BioRxiv 2025-02-11 Papers

标题	作者	PDF链接	代码仓库	Title
具有紫色背面叶片的植物：气孔分布指标的存储库	Almeida Filho, H. A.	PDF	N/A	Plants with purple abaxial leaves: A repository of metrics from stomata distribution
拟南芥肌醇多磷酸激酶在磷酸盐稳态中调节COP9信号体去neddyl化酶功能	Walia, Y.	PDF	N/A	Arabidopsis inositol polyphosphate kinases regulate COP9 signalosome deneddylase functions in phosphate-homeostasis
斑胸草雀的听觉皮层能够重建同类歌曲中被遮挡的音节。	Le, B.	PDF	N/A	The zebra finch auditory cortex reconstructs occluded syllables in conspecific song
在氮缺乏的环境中，来自根瘤菌目（Rhizobiales）的非蓝藻固氮菌能够支持海洋微藻的生长。	Chandola, U.	PDF	N/A	Non-cyanobacterial diazotrophs from the Rhizobiales order support marine microalgae in nitrogen-depleted environments
卡尔文-本森-巴沙姆循环中的景天庚酮糖-1,7-二磷酸酶（SBPase）结构，来自模式微藻莱茵衣藻（Chlamydomonas reinhardtii）。	Le Moigne, T.	PDF	N/A	Structure of the Calvin-Benson-Bassham sedoheptulose-1,7-bisphosphatase SBPase from the model microalga Chlamydomonas reinhardtii
随着手势和语音熵及互信息（MI）的增加，IFG-pMTG回路中的渐进性神经参与。	Zhao, W.	PDF	N/A	Progressive neural engagement within the IFG-pMTG circuit as gesture and speech entropy and MI advances
组氨酸73的甲基化协调了β-肌动蛋白的可塑性，以响应关键环境因素的变化。	Schahl, A.	PDF	N/A	Histidine 73 methylation coordinates ????-actin plasticity in response to key environmental factors
深度学习揭示内源性甾醇作为GPCR-Gα界面的变构调节剂	Mohanty, S. K.	PDF	N/A	Deep Learning Reveals Endogenous Sterols as Allosteric Modulators of the GPCR-Gα Interface
复发性外阴阴道念珠菌病中阴道和直肠酵母菌群的迁移与静态变异	Adamu Bukari, A.-R.	PDF	N/A	Migration and standing variation in vaginal and rectal yeast populations in recurrent vulvovaginal candidiasis
利用基于深度学习的工具预测拟南芥MCTP4的结构，并通过粗粒度分子动力学模拟探索其跨膜结构域的动力学特性。	Sritharan, S.	PDF	N/A	Prediction of A. thaliana's MCTP4 Structure using Deep Learning-Based tools and Exploration of Transmembrane domain Dynamics using Coarse-Grained Molecular Dynamics Simulations
维生素D促进DNase1L3降解ecDNA并抑制肝细胞癌的恶性进展	Zhang, H.	PDF	N/A	Vitamin D promotes DNase1L3 to degrade ecDNA and inhibit the malignant progression of hepatocellular carcinoma
长时间的第二次减数分裂中期停滞会削弱小鼠卵母细胞中依赖于Aurora B/C的错误纠正机制。	Langeoire, A.	PDF	N/A	Prolonged metaphase II arrest weakens Aurora B/C- dependent error correction in mouse oocytes
所有CDKN2A错义变体的功能特征分析及其与致病性计算机模型的比较	Kimura, H.	PDF	N/A	Functional characterization of all CDKN2A missense variants and comparison to in silico models of pathogenicity
刺激诱导的伽马源在健康老龄化过程中功率降低，但在人类脑电图（EEG）中的空间范围并未减少。	Biswas, A.	PDF	N/A	Stimulus-induced gamma sources reduce in power but not in spatial extent with healthy aging in human EEG
对乌干达流行性和地方性卡波西肉瘤（KS）个体的研究表明，T细胞对卡波西肉瘤相关疱疹病毒（KSHV）的应答特征在空间和时间上持续存在。	Ravishankar, S.	PDF	N/A	The signature of a T-cell response to KSHV persists across space and time in individuals with epidemic and endemic KS from Uganda
胸腺树突状细胞衍生的IL-27p28通过STAT1相关的表观遗传机制促进新生成的CD4+ T细胞中抗IFN-γ产生的功能偏向的建立。	Zhang, J.	PDF	N/A	Thymic dendritic cell-derived IL-27p28 promotes the establishment of functional bias against IFN-γ production in newly generated CD4+ T cells through STAT1-related epigenetic mechanisms
解读逆转录病毒Vpr/Vpx蛋白对抗HUSH和SAMHD1所需的关键因素，揭示了这些进化冲突中的分子可塑性。	Larrous, P.	PDF	N/A	Deciphering lentiviral Vpr/Vpx determinants required for HUSH and SAMHD1 antagonism highlights the molecular plasticity of these evolutionary conflicts
DNA甲基化在克隆植物物种野草莓（Fragaria vesca）中显示出海拔选择的足迹。	Le veve, A.	PDF	N/A	DNA methylation shows footprints of altitude selection in the clonal plant species Fragaria vesca
