2025-02-08 每日论文

来源	独立页面
arXiv	arXiv
bioRxiv	bioRxiv
medRxiv	medRxiv

arXiv

标题	作者	PDF链接	代码仓库	Title

bioRxiv

标题	作者	PDF链接	代码仓库	Title
在序列抽样模型框架下的选择诱导偏好变化	Lee, D. G.	PDF	N/A	Choice-Induced Preference Change under a Sequential Sampling Model Framework
rsofun v5.0：一个用于模拟生态系统过程的模型-数据集成框架	Aran Paredes, J.	PDF	N/A	rsofun v5.0: A model-data integration framework for simulating ecosystem processes
日本鹌鹑（Coturnix japonica）的免疫-神经内分泌表型表达随生命周期变化	Marozzi, A.	PDF	N/A	Immune-neuroendocrine phenotypic expression changes through life in Coturnix japonica quails
组蛋白伴侣CAF-1在复制偶联的DNA双链断裂修复过程中，防止Rad52介导的芽殖酵母核糖体DNA的不稳定性。	Futami, H.	PDF	N/A	The histone chaperone CAF-1 prevents Rad52-mediated instability of the budding yeast ribosomal DNA during replication-coupled DNA double-strand break repair
通过整合杀虫剂抗性生物测定类型的数据，利用包含蚊子遗传变异和行为的机制模型	Denz, A.	PDF	N/A	Integrating data from across insecticide resistance bioassay types using a mechanistic model incorporating mosquito genetic variation and behaviour
在气候变暖和干燥的条件下，热带干旱森林树木的叶片和生殖物候的数量和时间变化	Lai, H. R.	PDF	N/A	Changes in quantity and timing of foliar and reproductive phenology of tropical dry-forest trees under a warming and drying climate
9p21.3冠状动脉疾病风险位点促使血管平滑肌细胞向骨软骨生成状态转变。	Salido, E.	PDF	N/A	The 9p21.3 coronary artery disease risk locus drives vascular smooth muscle cells to an osteochondrogenic state
在相关环境中进行规范性证据的权衡与积累	Tardiff, N.	PDF	N/A	Normative evidence weighing and accumulation in correlated environments
PAM：用于视觉感知神经解码的预测性注意力机制	Dado, T.	PDF	N/A	PAM: Predictive attention mechanism for neural decoding of visual perception
以下是将这段英文翻译成中文的结果：

体内筛选能够介导Notch激活的蛋白水解开关

翻译解释： - in vivo：体内，指在生物体内部进行的实验或研究。 - screen：筛选，指通过实验方法从大量样本中找出具有特定功能的分子或机制。 - proteolytic switches：蛋白水解开关，指通过蛋白质水解作用调控生物过程的分子机制。 - mediate：介导，指在生物过程中起到传递或调控作用。 - Notch activation：Notch激活，Notch是一种重要的信号通路，其激活在细胞分化、发育等过程中起关键作用。

希望这个翻译对你有帮助！如果有其他问题，欢迎随时提问。 | Baker, F. | PDF | N/A | An in vivo screen for proteolytic switches that can mediate Notch activation | | 设计内源性无序区域结合蛋白 | Wu, K. | PDF | N/A | Design of intrinsically disordered region binding proteins | | 空间转录组数据通过马赛克假说揭示了纯细胞类型。 | Wang, Y. | PDF | N/A | Spatial transcriptomic data reveals pure cell types via the mosaic hypothesis | | 控制大肠杆菌中菌毛合成和腐胺稳态 | Mehta, I. | PDF | N/A | Control of pili synthesis and putrescine homeostasis in Escherichia coli | | 温带植物在分布区后缘的春化和物候变化，为理解其对未来更温和冬季的适应提供了重要见解。 | Perrier, A. | PDF | N/A | Shifts in vernalization and phenology at the rear edge hold insight into adaptation of temperate plants to future milder winters | | 使用单细胞多组学数据集对拷贝数变异推断工具进行基准测试 | Song, M. | PDF | N/A | Benchmarking copy number aberrations inference tools using single-cell multi-omics datasets | | TE-Seq：一种转座子注释与RNA测序分析流程 | Kelsey, M. M. G. | PDF | N/A | TE-Seq: A Transposable Element Annotation and RNA-Seq Pipeline | | 小脑性共济失调对运动学和动力学需求的敏感性 | Oh, K. | PDF | N/A | Sensitivity of Cerebellar Reaching Ataxia to Kinematic and Dynamic Demands | | 以下是这段英文的中文翻译：

谷氨酸棒状杆菌的系统代谢工程用于高效生产L-色氨酸

甲磺酸去铁胺在含血清和无血清培养基中的功效：过氧化氢诱导细胞死亡后成年雪旺细胞的存活情况

翻译说明： 1. "Efficacy" 翻译为“功效”。 2. "Deferoxamine Mesylate" 是药物名称，翻译为“甲磺酸去铁胺”。 3. "Serum and Serum-Free Media" 翻译为“含血清和无血清培养基”。 4. "Adult Schwann Cell Survival" 翻译为“成年雪旺细胞的存活情况”。 5. "Hydrogen Peroxide Induced Cell Death" 翻译为“过氧化氢诱导的细胞死亡”。 | Ma, Y. H. E. | PDF | N/A | Efficacy of Deferoxamine Mesylate in Serum and Serum-Free Media: Adult Schwann Cell Survival Following Hydrogen Peroxide Induced Cell Death | | 比较基因组学分析性别决定相关基因揭示了双壳类动物与哺乳动物之间存在共同的进化模式，但与果蝇不同。 | Nicolini, F. | PDF | N/A | Comparative genomics of sex determination related genes reveals shared evolutionary patterns between bivalves and mammals, but not Drosophila | | 使用rdeval对大规模测序数据进行评估 | Formenti, G. | PDF | N/A | Evaluation of sequencing reads at scale using rdeval | | 一种定量方法用于绘制线粒体特化与可塑性图谱 | Monzel, A. S. | PDF | N/A | A Quantitative Approach to Mapping Mitochondrial Specialization and Plasticity | | 小鼠大脑皮层中稀疏蓝斑去甲肾上腺素神经元的轴突侧支模式。 | Wu, Y.-M. | PDF | N/A | Axon collateral pattern of a sparse locus coeruleus norepinephrine neuron in mouse cerebral cortex. | | 编程体内切除前噬菌体{varphi}13是金黄色葡萄球菌感染过程中的关键时间调控机制。 | Poupel, O. | PDF | N/A | Programmed in vivo excision of prophage {varphi}13 is an essential timing device for the Staphylococcus aureus infectious process | | 通过将工程化的胞苷脱氨酶APOBECs与PUF蛋白融合，实现有效的体内RNA碱基编辑。 | Han, W. | PDF | N/A | Effective in vivo RNA base editing via engineered cytidine deaminase APOBECs fused with PUF proteins | | 物质使用障碍与HIV对人类腹侧中脑神经元和小胶质细胞的转录影响 | Wilson, A. M. | PDF | N/A | Transcriptional impacts of substance use disorder and HIV on human ventral midbrain neurons and microglia | | xOmicsShiny：一个用于跨组学数据分析和通路映射的R Shiny应用程序 | Gao, B. | PDF | N/A | xOmicsShiny: an R Shiny application for cross-omics data analysis and pathway mapping | | 加速抗体开发：基于序列和结构的模型，用于通过尺寸排阻色谱预测可开发性特性 | Abeer, A. N. M. N. | PDF | N/A | Accelerating Antibody Development: Sequence and Structure-Based Models for Predicting Developability Properties through Size Exclusion Chromatography | | 生育力与免疫权衡的强度调节了宿主的进化动态、病原体的传播以及宿主的丰度。 | Djahoui, E. | PDF | N/A | The strength of the fecundity-immunity trade-off modulates host evolutionary dynamics, pathogen propagation, and host abundance | | 解剖后扣带皮层输入：来自前丘脑的普遍驱动 | Margetts-Smith, G. | PDF | N/A | Dissection of retrosplenial cortex inputs: ubiquitous drive from anterior thalamus | | 导航参考框架作为海马中间神经元编码特性的关键调节器 | Bott, J.-B. | PDF | N/A | Navigational Frames of Reference as Critical Regulators of Hippocampal Interneuron Coding Properties | | 多巴胺能轴突膨体的冷冻关联光镜和电子断层扫描揭示了皮质-纹状体突触的非突触调节 | Lapios, P. | PDF | N/A | Cryo-correlative light and electron tomography of dopaminergic axonal varicosities reveals non-synaptic modulation of cortico-striatal synapses | | 早期细胞周期基因在皮质类器官祖细胞中的表达预测了婴儿大脑生长轨迹的个体间变异性 | Glass, M. R. | PDF | N/A | Early cell cycle genes in cortical organoid progenitors predict interindividual variability in infant brain growth trajectories | | 小脑攀缘纤维在决策过程中传递感知选择。 | Yiu, T. L. | PDF | N/A | Cerebellar climbing fibers convey perceptual choice during decision-making | | 利用单细胞扰动筛选解码剪接因子程序的调控架构 | Anglada-Girotto, M. | PDF | N/A | Using single-cell perturbation screens to decode the regulatory architecture of splicing factor programs | | 神经元发育过程中稳定微管的极性反转 | Iwanski, M. K. | PDF | N/A | Polarity reversal of stable microtubules during neuronal development | | 亨廷顿病相关锚蛋白重复序列棕榈酰转移酶是溶酶体形成和融合的限速因素。 | Szenci, G. | PDF | N/A | Huntington's disease-associated ankyrin repeat palmitoyl transferases are rate-limiting factors in lysosome formation and fusion | | 多次相互作用介导了BLTP2在内质网-质膜接触点的定位，从而调控质膜动力学。 | Dai, A. | PDF | N/A | Multiple interactions mediate the localization of BLTP2 at ER-PM contacts to control plasma membrane dynamics | | CellFateExplorer：一个用于探索细胞命运的集成平台 | Huang, Z. | PDF | N/A | CellFateExplorer: An integrated platform for exploring cell fate | | 生物数学方法模型用于识别人类血小板对不同激动剂的激活特征 | Cognasse, F. | PDF | N/A | A biomathematical approaches models to identify human platelet activation signature in response to various agonists | | 长期饮酒会增强造血干细胞和祖细胞向破骨细胞前体分化的能力。 | Hemati, H. | PDF | N/A | Chronic alcohol consumption enhances the differentiation capacity of hematopoietic stem and progenitor cells into osteoclast precursors | | 先天免疫因子Trim69通过重塑微管结构，影响了HIV病毒粒子核心向细胞核迁移过程中依赖动力蛋白的运动。 | Vadon, C. | PDF | N/A | Microtubule remodeling by the innate immune factor Trim69 compromises dynein-dependent migration of HIV virion cores towards the nucleus | | 针对丝虫丝氨酸蛋白酶抑制剂Wb123的单克隆抗体阻碍了尿激酶型纤溶酶原激活物受体介导的巨噬细胞替代性激活。 | Upadhyay, P. | PDF | N/A | Monoclonal antibody to Filarial serpin Wb123 impedes the urokinase plasminogen activator receptor-mediated Alternative activation of macrophages | | 三甲胺-N-氧化物（Trymethylamine-N-oxide），一种源自肠道的代谢物，通过内质网应激诱导瓣膜间质细胞向肌成纤维细胞活化。 | Sudi, S. | PDF | N/A | Trymethylamine-N-oxide, a gut-derived metabolite, induces myofibroblastic activation of valvular interstitial cells through endoplasmic reticulum stress | | 以下是将这段英文翻译成中文的结果：

