BioRxiv 2025-02-14 Papers

标题	作者	PDF链接	代码仓库	Title
Onlinemeta：基于Shiny框架的元分析网络服务器	Dai, W.	PDF	N/A	Onlinemeta: A Web Server for Meta-Analysis Based on Shiny Framework
捕捉LIS1型无脑回畸形类器官模型中疾病严重程度的生物学特征	Zillich, L.	PDF	N/A	Capturing the biology of disease severity in an organoid model of LIS1-lissencephaly
评估环境DNA（eDNA）分析在海洋环境产卵调查中的潜力：以日本竹荚鱼为例的研究	Tsuji, S.	PDF	N/A	Assessing the potential of eDNA analysis for spawning surveys in marine environments: A case study on Japanese jack mackerel
一种促凋亡脂质对线粒体蛋白质导入和蛋白质稳态的抑制作用	Fita-Torro, J.	PDF	N/A	Inhibition of mitochondrial protein import and proteostasis by a pro-apoptotic lipid
PIM激酶对CD8 T细胞蛋白质合成和细胞运输的调控	Marchingo, J. M.	PDF	N/A	PIM kinase control of CD8 T cell protein synthesis and cell trafficking
从空间快照看时间组织动态	Somer, J.	PDF	N/A	Temporal tissue dynamics from a spatial snapshot
Locityper：复杂多态性基因的定向基因分型	Prodanov, T.	PDF	N/A	Locityper: targeted genotyping of complex polymorphic genes
Locityper：复杂多态性基因的定向基因分型	Prodanov, T.	PDF	N/A	Locityper: targeted genotyping of complex polymorphic genes
STEMorph：一组从愤怒到快乐的情绪面部刺激，源自NimStim	Katebi, M. E.	PDF	N/A	STEMorph: A Set of Morphed Emotional Face Stimuli from Angry to Happy Derived from NimStim
使用铁氧体微粒（ferumoxytol）加权层析MRI技术绘制灵长类大脑血管网络结构	Autio, J. A.	PDF	N/A	Mapping vascular network architecture in primate brain using ferumoxytol-weighted laminar MRI
小脑浦肯野细胞对舌头运动的控制	Hage, P.	PDF	N/A	Control of tongue movements by the Purkinje cells of the cerebellum
分层截断精确检验的伽马近似法（GASTE检验）及应用	Wendling, A.	PDF	N/A	Gamma Approximation of Stratified Truncated Exact test (GASTE-test) & Application
通过调节GSK3活性重新编程依赖GM-CSF的肺泡巨噬细胞	Rios, I.	PDF	N/A	Re-programming of GM-CSF-dependent alveolar macrophages through GSK3 activity modulation
病毒介导的Oct4过表达和Notch信号抑制协同诱导哺乳动物Muller胶质细胞的神经源性能力。	Le, N.	PDF	N/A	Viral-mediated Oct4 overexpression and inhibition of Notch signaling synergistically induce neurogenic competence in mammalian Muller glia.