白蚁基因组中出乎意料的低重组率及热点区域的存在	Everitt, T.	PDF	N/A	Unexpectedly low recombination rates and presence of hotspots in termite genomes
在三维脑微血管模型中，恶性疟原虫损害了周细胞分泌Ang-1的能力。	Long, R. K. M.	PDF	N/A	Plasmodium falciparum impairs Ang-1 secretion by pericytes in a 3D brain microvessel model
基于本体的异质临床、病理和分子肾脏数据建模、整合与分析，以推进精准医学	He, Y.	PDF	N/A	Ontology-based modeling, integration, and analysis of heterogeneous clinical, pathological, and molecular kidney data for precision medicine
Drp1在膜上的晶格结构	Peng, R.	PDF	N/A	The Structure of the Drp1 Lattice on Membrane
长寿通过减缓生长速度阻碍了进化救援，但并不一定减缓了适应速度。	Nordstrom, S. W.	PDF	N/A	Longevity hinders evolutionary rescue through slower growth but not necessarily slower adaptation
T滤泡辅助细胞（T follicular helper cell）的特征因疟疾抗原的不同而异，并且在儿童与成人之间也存在差异。	Forconi, C. S.	PDF	N/A	T follicular helper cell profiles differ by malaria antigen and for children compared to adults
在人类多能干细胞中工程化荧光报告基因及活体成像人类神经发生的策略	Dady, A.	PDF	N/A	Engineering fluorescent reporters in human pluripotent cells and strategies for live imaging human neurogenesis
机车动作可供性在人类行为、大脑和深度神经网络中的表征	Bartnik, C. G.	PDF	N/A	Representation of locomotive action affordances in human behavior, brains and deep neural networks
额外教育对长期大脑结构无影响：一项在数千人中进行的预注册自然实验。	Judd, N.	PDF	N/A	No effect of additional education on long-term brain structure: a preregistered natural experiment in thousands of individuals.
可扩展的三联码DNA甲基化动态与人类性状相关性的筛选研究。	Goldberg, D. C.	PDF	N/A	Scalable Screening of Ternary-Code DNA methylation Dynamics Associated with Human Traits.
Let-7抑制AT2细胞中的致癌回路，以防止肺纤维化中的纤维化细胞中间体	Seasock, M. J.	PDF	N/A	Let-7 restrains an oncogenic circuit in AT2 cells to prevent fibrogenic cell intermediates in pulmonary fibrosis
ProtMamba：一种同源感知但无需比对的蛋白质状态空间模型	Sgarbossa, D.	PDF	N/A	ProtMamba: a homology-aware but alignment-free protein state space model
AATF的缺失通过抑制AKT-mTORC1信号通路改善代谢功能障碍相关的脂肪性肝炎	N. Srinivas, A.	PDF	N/A	Loss of AATF ameliorates metabolic dysfunction-associated steatohepatitis by suppressing the AKT-mTORC1 signaling pathway
用于可寻址和模式化脑电刺激的植入式微刺激器无线网络	Lee, J.	PDF	N/A	A Wireless Network of Implantable Microstimulators for Addressable and Patterned Electrical Brain Stimulation
基于似然的蛋白质语言模型微调用于少量样本适应性预测与设计	Hawkins-Hooker, A.	PDF	N/A	Likelihood-based fine-tuning of protein language models for few-shot fitness prediction and design
ATP合酶动力学的改变导致衰老hiPS-心肌细胞功能异常	Morris, S.	PDF	N/A	Altered dynamics of ATP synthase cause functional irregularities in senescent hiPS-cardiomyocytes
自主神经系统中的双眼组合	Segala, F. G.	PDF	N/A	Binocular combination in the autonomic nervous system
果蝇梳理过程中，抑制性回路为腿部运动生成节律	Syed, D. S.	PDF	N/A	Inhibitory circuits generate rhythms for leg movements during Drosophila grooming
空间频率适应调节群体感受野大小	Altan, E.	PDF	N/A	Spatial frequency adaptation modulates population receptive field sizes
解码蛋白质语言模型：来自嵌入空间分析的洞见	Rissom, P. F.	PDF	N/A	Decoding protein language models: insights from embedding space analysis
西欧沿海沙丘中与植物相关的无脊椎动物群落结构的驱动因素	Van De Walle, R.	PDF	N/A	Drivers of plant-associated invertebrate community structure in West-European coastal dunes
CD-GPT 作为生物基础模型，通过中心法则弥合分子序列之间的鸿沟	Zhu, X.	PDF	N/A	CD-GPT As a Biological Foundation Model Bridging the Gap between Molecular Sequences Through Central Dogma
听觉丘脑中声音处理的细胞特异性抑制调控。	Rolon-Martinez, S.	PDF	N/A	Cell-specific inhibitory modulation of sound processing in the auditory thalamus.