一个dWDR45敲除果蝇模型，用于解读自噬在BPAN中的作用

基于生态位的表型可塑性和修订后的肠道分泌分化模型的顺式调控动态

翻译说明： - "Niche-driven" 翻译为“基于生态位的”或“生态位驱动的”，指的是由特定微环境（生态位）所驱动的过程。 - "phenotypic plasticity" 翻译为“表型可塑性”，指的是生物体在不同环境下表现出不同表型的能力。 - "cis-regulatory dynamics" 翻译为“顺式调控动态”，指的是基因调控区域（如启动子、增强子等）在调控基因表达中的动态变化。 - "intestinal secretory differentiation" 翻译为“肠道分泌分化”，指的是肠道细胞向分泌型细胞分化的过程。

这篇文章探讨了如何通过谱分解的方法来解决自调节基因表达中蛋白质分布随时间变化的问题。自调节基因表达是生物学中一个重要的研究领域，它涉及到基因如何通过反馈机制调控自身的表达水平。突发性基因表达则是指基因在短时间内产生大量蛋白质的现象。本文提出的谱分解方法为理解这些复杂的生物过程提供了新的视角和工具。通过这种方法，研究人员可以更准确地预测和分析蛋白质在细胞内的分布和动态变化，从而深入理解基因表达的调控机制及其对细胞功能的影响。 | Ferreira Ramos, A. | PDF | N/A | Comment on "Solving the time-dependent protein distributions for autoregulated bursty gene expression using spectral decomposition" | | LSD和MDMA对健康受试者纹状体-皮质连接的可分离效应 | Ertl, N. | PDF | N/A | Dissociable effects of LSD and MDMA on striato-cortical connectivity in healthy subjects | | 裸盖菇素改变了视觉-情境的计算处理。 | Aqil, M. | PDF | N/A | Psilocybin alters visual-contextual computations | | 微生物组研究中的FAIR序列数据和元数据共享的分级标准 | Kim, L. | PDF | N/A | Tier-based standards for FAIR sequence data and metadata sharing in microbiome research | | 一种简单的方法用于Vermivora莺类羽毛相关位点的多重PCR扩增子测序 | Toews, D. P. | PDF | N/A | A simple approach to multiplexed PCR amplicon sequencing of plumage-associated loci in Vermivora warblers | | LimROTS：一种结合经验贝叶斯和可重复性优化统计的混合方法，用于蛋白质组学数据的稳健分析 | Anwar, A. M. | PDF | N/A | LimROTS: A Hybrid Method Integrating Empirical Bayes and Reproducibility-Optimized Statistics for Robust Analysis of Proteomics Data | | 花酵母模糊了熊蜂授粉植物花蜜糖浓度的内在个体差异。 | Herrera, C. M. | PDF | N/A | Flower yeasts obfuscate intrinsic individual variation in nectar sugar concentration in a bumble bee-pollinated plant | | 心血管系统、静脉-动脉体外膜肺氧合（VA ECMO）与主动脉内球囊反搏（IABP）之间相互作用的建模与模拟：何时是合适的组合？ | De Lazzari, B. | PDF | N/A | Modelling and simulation of the interactions between the cardiovascular system, VA ECMO and IABP: when is it an appropriate combination? | | 具有自我更新潜力的微型肌肉的丝状光（FLight）生物打印 | Liu, H. | PDF | N/A | Filamented Light (FLight) Bioprinting of Mini-Muscles with Self-Renewal Potential | | rplec: 一个基于DNA甲基化的胎盘表观遗传时钟R包，用于通过DNA甲基化估计妊娠年龄 | Sufriyana, H. | PDF | N/A | rplec: An R package of placental epigenetic clock to estimate aging by DNA-methylation-based gestational age | | 使用SVGAP流程对一组全基因组组装中的结构变异进行基准测试、检测和基因分型 | Hu, M. | PDF | N/A | Benchmarking, detection, and genotyping of structural variants in a population of whole-genome assemblies using the SVGAP pipeline | | ChemEmbed：一个利用增强的MS/MS数据和多维分子嵌入进行代谢物识别的深度学习框架 | Faizan-Khan, M. | PDF | N/A | ChemEmbed: A deep learning framework for metabolite identification using enhanced MS/MS data and multidimensional molecular embeddings | | scKAN：通过Kolmogorov-Arnold网络进行可解释的单细胞分析，用于细胞类型特异性基因发现和药物再利用 | He, H. | PDF | N/A | scKAN: Interpretable Single-cell Analysis for Cell-type-specific Gene Discovery and Drug Repurposing via Kolmogorov-Arnold Networks | | 改进空间转录组学聚类：使用嵌套图神经网络 | Jain, A. | PDF | N/A | Improved Spatial Transcriptomics Clustering with Nested Graph Neural Networks | | 利用减数基因组学在无乳链球菌血清型V（ATCC BAA-611 / 2603 V/R）菌株中识别药物靶点：一种计算机模拟方法 | Chowdhury, A. R. K. | PDF | N/A | Harnessing subtractive genomics for drug target identification in Streptococcus agalactiae serotype v (atcc baa-611 / 2603 v/r) strain: An in-silico approach | | ibaqpy：一个可扩展的Python包，用于利用SDRF元数据进行蛋白质组学中的基线定量 | Zheng, P. | PDF | N/A | ibaqpy: A scalable Python package for baseline quantification in proteomics leveraging SDRF metadata | | 系统性地识别DNA甲基化与转录相关的区域，有助于在正常和肿瘤组织中精炼调控逻辑。 | Heery, R. | PDF | N/A | Systematic identification of regions where DNA methylation is correlated with transcription refines regulatory logic in normal and tumour tissues | | 皮肤转录组分类揭示了化脓性汗腺炎中的两种分子亚型 | Wang, J. | PDF | N/A | Classification of skin transcriptome reveals two molecular subtypes in hidradenitis suppurativa | | 广泛的克隆繁殖驱动了森林破碎化后藤本植物的扩散 | Mori, H. | PDF | N/A | Extensive clonal reproduction drives liana proliferation following forest fragmentation | | 设计、监测与应用一种经济高效的生物反应器用于沼气生产 | Ventura-Prados, A. | PDF | N/A | Design, Monitoring, and Application of a Cost-Effective Bioreactor for Biogas Production | | 美国西部库蠓幼虫发育栖息地 | Barbera, C. | PDF | N/A | Larval development habitats of Culicoides midges in the western United States | | 丝状光（FLight）生物制造微型肌腱模型展示可调节的基质限制和核形态 | Liu, H. | PDF | N/A | Filamented Light (FLight) Biofabrication of Mini-Tendon Models Show Tunable Matrix Confinement and Nuclear Morphology | | 剪切应力条件促进猪心内膜内皮细胞的促炎反应 | Ji, P. | PDF | N/A | Shear Stress Conditioning Promotes a Pro-Inflammatory Response in Porcine Endocardial Endothelial Cells | | SpecImmune利用长读长数据精确地对多种免疫相关基因家族进行基因分型。 | Wang, S. | PDF | N/A | SpecImmune accurately genotypes diverse immune-related gene families using long-read data | | 结构组-TM：通过解决基于大小的偏差来补充结构系统发育学的数据集组装 | Malik, A. J. | PDF | N/A | Structome-TM: Complementing dataset assembly for structural phylogenetics by addressing size-based biases | | 使用PDBMine和数据分析方法进行新型蛋白质结构验证 | Pandala, N. | PDF | N/A | Novel Protein Structure Validation using PDBMine and Data Analytics Approaches | | 使用RNA004化学方法的纳米孔测序技术对RNA修饰检测的计算模型进行对比评估 | Zou, Y. | PDF | N/A | A Comparative Evaluation of Computational Models for RNA modification detection using Nanopore sequencing with RNA004 Chemistry | | 基于单倍型的并行PBWT用于生物库规模数据 | Tang, K. | PDF | N/A | Haplotype-based Parallel PBWT for Biobank Scale Data | | 实验性P53凝聚-淀粉样蛋白聚集的动力学机制 | Borkosky, S. S. | PDF | N/A | EXPERIMENTAL KINETIC MECHANISM OF P53 CONDENSATION-AMYLOID AGGREGATION | | 基于机器学习的肿瘤分割与分类：利用动态光学对比成像（DOCI）技术应用于甲状腺癌 | Vasse, T. | PDF | N/A | Machine Learning-Based Tumor Segmentation and Classification Using Dynamic Optical Contrast Imaging (DOCI) for Thyroid Cancer | | 长链非编码RNA LENT与DHX36的相互作用在黑色素瘤中调控翻译并抑制自噬。 | Haller, A. | PDF | N/A | Interaction of lncRNA LENT with DHX36 regulates translation and suppresses autophagy in melanoma. | | 激活2型甲酰肽受体可减轻炎症性关节炎中的继发性器官损伤 | Margraf, A. | PDF | N/A | Formyl-peptide receptor type 2 activation mitigates secondary organ damage in inflammatory arthritis | | 细胞色素P450抑制通过Nav通道调节阻碍了拟除虫菊酯对昆虫的作用。 | Niklas, B. | PDF | N/A | Cytochrome P450 inhibition impedes pyrethroid effects on insects through Nav channel regulation | | 在植物油脂合成过程中持续的脂肪酸分解代谢 | Koley, S. | PDF | N/A | Persistent fatty acid catabolism during plant oil synthesis | | 挥发性物质介导的植物防御网络：异戊二烯作为短距离免疫信号的田间证据 | Zhu, P. | PDF | N/A | Volatile-Mediated Plant Defense Networks: Field Evidence for Isoprene as a Short-Distance Immune Signal | | 赤霉素失活酶GA2OX在拟南芥根系生长调控中作为生长素-赤霉素交互作用的枢纽 | Kubalova, M. | PDF | N/A | Gibberellin-deactivating GA2OX enzymes act as a hub for auxin-gibberellin crosstalk in Arabidopsis thaliana root growth regulation | | 分析五种甲烷减排饲料添加剂对多个商业奶牛场牛奶产量及相关参数的影响 | Altshuler, Y. | PDF | N/A | ANALYSIS OF THE IMPACT OF FIVE METHANE MITIGATING FEED ADDITIVES ON MILK PRODUCTION AND ASSOCIATED PARAMETERS ACROSS MULTIPLE COMMERCIAL DAIRY FARMS | | Seq-Scope-eXpanded: 超越光学分辨率的空间组学 | Anacleto, A. | PDF | N/A | Seq-Scope-eXpanded: Spatial Omics Beyond Optical Resolution | | 一种受生物启发的潜在TGF-β共轭支架改善了新软骨的发育 | Wang, T. | PDF | N/A | A Bio-inspired Latent TGF-β Conjugated Scaffold Improves Neocartilage Development | | 狐猴（Lemur）：一种单细胞基础模型，无需微调即可实现果蝇（Drosophila melanogaster）的层次化细胞类型生成 | Botas, J. | PDF | N/A | Lemur: A Single-Cell Foundation Model with Fine-Tuning-Free Hierarchical Cell-Type Generation for Drosophila melanogaster | | 转录因子19是一种对雄激素有反应的基因，它调节血管稳态并维持转移性前列腺癌的发展。 | Carracedo, A. | PDF | N/A | Transcription factor 19 is an androgen responsive gene that modulates vessel homeostasis and sustains metastatic prostate cancer | | 条件性与先天性的基于努力的任务揭示了抗抑郁药物对雄性小鼠动机状态影响的分歧 | Xeni, F. | PDF | N/A | Conditioned versus innate effort-based tasks reveal divergence in antidepressant effect on motivational state in male mice | | 部分分化的回肠和远端结肠人类F508del-CF-肠类器官1在福斯高林和利那洛肽的刺激下分泌液体。 | Rong, Y. | PDF | N/A | Partially differentiated enterocytes in ileal and distal-colonic human F508del-CF-enteroids 1 secrete fluid in response to forskolin and linaclotide. | | 抗癫痫药物卡马西平在丘脑网状核中的作用：加重失神发作的潜在机制 | Jang, S.-S. | PDF | N/A | Actions of the Anti-Seizure Drug Carbamazepine in the Thalamic Reticular Nucleus: Potential Mechanism of Aggravating Absence Seizures | | 软木橡树叶挥发物排放的化学型多样性表明其质量和数量存在独立的地理变异。 | Staudt, M. | PDF | N/A | Chemotype diversity of foliar volatile emissions in Cork oak suggests independent geographic variations in quality and quantity | | 在模拟的核糖体中，近同源tRNA在密码子解码时间中占主导地位。 | Hedayioglu, F. | PDF | N/A | Near-cognate tRNAs dominate codon decoding times in simulated ribosomes | | 光氧化诱导轴突珠状结构的研究 | MEHTA, D. | PDF | N/A | Investigation of Axonal Beading Induced by Photo-oxidation | | 来自HIV-1 gp120处理小鼠的循环细胞外囊泡作为内源性致痛物质，介导并维持HIV相关的慢性疼痛。 | Yuan, S. | PDF | N/A | Circulating extracellular vesicles from HIV-1 gp120-treated mice act as endogenous algogens, mediating and maintaining HIV-associated chronic pain | | 线粒体代谢在成熟的中性粒细胞中迅速重新激活，以支持刺激诱导的反应。 | Lika, J. | PDF | N/A | Mitochondrial metabolism is rapidly re-activated in mature neutrophils to support stimulation-induced response | | 免疫诱导的TCR样抗体调节特异性T细胞反应 | Kishida, K. | PDF | N/A | Immune-induced TCR-like antibodies regulate specific T cell response | | 单细胞RNA测序揭示川崎病患者中浆细胞亚群改变及自然杀伤细胞（NK细胞）细胞毒性降低 | Zhou, Y. | PDF | N/A | Single-cell RNA-seq reveals altered plasma cell subsets and decreased cytotoxicity of NK cells in patients with Kawasaki diseas | | NLRC5在癌症免疫监视和癌症免疫编辑中的关键作用 | Shukla, A. | PDF | N/A | Essential role of NLRC5 in cancer immune surveillance and cancer immunoediting | | HSCs（造血干细胞）和Tregs（调节性T细胞）在慢性炎症条件下协同作用，以维持髓外造血功能。 | Kuzmina, M. | PDF | N/A | HSCs and Tregs cooperate to preserve extramedullary hematopoiesis under chronic inflammation | | 与真核生物相关的古菌谱系编码功能性二萜类环化酶。 | McShea, H. | PDF | N/A | Archaeal lineages related to eukaryotes encode functional diterpenoid cyclases | | 果蝇胚胎的细胞化过程受到皮质-膜相互作用的粘弹性动力学的调节。 | Stark, K. | PDF | N/A | Drosophila embryo cellularization is modulated by the viscoelastic dynamics of cortical-membrane interactions | | 一项多模型集成研究揭示了美国中西部农田通过再生农业实践实现土壤碳增益的情况 | Basso, B. | PDF | N/A | A Multi-Model Ensemble Reveals Soil Carbon Gains from Regenerative Practices in the U.S. Midwest Cropland | | 集成深度学习和地理定位技术，用于基于无人机的动物追踪，支持灵活相机角度 | Samad, I. | PDF | N/A | Integrated deep learning and geo-referencing for drone-based animal tracking with flexible camera angles | | 消费者韧性抑制了过度放牧生态系统的恢复 | Spindel, N. B. | PDF | N/A | Consumer resilience suppresses the recovery of overgrazed ecosystems | | 土壤微生物群落的功能多样性随着生态系统的发展而增加 | Ranheim Sveen, T. | PDF | N/A | Functional diversity of soil microbial communities increases with ecosystem development | | 旧版与新版HCHS/SOL本地祖先推断方法比较研究

