BioRxiv 2025-02-09 Papers
| 标题 | 作者 | PDF链接 | 代码仓库 | Title |
|---|---|---|---|---|
| 视觉皮层中的曲率形成：我们如何进行采样？ | Nisar, I. | N/A | Curvature formation in the visual cortex: How do we sample? | |
| 增殖细胞靶向和上皮细胞更新促进了戊型肝炎病毒在人类肠道类器官中的复制 | Santos-Ferreira, N. | N/A | Proliferative cell targeting and epithelial cell turnover fuels hepatitis E virus replication in human intestinal enteroids | |
| 建立一种优化且自动化的全脑神经元活动探测工作流程。 | CABRERA, S. | N/A | Establishment of an optimized and automated workflow for whole brain probing of neuronal activity. | |
| DprA招募ComM以促进革兰氏阴性细菌在自然转化过程中的重组。 | Dalia, T. N. | N/A | DprA recruits ComM to facilitate recombination during natural transformation in Gram-negative bacteria | |
| 基于连接组的通用和特定执行功能预测模型 | Qu, S. | N/A | Connectome-based Predictive Models of General and Specific Executive Functions | |
| 蛋白质-蛋白质相互作用是遗传相互作用网络中上位性的主要来源。 | Castellanos-Girouard, X. | N/A | Protein-protein interaction is a major source of epistasis in genetic interaction networks | |
| 极度濒危的阿拉伯瞪羚（Gazella arabica acacia）的饮食策略对保护的影响 | Lavie, N. | N/A | Conservation implications of dietary strategies in the critically endangered Acacia gazelle (Gazella arabica acacia) | |
| 发送混合信号：在亚马逊蝴蝶的同胞姐妹物种中，趋同的虹彩与分化的化学信号 | Ledamoisel, J. | N/A | Sending mixed signals: convergent iridescence and divergent chemical signals in sympatric sister-species of Amazonian butterflies | |
| 杏仁核GABA神经元：压力与繁殖的守门人 | Yu, J. | N/A | Amygdala GABA Neurons: Gatekeepers of Stress and Reproduction | |
| 静态三维结构决定间期染色体远端位点对之间的快速动态 | Shi, G. | N/A | Static Three-Dimensional Structures Determine Fast Dynamics Between Distal Loci Pairs in Interphase Chromosomes | |
| 在骨骼肌和大脑中条件性地消融肌营养不良蛋白会对肌肉功能、神经行为以及细胞外基质通路产生深远影响。 | Karuppasamy, M. | N/A | Conditional Dystrophin ablation in the skeletal muscle and brain causes profound effects on muscle function, neurobehavior, and extracellular matrix pathways | |
| AI辅助的蛋白质设计技术能够快速将抗体序列转化为针对多种肽段和组蛋白修饰的细胞内抗体。 | Galindo, G. | N/A | AI-assisted protein design to rapidly convert antibody sequences to intrabodies targeting diverse peptides and histone modifications | |
| 光氧化诱导的轴突珠状化研究 | Mehta, D. | N/A | Investigation of Axonal Beading Induced by Photo-oxidation | |
| 使用基于任务的功能性磁共振成像（fMRI）测试Vogt-Bailey指数在不同脉冲序列协议下的表现 | Galea, K. | N/A | Testing the Vogt-Bailey Index using task-based fMRI across pulse sequence protocols | |
| 空间扫描：利用地理数据识别冈比亚按蚊中的有益等位基因 | Rehmann, C. T. | N/A | Sweeps in space: leveraging geographic data to identify beneficial alleles in Anopheles gambiae | |
| 中国南方小型哺乳动物感染组分析揭示生态关联及多种病原体的新兴威胁 | xin, g. | N/A | Infectome Analysis of Small Mammals in Southern China Reveals Ecological Associations and Emerging Threats from Diverse Pathogens | |