从婴儿期到学龄期大脑发育的纵向轨迹及其与识字能力发展的关系	Turesky, T. K.	PDF	N/A	Longitudinal trajectories of brain development from infancy to school age and their relationship to literacy development
隐晦的重组和转座驱动结构变异，从而塑造了一种宿主通用型真菌植物病原体的基因组可塑性和生活史特征。	Derbyshire, M. C.	PDF	N/A	Cryptic recombination and transposition drive structural variation to shape genomic plasticity and life history traits in a host generalist fungal plant pathogen
脂肪体来源的细胞因子Upd2调控果蝇气管干细胞的定向迁移	Dong, P.	PDF	N/A	Fat body-derived cytokine Upd2 controls disciplined migration of tracheal stem cells in Drosophila
糖酵解通量通过调节Wnt信号通路控制视网膜祖细胞的分化	Hanna, J.	PDF	N/A	Glycolytic flux controls retinal progenitor cell differentiation via regulating Wnt signaling
快速眼动（REM）睡眠质量与清醒时期蓝斑核的平衡紧张性活动有关。	Mortazavi, N.	PDF	N/A	REM sleep quality is associated with balanced tonic activity of the locus coeruleus during wakefulness
现实世界中持续思维的模式及其与心理健康和幸福感的联系	Mulholland, B.	PDF	N/A	Patterns of Ongoing Thought in the Real World and Their Link to Mental Health and Well-Being
使用稀疏和低秩矩阵技术加速多电极阵列的模拟	Jensen, N.	PDF	N/A	Accelerated Simulation of Multi-Electrode Arrays Using Sparse and Low-Rank Matrix Techniques
来自韩国Duho组（中新世）的新金枪鱼标本（Auxis属）	Suh, D.	PDF	N/A	A new tuna specimen (Genus Auxis) from the Duho Formation (Miocene) of South Korea
MLCK/MLCP调节哺乳动物轴突再生并重新分配生长锥F-肌动蛋白	Saijilafu, N.	PDF	N/A	MLCK/MLCP regulates mammalian axon regeneration and redistributes the growth cone F-actin
植物免疫受体Sr50的复活以克服病原体免疫逃逸	Seong, K.	PDF	N/A	Resurrection of the Plant Immune Receptor Sr50 to Overcome Pathogen Immune Evasion
除了中性位点：探讨老虎（Panthera tigris）免疫基因的变异	Aditi, B.	PDF	N/A	Beyond neutral loci: Examining immune gene variation in tigers (Panthera tigris)
拟南芥的自然变异在花转变过程中引发了复杂的转录组异时性，并通过一种意想不到的遗传控制扰乱了叶片和花发育之间的耦合。	Dieudonne, S.	PDF	N/A	Arabidopsis natural variation induces complex transcriptomic heterochronies at the floral transition and perturbs the coupling between leaf and flower development by an unexpected genetic control
阻断毒素功能并调节肠道微生物群：咖啡酸苯乙酯作为治疗艰难梭菌感染的潜在方法	Guo, Y.	PDF	N/A	Blocking toxin function and modulating the gut microbiota: caffeic acid phenethyl ester as a potential treatment for Clostridioides difficile infection
苗圃环境及其对早期性状变异的影响	Perry, A.	PDF	N/A	Tree nursery environments and their effect on early trait variation
幼儿言语网络的结构发展	Curtis, M.	PDF	N/A	Structural Development of Speech Networks in Young Children
CRISPR/dCas介导的反沉默：将dCas蛋白重新编程为异源沉默因子的拮抗剂	Wiechert, J.	PDF	N/A	CRISPR/dCas-mediated counter-silencing: Reprogramming dCas proteins into antagonists of xenogeneic silencers
耳声发射而非行为学测量预测了鸟类声通讯专家中耳蜗神经的频率调谐。	Karosas, D. M.	PDF	N/A	Otoacoustic emissions but not behavioral measurements predict cochlear-nerve frequency tuning in an avian vocal-communication specialist
工程化大象模型：冷适应与抗癌能力研究	Karpinski, E.	PDF	N/A	Engineering elephant models of cold-adaptation and cancer resistance
哺乳动物肺纤维化中的神经-成纤维细胞轴	Ishikawa, G.	PDF	N/A	A Nerve-Fibroblast Axis in Mammalian Lung Fibrosis
腹侧被盖区多巴胺神经活动与前额叶皮层和海马中的规则表征同时切换	Ding, M.	PDF	N/A	Ventral tegmental area dopamine neural activity switches simultaneously with rule representations in the prefrontal cortex and hippocampus
海马体ERK2二聚化对于记忆再巩固和突触可塑性至关重要	Ojea Ramos, S.	PDF	N/A	Hippocampal ERK2 dimerization is critical for memory reconsolidation and synaptic plasticity
以下是这段英文的中文翻译：