在这项研究中，我们对比了HCHS/SOL（西班牙裔社区健康研究/拉丁裔研究）中使用的旧版和新版本地祖先推断方法。通过详细分析两种方法在准确性、效率和适用性等方面的差异，我们旨在为研究人员提供更清晰的指导，以便在未来的遗传学研究中选择最合适的工具。 | Chen, X. | PDF | N/A | Old vs. New Local Ancestry Inference in HCHS/SOL: A Comparative Study | | 非编码与编码机制在甲状腺功能障碍相关的射血分数保留型心力衰竭中的老化作用 | Chakraborty, S. | PDF | N/A | Noncoding and Coding Mechanisms of Aging Heart Failure with Preserved Ejection Fraction with Thyroid Dysfunction | | CobVar - 一个全面的维生素B12相关基因组变异资源 | HS, N. | PDF | N/A | CobVar - a comprehensive resource of Vitamin B 12-associated genomic variants | | 人类多能干细胞中药物-基因表达特征的综合分析揭示了ALS和单基因疾病的新型候选药物 | Roussange, F. | PDF | N/A | Integrative Analysis of Drug-Gene Expression Signatures in Human Pluripotent Stem Cells Identifies Novel Drug Candidates for ALS and Monogenic Diseases | | 关于近东火蜥蜴（Salamandra infraimmaculata）行为和发展的实验研究揭示了其应对水生捕食者的一般策略 | Reinhardt, T. | PDF | N/A | Experimental insights on the behaviour and development of Near Eastern Fire salamanders (Salamandra infraimmaculata) indicate general strategies to cope with aquatic predators | | 甘氨酸生物合成的阐明与从头重构 | Sun, Y. | PDF | N/A | Elucidation and de novo Reconstitution of Glyceollins Biosynthesis | | 尺寸可调的DNA折纸结构通过动态交叉实现 | Li, X. | PDF | N/A | Size switchable DNA origami structure enabled by dynamic crossovers | | 剪切应力调节猪内皮细胞的炎症反应，促进猪心脏成纤维细胞的纤维化反应 | Ji, P. | PDF | N/A | Shear Stress Modulates Inflammatory Responses in Porcine Endothelial Cells Contributing to the Fibrotic Response of Porcine Cardiac Fibroblasts | | 一种高效、快速且微创的方法，用于将带有穿透性亚细胞直径碳纤维电极的单个非功能性微尘植入大鼠皮层。 | Letner, J. G. | PDF | N/A | A method for efficient, rapid, and minimally invasive implantation of individual non-functional motes with penetrating subcellular-diameter carbon fiber electrodes into rat cortex | | 以下是这段文字的中文翻译：

由诱导多能干细胞衍生的间充质干细胞和功能性支架生物工程化的血管

翻译说明： - Blood Vessels：血管 - Bioengineered：生物工程化的 - Induced Pluripotent Stem Cell (iPSC)：诱导多能干细胞 - Mesenchymal Stem Cells (MSCs)：间充质干细胞 - Functional Scaffolds：功能性支架

局部拓扑结构与全局连接模式在络石（Trachelospermum jasminoides）中的初步研究

翻译说明： - "Local Topological Structures" 翻译为“局部拓扑结构”，指的是在特定区域内（如植物组织或网络）的形态或连接方式。 - "Global Connectivity Patterns" 翻译为“全局连接模式”，指的是整体范围内的连接或相互作用方式。 - "Trachelospermum jasminoides" 是植物学名，中文名为“络石”或“茉莉络石”。 - "Pilot Study" 翻译为“初步研究”或“试点研究”，表示这是一项探索性的研究。

这段翻译将原文的科技内容准确地转换为中文，同时保持了原文的学术语气和结构。翻译中，“Peptide-induced hydration of lipid bilayers”被译为“肽诱导的脂质双层水合作用”，准确传达了肽对脂质双层水合作用的影响。“modulates packing pattern and conformations of hydrocarbon chains”译为“调节烃链的堆积模式和构象”，清晰地表达了肽对烃链结构的影响。最后，“a potential pathway for peptide translocation?”译为“肽转运的潜在途径？”，保留了原文的疑问语气，暗示了这一现象可能对肽转运机制的重要性。整体翻译既忠实于原文，又符合中文表达习惯，适合在学术或专业场合使用。 | Pasalic, L. | PDF | N/A | Peptide-induced hydration of lipid bilayers modulates packing pattern and conformations of hydrocarbon chains - a potential pathway for peptide translocation? | | 小鼠体内视网膜电图（Electroretinogram, ERG）的生物物理基础：通过遗传学和药理学方法分离的杆状光感受器驱动电流的电流源密度分析

