BioRxiv 2025-02-12 Papers
| 标题 | 作者 | PDF链接 | 代码仓库 | Title |
|---|---|---|---|---|
| 当群体平均值失效时：能否一刀切？ | Grandy, T. H. | N/A | When Group Means Fail: Can One Size Fit All? | |
| 从Macoma balthica（一种以线粒体双重单亲遗传为特征的双壳类物种）的雄性和雌性型mtDNA推断出的不一致种群结构 | Le Cam, S. | N/A | Discordant population structure inferred from male- and female-type mtDNAs from Macoma balthica, a bivalve species characterized by doubly uniparental inheritance of mitochondria | |
| 斑马鱼（Danio rerio）群体决策中的诱饵效应 | Singh, A. | N/A | Decoy effect in shoaling decision making in zebrafish (Danio rerio) | |
| 前颗粒细胞在细胞周期依赖性原始卵泡激活之前启动了一种独特的转录程序。 | Taylor, G. | N/A | Pregranulosa cells engage a distinct transcriptional programme prior to cell-cycle dependent primordial follicle activation | |
| LIF神经元对α函数形状的兴奋性电流脉冲的尖峰响应的强度-持续时间分析曲线 | Paraskevov, A. | N/A | Analytical strength-duration curve for the spiking response of the LIF neuron to an alpha-function-shaped excitatory current pulse | |
| 在健康成年人中，对危险和安全信号之间的辨别能力减弱，但并未出现过度泛化，这与童年时期的逆境经历有关。 | Klingelhoefer-Jens, M. | N/A | Reduced discrimination between signals of danger and safety but not overgeneralization is linked to exposure to childhood adversity in healthy adults | |
| 糖基化SARS-CoV-2刺突蛋白中脂肪酸位点的变构调节 | Oliveira, A. S. F. | N/A | Allosteric modulation by the fatty acid site in the glycosylated SARS-CoV-2 spike | |
| 识别和药理学靶向治疗耐药性、干细胞样乳腺癌细胞以进行联合治疗 | Worley, J. | N/A | Identification and Pharmacological Targeting of Treatment-Resistant, Stem-like Breast Cancer Cells for Combination Therapy | |
| 如何测量细菌基因组的可塑性？一种新颖的时间整合指数有助于深入了解病原体 | Bellinzona, G. | N/A | How to measure bacterial genome plasticity? A novel time-integrated index helps gather insights on pathogens | |
| 在自然主义的多说话者场景中，联合人口编码和时间一致性将注意力集中的说话者的声音和位置特征联系起来。 | van der Heijden, K. | N/A | Joint population coding and temporal coherence link an attended talker's voice and location features in naturalistic multi-talker scenes. | |
| 理解间接的选型交配及其代际影响 | Sunde, H. F. | N/A | Understanding indirect assortative mating and its intergenerational consequences | |
| 噬菌体编码的Hm-oscar基因再现了沃尔巴克氏体在茶卷叶蛾（Homona magnanima）中诱导的雄性致死现象。 | Arai, H. | N/A | Prophage-encoded Hm-oscar gene recapitulates Wolbachia-induced male killing in the tea tortrix moth Homona magnanima | |
| 感官流中的时间间隙会放大后续输入对决策的影响。 | Sospedra, A. | N/A | A temporal gap in sensory streams amplifies the influence of subsequent input on decision making | |
| 识别微生物组数据中未测量的异质性通过分位数阈值法（QuanT） | Lu, J. | N/A | Identifying unmeasured heterogeneity in microbiome data via quantile thresholding (QuanT) | |
| 线粒体缺失与健康寿命：来自常见重复序列的启示 | Shamanskiy, V. A. | N/A | Mitochondrial Deletions and Healthspan: Lessons from the Common Repeat | |
| TopBP1生物分子凝聚体：晚期结直肠癌的新治疗靶点。 | Morano, L. | N/A | TopBP1 biomolecular condensates: a new therapeutic target in advanced-stage colorectal cancer. | |
| HNF4α-TET2-FBP1轴在糖异生和2型糖尿病中的作用 | Li, H. | N/A | HNF4α-TET2-FBP1 axis contributes to gluconeogenesis and type 2 diabetes | |
| 半监督组学因子分析（SOFA）能够解析多组学数据中已知和潜在的变异来源。 | Capraz, T. | N/A | Semi-supervised Omics Factor Analysis (SOFA) disentangles known and latent sources of variation in multi-omic data | |
| 以下是这段文字的中文翻译： |
使用针对NKp46和肿瘤表达抗原的化学合成约束性双环肽条件性激活NK细胞功能
解释： - Conditional activation：条件性激活，指的是在特定条件下激活某种功能。 - NK cell function：NK细胞功能，NK细胞（自然杀伤细胞）是免疫系统中的一种重要细胞。 - chemically synthetic：化学合成的，指的是通过化学方法合成的物质。 - constrained bicyclic peptides：约束性双环肽，指的是一种具有特定结构的肽类分子。 - directed against：针对，指的是这些肽类分子能够特异性地结合到某些目标上。 - NKp46：NKp46是NK细胞表面的一种受体。 - tumor-expressed antigens：肿瘤表达抗原，指的是在肿瘤细胞表面表达的特定抗原。