甲型H5N1流感病毒在生牛奶中的热灭活谱

翻译说明： - "Thermal inactivation spectrum" 翻译为“热灭活谱”，指的是在不同温度下病毒灭活的效果。 - "influenza A H5N1 virus" 翻译为“甲型H5N1流感病毒”，是一种高致病性禽流感病毒。 - "raw milk" 翻译为“生牛奶”，指未经加热处理的牛奶。

“关于Jyvaskylavirus的基因组和结构洞察，这是首个从芬兰分离出的巨型病毒。”

解释： - Genomic and structural insights：基因组和结构洞察，指的是对病毒的基因组和结构进行的研究和分析。 - Jyvaskylavirus：Jyvaskylavirus 是一种巨型病毒的名称。 - the first giant virus isolated from Finland：这是首个从芬兰分离出的巨型病毒，强调这是首次在芬兰发现的巨型病毒。

双功能II-B型CRISPR-Cas9的结构基础

解释： - Structural basis：结构基础，指的是从分子结构层面解释某种功能或机制的基础。 - dual-function：双功能，表示CRISPR-Cas9具有两种功能。 - type II-B CRISPR-Cas9：II-B型CRISPR-Cas9，是CRISPR-Cas系统的一种亚型，具有特定的结构和功能特性。

整句话的意思是：从分子结构的角度解释II-B型CRISPR-Cas9如何实现其双功能的机制。 | Hibshman, G. N. | PDF | N/A | Structural basis for a dual-function type II-B CRISPR-Cas9 | | 早衰症聚合物模型中核纤层蛋白的相行为与解离动力学 | Hameed, H. A. | PDF | N/A | Phase Behavior and Dissociation Kinetics of Lamins in a Polymer Model of Progeria | | 共享转录组特征揭示突触修剪是阿尔茨海默病与癫痫之间的关联 | Li, H. | PDF | N/A | Shared Transcriptomic Signatures Reveal Synaptic Pruning as a Link Between Alzheimer's Disease and Epilepsy | | 保守的转录因子通过抑制来协调突触基因的表达 | Kentro, J. A. | PDF | N/A | Conserved transcription factors coordinate synaptic gene expression through repression | | COSMOS：社区与单微生物优化系统 | Raajaraam, L. | PDF | N/A | COSMOS: COmmunity and Single Microbe Optimisation System | | 基因复制后的表达变异性有助于基因保留 | Cai, H. | PDF | N/A | Expression variability following gene duplication facilitates gene retention | | 通过信号传输的马尔可夫模型探讨结构连接性对大脑功能的作用 | Razban, R. | PDF | N/A | The role of structural connectivity on brain function through a Markov model of signal transmission | | 小脑神经计算中的向量微积分 | Fakharian, M. A. | PDF | N/A | A vector calculus for neural computation in the cerebellum | | 果糖-2,6-二磷酸可恢复运动神经元疾病中由TDP-43病理驱动的基因组修复缺陷 | Chakraborty, A. | PDF | N/A | Fructose-2,6-bisphosphate restores TDP-43 pathology-driven genome repair deficiency in motor neuron diseases | | 多级混合控制脂质纳米颗粒的超分子结构，从而形成核壳排列，使性能提升数个数量级。 | Nong, J. | PDF | N/A | Multi-stage-mixing to control the supramolecular structure of lipid nanoparticles, thereby creating a core-then-shell arrangement that improves performance by orders of magnitude | | 基于深度学习的酶最适pH值预测及点突变设计以提高酸抗性 | Qiu, S. | PDF | N/A | Deep learning-based prediction of enzyme optimal pH and design of point mutations to improve acid resistance | | 单细胞转录组学分析揭示了X射线照射后的果蝇翅盘细胞存在与细胞周期状态和细胞位置相关的异质性。 | Cruz, J. | PDF | N/A | Single-cell transcriptomics of X-ray irradiated Drosophila wing discs reveals heterogeneity related to cell-cycle status and cell location | | 以下是这段文字的中文翻译：

德克萨斯州中部海岸科帕诺湾、阿兰萨斯湾和红鱼湾中活体（玫瑰红染色）底栖有孔虫的分布

翻译说明： - DISTRIBUTION OF LIVING (ROSE BENGAL STAINED) BENTHIC FORAMINIFERA：活体（玫瑰红染色）底栖有孔虫的分布 - COPANO, ARANSAS, AND REDFISH BAYS：科帕诺湾、阿兰萨斯湾和红鱼湾 - CENTRAL TEXAS COAST：德克萨斯州中部海岸

希望这对你有帮助！ | Barrera, A. | PDF | N/A | DISTRIBUTION OF LIVING (ROSE BENGAL STAINED) BENTHIC FORAMINIFERA IN COPANO, ARANSAS, AND REDFISH BAYS, CENTRAL TEXAS COAST | | 蜜蜂社交性个体差异的分子分析 | Traniello, I. M. | PDF | N/A | Molecular analyses of individual variation in honey bee sociability | | 异位基因转换导致数量性状变异 | Pfalz, M. | PDF | N/A | Ectopic gene conversion causing quantitative trait variation | | 非典型短潜伏期听觉通路直接激活深层皮质 | Garcia, M. M. | PDF | N/A | Noncanonical Short-Latency Auditory Pathway Directly Activates Deep Cortical Layers | | 综合感染组分析揭示野生动物中具有人畜共患潜力的多种传染性病原体 | Hou, X. | PDF | N/A | Comprehensive Infectome Analysis Reveals Diverse Infectious Agents with Zoonotic Potential in Wildlife | | 自动暗示和心理意象会影响对社会情绪的感知 | Myga, K. A. | PDF | N/A | Autosuggestion and Mental Imagery Bias the Perception of Social Emotions | | 皮质类固醇耐药性在急性移植物抗宿主病（Graft Versus Host Disease, GVHD）发作时由早期免疫反应动态预先决定。 | Le Grand, S. | PDF | N/A | Corticosteroid resistance is predetermined by early immune response dynamics at acute Graft Versus Host disease onset | | I型nNOS神经元协调皮质神经活动和血管运动 | Turner, K. | PDF | N/A | Type-I nNOS neurons orchestrate cortical neural activity and vasomotion | | CD33KO-CD33-间皮素环状CAR设计避免了自相残杀，并提高了iNK细胞对急性髓性白血病的疗效 | Wang, Y. | PDF | N/A | CD33KO-CD33-mesothelin loop CAR design avoids fratricide and improves efficacy of iNK cells against acute myeloid leukemia | | RegFormer：一个由基因调控层次结构驱动的单细胞基础模型 | Hu, L. | PDF | N/A | RegFormer: A Single-Cell Foundation Model Powered by Gene Regulatory Hierarchies | | 深度学习揭示了成年人类肠道微生物组中的功能原型，这些原型构成了个体间差异的基础，并混淆了疾病信号。 | Meawad, M. | PDF | N/A | Deep learning reveals functional archetypes in the adult human gut microbiome that underlie interindividual variability and confound disease signals | | 发育信号中的反共振调节细胞命运决定 | Rosen, S. J. | PDF | N/A | Anti-resonance in developmental signaling regulates cell fate decisions | | 量化落叶树与植食性昆虫系统中的物候：方法学比较 | Morley, L. M. | PDF | N/A | Quantifying phenology in the deciduous tree and phytophagous insect system: a methodological comparison | | 基于蛋白质组学的棉花纤维发育基因表达及细胞调控模型 | Lee, Y. | PDF | N/A | Proteomics-based models of gene expression and cellular control of cotton fiber development | | 营养响应的PMv DAT神经元在青春期过渡期间受到动态调控。 | Saenz de Miera, C. | PDF | N/A | Nutritionally responsive PMv DAT neurons are dynamically regulated during pubertal transition | | 标题：裸盖菇素作为重复性轻度头部损伤的治疗：来自神经放射学和分子生物学的证据

