |
| 分歧的生态选择导致酵母部分生殖隔离和广泛的基因组不稳定性 | Bendixsen, D. P. | N/A | Divergent ecological selection causes partial reproductive isolation and vast genomic instability in yeast | |
| 在高维组学中介变量的病例对照研究中，对二元性状的总中介效应进行估计 | Kang, Z. | N/A | Estimation of total mediation effect for a binary trait in a case-control study for high-dimensional omics mediators | |
| DyAb：在数据稀缺情况下的基于序列的抗体设计与属性预测 | Lin, J. Y.-Y. | N/A | DyAb: sequence-based antibody design and property prediction in a low-data regime | |
| 粒子间交联的离子响应性微凝胶在3D和4D（生物）打印应用中的应用 | Pal, V. | N/A | Interparticle Crosslinked Ion-responsive Microgels for 3D and 4D (Bio)printing Applications | |
| 采样如何影响AI对肽理化性质预测的准确性？ | Yan, M. | N/A | How Does Sampling Affect the AI Prediction Accuracy of Peptides' Physicochemical Properties? | |
| 北美树木稳定氢同位素的纬度梯度 | Keppler, F. | N/A | Latitudinal gradients in stable hydrogen isotopes of North American trees | |
| 以下是这段文字的中文翻译： |
对B群链球菌阴道定植的细胞免疫反应的表征
希望这对你有帮助！ | Spencer, B. L. | PDF | N/A | Characterization of the Cellular Immune Response to Group B Streptococcal Vaginal Colonization | | 膳食宏量营养素调节雄性及其雌性后代棕色脂肪组织的蛋白质组 | Macartney, E. L. | PDF | N/A | Dietary macronutrients modulate the proteome of brown adipose tissue in males and their female offspring | | 自噬受体Ncoa4调控棕色脂肪组织中PPARγ的活性和产热作用。 | Rowland, L. A. | PDF | N/A | The autophagy receptor Ncoa4 controls PPARγ activity and thermogenesis in brown adipose tissue | | 细菌IF2的N端无序区域（IDR）在寒冷条件下诱导相分离，并在寒冷应激期间促进适应性。 | Ghosh, A. | PDF | N/A | Bacterial IF2's N-terminal IDR drives cold-induced phase separation and promotes fitness during cold stress | | 向北推进：入侵性绿蟹（Carcinus spp.）向西南大西洋扩张 | Baigorria, M. M. | PDF | N/A | Moving northwards: Invasive Green Crab (Carcinus spp.) Expands into the Southwestern Atlantic | | 佛罗里达州阿巴拉契科拉河中墨西哥湾鲟（Acipenser oxyrinchus desotoi）秋季产卵群体的遗传证据 | Zona, J. O. | PDF | N/A | Genetic evidence for a fall spawning group of Gulf sturgeon (Acipenser oxyrinchus desotoi) in the Apalachicola River, Florida | | 以下是这段英文的中文翻译：
一种用于基孔肯雅病毒蛋白酶（nsP2）活性的稳健荧光底物
翻译说明： - "A Robust Fluorogenic Substrate" 翻译为 "一种稳健的荧光底物"，"robust" 表示该底物具有稳定性或可靠性。 - "Chikungunya Virus Protease (nsP2)" 翻译为 "基孔肯雅病毒蛋白酶（nsP2）"，这是病毒中的一种蛋白酶。 - "Activity" 翻译为 "活性"，指的是该蛋白酶的功能表现。
希望这对你有帮助！ | Makhaik, S. | PDF | N/A | A Robust Fluorogenic Substrate for Chikungunya Virus Protease (nsP2) Activity | | 无混杂因素的微生物组宿主表型预测模型 | Monshizadeh, M. | PDF | N/A | Confounder-free Predictive Models for Microbiome-based Host Phenotype Prediction | | 解码四种与公共卫生相关的微生物物种的甲基化组：纳米孔测序技术实现DNA修饰的可重复性分析 | Galeone, V. | PDF | N/A | Decoding bacterial methylomes in four public health-relevant microbial species: Nanopore sequencing enables reproducible analysis of DNA modifications | | 长期吸入苯暴露加剧了低密度脂蛋白受体敲除小鼠的动脉粥样硬化 | Zelko, I. N. | PDF | N/A | Chronic Inhaled Benzene Exposure Exacerbates Atherosclerosis in LDL Receptor-Knockout Mice | | 一个玉米近等基因系群体，专为基因发现和等位基因效应表征而设计。 | Zhong, T. | PDF | N/A | A maize near-isogenic line population designed for gene discovery and characterization of allelic effects | | 脂肪细胞祖细胞中的Dnmt3b缺乏可改善雌性小鼠的肥胖症。 | Huang, Y. | PDF | N/A | Dnmt3b deficiency in adipocyte progenitor cells ameliorates obesity in female mice | | 标题翻译为中文是：“植食性的演化：基于超保守元素的广肩小蜂科（膜翅目：小蜂总科）系统发育与进化研究”。 | Zhang, Y. M. | PDF | N/A | Phasing in and out of phytophagy: phylogeny and evolution of the family Eurytomidae (Hymenoptera: Chalcidoidea) based on Ultraconserved Elements | | 戊四氮点燃模型中的剂量递增揭示了慢性癫痫易感性的差异 | Moyer, M. B. | PDF | N/A | Dose Escalation in Pentylenetetrazol Kindling Detects Differences in Chronic Seizure Susceptibility | | 志贺氏菌OspF蛋白阻断NAIP-NLRC4炎症小体的快速p38依赖性启动。 | Turcotte, E. A. | PDF | N/A | Shigella OspF blocks rapid p38-dependent priming of the NAIP-NLRC4 inflammasome | | 新辅助抗4-1BB治疗通过低亲和力肿瘤内CD8+ T细胞在三阴性乳腺癌中提供对自发转移的保护。 | Lim, B. J. W. | PDF | N/A | Neoadjuvant anti-4-1BB confers protection against spontaneous metastasis through low-affinity intratumor CD8+ T cells in triple-negative breast cancer | | 将功能性古菌鞭毛机制的水平基因转移至细菌 | Sivabalasarma, S. | PDF | N/A | Horizontal gene transfer of the functional archaellum machinery to Bacteria | | 蚊子宿主背景对野外和实验室饲养的埃及伊蚊中微生物群与寨卡病毒（ZIKV）相互作用的影响 | Cansado-Utrilla, C. | PDF | N/A | Mosquito host background influences microbiome-ZIKV interactions in field and laboratory-reared Aedes aegypti | | 最佳膜流动性调节大肠杆菌中生物膜的形成 | Hong, Y. | PDF | N/A | Optimal membrane fluidity modulates biofilm formation in Escherichia coli | | 铜绿假单胞菌中氮磷转移酶系统对群体感应的调控 | Banerjee, S. | PDF | N/A | Quorum sensing regulation by the nitrogen phosphotransferase system in Pseudomonas aeruginosa | | PER-DBT相互作用对昼夜节律计时和温度补偿的显著影响 | Petersen, E. N. | PDF | N/A | The dramatic impact of the PER-DBT interaction on circadian timekeeping andtemperature compensation | | ROR2通过破坏蛋白质稳态引发右心室心力衰竭 | Hartman, H. | PDF | N/A | ROR2 drives right ventricular heart failure via disruption of proteostasis | | 关于角蚜决斗的亲缘选择背景：合作还是冲突？ | Uematsu, K. | PDF | N/A | The kin-selected context of duelling in horned aphids: cooperation or conflict? | | 取食生态位驱动同种昆虫对生物防治中植物防御的特化性反应 | Kaur, J. | PDF | N/A | Feeding niches drive specialist herbivore responses of conspecific insects to plant defenses in biocontrol | | 专性细胞内寄生虫通过微生物的代谢重塑改变了互利共生群落的组成。 | Bisesi, A. | PDF | N/A | Metabolic remodeling of microorganisms by obligate intracellular parasites alters mutualistic community composition | | 地下竞争增加了根的分配，这与博弈论的预测一致，但仅当植物同时在地上竞争时才会发生。 | Kopp, E. B. | PDF | N/A | Belowground competition increases root allocation in agreement with game-theoretical predictions, but only when plants simultaneously compete aboveground. | | 在Lomax广义线性模型框架下估计极端位移：样本大小和阈值选择的作用 | Rudolph, F. J. | PDF | N/A | Estimating extreme displacements under a Lomax generalized linear model framework: the role of sample size and threshold choice | | 根际细菌和真菌在阿拉斯加苔原中因宿主植物、土壤矿物学和外生菌根群落的不同而呈现出差异化的结构。 | Schaefer, S. R. | PDF | N/A | Rhizosphere Bacteria and Fungi are Differentially Structured by Host Plants, Soil Mineralogy and Ectomycorrhizal Communities in the Alaskan Tundra | | 伙计，每个人都想要模式分析工具（DEWPAT）：用于从数字图像中测量视觉模式多样性的工具 | Sanderson, J. A. | PDF | N/A | Dude, Everyone Wants Pattern Analysis Tools (DEWPAT): Tools for measuring visual pattern diversity from digital images | | 在Rhinella horribilis（一种蟾蜍）中，对人为改造的景观产生了一致但独特的中性和适应性基因组反应。 | Soria-Ortiz, G. J. | PDF | N/A | Concordant yet unique neutral and adaptive genomic responses to anthropogenically modified landscapes in Rhinella horribilis | | 性选择与杂交的相互作用可以推动性辐射。 | Kagawa, K. | PDF | N/A | The interplay of sexual selection and hybridization can drive sexual radiation | | 遗传变异对血浆APOL1的平台依赖性效应及其对肾脏疾病的影响 | Wang, Q. S. | PDF | N/A | Platform-dependent effects of genetic variants on plasma APOL1 and their implications for kidney disease | | B细胞刺激改变了失活X染色体的结构和高级组织。 | Toothacre, N. | PDF | N/A | B cell stimulation changes the structure and higher-order organization of the inactive X chromosome | | 利用基因组学鉴定多发性骨髓瘤高危亚群中的新型免疫治疗靶点 | liu, e. | PDF | N/A | Utilizing Genomics to Identify Novel Immunotherapeutic Targets in Multiple Myeloma High-Risk Subgroups | | 谷氨酸甲基化，硅藻中的一种新型组蛋白标记：质谱鉴定与结构表征 | Teletchea, S. | PDF | N/A | Glutamate methylation, a novel histone mark in diatoms: Mass spectrometry identification and structural characterization | | 通过结合递归神经网络和偏最小二乘分析对血小板钙信号进行扩展建模 | Tantiwong, C. | PDF | N/A | Extended Modelling of Platelet Calcium Signaling by Combined Recurrent Neural Network and Partial Least Squares Analyses | | 用户辅助方法用于图像和轨迹的精确非刚性配准 | Baig, M. M. J. | PDF | N/A | User-Assisted Approach for Accurate Nonrigid Registration of Images and Traces | | 神经标记动态功能网络连接模式：一种全自动化流程，用于通过超过10万名受试者的动态功能网络连接约束独立成分分析，从静息态功能磁共振成像数据中估计受试者特定状态。 | Esfahani, M. M. | PDF | N/A | Neuromark dFNC Patterns: A fully automated pipeline to estimate subject-specific states from rs-fMRI data via constrained ICA of dFNC in +100k Subjects | | DARG：一个关于模型生物中阿尔茨海默病相关基因的数据库 | Hu, Y. | PDF | N/A | DARG: a Database of Alzheimer Related Genes in Model Organisms | | 基准测试用于染色体末端特异性端粒分析的长读长测序工具 | Reed, J. | PDF | N/A | Benchmarking Long-read Sequencing Tools for Chromosome End-specific Telomere Analysis | | vcfsim: 支持缺失数据的全位点VCF文件的灵活模拟 | Goulart, P. | PDF | N/A | vcfsim: flexible simulation of all-sites VCFs with missing data | | FISHNET：一种基于网络的分析工具，用于分析基因水平的P值，以识别标准方法遗漏的重要基因 | Acharya, S. | PDF | N/A | FISHNET: A Network-based Tool for Analyzing Gene-level P-values to Identify Significant Genes Missed by Standard Methods | | MassVision：一个开源的端到端平台，用于AI驱动的质谱成像分析 | Jamzad, A. | PDF | N/A | MassVision: An Open-Source End-to-End Platform for AI-Driven Mass Spectrometry Image Analysis | | 针对VatD进行X射线片段筛选初步发现了对抗链霉素耐药性的线索 | Asthana, P. - | PDF | N/A | Initial leads to combat streptogramin resistance generated from X-ray fragment screening against VatD | | CDK8重塑肿瘤微环境以抵抗靶向KRASG12D抑制在胰腺导管腺癌中的治疗效果。 | McAndrews, K. M. | PDF | N/A | CDK8 remodels the tumor microenvironment to resist the therapeutic efficacy of targeted KRASG12D inhibition in pancreatic ductal adenocarcinoma | | B细胞特异性Wwox缺失在多发性骨髓瘤小鼠模型中促进浆母细胞肿瘤发展和促炎性信号特征 | Hussain, T. | PDF | N/A | B-cell-Specific Wwox Deletion Promotes Plasmablastic Tumor Development and Pro-Inflammatory Signatures in a Myeloma Mouse Model | | 慢性抗原刺激在实体瘤中诱导T细胞耗竭并限制T细胞双特异性疗法的疗效 | Hutter-Karakoc, I. | PDF | N/A | Chronic Antigen Stimulation in Solid Tumors Induces T Cell Exhaustion and Limits Efficacy of T Cell Bispecific Therapies | | 肿瘤微环境中巨噬细胞对卵巢癌生长及治疗反应的影响 | Nikeghbal, P. | PDF | N/A | The Influence of Macrophages within the Tumor Microenvironment on Ovarian Cancer Growth and Response to Therapies | | 生长抑素受体2在肝细胞癌中的过度表达：对癌症生物学和治疗诊断应用的意义 | Momeny, M. | PDF | N/A | Somatostatin Receptor 2 Overexpression in Hepatocellular Carcinoma: Implications for Cancer Biology and Theranostic Applications | | 超突变过程为非最佳癌症驱动突变提供了先机，解释了非典型KRAS变异的存在。 | Nicholson, M. D. | PDF | N/A | Hyper-mutational processes provide a head-start for non-optimal cancer driver mutations explaining atypical KRAS variants | | 弱刺激下动态电阻抗成像揭示的功能性肿瘤边界：黑色素瘤区域的耗散结构 | Babich, Y. F. | PDF | N/A | Functional Tumor Boundaries Revealed by Dynamic Electroimpedance Imaging Under Weak Stimuli: Dissipative Structures in Melanoma Area | | 微生物代谢物4-乙基苯基硫酸酯（4EPS）与AT1R相互作用，降低血压并影响AngII诱导的主动脉瘤的结果。 | Harford, T. | PDF | N/A | Microbial metabolite 4-ethylphenylsulfate (4EPS) interacts with AT1R, reduces blood pressure and outcome of AngII-induced aortic aneurysm | | 膳食中补充甲基萘醌-9对小鼠骨组织质量或骨密度无影响 | Liu, M. | PDF | N/A | Dietary Menaquinone-9 Supplementation Does Not Influence Bone Tissue Quality or Bone Mineral Density in Mice | | 神经元内溶酶体的酸化依赖于跨膜蛋白184B（TMEM184B）与囊泡质子泵之间的相互作用。 | Wright, E. B. | PDF | N/A | Neuronal endolysosomal acidification relies on interactions between transmembrane protein 184B (TMEM184B) and the vesicular proton pump | | 一种敏感的体细胞定位红色荧光钙指示剂，用于体内神经元群体的多模态成像 | Zhou, S. | PDF | N/A | A Sensitive Soma-localized Red Fluorescent Calcium Indicator for Multi-Modality Imaging of Neuronal Populations In Vivo | | 溶解性干扰素γ（Lytic IFNγ）储存在含有颗粒酶B的细胞毒性颗粒中，并由效应CD8⁺ T细胞共同分泌。 | Li, X. | PDF | N/A | Lytic IFNγ is stored in granzyme B-containing cytotoxic granules and co-secreted by effector CD8⁺ T cells | | 缅甸密支那沿海地区可食用热带牡蛎的系统分类地位及Talonostrea属（牡蛎科）的首次记录 | TOYOKAWA, M. | PDF | N/A | Systematic position of edible tropical oysters and first record of genus Talonostrea (Ostreidae) in the Myeik coastal area, Myanmar | | β-三酮类化合物尼替西农通过表皮吸收杀死抗药性蚊子。 | Stavrou-Dowd, Z. T. | PDF | N/A | The beta-triketone, nitisinone, kills insecticide-resistant mosquitoes through cuticular uptake | | SNP基础模型：在全基因组单倍型定相和基因型插补中的应用 | Xu, A. G. | PDF | N/A | A SNP Foundation Model: Application in Whole-Genome Haplotype Phasing and Genotype Imputation | | 在微米尺度上对热响应水凝胶进行光刻结构化 | Esch, K. | PDF | N/A | Lithographic structuring of thermoresponsive hydrogel on a micron scale | | 超高通量体外翻译测定法用于鉴定克氏锥虫特异性蛋白质合成抑制剂 | Mantovani, C. C. | PDF | N/A | Ultra-high throughput in vitro translation assay for identification of Trypanosoma cruzi-specific protein synthesis inhibitors | | 产前逆境会塑造一部分腹侧齿状回颗粒细胞，使其易于被招募，从而驱动先天性焦虑。 | Nabila, A. | PDF | N/A | Prenatal adversity configures a subpopulation of ventral dentate granule cells for recruitment to drive innate anxiety |