在这项研究中，我们探讨了小鼠体内视网膜电图（ERG）的生物物理基础，特别是通过遗传学和药理学方法分离的杆状光感受器驱动的电流。我们采用了电流源密度分析（Current Source Density Analysis, CSDA）技术，以精确地定位和量化这些电流的来源和分布。通过这种方法，我们能够更好地理解杆状光感受器在视觉信号传递中的作用，以及它们在视网膜电图中的具体贡献。这项研究不仅增进了我们对视网膜生理学的理解，也为相关视觉疾病的诊断和治疗提供了新的视角。 | Peinado Allina, G. | PDF | N/A | Biophysical Basis of the in vivo Electroretinogram of the Mouse: Current Source Density Analysis of Genetically and Pharmacologically Isolated Rod photoreceptor-driven Currents | | 核磁共振光谱用于验证AlphaFold2结构 | Sachleben, J. R. | PDF | N/A | NMR Spectroscopy for the Validation of AlphaFold2 Structures | | SPTnet：一种用于端到端单粒子追踪和运动动力学分析的深度学习框架 | Bi, C. | PDF | N/A | SPTnet: a deep learning framework for end-to-end single-particle tracking and motion dynamics analysis | | 癌症功能基因组学中的性别差异：基因依赖性与药物敏感性 | Zeltser, N. | PDF | N/A | Sex Differences in Cancer Functional Genomics: Gene Dependency and Drug Sensitivity | | PARP抑制剂在同源重组能力强的去势抵抗性前列腺癌中引发不同的转录程序 | Cunningham, M. L. | PDF | N/A | PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration-resistant prostate cancer | | 胰腺癌中的垂直RAS通路抑制驱动了可治疗性利用的线粒体改变 | Hafner, P. | PDF | N/A | Vertical RAS-pathway inhibition in pancreatic cancer drives therapeutically exploitable mitochondrial alterations | | 稳健预测患者特异性癌症标志的神经多任务学习模型：一项模型开发与验证研究 | Priyadarshi, S. | PDF | N/A | Robust Prediction of Patient-Specific Cancer Hallmarks Using Neural Multi-Task Learning: a model development and validation study | | 黑种草（Nigella sativa）和菊苣（Cichorium intybus）在动物实验模型中的抗糖尿病作用 | Kashif, M. | PDF | N/A | Anti-Diabetic Effects of Nigella sativa and Cichorium intybus in Animal Experimental Model | | 通过Cell Painting技术在3D球状体中进行高内涵形态学分析。 | Ringers, C. | PDF | N/A | High-content morphological profiling by Cell Painting in 3D spheroids. | | 高温和低溶解氧的累积效应会改变湖鳟的急性热耐受性和细胞应激反应。 | Weinrauch, A. M. | PDF | N/A | Cumulative effects of high temperature and low dissolved oxygen alter the acute thermal tolerance and cellular stress response in lake trout | | 在射血分数保留的心力衰竭双重打击小鼠模型中，纠正饮食和自主运动对心肌恢复的相对贡献。 | Labbe, E.-A. | PDF | N/A | Relative contributions of correcting the diet and voluntary exercise to myocardial recovery in a two-hit murine model of heart failure with preserved ejection fraction. | | ABCG1转运蛋白对于地钱（Marchantia polymorpha）油体腔内萜类化合物的生物合成是必需的。 | Forestier, E. C. F. | PDF | N/A | The ABCG1 transporter is required for terpene biosynthesis in the lumen of Marchantia polymorpha oil bodies. | | 干扰素-β增强子的基因调控逻辑包含多种选择性部署的转录因子协同模式。 | Schiffman, A. | PDF | N/A | Gene regulatory logic of the interferon-β enhancer contains multiple selectively deployed modes of transcription factor synergy | | 大多数常见的鹿角异常的原因并非骨折，而是一种类似骨髓炎的疾病——慢性变形性蒂炎（Pedunculitis Chronica Deformans）。 | Sukosd, F. | PDF | N/A | The Cause of Most Common Antler Abnormality is Not a Fracture But an Osteomyelitis Like Disease the Pedunculitis Chronica Deformans | | 空间转录组学揭示了在铜宗（cuprizone）模型中，与多发性硬化症病变一致的大脑区域之间存在异质性细胞-细胞相互作用。 | Tsai, H.-H. | PDF | N/A | Spatial transcriptomics reveals heterogeneous cell-cell interactions among brain regions in a cuprizone model consistent with multiple sclerosis lesions | | 初级视觉皮层的跨丘脑回路破坏会影响小鼠的视觉辨别能力 | McKinnon, C. | PDF | N/A | Disruption of transthalamic circuitry from primary visual cortex impairs visual discrimination in mice | | 慢性不可预测轻度应激小鼠中的调节性T细胞和活化T细胞：性别差异及治疗效果 | Niu, M. | PDF | N/A | Regulatory T and activated T cells in the chronic unpredictable mild stress mice: sex differences and effects of treatments | | B细胞IgD低表达（BDL）B细胞过表达GITRL是一种治疗策略，旨在增加内源性CD4+Foxp3+调节性T细胞，以用于治疗自身免疫性疾病。 | Khalil, M. I. | PDF | N/A | Overexpression of GITRL by B cell IgD low (BDL) B cells is a therapeutic strategy to increase endogenous CD4+Foxp3+ T regulatory cells for the treatment of autoimmunity | | IRF7控制自发性自身免疫性生发中心和浆细胞检查点。 | Fike, A. J. | PDF | N/A | IRF7 controls spontaneous autoimmune germinal center and plasma cell checkpoints | | 一种新型CAR T细胞混合物，靶向PDPN和GD2以克服胶质母细胞瘤的异质性 | Nickl, V. | PDF | N/A | A novel CAR T cell blend targeting PDPN and GD2 to overcome glioblastoma heterogeneity | | 在白尾鹿接种蜱细胞外囊泡疫苗后，对美洲钝眼蜱抗原的鉴定 | Oliva Chavez, A. | PDF | N/A | Identification of Amblyomma americanum antigens after vaccination with tick extracellular vesicles in white-tailed deer | | G蛋白偶联受体OXER1是一种组织氧化还原传感器，对于肠上皮屏障的完整性至关重要。 | Lengyel, M. | PDF | N/A | The G-protein coupled receptor OXER1 is a tissue redox sensor essential for intestinal epithelial barrier integrity. | | NKG7是跨免疫环境和肿瘤微环境内细胞毒性的稳定标志物。 | Turiello, R. | PDF | N/A | NKG7 is a stable marker of cytotoxicity across immune contexts and within the tumor microenvironment | | DHRS7通过氧代二十烷酸途径将NADP+/NADPH氧化还原感应与炎症性脂质信号传导整合在一起。 | Ma, Y. | PDF | N/A | DHRS7 Integrates NADP+/NADPH Redox Sensing with Inflammatory Lipid Signalling via the Oxoeicosanoid Pathway | | 被抑制的巨噬细胞对具有群体感应活性的化脓性链球菌的反应发生在细胞核水平。 | Feldstein, S. F. | PDF | N/A | Suppressed macrophage responses to quorum-sensing-active Streptococcus pyogenes occurs at the level of the nucleus | | 持续的糖酵解定义了对外来聚合物植入物的异物反应。 | Rempe, C. | PDF | N/A | Persistent glycolysis defines the foreign body response to polymeric implants. | | 从富含菌株的宏基因组样本中进行的种内关联分析 | Qu, E. B. | PDF | N/A | Intraspecies associations from strain-rich metagenome samples | | 蜘蛛螨唾液蛋白的双重角色：在摄食和丝纤维涂层中的作用 | Arai, Y. | PDF | N/A | Salivary proteins in spider mites: dual roles in feeding and silk fiber coating | | Igf2调控出生后早期DPP4+前脂肪细胞池的扩张 | Altun, I. | PDF | N/A | Igf2 regulates early postnatal DPP4+ preadipocyte pool expansion | | 渗漏碳酸盐岩内部和表面的独特微生物群落支持长期甲烷厌氧氧化及新型甲烷单加氧酶（pMMO）多样性 | Mayr, M. J. | PDF | N/A | Distinct Microbial Communities Within and On Seep Carbonates Support Long-term Anaerobic Oxidation of Methane and Novel pMMO Diversity | | 青蛙的皮肤微生物群在个体和身体部位之间存在差异，这些差异反映了已知的壶菌感染模式。 | Ghose, S. L. | PDF | N/A | Skin microbiomes of frogs vary among individuals and body regions, revealing differences that reflect known patterns of chytrid infection | | 基于Transformer的时间因果分析解析动态基因调控网络 | Peng, R. | PDF | N/A | Dissecting dynamic gene regulatory network using transformer-based temporal causality analysis | | {Phi}-Space ST：一种平台无关的方法，用于在空间转录组学研究中识别细胞状态 | Mao, J. | PDF | N/A | {Phi}-Space ST: a platform-agnostic method to identify cell states inspatial transcriptomics studies | | 动态μ-PBWT：面向生物样本库规模数据的动态游程压缩PBWT | Shakya, P. | PDF | N/A | Dynamic μ-PBWT: Dynamic Run-length Compressed PBWT for Biobank Scale Data | | 分子动力学模拟的机器学习为病毒衣壳组装的调控提供了深入见解。 | Pavlova, A. | PDF | N/A | Machine learning of molecular dynamics simulations provides insights into modulation of viral capsid assembly | | 6-硫代-2'-脱氧鸟苷通过诱导形成无功能的停滞端粒酶复合物来抑制端粒延长。 | Sanford, S. L. | PDF | N/A | 6-thio-2-deoxyguanosine inhibits telomere elongation by inducing a non-productive stalled telomerase complex | | IAP拮抗剂增强TNFα触发的细胞凋亡，但能够独立于TNFα选择性清除衰老的肿瘤细胞。 | Ochiiwa, H. | PDF | N/A | IAP antagonists potentiate TNFα-triggered apoptosis but selectively eliminate senescent tumor cells independently of TNFα | | 冷冻电镜揭示了M5毒蕈碱型乙酰胆碱受体的一个新的变构结合位点。 | Burger, W. A. C. | PDF | N/A | Cryo-EM reveals a new allosteric binding site at the M5 mAChR | | 游泳运动通过机械激活Piezo1引发斑马鱼幼体血管内皮细胞中的Ca2+事件。 | Jia, B. Z. | PDF | N/A | Swimming motions evoke Ca2+ events in vascular endothelial cells of larval zebrafish via mechanical activation of Piezo1 | | 自然变异的光保护：蕨类植物中快速的NPQ动力学 | Maryn, N. | PDF | N/A | Natural Variation in Photoprotection: Rapid NPQ Kinetics in Ferns | | 瘤胃经济学：对健康绵羊瘤胃代谢物的评估揭示了不同性别、年龄和体重间差异产生的代谢物 | Munoz-Briones, J. | PDF | N/A | Rumenomics: Evaluation of rumen metabolites from healthy sheep identifies differentially produced metabolites across sex, age, and weight | | CCR2在肺结核期间招募单核细胞到肺部，而CX3CR1则调节单核细胞衍生的CD11c阳性细胞在淋巴结中的定位。 | Mohapatra, A. | PDF | N/A | CCR2 recruits monocytes to the lung, while CX3CR1 modulates positioning of monocyte-derived CD11cpos cells in the lymph node during pulmonary tuberculosis | | 通过对奥斯陆峡湾水环境DNA（eDNA）的时间序列分析，研究水生群落的动态变化。 | Mahlangu, S. | PDF | N/A | Investigating the dynamics of the aquatic community in Oslofjord through time series analysis of eDNA | | 翻译终止因子eRF3在核糖体上依次与eRF1和ABCE1相互作用 | Wada, M. | PDF | N/A | The Translation Termination Factor eRF3 Interacts Sequentially with eRF1 and ABCE1 on the Ribosome | | 以下是这段文字的中文翻译：