整体意思是：通过化学合成的约束性双环肽，这些肽类分子能够特异性地结合到NK细胞表面的NKp46受体和肿瘤细胞表达的抗原上，从而在特定条件下激活NK细胞的功能。 | Dufort, F. J. | PDF | N/A | Conditional activation of NK cell function using chemically synthetic constrained bicyclic peptides directed against NKp46 and tumor-expressed antigens | | 强化身份赋予细胞癌症特征 | Yang, H. | PDF | N/A | Reinforced identity confers cells with cancer hallmarks | | CD2的表达与人类T细胞中的干细胞特性相关因子和耗竭相关因子共同调控。 | Demetriou, P. | PDF | N/A | CD2 expression is co-regulated with stemness- and exhaustion-associated factors in human T cells | | SpatialFormer：从亚细胞分子到多细胞景观的通用空间表示学习 | Wang, J. | PDF | N/A | SpatialFormer: Universal Spatial Representation Learning from Subcellular Molecular to Multicellular Landscapes | | 使用语言模型预测CRISPR碱基编辑器在组织特异性转录组中的RNA脱靶风险 | Nakamae, K. | PDF | N/A | Risk Prediction of RNA Off-Targets of CRISPR Base Editors in Tissue-Specific Transcriptomes Using Language Models | | 通过基因型似然从古代DNA推断人类色素沉着 | Perretti, S. | PDF | N/A | Inference of human pigmentation from ancient DNA by genotype likelihood | | P3a位点特异性和盒式诱变用于无缝蛋白质和质粒工程 | Yang, X.-J. | PDF | N/A | P3a site-specific and cassette mutagenesis for seamless protein and plasmid engineering | | 启动裸子植物基因功能研究：麻黄（Ephedra tweedieana）中的病毒诱导基因沉默（VIGS）技术 | Garcia, A. G. | PDF | N/A | Enabling the Study of Gene Function in Gymnosperms: VIGS in Ephedra tweedieana | | 基于扰动蛋白质组学的虚拟细胞构建基础模型 | Sun, R. | PDF | N/A | A perturbation proteomics-based foundation model for virtual cell construction | | 一种用于室内高秆一年生作物快速生长周期的垂直堆叠方法——以蚕豆（Vicia faba）为例 | Pazos Navarro, M. | PDF | N/A | A vertical stacking approach to rapid generation cycling for indoor growth of tall annual crops - the case of Vicia faba | | Plat通过激活Erk1/2通路，保护高龄母源卵母细胞免受程序性细胞死亡的影响。 | He, X. | PDF | N/A | Plat safeguards maternally aged oocytes against programmed cell death through activating the Erk1/2 pathway | | 小鼠上丘中多感官时间整合的功能特化 | Bianchini, G. | PDF | N/A | Functional specialisation of multisensory temporal integration in the mouse superior colliculus | | 动机控制是通过一个扣带-前额叶通路来实现的。 | Gandaux, C. | PDF | N/A | Motivational control is implemented by a cingulo-prefrontal pathway | | 评估成年敲入斑马鱼中意义未明的变异：以COL1A2变异为例的概念验证
在成年敲入斑马鱼模型中，对意义未明的变异（Variants of Uncertain Significance, VUS）进行评估是一项重要的研究。本文以COL1A2基因为例，展示了如何通过敲入技术将人类基因变异引入斑马鱼基因组，并对其进行功能验证。这一方法为研究人类疾病相关基因变异的功能提供了新的途径，尤其是在缺乏足够临床数据的情况下，能够帮助确定这些变异是否具有致病性。通过这一概念验证，我们证明了斑马鱼模型在功能基因组学研究中的潜力，并为未来的类似研究提供了参考。 | Vanhooydonck, M. | PDF | N/A | Evaluating Variants of Uncertain Significance in Adult Knock-in Zebrafish: A Proof of Concept with a COL1A2 Variant | | TMEM145是外毛细胞静纤毛连接结构中的关键组成部分。 | Roh, J. W. | PDF | N/A | TMEM145 is a key component in stereociliary link structures of outer hair cells | | 在听音乐时，眨眼与音乐节拍同步。 | Wu, Y. | PDF | N/A | Eye blinks synchronize with musical beats during music listening | | 空间上不同的细胞和分子景观决定了三阴性乳腺癌的预后 | Mukund, K. | PDF | N/A | Spatially distinct cellular and molecular landscapes define prognosis in triple negative breast cancer | | 识别神经生物学精神病生物类型使用多尺度功能网络连接及其潜在独立子空间 | Ballem, R. | PDF | N/A | Identifying Neurobiological Psychosis Biotypes Using Multi-Scale Functional Network Connectivity and its Latent Independent Subspace | | 睡眠期间意识体验的电生理相关：清醒梦、睡眠瘫痪、体外体验和假醒 | Herrero, N. | PDF | N/A | ELECTROPHYSIOLOGICAL CORRELATES OF CONSCIOUS EXPERIENCES DURING SLEEP: LUCID DREAMS, SLEEP PARALYSIS, OUT-OF-BODY EXPERIENCES, AND FALSE AWAKENINGS | | 首次在法国南部大陆的牛和野生动物中发现克里米亚-刚果出血热抗体：解释性因素的调查 | Bernard, C. | PDF | N/A | First detection of Crimean Congo Hemorrhagic Fever antibodies in cattle and wild fauna of southern continental France: investigation of explicative factors | | ML-MAGES：一个用于多变量基因关联分析及效应大小缩减的机器学习框架 | Liu, X. | PDF | N/A | ML-MAGES: A machine learning framework for multivariate genetic association analyses with genes and effect size shrinkage | | ERGA-BGE 基因组：Coenonympha oedippus，一种IUCN濒危的欧洲蝴蝶物种，具有两种生态型 | Celik, T. | PDF | N/A | ERGA-BGE genome of Coenonympha oedippus: an IUCN endangered European butterfly species occurring in two ecotypes | | 将“AI-qualizing Science”翻译成中文，可以理解为“AI赋能科学”或“AI使科学平等化”。具体翻译取决于上下文语境：
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AI赋能科学：如果指的是人工智能技术为科学研究提供支持和增强，使其更加高效和精准。
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AI使科学平等化：如果强调的是人工智能技术让科学资源或机会更加平等地分配，缩小差距。
请根据具体语境选择合适的翻译！如果需要更详细的解释或调整，可以告诉我更多背景信息。 | Divakaruni, A. | PDF | N/A | AI-qualizing Science | | 直接观察斜平面显微镜 | Lamb, J. R. | PDF | N/A | Direct-view oblique plane microscopy | | 姜（Zingiber officinale）和柠檬（Citrus limon）汁液的组合效应：来自体内、体外和计算机研究的降血脂和抗氧化见解
这段文字主要描述了一项研究，探讨了姜和柠檬汁液在降血脂和抗氧化方面的联合效果。研究采用了体内实验（in vivo）、体外实验（in vitro）以及计算机模拟（in silico）等多种方法来进行综合分析。 | Bekkouch, O. | PDF | N/A | Combinatorial effects of Zingiber officinale and Citrus limon juices: Hypolipidemic and antioxidant insights from in vivo, in vitro, and in silico investigations | | 静息状态下的钙离子流动保护细胞免受快速的线粒体断裂、细胞应激反应以及即时的转录重编程的影响。 | Fecher, C. | PDF | N/A | Resting calcium ion fluxes protect cells from fast mitochondrial fragmentation, cell stress responses, and immediate transcriptional reprogramming | | 子宫疾病对产后奶牛卵母细胞发育能力的短期和长期影响 | Caldeira, M. | PDF | N/A | Short- and long-term effects of uterine disease on oocyte developmental capacity in postpartum dairy cows | | 面对气候变化的小麦植物可塑性——CO2对升温和水分亏缺的抵消效应。一篇综述。 | Gawinowski, M. | PDF | N/A | Plant plasticity in the face of climate change - CO2 offsetting effects to warming and water deficit in wheat. A review. | | 蛋白质降解和生长依赖的稀释作用显著塑造了哺乳动物蛋白质组的组成。 | Leduc, A. | PDF | N/A | Protein degradation and growth dependent dilution substantially shape mammalian proteomes | | 美国国立卫生研究院（NIH）脑计划中的团队研究实验 | Bader, F. | PDF | N/A | The NIH BRAIN Initiative's Experiment in Team Research | | 消除分离酶抑制揭示了卵母细胞中期II中缺乏粘连蛋白保护。 | El Jailani, S. | PDF | N/A | Elimination of separase inhibition reveals absence of cohesin protection in oocyte metaphase II | | TDP-43聚集体的形成会损害其自身的调节功能，并导致TDP-43功能障碍。 | Mamede, L. D. | PDF | N/A | TDP-43 Aggregate Seeding Impairs Autoregulation and Causes TDP-43 Dysfunction | | Hoi1靶向酵母BLTP2蛋白至内质网-质膜接触位点，以调节脂质稳态 | Dziurdzik, S. K. | PDF | N/A | Hoi1 targets the yeast BLTP2 protein to ER-PM contact sites to regulate lipid homeostasis | | CD47通过Vav1去磷酸化阻止Rac介导的吞噬作用 | Miller, W. D. | PDF | N/A | CD47 prevents Rac-mediated phagocytosis through Vav1 dephosphorylation | | 线粒体动力学紊乱和停滞导致肝损伤和肿瘤发生 | Ma, X. | PDF | N/A | Disruption of Mitochondrial Dynamics and Stasis Leads to Liver Injury and Tumorigenesis | | 中心体协助的Balbiani体组装 | Divyanshi, | PDF | N/A | Centrosome-assisted assembly of the Balbiani body | | 树突引导受体在配体依赖和独立模式下均发挥功能。 | Reddy, A. R. | PDF | N/A | A dendritic guidance receptor functions in both ligand dependent and independent modes | | 分子动力学模拟揭示的MscL通道开放的不对称性 | Rogacheva, O. N. | PDF | N/A | Asymmetric nature of MscL opening revealed by molecular dynamics simulations | | 使用生成式人工智能和密度引导模拟在冷冻电镜中建模配体 | Haloi, N. | PDF | N/A | Modeling ligands in cryo-EM with generative AI and density-guided simulations | | 使用铁蛋白笼设计的一种人工无金属过氧化物酶 | Tian, J. | PDF | N/A | An artificial metal-free peroxidase designed using a ferritin cage | | 评估转录组学整合对基于约束的蓝藻代谢建模的影响 | Pugsley, T. | PDF | N/A | Evaluating Transcriptomic Integration for Cyanobacterial Constraint-based Metabolic Modelling | | 研究盘尾丝虫（Onchocerca ochengi）在癫痫发展中的作用：沙鼠模型研究 | Ayiseh, R. B. | PDF | N/A | Investigating the Role of Onchocerca ochengi in Epilepsy Development: A Gerbil Model Study | | 范围常驻逻辑模型：一个用于形式化范围常驻对种群动态影响的新框架 | Menezes, R. | PDF | N/A | The range-resident logistic model: a new framework to formalize the population-dynamics consequences of range residency | | 声流体图案化技术用于改善微组织组织学 | Deshmukh, D. | PDF | N/A | Acoustofluidic patterning for improved microtissue histology | | 丙型肝炎病毒非结构蛋白5B的多态性、溶剂可及性与保守性 | Lian, D. | PDF | N/A | The Polymorphisms, Solvent Accessibility and Conservatism of Hepatitis C Virus Nonstructural 5B Protein | | MilkOligoCorpus：一个用于哺乳动物乳寡糖知识提取的语义注释资源 | Rumeau, M. | PDF | N/A | MilkOligoCorpus: a semantically annotated resource for knowledge extraction on mammalian milk oligosaccharides | | TOPOLOW：一种用于抗原交叉反应性和结合亲和力测定结果的映射算法 | Arhami, O. | PDF | N/A | TOPOLOW: A MAPPING ALGORITHM FOR ANTIGENIC CROSS-REACTIVITY AND BINDING AFFINITY ASSAY RESULTS | | 高Tau表达与尤文肉瘤的侵袭性降低和生存期延长相关 | Cidre-Aranaz, F. | PDF | N/A | High Tau Expression Correlates with Reduced Invasion and Prolonged Survival in Ewing Sarcoma | | 半球切开术：清醒人类中类似睡眠活动的皮质孤岛 | Colombo, M. A. | PDF | N/A | Hemispherotomy: a cortical island of sleep-like activity in awake humans | | 光系统II的小天线对拟南芥中的qH能量耗散有贡献。 | Bru, P. | PDF | N/A | The minor antennae of photosystem II contribute to qH-energy dissipation in Arabidopsis | | 拟南芥PIEZO调控蓝光下磁场介导的根生长 | Ai, P. Z. | PDF | N/A | Arabidopsis PIEZO regulates magnetic field-mediated root growth under blue light | | 江西省不同来源地古樟树果实表型性状的变异分析 | Zhao, J. | PDF | N/A | Variation analysis of fruit phenotypic traits of different provenances of ancient Cinnamomum camphora in Jiangxi Province of China | | 揭示1-脱氧野尻霉素（DNJ）积累机制：桑叶叶绿体中SWEET3的作用 | Yang, Z. | PDF | N/A | Unraveling the mechanism of 1-deoxynojirimycin (DNJ) accumulation: the role of SWEET3 in mulberry chloroplasts | | 纳米材料诱导Raphidocelis subcapitata中脂滴形成的机制是由电荷特性介导的 | McKeel, E. | PDF | N/A | Mechanism of Nanomaterial-Induced Lipid Droplet Formation in Raphidocelis subcapitata is Mediated by Charge Properties | | 针对病毒CC趋化因子的病毒对抗病毒显性负性干扰策略可预防巨细胞病毒相关的神经发育病理 | Bauer, S. | PDF | N/A | Virus-against-virus dominant-negative interference strategy targeting a viral CC chemokine prevents cytomegalovirus-related neurodevelopmental pathogenesis | | 识别V0g固有脊髓神经元及其在运动控制中的作用 | Toscano, E. | PDF | N/A | Identification of V0g propriospinal neurons and their role in locomotor control | | Gpnmb定义了与朊病毒病中神经元丢失相关的小胶质细胞的吞噬状态 | Caredio, D. | PDF | N/A | Gpnmb Defines a Phagocytic State of Microglia Linked to Neuronal Loss in Prion Disease | | 预扫视侧向交互调制 | Mueller de Melo, G. | PDF | N/A | Presaccadic modulation of lateral interactions | | 以下是这段英文的中文翻译：
"呼吸观察冥想期间脑电图（EEG）的起始时间和时间动态"
翻译说明： - "Time-to-onset" 翻译为 "起始时间"，指的是某种现象开始出现的时间。 - "temporal dynamics" 翻译为 "时间动态"，指的是随时间变化的动态过程。 - "EEG" 是 "脑电图" 的缩写，用于记录大脑电活动。 - "breath-watching meditation" 翻译为 "呼吸观察冥想"，是一种专注于呼吸的冥想练习。