内容：裸盖菇素，一种源自某些蘑菇的天然化合物，近年来在医学研究中引起了广泛关注。最近的研究表明，裸盖菇素可能对治疗重复性轻度头部损伤（RMHI）具有潜在的治疗效果。这种类型的头部损伤常见于运动员，尤其是那些参与接触性运动如足球、橄榄球和拳击的运动员。

神经放射学的研究揭示了裸盖菇素在促进神经可塑性和神经发生方面的潜力。通过使用先进的成像技术，如功能性磁共振成像（fMRI）和扩散张量成像（DTI），科学家们能够观察到裸盖菇素如何影响大脑的结构和功能。这些研究表明，裸盖菇素能够增强大脑的自我修复能力，特别是在那些受到重复性轻度头部损伤影响的区域。

此外，分子生物学的研究进一步支持了裸盖菇素的治疗潜力。研究发现，裸盖菇素能够激活特定的神经递质系统，如5-羟色胺受体，从而促进神经元的生长和突触的形成。这些分子机制不仅有助于解释裸盖菇素如何减轻RMHI的症状，还为其在治疗其他神经系统疾病中的应用提供了理论基础。

尽管这些研究结果令人鼓舞，但裸盖菇素作为治疗RMHI的临床应用仍需进一步的临床试验来验证其安全性和有效性。此外，研究人员还需要探索裸盖菇素的最佳剂量、给药方式以及长期使用的潜在副作用。

大型须鲸（如蓝鲸、长须鲸、座头鲸等）在种内存在显著的体型变化。这种变化通常与地理分布、性别、年龄以及生态因素有关。例如，南半球的蓝鲸通常比北半球的蓝鲸体型更大，雌性个体也往往比雄性更大。此外，不同种群的须鲸在体型上也可能存在差异，这可能与食物资源的分布和丰富度有关。体型变化对须鲸的生存、繁殖和迁徙行为具有重要影响，因此在保护和管理这些物种时，需要充分考虑这些因素。 | McClure, J. | PDF | N/A | A summary of intraspecific size variation for large mysticetes | | 早产与足月受试者多尺度脑网络中功能网络能量的改变：来自青少年脑认知发展（ABCD）研究的见解 | Li, Q. | PDF | N/A | Altered Functional Network Energy Across Multiscale Brain Networks in Preterm vs. Full-Term Subjects: Insights from the Adolescent Brain Cognitive Development (ABCD) Study | | 苍白球原型神经元和星形胶质细胞活动调节灵活的奖赏寻求行为 | Kang, S. | PDF | N/A | Pallidal prototypic neuron and astrocyte activities regulate flexible reward-seeking behaviors | | 分子引导的空间蛋白质组学揭示了神经系统的单细胞身份和异质性 | Dutta, S. | PDF | N/A | Molecularly-guided spatial proteomics captures single-cell identity and heterogeneity of the nervous system | | 17β-雌二醇状态改变雌性大鼠的NMDAR功能和抗精神病样活性 | Holter, K. M. | PDF | N/A | 17β-estradiol status alters NMDAR function and antipsychotic-like activity in female rats | | 心肌细胞中的双重翻译控制：通过异质性mTORC1和肥大性ERK激活 | Uchida, K. | PDF | N/A | Dual Translational Control in Cardiomyocytes by Heterogeneous mTORC1 and Hypertrophic ERK Activation | | 一种垂直堆叠方法用于快速生成室内高秆一年生作物的生长周期——以蚕豆为例 | Pazos Navarro, M. | PDF | N/A | A vertical stacking approach to rapid generation cycling for indoor growth of tall annual crops - the case of Vicia faba | | 以下是这段内容的中文翻译：

来自嗜热紫色硫细菌Thermochromatium tepidum的热稳定形式-IAq RuBisCO的超高分辨率结构

翻译说明： - "Ultrahigh Resolution Structure" 翻译为 "超高分辨率结构" - "Heat-stable" 翻译为 "热稳定的" - "Form-IAq RuBisCO" 直接保留原文，因为它是专业术语 - "Thermophilic Purple Sulfur Bacterium" 翻译为 "嗜热紫色硫细菌" - "Thermochromatium tepidum" 是细菌的拉丁学名，直接保留原文

在科学研究中，尤其是涉及生物图像分析的领域，确保实验结果的可靠性和可重复性至关重要。本文将探讨如何通过关注效应大小（effect sizes）和合理设置控制组（controls）来增强研究的可重复性。

效应大小的重要性

效应大小是指研究中观察到的效应或差异的量化指标。与仅仅报告统计显著性（p值）不同，效应大小提供了关于效应实际大小的信息，这对于评估研究结果的科学意义至关重要。在生物图像分析中，效应大小可以帮助研究人员确定观察到的差异是否具有生物学意义，而不仅仅是统计上的偶然现象。

控制组的作用

控制组是实验设计中不可或缺的一部分，用于确保观察到的效应确实是由实验变量引起的，而不是其他未控制的因素。在生物图像分析中，合理设置控制组可以帮助排除技术误差、背景噪声等干扰因素，从而提高实验结果的可靠性。