染色体水平的基因组组装：Protandrena (Anthemurgus) passiflorae（膜翅目：地蜂科），一种专性寄主植物蜜蜂

这段文字描述了一种通过模拟伤口反应来促进植物体内基因转化、再生和基因编辑的技术。具体来说，研究者利用一系列由伤口触发的发育调控因子，来增强植物的转化效率和再生能力，从而更有效地进行基因编辑。这种方法可能通过模拟植物在自然环境中受到伤害后的修复机制，来激活特定的基因表达和发育途径，进而提高基因操作的效率和成功率。 | Kshetry, A. | PDF | N/A | Shoot at Site: Advancing in planta transformation, regeneration and gene-editing through a cascade of wounding-mediated developmental regulators | | 对禾谷镰刀菌核心效应子候选物进行排序显示，在赤霉病期间，多种真菌蛋白靶向小麦细胞核。 | Ayilalath, S. | PDF | N/A | Sorting F. graminearum core effector candidates shows multiple fungal proteins that target the wheat cell nucleus during Fusarium Head Blight | | 一种卵菌效应子能够诱导植物产生类似避荫反应的生长，并抑制植物的防御反应，其作用靶标是AUX/IAA蛋白IAA11。 | Bogino, M. F. | PDF | N/A | An oomycete effector that induces shade avoidance like growth and suppresses plant defenses targets the AUX/IAA protein IAA11 | | 拟南芥叶质外体中模式触发免疫的蛋白质组学景观 | Chen, H.-C. | PDF | N/A | The Proteomics Landscape of Pattern Triggered Immunity in the Arabidopsis Leaf Apoplast | | 在简化基因组中的定量必需性：功能、调控和结构的适应性图谱 | Miravet-Verde, S. | PDF | N/A | Quantitative essentiality in a reduced genome: a functional, regulatory and structural fitness map | | BESTDR：细胞培养中机制特异性药物反应的贝叶斯量化 | McDonald, T. O. | PDF | N/A | BESTDR: Bayesian quantification of mechanism-specific drug response in cell culture | | 采用计算与实验相结合的方法，成功预测了人类乳腺癌中转移性肿瘤相关巨噬细胞的行为。 | Bekkar, A. | PDF | N/A | A combined computational and experimental approach to successfully predict the behavior of metastatic tumor-associated macrophages in humanbreast cancer | | 动态预测性空间编码在后顶叶皮层V6A区的运动意图 | Buonfiglio, A. R. | PDF | N/A | Dynamic Predictive Spatial Encoding of Motor Intentions In Area V6A of the Posterior Parietal Cortex | | KHSRP介导的轴突定位的Prenyl-Cdc42 mRNA降解减缓神经再生 | Zdradzinski, M. D. | PDF | N/A | KHSRP-mediated Decay of Axonally Localized Prenyl-Cdc42 mRNA Slows Nerve Regeneration | | 使用基于任务的功能磁共振成像（fMRI）在不同脉冲序列协议下测试Vogt-Bailey指数 | Galea, K. | PDF | N/A | Testing the Vogt-Bailey Index using task-based fMRI across pulse sequence protocols | | 阿尔茨海默病小鼠模型中白细胞介素-6失调的影响：揭示淀粉样变性之外的复杂性 | Canal, C. | PDF | N/A | Effects of Interleukin-6 dysregulation in a mouse model of Alzheimer's disease: unraveling the complexity beyond amyloidosis | | 在持续感染期间，新近从胸腺迁出的T细胞优先被招募到记忆池中。 | Hilt, Z. T. | PDF | N/A | Recent thymic emigrants are preferentially recruited into the memory pool during persistent infection | | 使用统计学习解码T细胞受体对人类白细胞抗原等位基因的限制 | ElAbd, H. | PDF | N/A | Decoding the restriction of T cell receptors to human leukocyte antigen alleles using statistical learning | | 一种自组装的交叉保护性抗原，用于对抗多种革兰氏阳性医院感染病原体 | Kramarska, E. | PDF | N/A | A self-assembling cross-protective antigen against multiple Gram-positive nosocomial pathogens | | 肥大细胞中的原始类固醇生成：肥大细胞功能的新调控机制 | Pramanik, J. | PDF | N/A | Primitive steroidogenesis in mast cells: A novel regulatory mechanism for mast cell function | | 有丝分裂极性振荡促进上皮肿瘤进展 | Jeyanathan, G. | PDF | N/A | Mitotic polarity oscillation promotes epithelial tumor progression | | 测量活体斑马鱼胚胎中多个空间尺度的形态素运输 | Nelanuthala, A. V. S. | PDF | N/A | Measuring morphogen transport over multiple spatial scales in live zebrafish embryos | | 生物生长曲线是两条不同的S型曲线的总和。 | S, S. I. | PDF | N/A | A biological growth curve is a sum of two distinct S-curves | | 超越代理：迈向森林管理中抗旱性的生态生理指标 | COPIE, A. | PDF | N/A | Beyond Proxies: Towards ecophysiological indicators of drought resistance for forest management | | 以下是这段文字的中文翻译：

寄生虫介导的野生马鹿近交衰退

解释： - Parasite-mediated：寄生虫介导的 - inbreeding depression：近交衰退（指近亲繁殖导致的种群适应性下降） - wild red deer：野生马鹿（红鹿）

全细胞类型连续染色质状态注释所有IHEC表观基因组

其中： - Pan-cell type 表示“全细胞类型” - continuous chromatin state annotation 表示“连续染色质状态注释” - IHEC epigenomes 表示“IHEC表观基因组”

整句话的意思是：对所有IHEC表观基因组进行全细胞类型的连续染色质状态注释。 | Daneshpajouh, H. | PDF | N/A | Pan-cell type continuous chromatin state annotation of all IHEC epigenomes | | 在牛的大环内酯类抗药性螨虫（Psoroptes ovis）中，一种细胞色素P450和两种UDP-葡萄糖醛酸转移酶基因的过表达和拷贝数增加。 | Hearn, J. | PDF | N/A | Over-expression and increased copy numbers of a cytochrome P450 and two UDP-glucuronosyltransferase genes in macrocyclic lactone resistant Psoroptes ovis of cattle | | 基因组报告：柑橘入侵性害虫——木槿粉蚧（Nipaecoccus viridis，Newstead）的基因组序列 | Liesenfelt, T. | PDF | N/A | Genome report: Genome sequence of the hibiscus mealybug, Nipaecoccus viridis (Newstead), an invasive pest of citrus | | ERGA-BGE 参考基因组：Loboptera subterranea，一种适应洞穴生活的蟑螂，为加那利群岛特有物种 | Lopez, H. | PDF | N/A | ERGA-BGE Reference Genome of Loboptera subterranea: a cave adapted cockroach endemic to the Canary Islands | | 基因组范围内不确定性调节的多样本功能基因组学数据信号注释提取 | Hamilton, N. H. | PDF | N/A | Genome-Wide Uncertainty-Moderated Extraction of Signal Annotations from Multi-Sample Functional Genomics Data | | CD4+ 黏膜相关不变性T细胞（MAIT细胞）表达高度多样化的T细胞受体。 | Kaur, R. | PDF | N/A | CD4+ Mucosal-associated Invariant T (MAIT) cells express highly diverse T cell receptors | | 全反式视黄酸与近视发生中的液体转运 | Dvoriashyna, M. | PDF | N/A | All-trans retinoic acid and fluid transport in myopigenesis | | 延迟注射润滑素可提高兔体内骨软骨缺损模型中软骨修复组织的质量 | Yoon, D. | PDF | N/A | Delayed lubricin injection improves cartilage repair tissue quality in an in vivo rabbit osteochondral defect model | | 通过分离特定于不同分类群的肽序列来揭示多样性 | Bochalis, E. | PDF | N/A | Unraveling diversity by isolating peptide sequences specific to distinct taxonomic groups | | VirMake：一个灵活且用户友好的流程，用于从鸟枪法宏基因组测序数据中进行病毒分类和功能特征分析 | Birkeland, E. | PDF | N/A | VirMake: a flexible and user-friendly pipeline for viral taxonomic and functional characterisation from shotgun metagenomic sequencing data | | 随机区组设计的通用核机器比较分析框架 | Koh, H. | PDF | N/A | A general kernel machine comparative analysis framework for randomized block designs | | 超越黑名单：对排除集生成策略及替代方法的批判性评估 | Wall, B. P. G. | PDF | N/A | Beyond Blacklists: A Critical Assessment of Exclusion Set Generation Strategies and Alternative Approaches | | 超越单一的RNA结构：基于三级结构的复杂感知特征融合用于RNA设计 | Zhang, Z. | PDF | N/A | Beyond RNA Structure Alone: Complex-Aware Feature Fusion for Tertiary Structure-based RNA Design | | 环境污染物对单核多组学实验中的去复用方法的影响 | Li, T. | PDF | N/A | The impact of ambient contamination on demultiplexing methods for single-nucleus multiome experiments | | 通过随机子序列草图进行序列相似性估计 | Chen, K. | PDF | N/A | Sequence similarity estimation by random subsequence sketching | | 从机制解释性到机制生物学：在蛋白质语言模型上训练、评估和解释稀疏自编码器 | Adams, E. | PDF | N/A | From Mechanistic Interpretability to Mechanistic Biology: Training, Evaluating, and Interpreting Sparse Autoencoders on Protein Language Models | | 评估时间序列单细胞RNA测序数据降维中的差异 | Hackenberg, M. | PDF | N/A | Evaluating discrepancies in dimensionality reduction for time-series single-cell RNA-sequencing data | | SAMCell：基于Segment Anything的通用无标签生物细胞分割 | VandeLoo, A. D. | PDF | N/A | SAMCell: Generalized Label-Free Biological Cell Segmentation with Segment Anything | | 非线性三维牵引力显微镜（3DTFM）中异质细胞外基质（ECM）力学特性的逆向建模 | Apolinar-Fernandez, A. | PDF | N/A | Inverse modeling of heterogeneous ECM mechanical properties in nonlinear 3DTFM | | 在tau蛋白凝聚体老化过程中，以单纤维分辨率观察到的液-固共存现象 | Sahu, M. S. R. | PDF | N/A | Liquid-solid coexistence at single fibril resolution during tau condensate ageing | | 大肠杆菌生物膜在基质成分改变下的机械性能比较：结合剪切流变学和微压痕技术的研究 | Siri, M. | PDF | N/A | Mechanical comparison of Escherichia coli biofilms with altered matrix composition: a study combining shear-rheology and microindentation | | 脂多糖纳米盘，一种用于研究细菌表面的仿生平台。 | Abbas, M. | PDF | N/A | Lipopolysaccharides nanodiscs, a biomimetic platform to study bacterial surface. | | 核糖核蛋白凝聚物中核苷酸特异的RNA构象和动力学 | Wang, T. | PDF | N/A | Nucleotide-specific RNA conformations and dynamics within ribonucleoprotein condensates | | 渗透调节剂对蛋白质折叠景观的结构和热力学效应 | Pereira, A. F. | PDF | N/A | Osmolyte-Induced Structural and Thermodynamic Effects on the Protein Folding Landscape | | 光谱STED显微镜通过使用对极性敏感的探针提高了光谱灵敏度，并能够对膜的有序性和异常脂质扩散进行相关测量。 | Urbancic, I. | PDF | N/A | Spectral STED microscopy improves spectral sensitivity with polarity-sensitive probes and enables correlative measurements of membrane order and anomalous lipid diffusion | | 利用生成式人工智能和密度引导模拟对冷冻电镜结构进行替代状态建模 | Shugaeva, T. | PDF | N/A | Modeling cryo-EM structures in alternative states with generative AI and density-guided simulations | | 针对BRAF激酶融合，采用泛RAF和垂直MAPK抑制策略 | Turner, J. A. | PDF | N/A | Targeting BRAF kinase fusions with pan-RAF and vertical MAPK inhibition | | 磁铁矿纳米颗粒光热疗法在胰腺肿瘤芯片中的应用：一种针对癌细胞及其微环境的双重作用方法 | Dubrova, A. | PDF | N/A | Magnetite Nanoparticle Photothermal Therapy in a Pancreatic Tumor-on-Chip: A Dual-Action Approach Targeting Cancer Cells and their Microenvironment | | 系统药理学筛选揭示幕上室管膜瘤中Mertk及其他可靶向激酶的存在