GeneCover：一种用于无标记基因选择的组合方法	Wang, A.	PDF	N/A	GeneCover: A Combinatorial Approach for Label-free Marker Gene Selection
Nano3P-seq：以单分子分辨率绘制编码和非编码转录组图谱	Begik, O.	PDF	N/A	Nano3P-seq: charting the coding and non-coding transcriptome at single molecule resolution
通过DNA语言模型解读宏基因组读段中的酶潜力	R, P.	PDF	N/A	Deciphering enzymatic potential in metagenomic reads through DNA language model
非稀释结合与表面相分离理论在膜结合蛋白中的应用	Zhao, X.	PDF	N/A	Theory of non-dilute binding and surface phase separation applied to membrane-binding proteins
表皮细胞动力学通过调控OsZHD1和OsZHD2来调节水稻叶枕关节形态发生和叶片角度形成。	Xu, Y.	PDF	N/A	Epidermal Cell Dynamics Regulates Rice Lamina Joint Morphogenesis and Leaf Angle Formation through OsZHD1 and OsZHD2 Regulation
通过脑电图和模型指导的功能性磁共振成像揭示人类顶内沟在证据累积中的作用	Wongtrakun, J.	PDF	N/A	The role of human intraparietal sulcus in evidence accumulation revealed by EEG and model-informed fMRI
互联网上的图片揭示了一种模仿大黄蜂的食蚜蝇，它们已经进化到能够追随其模仿对象——大黄蜂对花朵颜色的偏好。	Gilbert, J. D.	PDF	N/A	Internet images reveal bumblebee-mimicking hoverflies have evolved to follow flower colour preferences of their models
胆固醇介导的APOE4星形胶质细胞溶酶体功能障碍促进人脑组织中α-突触核蛋白病理	Mesentier-Louro, L. A.	PDF	N/A	Cholesterol-mediated Lysosomal Dysfunction in APOE4 Astrocytes Promotes α-Synuclein Pathology in Human Brain Tissue
后生动物幼虫纤毛带中同步波的动态与涌现	Poon, R. N.	PDF	N/A	Dynamics and emergence of metachronal waves in the ciliary band of a metazoan larva
突触的纳米级组织结构决定了皮质神经元树突棘的突触释放特性。	Jafri, H.	PDF	N/A	Nano-organization of synapses defines synaptic release properties at cortical neuron dendritic spines
信息复杂性作为认知储备的神经标记	Stolp, L.	PDF	N/A	Informational Complexity as a Neural Marker of Cognitive Reserve
感知加速过程中的变量处理变化：来自时间整合的证据	Wolff, M. J.	PDF	N/A	Variable processing shifts during perceptual acceleration: Evidence from temporal integration
在细胞周期进程中，Sec24C通过磷酸化和O-GlcNAc糖基化进行动态调控	Georgiou, G. R.	PDF	N/A	Dynamic regulation of Sec24C by phosphorylation and O-GlcNAcylation during cell cycle progression
糖皮质激素在小鼠皮层神经元发育过程中调节神经元周围网络组分基因和小白蛋白的表达。	Morris, B.	PDF	N/A	Glucocorticoids modulate expression of perineuronal net component genes and parvalbumin during development of mouse cortical neurons
研究自然行为之外肌肉活动模式学习的一种范式	Ghavampour, A.	PDF	N/A	A paradigm to study the learning of muscle activity patterns outside of the natural repertoire
整合的人类和小鼠星形胶质细胞跨疾病图谱揭示了神经退行性疾病中星形胶质细胞亚型的异质性和保守性	Lucas, T. A.	PDF	N/A	Integrated Cross-Disease Atlas of Human And Mouse Astrocytes Reveals Heterogeneity and Conservation of Astrocyte Subtypes in Neurodegeneration
婴儿从出生到6个月期间白质成熟的动态变化	Risk, B.	PDF	N/A	Dynamics of infant white matter maturation from birth to 6 months
在群体基因组数据中识别单一来源的稀有变异	Reynolds, J. J.	PDF	N/A	Identifying single origin rare variants in population genomic data
StackGlyEmbed：使用蛋白质语言模型预测N-连接糖基化位点	Nafi, M. M. I.	PDF	N/A	StackGlyEmbed: Prediction of N-linked Glycosylation sites using protein language models
钙离子诱导的N端门控和孔道塌陷在连接蛋白46/50间隙连接中的作用	Flores, J. A.	PDF	N/A	Calcium induced N-terminal gating and pore collapse in connexin-46/50 gap junctions
TinA 使驱动蛋白-14/KlpA 能够表现出持续的向负端运动的特性。	Visootsat, A.	PDF	N/A	TinA enables kinesin-14/KlpA to exhibit processive minus-end-directed motility
使用全原子模拟和人工智能发现新的类淀粉样肽。	Kuang, X.	PDF	N/A	Discovering new amyloid-like peptides using all-atom simulations and artificial intelligence.