提高可重复性的策略

报告效应大小：在发表研究结果时，除了统计显著性外，还应报告效应大小，以便其他研究人员能够评估结果的科学意义。
合理设置控制组：确保实验设计中包含适当的控制组，以排除潜在的干扰因素。
透明化实验流程：详细记录实验步骤、参数设置和分析方法，以便其他研究人员能够重复实验。
数据共享：公开原始数据和图像，允许其他研究人员验证和重复分析。

通过关注效应大小和合理设置控制组，研究人员可以显著提高生物图像分析研究的可重复性，从而推动科学知识的积累和进步。 | Barry, D. J. | PDF | N/A | Enhancing Reproducibility Through Bioimage Analysis: The Significance of Effect Sizes and Controls | | 组织蛋白酶K的缺失会损害胶原蛋白的生物生成，并增强小梁网中的肌动蛋白聚合。 | Soundararajan, A. | PDF | N/A | Loss of Cathepsin K impairs collagen biogenesis and enhances actin polymerization in trabecular meshwork | | TRPV4在高剪切力诱导的初始牵引反应和长期松弛过程中优于Piezo1。 | Chandurkar, M. K. | PDF | N/A | TRPV4 Dominates High Shear-Induced Initial Traction Response and Long-Term Relaxation Over Piezo1 | | 识别高尔基体膜蛋白适配器Vps74上的客户结合位点 | Lesniak, A. M. | PDF | N/A | Identification of the client-binding site on the Golgi membrane protein adaptor Vps74 | | 在RAD51介导的同源搜索过程中，Cohesin驱动染色质扫描。 | Marin-Gonzalez, A. | PDF | N/A | Cohesin drives chromatin scanning during the RAD51-mediated homology search. | | 一种荧光折叠报告基因揭示了肌球蛋白错误折叠是肥厚型心肌病的驱动因素 | Arnese, R. | PDF | N/A | A fluorescent folding reporter uncovers myosin misfolding as a driver of Hypertrophic Cardiomyopathy | | 在3D组织模型中识别衰老成纤维细胞活化的调节因子 | Liu, H. | PDF | N/A | Identifying regulators of aged fibroblast activation in 3D tissue models | | 肾发生过程中的缺陷会导致Foxd1+基质祖细胞群的扩增。 | Michalopulos, M. G. | PDF | N/A | Defects in nephrogenesis result in an expansion of the Foxd1+ stromal progenitor population | | 迈向对稀有红秃猴（Cacajao ucayalii）的被动声学调查：利用自动信号识别和聚类分析来组织信号？ | Bowler, M. | PDF | N/A | Toward passive acoustic occupancy surveys of rare red uakari monkeys (Cacajao ucayalii): using automatic signal recognition and cluster analysis to organize signals? | | 植物根系分泌物生物防治对土壤微生物群落的非靶标效应 | Bedoya, E. T. | PDF | N/A | Non-target effects on the soil microbiome of a plant root exudate biocontrol for Fusarium wilt | | 树种植园对西高止山脉生物多样性热点地区一种特有蜥蜴种群数量及栖息生态的影响 | Gosavi, N. | PDF | N/A | Effects of tree plantations on population and roosting ecology of an endemic agamid lizard in Western Ghats Biodiversity Hotspot | | 验证十种联邦学习策略在异构源多对比度图像到图像MRI数据合成中的应用 | Fiszer, J. | PDF | N/A | Validation of ten federated learning strategies for multi-contrast image-to-image MRI data synthesis from heterogeneous sources | | CandyCollect 开放式到封闭式 (O2C) 微流体系统，用于快速且以用户为中心的 A 组链球菌检测 | Leong, K. M. | PDF | N/A | CandyCollect Open to Closed (O2C) Microfluidic System for Rapid and User-Centric Detection of Group A Streptococcus | | 通过构象采样和多样性整合，利用少量样本学习中的子采样Alphafold2预测突变引起的相对蛋白质-配体结合亲和力变化 | Xie, L. | PDF | N/A | Predicting Mutation-Induced Relative Protein-Ligand Binding Affinity Changes via Conformational Sampling and Diversity Integration with Subsampled Alphafold2 in Few-Shot Learning | | DiatomNet：一种通过显微图像和深度学习实现的自动硅藻属识别系统 | Tabik, S. | PDF | N/A | DiatomNet: An automatic Diatom genus identification system through microscopic images and Deep Learning | | 三维多细胞球体中从轨道运动到基质侵袭的集体转变 | Kim, J. | PDF | N/A | Collective Transitions from Orbiting to Matrix Invasion in 3D Multicellular Spheroids | | 原位生成疫苗样焦亡体用于个性化癌症免疫治疗 | Chen, B. | PDF | N/A | In situ generated vaccine-like pyroptosome for personalized cancer immunotherapy | | GL261胶质母细胞瘤在年轻小鼠中诱导了延迟的体重增加和骨骼肌生长受阻。 | Huot, J. | PDF | N/A | GL261 glioblastoma induces delayed body weight gain and stunted skeletal muscle growth in young mice | | 为STICS作物模型中新的冬小麦品种的校准，优化测量作物变量的类型和时间 | Gawinowski, M. | PDF | N/A | Refining type and timing of measured crop variables for the calibration of a new winter wheat cultivar in the STICS crop model | | 叶绿素a加氧酶（CAO）基因在绿色植物界（Viridiplantae）中的重复现象 | Poirier, M. 