双眼竞争中的呼吸诱发感知交替的储层模型

高羊茅新型内生菌株的基因组特征显示杂交后基因组片段化

翻译解释： - "Genomic Characterization" 翻译为 "基因组特征" - "Novel Endophyte Strains" 翻译为 "新型内生菌株" - "Tall Fescue" 翻译为 "高羊茅"（一种常见的牧草） - "Genome Fragmentation" 翻译为 "基因组片段化" - "Post-Hybridization" 翻译为 "杂交后"

整体翻译为：高羊茅新型内生菌株的基因组特征显示杂交后基因组片段化 | Lee, K. C. | PDF | N/A | Genomic Characterization of Novel Endophyte Strains from Tall Fescue Shows Genome Fragmentation Post-Hybridization | | 通过对群体范围内的基因组分析，揭示了褐藻（Undaria pinnatifida）中多个核质病毒门（Nucleocytoviricota）病毒谱系的感染特征。 | Ban, H. | PDF | N/A | Infection signatures of multiple Nucleocytoviricota virus lineages in the brown algae Undaria pinnatifida revealed by population-wide genome analysis | | 长读长检测低甲基化拟南芥个体体细胞中转座因子移动的情况 | Movilli, A. | PDF | N/A | Long-read detection of transposable element mobilization in the soma of hypomethylated Arabidopsis thaliana individuals | | EpiFoundation：通过峰到基因对齐的单细胞ATAC-seq基础模型 | Wu, J. | PDF | N/A | EpiFoundation: A Foundation Model for Single-Cell ATAC-seq via Peak-to-Gene Alignment | | 利用纵向基因分型数据在菌株水平上区分新发感染与持续感染 | Nickols, W. A. | PDF | N/A | Distinguishing new from persistent infections at the strain level using longitudinal genotyping data | | 对25种包括患者特异性突变的C. elegans疾病模型进行高通量行为表型分析 | O'Brien, T. J. | PDF | N/A | High-throughput behavioural phenotyping of 25 C. elegans disease models including patient-specific mutations | | 下一代蛋白质测序和单离子质谱技术能够实现白细胞介素-6的互补分析。 | Skinner, K. A. | PDF | N/A | Next-Generation Protein Sequencing and individual ion mass spectrometry enable complementary analysis of interleukin-6 | | 多功能模块化抗体用于灵敏且特异性检测聚ADP核糖 | Dauben, H. | PDF | N/A | Versatile Modular Antibodies for Sensitive and Specific Detection of Poly-ADP-Ribose | | ALK2:BMP6的冷冻电镜结构揭示了ALK2能够与BMP和Activin配体相互作用的不同机制。 | Goebel, E. J. | PDF | N/A | CryoEM structure of ALK2:BMP6 reveals distinct mechanisms that allow ALK2 to interact with both BMP and Activin ligands | | 实时捕获σN转录起始中间体揭示了ATP酶通过有限展开驱动的激活机制 | Mueller, A. U. | PDF | N/A | Real-time capture of σN transcription initiation intermediates reveals mechanism of ATPase-driven activation by limited unfolding | | 引导链延长微生物群以乙醇和乳酸为共电子供体生成特定中链羧酸盐：最大化C8或C6产量 | Wang, H. | PDF | N/A | Steering the chain-elongating microbiome to specific medium-chain carboxylates with ethanol and lactate as co-electron donors: maximizing C8 or C6 | | 在多阶段肿瘤生长模型中M1和M2巨噬细胞的时空动态 | Lampropoulos, I. | PDF | N/A | Spatio-temporal dynamics of M1 and M2 macrophages in a multiphase model of tumor growth | | 利用非发情期雌鼠和惠顿效应高效制备假孕雌鼠 | Noguchi, Y. | PDF | N/A | Efficient Production of Pseudopregnant Female Mice Using Non-Estrous Individuals and the Whitten Effect | | 基准测试参考基因组选择对分类学分析准确性的影响 | van Bemmelen, J. | PDF | N/A | Benchmarking the impact of reference genome selection on taxonomic profiling accuracy | | Coralysis通过多层次整合，能够在单细胞数据中敏感地识别出不平衡的细胞类型和状态。 | Sousa, A. G. G. | PDF | N/A | Coralysis enables sensitive identification of imbalanced cell types and states in single-cell data via multi-level integration | | 评估蒙特卡洛模拟在统计上评估系统发育树拓扑一致性中的应用 | DuBose, J. G. | PDF | N/A | Evaluating the use of Monte Carlo simulation for statistically assessing topological congruence of phylogenetic trees | | Top-DTI：整合拓扑深度学习和大型语言模型用于药物靶点相互作用预测 | Talo, M. | PDF | N/A | Top-DTI: Integrating Topological Deep Learning and Large Language Models for Drug Target Interaction Prediction | | 从未组装的长度读取中增强泛基因组图 | Denti, L. | PDF | N/A | Pangenome graph augmentation from unassembled long reads | | 以下是“The fluid genomic organisation of jingmenviruses”的中文翻译：

景门病毒的流动基因组结构

如果需要进一步的解释或调整，请告诉我！ | Valle, C. | PDF | N/A | The fluid genomic organisation of jingmenviruses | | X-CRISP：领域适应性强且可解释的CRISPR修复结果预测 | Seale, C. | PDF | N/A | X-CRISP: Domain-Adaptable and Interpretable CRISPR Repair Outcome Prediction | | LRTM：用于分子相互作用预测的左右转移矩阵 | Zheng, K. | PDF | N/A | LRTM: Left-Right Transition Matrices for Molecular Interaction Prediction | | IQI：个体化数量性状基因座（QTL）指数 | Xu, J. | PDF | N/A | IQI: Individualized Quantitative trait loci (QTL) Index | | 空间转录组学中细胞类型混合物的稀疏去卷积 | SOGUNMEZ ERDOGAN, N. | PDF | N/A | Sparse deconvolution of cell type medleys in spatial transcriptomics | | 基于预训练图编码器和语言模型的激酶-抑制剂结合亲和力预测 | Guo, X. | PDF | N/A | Kinase-Inhibitor Binding Affinity Prediction with Pretrained Graph Encoder and Language Model | | 计算人类细胞色素P450超家族中突变的致病性 | Mondal, S. | PDF | N/A | Computing pathogenicity of mutations in human cytochrome P450 superfamily | | 抗原依赖性IgG寡聚化及补体结合的动力学模型 | Strasser, J. | PDF | N/A | A kinetic model of antigen-dependent IgG oligomerization and complement binding | | 电活性细胞的磁激活 | Duret, G. | PDF | N/A | Magnetic activation of electrically active cells | | 细胞表面聚糖的埃级分辨率成像 | Masullo, L. | PDF | N/A | Angstrom-resolution imaging of cell-surface glycans | | CDKN2A低表达的癌细胞在与巨噬细胞竞争微环境中的锌时占据优势，从而驱动免疫治疗的抵抗性。 | Buj, R. | PDF | N/A | CDKN2ALow cancer cells outcompete macrophages for microenvironmental zinc to drive immunotherapy resistance | | 基于siRNA的靶向PRDM2的治疗候选药物用于抑制肺癌进展 | Kumar, S. | PDF | N/A | siRNA-based Therapeutic Candidate Targeting PRDM2 for Inhibition of Lung Cancer Progression | | 己糖激酶从线粒体上解离驱动了瓦伯格效应，以支持区室化的ATP生成。 | Huggler, K. S. | PDF | N/A | Hexokinase detachment from mitochondria drives the Warburg effect to support compartmentalized ATP production | | 整合多组学分析揭示了DNA甲基化景观在塑造转移性黑色素瘤生物学异质性和临床行为中的作用 | Anichini, A. | PDF | N/A | Integrated multi-omics profiling reveals the role of the DNA methylation landscape in shaping biological heterogeneity and clinical behaviour of metastatic melanoma | | 靶向FGFR4消除HNF1A驱动的胰腺导管腺癌转移 | Crawford, K. J. | PDF | N/A | Targeting FGFR4 Abrogates HNF1A-driven Metastasis in Pancreatic Ductal Adenocarcinoma | | SARS-CoV-2感染大脑：K18-hACE2小鼠模型揭示血管系统在嗜神经病毒感染中的作用和反应