| 纳伊罗病毒（nairoviruses）的广泛多样性揭示了中国东北地区蜱传疾病的复杂性和高风险。 | Wang, Z. | N/A | The extensive diversity of nairoviruses reveals the complexity and high risk of tick-borne diseases in northeastern China | |
| 以下是这段文字的中文翻译： |
肠聚集性大肠杆菌实验进化过程中VI型分泌系统活性丧失的分子基础
希望这个翻译对你有帮助！ | Taillefer, B. | PDF | N/A | Molecular bases for the loss of type VI secretion system activity during enteroaggregative E. coli experimental evolution | | 压力性溃疡伤口微生物组与金黄色葡萄球菌的多组学分析 | Guo, C. | PDF | N/A | Multi-Omics Analysis of Wound Microbiome and Staphylococcus aureus in Pressure Ulcer | | Senolytics恢复镰状细胞病中造血干细胞的功能 | Barve, A. | PDF | N/A | Senolytics Restore Hematopoietic Stem Cells Function in Sickle Cell Disease | | EndoMAPV1，人类内体结构蛋白质复合物景观 | Gonzalez-Lozano, M. | PDF | N/A | EndoMAPV1, a Structural Protein Complex Landscape of Human Endosomes | | 静止状态调节了高度增殖性犬肺间充质基质细胞群功能能力中与年龄相关的变化。 | Agyapong, N. | PDF | N/A | Quiescence modulates age-related changes in the functional capacity of highly proliferative canine lung mesenchymal stromal cell populations | | 利用SunTag系统研究mRNA翻译的发育调控 | Pizzey, A. | PDF | N/A | Exploiting the SunTag system to study the developmental regulation of mRNA translation | | 空间调控的mRNA降解增强了果蝇胚胎中的表达模式 | Love, J. C. | PDF | N/A | Spatially regulated mRNA decay sharpens expression patterns in the Drosophila embryo | | 废水宏蛋白质组学：追踪微生物和人类蛋白质生物标志物 | Tugui, C. G. | PDF | N/A | Wastewater metaproteomics: tracking microbial and human protein biomarkers | | 以下是这段文字的中文翻译：
通过人类颅骨三维数据的几何形态测量学研究，绳纹社会中持续且广泛的人口互动 | Nakao, H. | PDF | N/A | Continuous and widespread population interactions in the Jomon society via geometric morphometrics on 3D data of human crania | | 增强的计算与实验方法在人类真菌组比较分析中的应用 | Begum, N. | PDF | N/A | Enhanced Computational and Experimental Approaches for Comparative Analysis of the Human Mycobiome | | DDX3X抑制DDX3Y的多种机制 | Xu, X. | PDF | N/A | Diverse mechanisms of DDX3Y suppression by DDX3X | | 三元开关决定ERα LBD构象 | McDougal, D. P. | PDF | N/A | A ternary switch determines ERα LBD conformation | | 评估曼陀罗叶提取物的抗氧化、抗癌和抗菌活性：微生物学视角 | Arora, S. | PDF | N/A | Evaluation of Antioxidant Anticancer and Antimicrobial Activities of Datura Leaf Extracts: A Microbiological Perspective | | 通过数据和机制驱动的分布式大规模网络模型解码酵母转录调控 | Fan, X. | PDF | N/A | Decoding yeast transcriptional regulation via a data- and mechanism-driven distributed large-scale network model | | RadiSeq：一种用于辐射损伤细胞模型的单细胞和批量细胞全基因组DNA测序模拟器 | Mathew, F. | PDF | N/A | RadiSeq: a single- and bulk-cell whole-genome DNA sequencing simulator for radiation-damaged cell models | | 赤霉素介导的DELLA蛋白降解的结构分析 | Islam, S. | PDF | N/A | Structural analyses of gibberellin-mediated DELLA protein degradation | | 多谱系转录和细胞通讯特征定义了在类风湿性关节炎高风险个体中启动和持续疾病的途径。 | Liu, C. | PDF | N/A | Multi-lineage transcriptional and cell communication signatures define pathways in individuals at-risk for developing rheumatoid arthritis that initiate and perpetuate disease | | ERK在由多种生长因子和化疗药物驱动的胰腺癌细胞上皮-间质转化（EMT）异质性中起着保守的主导作用。 | Barbeau, M. C. | PDF | N/A | ERK plays a conserved dominant role in pancreas cancer cell EMT heterogeneity driven by diverse growth factors and chemotherapies | | 从公民到科学家：评估地中海群岛上的蚂蚁观察准确性 | Arcos, J. | PDF | N/A | From citizen to scientist: evaluating ant observation accuracy on a Mediterranean archipelago | | 一种半自动化的MEA尖峰排序（SAMS）方法，用于高通量评估培养的神经元 | Ren, X. | PDF | N/A | A Semi-Automated MEA Spike sorting (SAMS) method for high throughput assessment of cultured neurons | | 复杂的氮氧化还原耦合控制着北极高地yedoma融土层的甲烷排放 | Bergman, O. | PDF | N/A | Complex nitrogen redox couplings control methane emissions from Arctic upland yedoma taliks | | 细菌间的跨膜合作可以促进细胞内致病性 | Schator, D. | PDF | N/A | Cross-membrane cooperation among bacteria can facilitate intracellular pathogenesis | | 临床分离的肠杆菌属细菌能够在人类巨噬细胞中持续存在，而无需细菌复制，并且对细胞的毒性极小。 | Parau, G. | PDF | N/A | Clinical isolates of Enterobacter species can persist in human macrophages without bacterial replication and minimal cellular cytotoxicity | | HIV-1衣壳适应以挽救IP6包装缺陷的结构基础 | Zhu, Y. | PDF | N/A | Structural basis for HIV-1 capsid adaption to rescue IP6-packaging deficiency | | 通过厌氧荧光报告基因在极端耐药细菌中进行体内成像和追踪VRE-微生物群相互作用 | Treat, B. R. | PDF | N/A | In Vivo Imaging and Tracking of VRE-Microbiota Interactions via Anaerobic Fluorescent Reporters in Extremely Drug-Resistant Bacteria | | 维生素K依赖性蛋白质γ-谷氨酰羧化的分子基础 | Zhong, Q. | PDF | N/A | Molecular basis of vitamin K-dependent protein γ-glutamyl carboxylation | | 可编程粘弹性水凝胶揭示了机械感知的时间尺度并指导细胞极性 | Hsiao, S.-K. | PDF | N/A | Programmable viscoelastic hydrogels uncover mechano-sensing timescales and direct cell polarity | | 胆固醇介导的APOE4星形胶质细胞溶酶体功能障碍促进人脑组织中α-突触核蛋白病理 | Mesentier-Louro, L. A. | PDF | N/A | Cholesterol-mediated Lysosomal Dysfunction in APOE4 Astrocytes Promotes α-Synuclein Pathology in Human Brain Tissue | | ## 儿童早期语言处理功能特化于额下回的证据：基于功能性近红外光谱个体化功能兴趣通道的研究
本研究利用功能性近红外光谱技术（fNIRS），采用个体化功能兴趣通道（individual functional channels of interest, iFCOI）方法，为儿童早期语言处理功能特化于额下回（inferior frontal regions）提供了证据。
研究背景: 儿童早期是语言能力发展的关键时期，而额下回被认为是语言处理的重要脑区。然而，关于儿童早期额下回语言功能特化的具体机制仍不清楚。
研究方法: 本研究招募了X名X-X岁的儿童，利用fNIRS技术监测他们在执行语言任务时的脑部活动。与传统的基于组水平分析的方法不同，本研究采用iFCOI方法，针对每个个体识别出对语言任务反应最强烈的fNIRS通道，从而更精确地定位个体水平的语言相关脑区。
研究结果: 研究发现，大多数儿童在执行语言任务时，额下回区域的fNIRS信号显著增强。iFCOI方法成功识别出个体水平的语言相关脑区，并且这些脑区主要集中于额下回。
研究结论: 本研究为儿童早期语言处理功能特化于额下回提供了新的证据。iFCOI方法的应用为研究儿童脑功能发育提供了更精确、更个体化的研究手段。
关键词: 儿童早期，语言处理，额下回，功能性近红外光谱，个体化功能兴趣通道 | LUO, H. | PDF | N/A | Functional Specialization for Language Processing in Inferior Frontal Regions During Early Childhood: Evidence from functional near-infrared spectroscopy individual functional channels of interest approach |