微管细胞骨架对β细胞中胰岛素运输的影响：一项三维计算研究	Thieu, T.	PDF	N/A	Impact of the Microtubule Cytoskeleton on Insulin Transport in Beta Cells: A 3D Computational Study
通过分子模拟揭示H2A和H2B泛素化在核小体动力学中的相反作用	Baweja, L.	PDF	N/A	The Opposing Roles of H2A and H2B Ubiquitination on Nucleosome Dynamics Revealed by Molecular Simulations
通过冷冻电镜技术揭示连接蛋白-46/50的pH门控机制及其可逆性脂质调控	Jarodsky, J. M.	PDF	N/A	Reversible lipid mediated pH-gating of connexin-46/50 by cryo-EM
分子动力学模拟揭示了M. smegmatis拓扑异构酶1A的DNA门开启机制	Sigdel, D.	PDF	N/A	Molecular dynamics simulations reveal DNA gate opening mechanisms for M. smegmatis topoisomerase 1A
使用能量函数对多室植物细胞中的离子稳态进行多物理场建模	Mestdagh, G.	PDF	N/A	Multi-physics modeling for ion homeostasis in multi-compartment plant cells using an energy function
使用AlphaFold2预测折叠蛋白质中侧链的构象	Maisuradze, G.	PDF	N/A	Using AlphaFold2 to Predict the Conformations of Side Chains in Folded Proteins
探究膜在抗流感病毒抗体中和活性中的作用	Ozgulbas, D. G.	PDF	N/A	Probing the Role of Membrane in Neutralizing Activity of Antibodies Against Influenza Virus
通过茎/连接区域控制微管相关蛋白的受力特性：来自NDC80复合物的见解	Kovalenko, I. B.	PDF	N/A	Control of the force-bearing properties of microtubule-associated proteins via stalk/linker regions: insights from the NDC80 complex
两步发条机制在PIEZO2通道中打开一个蛋白质-脂质孔	Li, S.	PDF	N/A	A two-step clockwork mechanism opens a proteo-lipidic pore in PIEZO2 channels
长程静电力决定了蛋白质在核糖体上的折叠方式。	Streit, J.	PDF	N/A	Long-range electrostatic forces govern how proteins fold on the ribosome
细菌病原体利用亚氨基糖半乳糖苷来操纵植物糖生物学	Sanguankiattichai, N.	PDF	N/A	Bacterial pathogen deploys iminosugar galactosyrin to manipulate plant glycobiology
烟雾暴露会引发快速的转录变化，并揭示出与成熟葡萄浆果中烟雾污染相关的糖基转移酶。	Paineau, M.	PDF	N/A	Smoke exposure triggers rapid transcriptional changes and reveals glycosyltransferases linked to smoke taint in ripening grape berries
一个世纪的平衡选择理论	Ruzicka, F.	PDF	N/A	A century of theories of balancing selection
TF2TG：一个挖掘果蝇转录因子潜在基因靶标的在线资源	Hu, Y.	PDF	N/A	TF2TG: an online resource mining the potential gene targets of transcription factors in Drosophila
基于现场可编程门阵列的超低功耗离散傅里叶变换用于闭环神经传感	Yang, R.	PDF	N/A	Field-Programmable Gate Array Based Ultra-Low Power Discrete Fourier Transforms for Closed-Loop Neural Sensing
来自经验和观察的证据在扣带皮层中的积累	Chen, R.	PDF	N/A	Evidence accumulation from experience and observation in the cingulate cortex
阶段性疼痛和持续性疼痛在适应行为中发挥不同的功能。	Tong, S.	PDF	N/A	Phasic and tonic pain serve distinct functions during adaptive behaviour
《在清醒的极限中游走：探索梦境中运动实践的认知限制》	Peters, E.	PDF	N/A	Juggling the Limits of Lucidity: Searching for Cognitive Constraints in Dream Motor Practice