这段翻译成中文为：SARS-CoV-2感染大脑：K18-hACE2小鼠模型用于说明血管系统在嗜神经病毒感染中的角色和反应。 | De Neck, S. | PDF | N/A | SARS-CoV-2 infection of the brain: the K18-hACE2 mouse model to illustrate the role and response of the vasculature in neurotropic viral infection | | 开启裸子植物基因功能研究的新篇章：麻黄（Ephedra tweedieana）中的病毒诱导基因沉默技术（VIGS）应用 | Garcia, A. G. | PDF | N/A | Enabling the Study of Gene Function in Gymnosperms: VIGS in Ephedra tweedieana | | 定义差异性蒸腾的极限 | Sinha, R. | PDF | N/A | Defining the limits of differential transpiration | | 将玉米叶绿体atpB基因功能性地重新定位到细胞核中，可以恢复经过基因编辑的非光合作用突变体的光合能力。 | Mangu, V. R. | PDF | N/A | Functional relocation of the maize chloroplast atpB gene to the nucleus restores photosynthetic competence to a gene-edited non-photosynthetic mutant | | 绿藻Auxenochlorella中的异源二倍体杂交、杂合性丢失和非整倍体现象，这一新兴模型在发现研究和生物工程中的应用 | Craig, R. J. | PDF | N/A | Allodiploid hybridization, loss-of-heterozygosity and aneuploidy in the green alga Auxenochlorella, an emerging model for discovery research and bioengineering | | 在Physcomitrella光生物反应器中生产HPV-16 L1病毒样颗粒 | Niederau, P. A. | PDF | N/A | Production of HPV-16 L1 virus-like particles in Physcomitrella photobioreactors | | 木薯预育种群体增强粉虱耐受性的代谢组学特征分析 | Perez-Fons, L. | PDF | N/A | Metabolomics characterisation of cassava pre-breeding populations with enhanced whitefly tolerance | | 从成像到计算领域：物理驱动的分子生物学模拟——血小板团块中的受阻扩散 | House, C. | PDF | N/A | From imaging to computational domains for physics-driven molecular biology simulations: Hindered diffusion in platelet masses | | OTULIN相互作用组揭示小鼠模型中与Tau蛋白病相关的免疫反应和自噬 | Li, L. | PDF | N/A | OTULIN Interactome Reveals Immune Response and Autophagy Associated with Tauopathy in a Mouse Model | | 多重CRISPRi揭示了在成熟新皮层中KLF激活因子与抑制因子之间的转录开关 | Kirk, R. W. | PDF | N/A | Multiplexed CRISPRi Reveals a Transcriptional Switch Between KLF Activators and Repressors in the Maturing Neocortex | | 结直肠癌中不同调节性T细胞亚群的抗肿瘤和促肿瘤功能 | Huang, X. | PDF | N/A | Anti- and Pro-tumor Functions of Distinct Regulatory T Cell Subsets in Colorectal Cancer | | 人类结肠干细胞是对细菌抗原的主要上皮反应者。 | de Vries, M. H. | PDF | N/A | Human colon stem cells are the principal epithelial responders to bacterial antigens | | 早期感染隐孢子虫（Cryptosporidium parvum）会引发对膳食抗原的炎症反应。 | Saraav, I. | PDF | N/A | Early-life infection with Cryptosporidium parvum induces inflammatory responses to dietary antigens | | 来自Shewanella oneidensis多鞭毛蛋白鞭毛的曲率生成与工程原理 | Lou, Q. | PDF | N/A | Curvature generation and engineering principles from Shewanella oneidensis multi-flagellin flagellum | | 第三代头孢菌素抗生素在人类肠道微生物组中诱导噬菌体爆发。 | PFEIFER, E. | PDF | N/A | Third-generation cephalosporin antibiotics induce phage bursts in the human gut microbiome. | | 在厌氧消化反应器的稳定运行期、故障期及恢复期进行以微生物组为导向的操作监测数据挖掘。 | Panou, M. | PDF | N/A | Microbiome-oriented data mining of operational monitoring of anaerobic digestion reactor during steady operation period, failure, and restoration. | | 构建一个低温降解玉米秸秆的合成细菌群落 | Fang, Y. | PDF | N/A | Construction of a low-temperature degrading synthetic bacterial community of corn straw | | 乳酸脱氢酶是莱姆病细菌伯氏疏螺旋体（Borrelia burgdorferi）的阿喀琉斯之踵。 | Sze, C. W. | PDF | N/A | Lactate dehydrogenase is the Achilles' heel of Lyme disease bacterium Borreliella burgdorferi | | 将染色体组织与古菌的基因组分离相耦合 | Kabli, A. F. | PDF | N/A | Coupling chromosome organization to genome segregation in Archaea | | 体外生物膜形成能力与抗生素耐药性大肠杆菌在无菌羔羊生菜上持久性的相关性 | Schlechter, R. O. | PDF | N/A | Correlation of in vitro biofilm formation capacity with persistence of antibiotic-resistant Escherichia coli on gnotobiotic lamb's lettuce | | 组蛋白H2B在赖氨酸120位点的乙酰化调控BRD4与基因间增强子的结合 | Hamilton, G. A. | PDF | N/A | Acetylation of histone H2B on lysine 120 regulates BRD4 binding to intergenic enhancers | | 体细胞突变区分了人类皮肤中黑色素细胞的不同亚群。 | Tandukar, B. | PDF | N/A | Somatic mutations distinguish melanocyte subpopulations in human skin | | 蛾类相机灯光陷阱是否提供与传统漏斗灯光陷阱相似的数据？ | Brehm, G. | PDF | N/A | Do camera light traps for moths provide similar data as conventional funnel light traps? | | 以下是这段英文的中文翻译：

"Bivalent启动子的从头DNA甲基化通过PRC2的置换诱导基因激活"

解释： - De-novo DNA Methylation：从头DNA甲基化，指的是在DNA上新增甲基化修饰的过程。 - Bivalent Promoters：双价启动子，指同时具有激活和抑制标记的基因启动子区域。 - PRC2 Displacement：PRC2（Polycomb Repressive Complex 2，多梳抑制复合物2）的置换，即PRC2从DNA上被移除。 - Gene Activation：基因激活，指基因从沉默状态转变为表达状态。

"喂养对厌氧连续搅拌槽反应器（CSTR）中微生物组和沼气组成的影响"

翻译说明： 1. "feeding" 在这里翻译为"喂养"，指的是向反应器中添加底物或营养物质的过程。 2. "microbiome" 翻译为"微生物组"，指反应器中的微生物群落。 3. "biogas composition" 翻译为"沼气组成"，指沼气中各成分的比例和含量。 4. "anaerobic CSTR" 翻译为"厌氧连续搅拌槽反应器"，是一种常见的厌氧消化反应器类型。

来自库克湾兔子溪的海洋三刺棘鱼（Gasterosteus aculeatus）基因组序列

翻译说明： - Genome Sequence 翻译为“基因组序列”。 - Marine Threespine Stickleback 是“海洋三刺棘鱼”，这是一种小型鱼类。 - Gasterosteus aculeatus 是这种鱼的学名，通常直接保留拉丁名。 - Rabbit Slough 是地名，翻译为“兔子溪”。 - Cook Inlet 是阿拉斯加的一个海湾，翻译为“库克湾”。

希望这段翻译对你有帮助！ | Au, E. H. | PDF | N/A | Genome Sequence of a Marine Threespine Stickleback (Gasterosteus aculeatus) from Rabbit Slough in the Cook Inlet | | 联合单细胞CRISPR-Cas9编辑与转录组分析揭示了广泛的脱靶事件及其对基因表达的影响 | Lorenzini, M. H. | PDF | N/A | Joint single-cell profiling of CRISPR-Cas9 edits and transcriptomes reveals widespread off-target events and their effects on gene expression | | 从多模态数据中发现细胞信号通路 | He, C. | PDF | N/A | Cell signaling pathways discovery from multi-modal data | | 细胞膜系链上力的幂律衰减反映了膜张力的长程松弛。 | Laborie, E. | PDF | N/A | Power-law decay of force on cell membrane tethers reflects long-ranged relaxation of membrane tension | | 胰腺癌内在的HuR调控细胞外囊泡的促肿瘤特性 | Finan, J. M. | PDF | N/A | Pancreatic cancer-intrinsic HuR regulates the pro-tumorigenic properties of extracellular vesicles | | 探索ID4作为三阴性乳腺癌中侵袭性的驱动因素及治疗靶点 | Toro, C. D. | PDF | N/A | Exploring ID4 as a Driver of Aggression and a Therapeutic Target in Triple-Negative Breast Cancer | | 七个血液生物标志物与透明细胞肾细胞癌患者的TGF-β和VHL-HIF信号通路相关 | Mallikarjuna, P. | PDF | N/A | Seven blood biomarkers are associated with TGF-β and VHL-HIF signaling in patients with clear cell renal cell carcinoma | | 内皮细胞Pannexin1过表达以性别依赖性方式影响缺血性中风的结果 | Tomas-Gracia, M. | PDF | N/A | Endothelial cell Pannexin1 overexpression impairs ischemic stroke outcome in a sex-dependent manner | | 黄斑病变患者视觉皮层中的运动处理 | Michaud, C. | PDF | N/A | Motion processing in visual cortex of maculopathy patients | | 皮质星形胶质细胞激活引发脑膜伤害感受和偏头痛样疼痛 | Bree, D. | PDF | N/A | Cortical astrocyte activation triggers meningeal nociception and migraine-like pain | | 可卡因长期接触会导致大鼠出现类似强迫性的寻求行为。 | Tapia-Pacheco, M. | PDF | N/A | Cocaine extended access gates compulsive-like seeking in rats | | 可长期植入的μLED阵列用于小鼠皮层表面光遗传学刺激 | Greer, R. | PDF | N/A | Chronically implantable μLED arrays for optogenetic cortical surface stimulation in mice | | DMT引发的临界状态变化与自我消解相关。 | Irrmischer, M. | PDF | N/A | DMT-induced shifts in criticality correlate with ego-dissolution | | 桥接蛋白介导的病毒靶向表达内源性μ-阿片G蛋白偶联受体的小鼠和猴脑细胞 | Kamaguchi, R. | PDF | N/A | Bridge protein-mediated viral targeting of cells expressing endogenous μ-opioid G protein-coupled receptors in the mouse and monkey brain | | 光遗传学对侧线感觉系统的探究揭示了斑马鱼大脑中模式分离的机制 | Velez, N. | PDF | N/A | Optogenetic interrogation of the lateral-line sensory system reveals mechanisms of pattern separation in the zebrafish brain | | 协同性MAPT突变作为揭示tau蛋白病理修饰因子的平台 | Bryan, M. R. | PDF | N/A | Synergistic MAPT mutations as a platform to uncover modifiers of tau pathogenesis | | 计算通过动力学基准：神经活动动力学模型的模拟数据集与质量评估指标 | Versteeg, C. | PDF | N/A | Computation-through-Dynamics Benchmark: Simulated datasets and quality metrics for dynamical models of neural activity | | 分枝杆菌感染揭示了库普弗细胞的可塑性 | Neuber, J. | PDF | N/A | Mycobacterial infection uncovers plasticity of Kupffer cells | | NEk8激酶的过表达抑制同源重组 | Turner, J. L. | PDF | N/A | Overexpression of the NEk8 kinase inhibits homologous recombination | | 群落层面的植物功能策略解释了热带海拔梯度上生态系统碳储存的变化 | Mauki, D. G. | PDF | N/A | Community-level plant functional strategies explain ecosystem carbon storage across a tropical elevational gradient | | 迈向通过地质时间追踪鸟类迁徙行为：一种同位素和组织学方法 | Duhamel, A. | PDF | N/A | Towards a tracking of bird migratory behaviour through geological time: an isotopic and histological approach | | 使用脂质纳米颗粒在胎盘中进行细胞因子mRNA传递及局部免疫调节 | Hofbauer, S. I. | PDF | N/A | Cytokine mRNA Delivery and Local Immunomodulation in the Placenta using Lipid Nanoparticles | | 使用经验贝叶斯方法进行多样本、多平台的异构体定量分析 | Talukder, A. | PDF | N/A | Multi-sample, multi-platform isoform quantification using empirical Bayes | | IgG4的另一种折叠状态：酸诱导的紧缩在IgG1和IgG4之间是常见的 | Imamura, H. | PDF | N/A | Alternatively Folded State of IgG4: Acid-Induced Compaction is Common between IgG1 and IgG4 | | 基质改变了基质金属蛋白酶-1的动态性、变构性及配体结合亲和力。 | SARKAR, S. K. | PDF | N/A | The substrate changes matrix metalloprotease-1 dynamics, allostery, and ligand binding affinity | | 具有20纳米内径的肺炎球菌溶菌素纳米孔，用于表征Tau寡聚体的大小和形状。 | Mukhopadhyay, A. | PDF | N/A | Pneumolysin nanopores with 20 nm inner diameter to characterize the size and shape of Tau oligomers | | TLR4调节辛伐他汀对HDL胆固醇和血糖控制的影响 | Tian, X. | PDF | N/A | TLR4 Modulates Simvastatin's Impact on HDL Cholesterol and Glycemic Control | | 一个整合性的AMPA受体运输模型揭示了局部翻译在亚型特异性动力学中的核心贡献 | Wagle, S. | PDF | N/A | An integrative model of AMPA receptor trafficking reveals the central contribution of local translation in subtype-specific kinetics | | 一个基因多样性的小鼠模型揭示了认知弹性和阿尔茨海默病易感性的复杂基因-环境调控机制。 | Dunn, A. R. | PDF | N/A | A genetically-diverse mouse model reveals a complex gene-environment regulation of cognitive resilience and susceptibility to Alzheimer disease | | 迷走神经刺激以层次特异性的方式调节大鼠听觉皮层中持续活动的信息表征。 | Shiramatsu, T. I. | PDF | N/A | Vagus nerve stimulation modulates information representation of sustained activity in layer specific manner in the rat auditory cortex | | 补充性磁共振（MR）白质测量及其与心血管健康和认知功能的关系 | Raykov, P. P. | PDF | N/A | Complementary MR measures of white matter and their relation to cardiovascular health and cognition | | 分子趋同分析鉴定出对白蜡树枯梢病病原体低易感性的候选基因 | Kelly, L. J. | PDF | N/A | Molecular convergence analyses identify candidate genes for low susceptibility to the ash dieback pathogen |