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N. | PDF | N/A | Current and future relevance of marine spatial planning for the distribution of epibenthic invertebrate and fish species in a heavily used regional sea | | 中国新哺乳动物记录的时空分布格局及其生态相关性 | Ding, C. | PDF | N/A | Spatio-temporal distribution patterns and ecological correlates of new mammal records in China | | 大型语言模型具备一定的生态知识，但具体掌握多少呢？ | Dorm, F. | PDF | N/A | Large language models possess some ecologicalknowledge, but how much? | | 微小杀手：首次记录下棒肠涡虫以水蚤胚胎为食 | Tuzun, N. | PDF | N/A | Tiny killers: first record of rhabdocoel flatworms feeding on water flea embryos | | 来自实验室大鼠皮层的Hi-C测序数据 | Kim, P. | PDF | N/A | Hi-C sequencing data from cortex laboratory rats | | 半自动定量分析拟南芥根尖分生组织细胞分裂过程中3D组蛋白H3磷酸化信号 | Kelemen, A. | PDF | N/A | Semi-automatic quantification of 3D Histone H3 phosphorylation signals during cell division in Arabidopsis root meristems | | 特定细胞状态支撑了刺鼠复杂组织再生的基础 | Rivadeneira, E. O. | PDF | N/A | Specific cell states underlie complex tissue regeneration in spiny mice | | 特定细胞状态是棘鼠复杂组织再生的基础 | Rivadeneira, E. O. | PDF | N/A | Specific cell states underlie complex tissue regeneration in spiny mice | | RAB23功能丧失突变导致卡彭特综合征中与上下文相关的纤毛病。 | Leong, W. Y. | PDF | N/A | RAB23 loss-of-function mutation causes context-dependent ciliopathy in Carpenter syndrome | | 分析蜜蜂蘑菇体发育的分子和细胞基础 | Kamata, S. | PDF | N/A | Analysis of molecular and cellular bases of honey bee mushroom body development | | MicroSplit：荧光显微镜数据的语义解混 | Ashesh, A. | PDF | N/A | MicroSplit: Semantic Unmixing of Fluorescent Microscopy Data | | 一群RNA聚合酶II分子与一个活跃的基因稳定地结合在一起。 | Mukherjee, A. | PDF | N/A | A cluster of RNA Polymerase II molecules is stably associated with an active gene | | 哺乳动物的卵母细胞从颗粒细胞接收母源效应RNA。 | Munger, S. C. | PDF | N/A | Mammalian oocytes receive maternal-effect RNAs from granulosa cells | | 哺乳动物的卵母细胞从颗粒细胞中接收母体效应RNA。 | Doherty, C. A. | PDF | N/A | Mammalian oocytes receive maternal-effect RNAs from granulosa cells | | 帮我将这段翻译成中文：在蝾螈中，控制主要体轴和附肢再生的不同干细胞机制 | Wang, L. | PDF | N/A | Divergent stem cell mechanisms governing the primary body axis and appendage regeneration in the axolotl | | 扩展后的Bostrychia moritziana基因组揭示了红藻中最多样化和复杂类群的进化历程。 | Petroll, R. | PDF | N/A | The expanded Bostrychia moritziana genome unveils evolution in the most diverse and complex order of red algae | | 联合视觉-前庭系统对头部方向和反射性眼动的计算 | Dalmay, T. | PDF | N/A | Joint visual-vestibular computation of head direction and reflexive eye movement | | 负面记忆的泛化而非强化驱动了抑郁样行为的发展。 | Cheng, X. | PDF | N/A | Generalization but not strengthening of negative memories drives the development of depression-like behaviors | | KYLO-0603是一种新型的肝脏靶向性甲状腺激素受体-β激动剂，用于治疗MASH（代谢相关脂肪性肝炎）。 | Lu, X. | PDF | N/A | KYLO-0603, a novel liver-targeting, thyroid hormone recep-tor-β agonist for the treatment of MASH | | 一种新型的紫杉醇诱导的周围神经病变模型在小鼠中产生了临床相关的表型 | Osborn, L. 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C. | PDF | N/A | Decoding semantics from natural speech using human intracranial EEG | | 使用超精确CRISPR-Cas13b系统性地沉默致癌融合转录本 | Hu, W. | PDF | N/A | Systematic silencing of oncogenic fusion transcripts with ultra-precise CRISPR-Cas13b | | Plat通过激活Erk1/2通路，保护高龄母源性卵母细胞免于程序性细胞死亡。 | He, X. | PDF | N/A | Plat safeguards maternally aged oocytes against programmed cell death through activating the Erk1/2 pathway | | 斑马鱼前侧线系统的发育受到下方颅神经嵴的影响。 | Venkataraman, V. | PDF | N/A | Development of the zebrafish anterior lateral line system is influenced by underlying cranial neural crest | | 胎儿雄性化编程窗口期间的睾酮暴露决定了成年小鼠的肾脏大小。 | Junnila, A. | PDF | N/A | Testosterone exposure during fetal masculinization programming window determines the kidney size in adult mice. | | 所见即所闻：声音强度在大鼠时间频率分类任务中改变其视觉感知 | Zanzi, M. | PDF | N/A | Seeing what you hear: sound intensity alters rat visual perception in a temporal frequency classification task | | 精确调控嵌合抗原受体表达水平决定了T细胞的特性和功能 | Ramos, A. S. | PDF | N/A | Precise engineering of chimeric antigen receptor expression levels defines T cell identity and function | | 复杂人类毛发皮肤类器官作为皮肤中单纯疱疹病毒1型感染的模型 | Wyler, E. | PDF | N/A | Complex Human Hair Bearing Skin Organoids as Model for Herpes Simplex Virus 1 Infection in the Skin | | 中国西部多民族人群中儿童队列肠道双歧杆菌微生物组多样性的年龄依赖性模式 | Huang, J. | PDF | N/A | Age-Dependent Patterns of Gut Bifidobacterium Microbiome Diversity across child Cohorts in a Multi-Ethnic population, Western China | | 一种新型病毒vB_PshM_Y4，与已培养和未培养的病毒相似度均较低。 | Zheng, Z. | PDF | N/A | A novel virus vB_PshM_Y4 with low similarity to both cultured and uncultured viruses | | 人类肠道微生物群中化学感受受体的特异性 | Xu, W. | PDF | N/A | Specificities of Chemosensory Receptors in the Human Gut Microbiota | | 布鲁氏菌脯氨酸消旋酶蛋白A靶向Tpl2以促进IL-10的分泌，从而建立慢性感染。 | Zhang, H. | PDF | N/A | Brucella proline racemase protein A targets Tpl2 to promote IL-10 secretion for establishment of chronic infection | | 功能动态揭示了海棠（Malus sp.）叶际微生物组对山田胶锈菌（Gymnosporangium yamadae）感染的响应。 | Xu, Q. | PDF | N/A | Functional dynamics reveal the response of the crabapple (Malus sp.) phyllosphere microbiome to Gymnosporangium yamadae infection | | 大型接合质粒的持续存在依赖于主动分配机制和成瘾机制的结合。 | Effe, J. | PDF | N/A | Persistence of large conjugative plasmids relies on the combination of active partitioning and addiction mechanisms | | 基于Crispr/Cas9的单附加体分辨率三维活细胞成像技术对新生KSHV感染的时空分析 | Guenther, T. | PDF | N/A | Spatiotemporal analysis of de novo KSHV infection using Crispr/Cas9-based 3D live cell imaging at single episome resolution | | mecA基因的表达降低了金黄色葡萄球菌对达托霉素的敏感性。 | Ledger, E. V. | PDF | N/A | Expression of mecA reduces the daptomycin susceptibility of Staphylococcus aureus | | Cethromycin 单剂量治疗伯氏疟原虫肝期的药代动力学和药效学研究 | Kennedy, G. J. | PDF | N/A | Cethromycin Pharmacokinetics and Pharmacodynamics for Single Dose Cure of Plasmodium berghei Liver Stages | | 高通量单病毒DNA-PAINT揭示流感病毒选择性包装过程中的结构多样性、协同性和灵活性 | Hepp, C. | PDF | N/A | High-throughput Single-Virion DNA-PAINT Reveals Structural Diversity, Cooperativity and Flexibility during Selective Packaging in Influenza | | TAC1B基因的突变驱动了耳念珠菌（C. auris）中CDR1和MDR1基因的表达，从而导致对唑类药物的耐药性。 | Barker, K. S. | PDF | N/A | Mutations in TAC1B drive CDR1 and MDR1 expression and azole resistance in C. auris | | 甲烷生成标记物16金属蛋白是乙酸甲烷八叠球菌（Methanosarcina acetivorans）中主要的辅酶M合成酶。 | Chadwick, G. L. | PDF | N/A | Methanogenesis marker 16 metalloprotein is the primary coenzyme M synthase in Methanosarcina acetivorans | | 和谐吗？结合多个16S扩增子数据集的方法范围综述 | Li, Z. | PDF | N/A | In harmony? A scoping review of methods to combine multiple 16S amplicon data sets | | 通过对海草（Zostera marina）进行深度宏基因组测序，从中恢复的真核生物MAGs（宏基因组组装基因组）包括一种属于Lobulomycetales目中的新型壶菌。 | Ettinger, C. 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M. | PDF | N/A | Delivery of caspase inhibitors through GSDMD pores to inhibit pyroptosis | | 基因缺失与环境之间复杂的相互作用揭示了未知功能基因在大肠杆菌中的细胞角色。 | Sondervorst, K. | PDF | N/A | Complex interplay between gene deletions and the environment uncovers cellular roles for genes of unknown function in Escherichia coli | | 嵌合感染颗粒扩展了噬菌体诱导染色体岛动员中的物种边界 | He, L. | PDF | N/A | Chimeric infective particles expand species boundaries in phage inducible chromosomal island mobilization | | 短5'非翻译区（UTR）作为IFIT2-IFIT3抗病毒复合物抑制病毒mRNA翻译的标记 | Glasner, D. R. | PDF | N/A | Short 5' UTRs serve as a marker for viral mRNA translation inhibition by the IFIT2-IFIT3 antiviral complex | | 高保真长读长测序揭示禽类疱疹病毒在串联重复区域中存在广泛的种群内多样性 | Ortigas-Vasquez, A. | PDF | N/A | High-Fidelity Long-Read Sequencing of an Avian Herpesvirus Reveals Extensive Intrapopulation Diversity in Tandem Repeat Regions | | 以下是翻译成中文的内容：

产气荚膜梭菌肠毒素的肠道蛋白酶处理

翻译说明： - "Processing" 翻译为“处理”，指的是对产气荚膜梭菌肠毒素进行某种加工或修饰。 - "Clostridium perfringens Enterotoxin" 翻译为“产气荚膜梭菌肠毒素”，这是由产气荚膜梭菌产生的一种毒素。 - "Intestinal Proteases" 翻译为“肠道蛋白酶”，指的是存在于肠道中的能够分解蛋白质的酶。