长期评估支配地位、围兜尺寸、性别和年龄之间的关联	Silva, N. J.	PDF	N/A	Long-term evaluation of the association between dominance, bib size, sex and age
比较计算对接分析：MPP+和多巴胺与人类和斑马鱼多巴胺转运体的结合——MPTP神经毒性的机制研究

这段翻译将英文标题转换为中文，同时保持了原文的专业性和准确性。标题中的“Comparative Computational Docking Analysis”翻译为“比较计算对接分析”，“MPP+ and Dopamine Binding to Dopamine Transporter”翻译为“MPP+和多巴胺与多巴胺转运体的结合”，“in Human and Zebrafish”翻译为“在人类和斑马鱼中”，“Mechanistic Insights into MPTP Neurotoxicity”翻译为“MPTP神经毒性的机制研究”。整体翻译流畅，符合中文表达习惯。 | Razali, K. | PDF | N/A | Comparative Computational Docking Analysis of MPP+ and Dopamine Binding to Dopamine Transporter in Human and Zebrafish: Mechanistic Insights into MPTP Neurotoxicity | | 对C9orf72突变诱导多能干细胞（iPSC）衍生的微胶质细胞进行转录组分析表明，在运动神经元退化过程中，特定的NLRP3炎症小体基因在细胞自主性上上调。 | Pulimood, N. S. | PDF | N/A | Transcriptomic analysis of C9orf72-mutated iPSC-derived microglia implicates cell-autonomous upregulation of selected NLRP3 inflammasome genes in motor neuron degeneration | | 斑马鱼行为信用分配的神经回路 | Paoli, E. | PDF | N/A | A zebrafish circuit for behavioral credit assignment | | SpaceBar 能够在空间转录组数据中实现克隆追踪。 | Kinsler, G. | PDF | N/A | SpaceBar enables clone tracing in spatial transcriptomic data | | 珊瑚毒液和毒素作为对抗棘冠海星攻击的防护手段 | Gorman, L. M. | PDF | N/A | Coral venom and toxins as protection against crown-of-thorns sea star attack | | 土地利用历史导致公园夜间降温能力和森林结构存在差异 | Richmond, I. C. | PDF | N/A | Land-use history causes differences in park nighttime cooling capacity and forest structure | | 酵母中金属交叉耐受性的进化 | Bazzicalupo, A. | PDF | N/A | Evolution of cross-tolerance to metals in yeast | | Res ipSAE loquunt: AlphaFold的ipTM评分出了什么问题以及如何修复 | Dunbrack, R. | PDF | N/A | Res ipSAE loquunt: What's wrong with AlphaFold's ipTM score and how to fix it | | 在IMPACC研究中，识别出一种多组学因子可预测长期COVID（长新冠）。 | Gabernet, G. | PDF | N/A | Identification of a multi-omics factor predictive of long COVID in the IMPACC study | | 误导性的监测：更多的幼龟孵化并不代表海龟种群的恢复 | Norris, D. | PDF | N/A | Misleading monitoring: more hatchlings do not represent turtle population recovery | | 一款多功能微型双光子显微镜，可实现多色深脑成像 | Wu, R. | PDF | N/A | A versatile miniature two-photon microscope enabling multicolor deep-brain imaging | | 基于个体特征的个性化连接组深度生成 | Liu, Y. | PDF | N/A | Deep generation of personalized connectomes based on individual attributes | | 在生理性焦虑中，强化学习和工作记忆系统的双重过程损伤是学习缺陷的基础。 | Senta, J. | PDF | N/A | Dual process impairments in reinforcement learning and working memory systems underlie learning deficits in physiological anxiety | | 神经科学的发展演变 | Senden, M. | PDF | N/A | The Evolving Landscape of Neuroscience | | 单细胞RNA测序揭示感染十足目虹彩病毒1的罗氏沼虾（Macrobrachium rosenbergii）中血细胞异质性、分化轨迹及病毒趋向性