medRxiv

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Echo-Vision-FM：一种用于超声心动图视频视觉基础模型的预训练与微调框架	Zhang, Z.	PDF	N/A	Echo-Vision-FM: A Pre-training and Fine-tuning Framework for Echocardiogram Videos Vision Foundation Model
2024-2025呼吸道病毒季节流感疫苗的中期有效性	Shrestha, N. K.	PDF	N/A	Interim Effectiveness of the Influenza Vaccine for the 2024-2025 Respiratory Viral Season
改变医生行为表现：继续医学教育策略、持续职业发展和知识转化的效果系统综述与荟萃分析（1950-2024年，75年）	Abbasi, E.	PDF	N/A	Changing Physician Performance: A Systematic Review and Meta-Analysis (75 years 1950-2024) of the Effect of Continuing Medical Education Strategies, Continuous Professional Development and knowledge Translation
性别歧视与医学生发展	Venkataraman, S.	PDF	N/A	Gender Discrimination and Medical Student Development
应用双向孟德尔随机化评估肠道微生物组与食管癌之间的关系	Chataway, J.	PDF	N/A	Application of bidirectional Mendelian randomization to assess the relationship between the gut microbiome and esophageal cancer
组织多重化方法：从珍贵的病理标本中最大化空间转录组学输出	KAO, Y.-C.	PDF	N/A	A tissue multiplexing approach to maximise spatial transcriptomics output from precious pathology specimens
校准的功能数据降低了第一级单基因疾病的临床不确定性：以长QT综合征为例	Ng, C. A.	PDF	N/A	Calibrated Functional Data Decreases Clinical Uncertainty for Tier 1 Monogenic Disease: Application to Long QT Syndrome
在英国生物银行（UK Biobank）进行的一项全基因组研究中，发现了与痛风相关的新遗传变异（样本量N = 150,542）。	Tao, Y.	PDF	N/A	Novel Genetic Variants Associated with Gout Identified Through a Genome-Wide Study in the UK Biobank (N = 150,542)
患者咨询委员会对败血症幸存者康复的影响：一项案例研究	Sheehan, M.	PDF	N/A	Impacts of patient advisory councils on recovery for sepsis survivors: a case study
长期新冠（Long COVID）的生理-情感症状与急性感染期的严重程度、抗氧化剂水平降低、一氧化氮水平降低以及丙氨酸转氨酶水平降低密切相关。	Maes, M.	PDF	N/A	The physio-affective symptoms of Long COVID are strongly predicted by the severity of the acute infectious phase, and lowered antioxidants, nitric oxide, and alanine transaminase levels.
利用哨兵血清学数据重建西尼罗河病毒在加勒比海岛屿上15年间的隐性传播情况	Hamouche, C.	PDF	N/A	Reconstructing the silent circulation of West Nile Virus in a Caribbean island during 15 years using sentinel serological data
在单中心SpasT-SCI-T试验中，钙蛋白酶介导的钠通道片段：中枢神经系统损伤和痉挛预测的生物标志物	Baucher, G.	PDF	N/A	Calpain-mediated sodium channel fragments in the monocentric SpasT-SCI-T trial: Biomarkers for central nervous system injuries and spasticity prediction
心血管10年风险评分评估：一项快速系统综述	Adhikari, C.	PDF	N/A	Appraisal of Cardiovascular 10-yr Risk Scores: A Rapid Systematic Review
循环因果蛋白网络与未来心肌梗死风险相关	Emilsson, V.	PDF	N/A	Circulating causal protein networks linked to future risk of myocardial infarction
2019年丹麦成年人获得补贴牙科服务的实践水平差异：一项基于登记的研究	Raittio, E.	PDF	N/A	Practice-level variation in the provision of subsidized dental services to adult Danes in 2019: A register-based study
青少年心肺健康与未来抑郁及抗抑郁药物使用风险：一项基于全国队列的兄弟姐妹对照研究	Ballin, M.	PDF	N/A	Adolescent Cardiorespiratory Fitness and Future Risk of Depression and Antidepressants: A Nationwide Cohort Study with Sibling Comparators
新一代驱虫蚊帐在防治疟疾中的效果级联：从昆虫学试验到现实生活条件	Champagne, C.	PDF	N/A	Cascades of effectiveness of new-generation insecticide-treated nets against malaria, from entomological trials to real-life conditions
探索社区获得性大肠杆菌尿路感染的多药耐药模式与机器学习	Hodbert, E.	PDF	N/A	Exploring multidrug resistance patterns in community-acquired E. coli urinary tract infections with machine learning
短期系统性皮质类固醇对儿童和青少年的危害：随机对照试验的系统回顾与荟萃分析	Lima, J. P.	PDF	N/A	Harms of short-course systemic corticosteroids among children and adolescents: a systematic review and meta-analysis of randomized controlled trials
揭示婴儿在生命最初六个月中不同的运动发展轨迹	Elmer, R. C.	PDF	N/A	Uncovering distinct motor development trajectories in infants during the first half year of life
母亲育儿风格与黎巴嫩大学生饮食失调之间的关联：自尊自我评估维度的中介作用	El Khoury Malhame, M.	PDF	N/A	The association between maternal parenting styles and eating disorders among Lebanese university students: The mediating role of the self-assessment dimension of self-esteem
社区社会经济状况与牙买加城市地区心脏代谢结果的关系：探索新的测量方法	Dyer, H. P.	PDF	N/A	Neighborhood Socioeconomic Status and Cardiometabolic Outcomes in Urban Jamaica: Exploring Novel Measures
估计全球对抗流感大流行的口服抗病毒治疗储备需求及其潜在公共卫生影响：一项数学模型研究	Han, A. X.	PDF	N/A	Estimating the global demand and potential public health impact of oral antiviral treatment stockpile for influenza pandemics: a mathematical modelling study
练习水晶：推动国家国际卫生条例联络点能力强化的模拟训练	Goddard, L.	PDF	N/A	Exercise Crystal: simulations that drive National IHR Focal Point capacity strengthening
量化社会污名化身份对自我报告整体健康状况的加性和乘性影响	LeStage, K.	PDF	N/A	Quantifying additive and multiplicative effects of socially stigmatized identities on self-reported overall health
2022年哥伦比亚猴痘感染者中HIV病史的流行率及相关因素	MUNOZ LOZADA, C. M.	PDF	N/A	Prevalence of HIV history and associated factors in people affected by mpox in Colombia, 2022
贫困和社区食品环境对家庭食品环境、父母喂养方式以及儿童饮食行为、食物偏好和体重指数（BMI）的影响：伦敦家庭食品体验研究	Smith, A. D.	PDF	N/A	The impact of deprivation and neighbourhood food environments on home food environments, parental feeding practices, and child eating behaviours, food preferences and BMI: The Family Food Experience Study-London
探索海绵窦硬脑膜动静脉瘘中的“可见与不可见”范式	Zheng, J.	PDF	N/A	Exploring the 'Visible Versus Invisible' Paradigm in Cavernous Sinus Dural Arteriovenous Fistula
基于丘脑连接性的生物标志物用于难治性癫痫患者的神经调控	Aiello, G.	PDF	N/A	Thalamic connectivity-based Biomarkers for Neuromodulation in Patients with Refractory Epilepsies
人类肌萎缩侧索硬化症/运动神经元病：与疾病相关的小胶质细胞通路被上调，而APOE ε2具有保护作用。	Ashford, B.	PDF	N/A	Human amyotrophic lateral sclerosis/motor neuron disease: The disease-associated microglial pathway is upregulated and APOE ε2 is protective.
使用单细胞测序技术对中风血栓进行特征分析	Renedo, D.	PDF	N/A	Characterizing Stroke Clots Using Single-Cell Sequencing
探索床垫传感器睡眠技术：老年评估住院环境中跨学科团队的见解	Zhao, Y.	PDF	N/A	Exploring bed sensor sleep technology: insights from an interdisciplinary team in a geriatric assessment inpatient setting
通过混合浓度限制和摄入偏好进行个人饮食推断	Turkia, J.	PDF	N/A	Personal Diet Inference Through Mixture of Concentration Constraints and Intake Preferences
一项关于帕博利珠单抗/西妥昔单抗新辅助治疗在局部晚期下咽癌中的回顾性疗效与安全性研究	Yao, G.	PDF	N/A	A Retrospective Efficacy and Safety Study of Pembrolizumab/ Cetuximab Neoadjuvant Therapy in Locally Advanced Hypopharyngeal Cancer
验证来自变异效应多重分析（MAVEs）的数据：一项由CanVIG-UK进行的针对NHS临床科学家的全国调查	Allen, S.	PDF	N/A	Validating data from Multiplex Assays of Variant Effect (MAVEs): A CanVIG-UK National Survey of NHS Clinical Scientists
哮喘靶组织基因调控表达预测与特征分析	Slack, S. D.	PDF	N/A	Prediction and Characterization of Genetically Regulated Expression of Target Tissues in Asthma
对于那些旨在达成共识的会议领导者，人们有何期待？一项范围界定审查及其对提高健康研究资助同行评审和临床指南制定质量的影响	Ghannad, M.	PDF	N/A	What is expected of people who lead meetings where the goal is to reach consensus? A scoping review with implications for improving the quality of health research grant peer review and clinical guideline development
在传染病爆发期间，对“担忧健康者”行为进行数学建模	Singh, B.	PDF	N/A	Mathematically modeling worried-well behavior during infectious disease outbreaks
围手术期凝血因子VIII的药代动力学变化使得A型血友病患者的个体化治疗变得复杂。	Janssen, A.	PDF	N/A	Variable pharmacokinetics of coagulation factor VIII in the perioperative settting complicates personalisation of treatment in patients with haemophilia A
疫苗对5至17岁曾感染SARS-CoV-2个体的有效性：来自RECOVER项目的基于电子健康记录的目标试验模拟研究	Chen, J.	PDF	N/A	Vaccine Effectiveness Among 5- to 17-year-old Individuals with Prior SARS-CoV-2 Infection: An EHR-Based Target Trial Emulation Study from the RECOVER Project
评估结直肠癌中基因型与表型关联的深度学习：一项多中心研究	Gustav, M.	PDF	N/A	Assessing Genotype-Phenotype Correlations with Deep Learning in Colorectal Cancer: A Multi-Centric Study
马拉维霍乱死亡的决定因素：2022-23年疫情中患者层面和临床管理因素的病例对照研究。	Chitatanga, R.	PDF	N/A	Determinants of cholera fatalities in Malawi: A case-control study of patient-level and clinical management factors in the 2022-23 outbreak.