希望这个翻译对你有帮助！ | Malipeddi, S. | PDF | N/A | Time-to-onset and temporal dynamics of EEG during breath-watching meditation | | 将复杂的叙事融入梦境 | Palmieri, J. | PDF | N/A | Incorporation of complex narratives into dreaming | | 空间频率、朝向和熟悉度对面部刺激整合的影响 | Cuomo, M. | PDF | N/A | The Influence of Spatial Frequencies, Orientation and Familiarity on Face Stimuli Integration | | 通过星形胶质细胞调控诱导Hindmarsh-Rose神经元中的嵌合态：对学习机制的启示 | Azad, F. | PDF | N/A | Induction of Chimera States in Hindmarsh-Rose Neurons through Astrocytic Modulation: Implications for Learning Mechanisms | | 饲养条件以细胞类型特异性的方式双向调节海马神经元的认知能力和AP-1信号传导。 | Alaiz-Noya, M. | PDF | N/A | Rearing conditions bidirectionally modulate cognitive abilities and AP-1 signaling in hippocampal neurons in a cell type-specific manner. | | 跑步机运动对视网膜退行性病变小鼠模型视网膜血管形态、功能及循环免疫因子的影响 | Haupt, H. B. | PDF | N/A | Effects of treadmill exercise on retinal vascular morphology, function, and circulating immune factors in a mouse model of retinal degeneration | | 高密度探针揭示了癫痫致死性呼吸暂停模型中的髓质癫痫发作和快速髓质关闭。 | Budde, R. B. | PDF | N/A | High density probes reveal medullary seizure and rapid medullary shutdown in a model of fatal apnea in seizure | | 绘制与快感缺失相关的损伤网络：对经颅磁刺激（TMS）治疗的启示 | Chen, C. | PDF | N/A | Mapping Anhedonia-Related Damage Network: Insights for TMS Treatment | | 小鼠海马神经元中突触小泡融合的动态纳米级结构 | Kroll, J. | PDF | N/A | Dynamic nanoscale architecture of synaptic vesicle fusion in mouse hippocampal neurons | | 小鼠视网膜神经节细胞完整空间图谱揭示密度与基因表达的特化性
这项研究提供了小鼠视网膜神经节细胞的完整空间图谱，揭示了这些细胞在视网膜中的密度分布以及基因表达的特化性。通过高分辨率成像和单细胞RNA测序技术，研究人员能够详细描绘出不同类型神经节细胞在视网膜上的精确位置和分子特征。研究发现，某些特定类型的神经节细胞在视网膜的特定区域呈现出高密度分布，并且这些细胞的基因表达模式也表现出显著的特化性，这可能与其在视觉信息处理中的独特功能有关。这一全面的空间和分子图谱为理解视网膜神经节细胞的多样性和功能提供了重要基础，并可能为视网膜疾病的治疗提供新的思路。 | Budoff, S. A. | PDF | N/A | A Complete Spatial Map of Mouse Retinal Ganglion Cells Reveals Density and Gene Expression Specializations | | 暴露于鱼藤酮会引发氧化还原驱动的全身性脂质组改变和与帕金森病相关的代谢权衡。 | Tiwari, A. | PDF | N/A | Exposure to rotenone triggers redox driven systemwide lipidome alterations and metabolic tradeoffs linked to Parkinsons disease | | 太少与太多：内侧前额叶功能抑制会损害操作性逆转学习的早期习得，而内侧前额叶去抑制则会损害大鼠已建立的连续逆转表现。 | Renstrom, J. G. | PDF | N/A | Too little and too much: medial prefrontal functional inhibition impairs early acquisition of operant reversal learning, whereas medial prefrontal disinhibition impairs established serial-reversal performance in rats | | Spike sorting AI agent 可以翻译为“尖峰排序人工智能代理”或“尖峰分类人工智能代理”。具体翻译取决于上下文，但通常指的是利用人工智能技术对神经元的尖峰信号进行分类和排序的工具或系统。 | Lin, Z. | PDF | N/A | Spike sorting AI agent | | 锚蛋白（Ankyrins）对于小鼠视网膜外层中感光细胞的突触完整性至关重要。 | Zuniga-Sanchez, E. | PDF | N/A | Ankyrins are essential for synaptic integrity of photoreceptors in the mouse outer retina | | 轴突机械转导驱动细胞骨架对生理机械力的响应 | Swaim, G. L. | PDF | N/A | Axonal Mechanotransduction Drives Cytoskeletal Responses to Physiological Mechanical Forces | | 视觉雪综合征患者初级视觉皮层的神经可塑性增强：来自MEG伽马振荡的证据 | Orekhova, E. V. | PDF | N/A | Enhanced Neural Plasticity of the Primary Visual Cortex in Visual Snow Syndrome: Evidence from MEG Gamma Oscillations | | 人类能够在复杂的感知运动行为中学习双模态先验。 | Zahno, S. | PDF | N/A | Humans can learn bimodal priors in complex sensorimotor behaviour | | 后鼻阻塞减少了人脑中对蔗糖的神经处理。 | Ko, H. K. | PDF | N/A | Retro Nasal blockade reduces the Neural Processing of Sucrose in the Human Brain | | 识别在扁桃体、肠道和宫颈组织模型中可诱导的HIV潜伏库 | Cortes, A. G. | PDF | N/A | Identification of the Inducible HIV reservoir in Tonsillar, Intestinal and Cervical Tissue Models of HIV Latency | | 小鼠头皮发育需要Rac1和SRF来维持机械感应间充质。 | Rathnakar, B. H. | PDF | N/A | Mouse scalp development requires Rac1 and SRF for the maintenance of mechanosensing mesenchyme | | 皮肤中普遍存在的Krt8向Krt5细胞状态转变被p63用于釉质器官的发育。 | Tang, Q. | PDF | N/A | A prevalent Krt8-to-Krt5 cellular state transition in skin is co-opted by p63 for enamel organ development | | 在传递性推理任务中，学习将准确性和反应时间解耦，以实现快速决策。 | Silva, F. A. M. | PDF | N/A | Learning decouples accuracy and reaction time for rapid decisions in a transitive inference task | | 对称性破缺在大脑静息态动力学中的连接性与神经退行性中的作用 | Gudibanda, K. | PDF | N/A | The role of symmetry breaking in connectivity and neurodegeneracy in the brain's resting state dynamics | | 视觉运动检测阈值与视觉对内侧/外侧平衡控制敏感性之间的关系 | DiBianca, S. J. | PDF | N/A | The Relationship Between Visual Motion Detection Thresholds and Visual Sensitivity to Medial/Lateral Balance Control | | 氯胺酮改变神经和行为空间工作记忆精度的调谐 | Rahmati, M. | PDF | N/A | Ketamine Alters Tuning of Neural and Behavioral Spatial Working Memory Precision | | 注释比较探索器（ACE）：在健康和阿尔茨海默病研究中连接脑细胞类型 | Miller, J. A. | PDF | N/A | Annotation Comparison Explorer (ACE): connecting brain cell types across studies of health and Alzheimer's Disease | | 星形胶质细胞的PI3Kα通过丝氨酸代谢调控突触可塑性和认知功能 | Fernandez-Rodrigo, A. | PDF | N/A | Astrocytic PI3Kα controls synaptic plasticity and cognitive function via serine metabolism | | 人类步进过程中记录的可穿戴脑磁图（MEG）数据 | Spedden, M. E. | PDF | N/A | Wearable MEG data recorded during human stepping | | 与氧化代谢的联系在不同的静息态功能磁共振成像（rs-fMRI）指标中存在差异：使用大血管校正的全脑评估 | Zhong, X. Z. | PDF | N/A | The Link to Oxidative Metabolism Varies across rs-fMRI Metrics: A Whole-Brain Assessment Using Macrovascular Correction | | 纵向神经影像学中任意效应大小的半参数置信集 | Zhang, X. | PDF | N/A | Semiparametric Confidence Sets for Arbitrary Effect Sizes in Longitudinal Neuroimaging | | 组织损伤引发的感觉神经元轴突损伤相关反应——需求、预防及其在持续性术后疼痛中的潜在作用 | Rau, K. K. | PDF | N/A | Tissue damage-induced axon injury-associated responses in sensory neurons - requirements, prevention, and potential role in persistent post-surgical pain | | 在类天疱疮中，细胞分离而非自身抗体的结合，会引发细胞范围内的、持久的转录组和蛋白质组变化。 | Hartmann, V. | PDF | N/A | In pemphigus, cell detachment, but not autoantibody binding, induces cell-wide, long-lasting transcriptomic and proteomic changes | | 广泛表达的转录因子在早期心脏细胞特化中的不同作用 | Abbasi, S. | PDF | N/A | Differential Roles of Broadly Expressed Transcription Factors in Early Cardiac Cell Specification | | 无脊椎动物中对迫近刺激敏感的下降神经元的快速适应 | Sporar Klinge, K. | PDF | N/A | Fast adaptation in invertebrate looming-sensitive descending neurons | | 通过富集和宏蛋白质组学发现微生物糖苷水解酶 | van Ede, J. M. | PDF | N/A | Discovery of microbial glycoside hydrolases via enrichment and metaproteomics | | 磷酸化蛋白质组学揭示早期肝细胞癌的肿瘤异质性和治疗机会 | Ren, L. | PDF | N/A | Phosphoproteomics Uncovers Tumor Heterogeneity and Therapeutic Opportunities in Early-Stage Hepatocellular Carcinoma | | AI引导的基因融合延长了合成基因电路的进化半衰期 | Menuhin-Gruman, I. | PDF | N/A | AI-directed gene fusing prolongs the evolutionary half-life of synthetic gene circuits | | 查尔酮异构酶类似物阻碍了内酯支路，并增强了在分叉途径中向异黄酮生物合成的通量分配。 | Raytek, L. M. | PDF | N/A | Chalcone isomerase-like impedes the lactone shunt and enhances flux partitioning in a bifurcated pathway towards isoflavonoid biosynthesis | | 遗传数据和气象条件：揭示H5N1高致病性禽流感在商业家禽疫情间的风媒传播 | Nagy, A. | PDF | N/A | Genetic data and meteorological conditions: unravelling the windborne transmission of H5N1 high-pathogenicity avian influenza between commercial poultry outbreaks | | 从孢子形成到村庄分化：印度尼西亚农村到城市生活方式转变过程中社会微生物群的形成 | Febinia, C. A. | PDF | N/A | From sporulation to village differentiation: the shaping of