这段翻译将英文标题转换为中文，同时保持了科学术语的准确性和专业性。标题中提到的“Single-Cell RNA Sequencing”翻译为“单细胞RNA测序”，“Hemocyte Heterogeneity”翻译为“血细胞异质性”，“Differentiation Trajectories”翻译为“分化轨迹”，“Viral Tropism”翻译为“病毒趋向性”，而“Decapod Iridescent Virus 1”则翻译为“十足目虹彩病毒1”。整个标题清晰地传达了研究的核心内容和研究对象。 | Xiao, B. | PDF | N/A | Single-Cell RNA Sequencing Reveals Hemocyte Heterogeneity, Differentiation Trajectories, and Viral Tropism in Shrimp (Macrobrachium rosenbergii) Infected with Decapod Iridescent Virus 1 | | 探讨后疫情时代可持续洗手行为背景下日常卫生清洁产品的有效性 | Mukherjee, S. | PDF | N/A | Addressing efficacy of everyday hygiene cleansing products in context of sustainable handwashing behavior in the post-pandemic era | | 利用attP着陆位点和gypsy逆转录病毒绝缘子来识别和研究RNA沉默的病毒抑制因子 | Gupta, A. K. | PDF | N/A | Exploiting attP landing sites and gypsy retrovirus insulators to identify and study viral suppressors of RNA silencing | | 利用RiboMarker(R)增强的RNA测序技术对球孢子菌不同形态的转录组变化进行表征 | Howard, J. M. | PDF | N/A | Characterization of transcriptomic changes across Coccidioides morphologies using RiboMarker(R)-enhanced RNA sequencing | | 线粒体呼吸的改变与寄生性列当科植物中核编码的氧化磷酸化（OXPHOS）基因的丢失有关。 | Cai, L. | PDF | N/A | Altered mitochondrial respiration is associated with loss of nuclear-encoded OXPHOS genes in parasitic broomrapes | | 以下是将这段英文翻译成中文的结果：

一种用于英国兽医中心抗菌素耐药性一体化健康监测的宏基因组学方法

解释： - metagenomic approach：宏基因组学方法 - One Health surveillance：一体化健康监测（One Health 是一种跨学科合作的方法，旨在实现人类、动物和环境的最佳健康） - antimicrobial resistance：抗菌素耐药性 - UK veterinary centre：英国兽医中心

整体翻译为：一种用于英国兽医中心抗菌素耐药性一体化健康监测的宏基因组学方法。 | Elton, L. | PDF | N/A | A metagenomic approach to One Health surveillance of antimicrobial resistance in a UK veterinary centre | | 使用通勤时间矩阵进行单细胞轨迹推断的替代方法 | Houston, D. W. | PDF | N/A | Alternative approaches to single-cell trajectory inference using a commute time matrix | | 开发基础模型用于智能监测中预测病毒动物宿主范围 | Guo, J. | PDF | N/A | Developing Foundation Models for Predicting Viral Animal Host Range in Intelligent Surveillance | | 设计具有精确调控动力学特性的蛋白质序列 | Brotzakis, Z. F. | PDF | N/A | Design of Protein Sequences with Precisely Tuned Kinetic Properties | | LCLNCRdb：一个用于研究肺癌中长链非编码RNA的综合资源 | Dwivedi, A. | PDF | N/A | LCLNCRdb: A Comprehensive Resource for Investigating long non-coding RNAs in Lung Cancer | | SEEDS：模拟DNA存储中错误的出现 | Naznin, M. F. S. | PDF | N/A | SEEDS: Simulating Emergence of Errors in DNA Storage | | 淀粉样前体蛋白通过建立免疫排斥的肿瘤微环境促进肿瘤生长 | Yin, T. | PDF | N/A | Amyloid-β precursor protein promotes tumor growth by establishing an immune-exclusive tumor microenvironment | | 对热带大型钝眼蜱（Amblyomma variegatum）进行解剖和内部观察 | Pature, N. | PDF | N/A | Dissection and internal observation of the giant tropical bont tick Amblyomma variegatum | | 经颅磁刺激减少了感知决策中的非决策时间 | Gordleeva, S. | PDF | N/A | Transcranial Magnetic Stimulation Reduces Non-Decision Time in Perceptual Decisions | | TGIF2是神经干细胞命运和神经源性启动的主要调节因子。 | Li, Y. | PDF | N/A | TGIF2 is a major regulator of neural stem cell fate and neurogenic priming | | 脑磁图揭示COVID-19疫苗在非人类灵长类动物中的神经保护作用 | Stapleton-Kotloski, J. | PDF | N/A | Magnetoencephalography Reveals Neuroprotective Effects of COVID-19 Vaccination in Non-Human Primates | | 针对乙型肝炎病毒的mRNA-LNP疫苗在预防性和慢性小鼠挑战模型中诱导出保护性免疫反应。 | Limeres, M. J. | PDF | N/A | mRNA-LNP vaccines against Hepatitis B virus induce protective immune responses in preventive and chronic mouse challenge models | | 人类I型干扰素ω具有强效的抗病毒特性，并能促进细胞毒性CD8+ T细胞反应。 | Nguyen, H. O. | PDF | N/A | Human type-I interferon omega holds potent antiviral properties and promotes cytolytic CD8+ T cell responses | | SA55广泛中和SARS-CoV-2，并有效防止JN.1亚系的病毒逃逸。 | Shi, L. | PDF | N/A | SA55 broadly neutralizes SARS-CoV-2 and robustly prevents viral escape by JN.1 sublineages | | 大规模全球肺炎链球菌抗生素耐药性决定因素的分子流行病学研究 | Shawrob, K. S. M. | PDF | N/A | Large-scale global molecular epidemiology of antibiotic resistance determinants in Streptococcus pneumoniae | | MYRF在间皮细胞中对促进肺部发育和成熟至关重要 | Luna, G. | PDF | N/A | MYRF is Essential in Mesothelial Cells to Promote Lung Development and Maturation | | 通过基于序列图模型的局部泛基因组优化实现准确的体细胞结构变异检测 | Tu, K. | PDF | N/A | Accurate Somatic SV detection via sequence graph model-based local pan-genome optimization | | 通过多尺度图分析揭示COVID-19与神经退行性疾病之间的共病关系：对生物数据库和文本挖掘的系统性研究 | Babaiha, N. S. | PDF | N/A | Unraveling the Co-Morbidity between COVID-19 and Neurodegenerative Diseases Through Multi-scale Graph Analysis: A Systematic Investigation of Biological Databases and Text Mining | | 以下是您提供的内容的中文翻译：

药效团建模、二维定量构效关系（2D-QSAR）、分子对接及ADME研究用于发现MRSA中PBP2a的抑制剂

翻译说明： 1. Pharmacophore modeling 翻译为“药效团建模”，是药物设计中的一种方法，用于识别分子中与生物活性相关的关键化学特征。 2. 2D-QSAR 翻译为“二维定量构效关系”，是一种基于分子二维结构的定量构效关系分析方法。 3. Molecular Docking 翻译为“分子对接”，是一种计算机模拟技术，用于预测分子与靶标蛋白的结合模式。 4. ADME 翻译为“吸收、分布、代谢和排泄”，是药物研发中评估药物在体内行为的关键参数。 5. PBP2a 是“青霉素结合蛋白2a”的缩写，是MRSA（耐甲氧西林金黄色葡萄球菌）中的一种关键耐药蛋白。 6. MRSA 翻译为“耐甲氧西林金黄色葡萄球菌”，是一种常见的多重耐药细菌。

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与性别相关的肠道微生物群在三个地理上分隔的挪威龙虾（Nephrops norvegicus）种群中的研究