the social microbiome over rural-to-urban lifestyle transition in Indonesia | | 在最深的海洋中卤代有机化合物及其降解微生物的富集 | Liu, R. | PDF | N/A | Enrichment of halogenated organic compounds and their degrading microorganisms in the deepest ocean | | Crusty-Pinky：一种新型的多极端耐受真菌及其甲基杆菌共生体可能是生物土壤结皮群落中不可或缺的共生关系 | Carr, E. C. | PDF | N/A | Crusty-Pinky: A Novel Polyextremotolerant Fungus and its Methylobacterium Symbionts Could be an Essential Symbiosis for the Biological Soil Crust Consortium | | 肠道碱性磷酸酶在炎症性肠病相关非酒精性脂肪肝中的保护作用 | Liu, Y. | PDF | N/A | The Protective Role of Intestinal Alkaline Phosphatase in Inflammatory Bowel Disease-Associated Non-Alcoholic Fatty Liver Disease | | Mpox和牛痘病毒在初级进水及沉淀固体中的衰减与固液分配研究，以指导基于废水的流行病学实践 | Phaneuf, J. R. | PDF | N/A | Decay and Solid-Liquid Partitioning of Mpox and Vaccinia Viruses in Primary Influent and Settled Solids to Guide Wastewater-Based Epidemiology Practices | | 真核翻译起始因子eIF4E的转录后活性有助于HoxA9驱动的白血病发生 | Zhou, F. | PDF | N/A | Posttranscriptional activity of the eukaryotic translation initiation factoreIF4E contributes to HoxA9-driven leukemogenesis | | 梅克尔细胞多瘤病毒感染和持续性在皮肤类器官中的建模 | Albertini, S. | PDF | N/A | Merkel cell polyomavirus infection and persistence modelled in skin organoids | | 一个促进对较少了解蛋白质研究的生物信息学工作流程：以SH2D2A为例 | Gilmour, B. C. | PDF | N/A | A bioinformatic workflow to facilitate the study of less-understood proteins: the case of SH2D2A | | 胱氨酸素参与近端肾小管细胞中Na+/H+交换体3的运输：关于胱氨酸病中肾范可尼综合征的新见解 | Khare, V. | PDF | N/A | Cystinosin is involved in Na+/H+ Exchanger 3 trafficking in the proximal tubular cells: new insights in the renal Fanconi syndrome in cystinosis | | 发现一种紧凑型RNA引导的内切酶中广泛存在的激活突变 | Thornton, B. W.-L. | PDF | N/A | Discovery of widespread activating mutations in a compact RNA-guided endonuclease | | DNA G-四链体分析揭示了G-四链体在骨骼肌干细胞中的功能和机制作用 | Chen, X. | PDF | N/A | DNA G-quadruplex Profiling Reveals Functional and Mechanistic Role of G-quadruplexes in Skeletal Muscle Stem Cells | | 解析多RRM蛋白Rrm4的RNA结合能力，该蛋白对于内体mRNA运输至关重要 | Stoffel, N. K. | PDF | N/A | Dissecting the RNA binding capacity of the multi-RRM protein Rrm4 essential for endosomal mRNA transport | | 群体规模的细胞GUIDE-seq-2和生化CHANGE-seq-R分析揭示，人类遗传变异经常影响Cas9的脱靶活性。 | Tsai, S. | PDF | N/A | Population-scale cellular GUIDE-seq-2 and biochemical CHANGE-seq-R profiles reveal human genetic variation frequently affects Cas9 off-target activity | | 同时进行的单细胞CRISPR、RNA和ATAC测序技术使得多组学CRISPR筛选成为可能，从而能够识别基因调控关系。 | Shevade, K. | PDF | N/A | Simultaneous single-cell CRISPR, RNA, and ATAC-seq enables multiomic CRISPR screens to identify gene regulatory relationships | | 缓冲液离子浓度变化及突变对GH1 β-葡萄糖苷酶同源二聚体的影响 | Chagas, R. S. | PDF | N/A | Impact of changes in buffer ionic concentration and mutations on a GH1 β-Glucosidase homodimer | | KLP-6是一种对ADP抑制具有抵抗力的驱动蛋白超家族蛋白。 | Kita, T. | PDF | N/A | KLP-6 is a kinesin superfamily protein resistant to ADP inhibition | | 小分子揭示了G-四链体RNA在稳定性和蛋白质结合方面的差异变化 | Martyr, J. G. | PDF | N/A | Small molecules reveal differential shifts in stability and protein binding for G-quadruplex RNA | | 几何蛋白质优化 | Horn, C. | PDF | N/A | Geometric Protein Optimization | | 通过删除一种特殊的次要菌毛样基因来刺激新月柄杆菌表面感应途径 | Obeid Charrouf, F. | PDF | N/A | Stimulation of the Caulobacter crescentus surface sensing pathway by deletion of a specialized minor pilin-like gene | | 将这段翻译成中文为：VI型分泌系统的表型异质性确保了肠聚集性大肠杆菌在抗菌活性和抗性之间的权衡。 | Taillefer, B. | PDF | N/A | Type VI secretion phenotypic heterogeneity ensures trade-off between antibacterial activity and resistance in Enteroaggregative E. coli | | 优化Xenium自动化原位测序技术用于PAXgene固定组织样本 | Roberts, K. | PDF | N/A | Optimisation of Xenium automated in situ sequencing for PAXgene-fixed tissue samples | | 空间转录组学揭示了慢性结节病患者肺肉芽肿中的混合型、促炎性和促纤维化细胞微环境。 | Christian, L. | PDF | N/A | Spatial transcriptomics uncovers hybrid, pro-inflammatory and pro-fibrotic cellular niches in pulmonary granuloma of patients with chronic sarcoidosis | | 开发一种BiAD传感器，用于通过荧光显微镜对细胞组蛋白乙酰化动态进行位点特异性检测 | Koehler, A. R. | PDF | N/A | Development of a BiAD sensor for locus-specific detection of cellular histone acetylation dynamics by fluorescence microscopy | | 剖析人类细胞中DNA错配修复驱动的突变过程 | Weghorn, D. | PDF | N/A | Dissecting DNA-mismatch-repair-driven mutational processes in human cells | | 利用长读长组装和机器学习技术提升短读长转座元件检测与基因分型 | Daigle, A. T. | PDF | N/A | Leveraging long-read assemblies and machine learning to enhance short-read transposable element detection and genotyping | | 亚热带野生牛科动物牛（偶蹄目：牛科）的性别二态性和表型可塑性。 | Perroux, T. A. | PDF | N/A | Sexual dimorphism and phenotypic plasticity in a subtropical feral bovid Bos taurus (Artiodactyla: Bovidae). | | 蓝色是蜜蜂最具吸引力的颜色吗？探索风车陷阱中颜色的吸引力 | Renteria, E. | PDF | N/A | Is blue the most attractive color for bees? Exploring the attractiveness of colors in vane traps | | 潮间带贻贝（Mytilus trossulus）单次和重复冻结的能量后果 | Yang, J. C. C. | PDF | N/A | Energetic consequences of single and repeated freezing in the intertidal mussel, Mytilus trossulus | | 钙信号传导是一种普遍的碳源信号转导器，并对过去的碳源产生离子记忆效应。 | Simpson-Lavy, K. | PDF | N/A | Calcium signaling is a universal carbon source signal transducer and effects an ionic memory of past carbon sources | | 疟原虫生命周期中的异质性约束与适应 | Perkins, S. A. | PDF | N/A | Heterogeneous constraint and adaptation across the malaria parasite life cycle | | 跨视觉、听觉和视听决策的置信度判断常用算法 | West, R. K. | PDF | N/A | A common algorithm for confidence judgements across visual, auditory and audio-visual decisions | | 在人口统计学推断中考虑嵌合现象：利用高质量的全基因组群体数据重建普通狨猴（Callithrix jacchus）的历史 | Soni, V. | PDF | N/A | Accounting for chimerism in demographic inference: reconstructing the history of common marmosets (Callithrix jacchus) from high-quality, whole-genome, population-level data | | 基准测试DNA序列模型在人类遗传学中因果调控变异预测的应用 | Benegas, G. | PDF | N/A | Benchmarking DNA Sequence Models for Causal Regulatory Variant Prediction in Human Genetics | | 人类免疫球蛋白重链恒定区基因座富含大型复杂结构变异和编码多态性，这些变异和多样性在不同人类群体中的频率各不相同。 | Jana, U. | PDF | N/A | The human immunoglobulin heavy chain constant gene locus is enriched for large complex structural variants and coding polymorphisms that vary in frequency among human populations | | 标题翻译：Drimenol合酶的晶体结构与催化机制：一种双功能萜烯环化酶-磷酸酶
内容翻译： Drimenol合酶是一种独特的双功能酶，它结合了萜烯环化酶和磷酸酶的活性。这种酶在生物体内催化从法尼基二磷酸（FPP）到Drimenol的生物合成过程中起着关键作用。Drimenol是一种具有生物活性的二萜类化合物，具有多种药理作用。
晶体结构分析揭示了Drimenol合酶的三维结构，包括其活性位点的详细构象。萜烯环化酶结构域负责催化FPP的环化反应，而磷酸酶结构域则负责去除反应中间体的磷酸基团，从而促进Drimenol的最终形成。
催化机制研究表明，Drimenol合酶通过一系列精确的步骤实现其双功能催化。首先，萜烯环化酶结构域通过特定的氨基酸残基与FPP结合，并催化其环化形成中间体。随后，磷酸酶结构域通过水解反应去除中间体的磷酸基团，最终生成Drimenol。
这种双功能酶的发现不仅增进了我们对萜类生物合成途径的理解，也为开发新型生物催化剂和药物提供了新的思路。 | Osika, K. R. | PDF | N/A | Crystal Structure and Catalytic Mechanism of Drimenol Synthase, a Bifunctional Terpene Cyclase-Phosphatase | | 人类存在、限制以及压力邻居对家养虎皮鹦鹉（Melopsittacus undulatus）皮质酮水平的影响 | Reichard, D. G. | PDF | N/A | The effects of human presence, restraint, and stressed neighbors on corticosterone levels in domesticated budgerigars (Melopsittacus undulatus) |