2025-02-15 每日论文

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arXiv	arXiv
bioRxiv	bioRxiv
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arXiv

标题	作者	PDF链接	代码仓库	Title

bioRxiv

标题	作者	PDF链接	代码仓库	Title
使用PoE-VAE进行多模态单细胞数据的整合与查询	Litinetskaya, A.	PDF	N/A	Integration and querying of multimodal single-cell data with PoE-VAE
从混合感觉运动选择性到预测性感觉运动控制的神经几何学	Zhang, Y.	PDF	N/A	Neural Geometry from Mixed Sensorimotor Selectivity for Predictive Sensorimotor Control
使用等效电路对神经可塑性的机制解释	Nilsson, M. N. P.	PDF	N/A	Mechanistic explanation of neuroplasticity using equivalent circuits
信息瓶颈作为决策过程中多区域皮层表征的潜在原理	Kleinman, M.	PDF	N/A	The information bottleneck as a principle underlying multi-area cortical representations during decision-making
水母类水母Aurelia coerulea（原为sp.1）从水螅体到水母体的变态过程中细胞类型多样性的变化	Link, O.	PDF	N/A	Changes of cell-type diversity in the polyp-to-medusa metagenesis of the scyphozoan jellyfish Aurelia coerulea (formerly sp.1)
在果蝇Atlastin突变体中，突触内质网腔内蛋白质的包容性受到破坏	Quinones-Frias, M. C.	PDF	N/A	Disruption of Synaptic Endoplasmic Reticulum Luminal Protein Containment in Drosophila Atlastin Mutants
ANS: 调整邻域评分以改进基于单细胞RNA测序数据的基因特征细胞注释	Ciernik, L.	PDF	N/A	ANS: Adjusted Neighborhood Scoring to improve gene signature-based cell annotation in single-cell RNA-seq data
错误发现率控制：超越本杰明尼-霍赫伯格方法	Laha, N.	PDF	N/A	False discovery rate control: Moving beyond the Benjamini-Hochberg method
P66Shc 介导 SUMO2 诱导的内皮功能障碍	Kumar, J.	PDF	N/A	P66Shc Mediates SUMO2-induced Endothelial Dysfunction
佛罗里达群岛的Cassiopea（一种水母）的细菌群落与珊瑚微生物组共享主要的细菌类群。	Muffett, K. M.	PDF	N/A	Bacterial communities of Cassiopea in the Florida Keys share major bacterial taxa with coral microbiomes
针对KSHV（卡波西肉瘤相关疱疹病毒）和HIV（人类免疫缺陷病毒）的特异性T细胞会迁移到卡波西肉瘤肿瘤中，并随着时间的推移持续存在。	Ravishankar, S.	PDF	N/A	T-cells specific for KSHV and HIV migrate to Kaposi sarcoma tumors and persist over time
镜面决定了蝴蝶翅膀的远端后部区域。	Chatterjee, M.	PDF	N/A	mirror determines the far posterior domain in butterfly wings
微血管床及其周围间隙流动的三维建模	Rajeeva Pandian, N. K.	PDF	N/A	Three-dimensional modeling of flow through microvascular beds and surrounding interstitial spaces
急性肾损伤通过诱导血管内中性粒细胞滞留，减少肺部毛细血管血流，从而引发低氧血症。	Komaru, Y.	PDF	N/A	Acute kidney injury triggers hypoxemia by inducing intravascular neutrophil retention that reduces lung capillary blood flow
腹侧CA1神经元中性别特异性社会记忆的表征	Watarai, A.	PDF	N/A	Representation of sex-specific social memory in ventral CA1 neurons
视觉工作记忆表征在感觉干扰下的神经动力学	Degutis, J. K.	PDF	N/A	Neural dynamics of visual working memory representation during sensory distraction
静脉注射N,N-二甲基色胺对大鼠的神经化学和神经生理学影响	Glynos, N. G.	PDF	N/A	Neurochemical and Neurophysiological Effects of Intravenous Administration of N,N-Dimethyltryptamine in Rats
GLP-1R与VAPB和SPHKAP在内质网-线粒体接触位点（ERMCSs）上结合，以调节β细胞的线粒体重塑和功能。	Austin, G.	PDF	N/A	GLP-1R associates with VAPB and SPHKAP at ERMCSs to regulate β-cell mitochondrial remodelling and function
结合物理和药物合成代谢骨质疏松症治疗可协同增强骨反应和局部机械调节	Schulte, F. A.	PDF	N/A	Combined physical and pharmaceutical anabolic osteoporosis therapies synergistically increase bone response and local mechanoregulation
将工程化的心磷脂结合到人工膜蛋白上，揭示了脂质介导稳定性的决定因素	Abramsson, M. L.	PDF	N/A	Engineering cardiolipin binding to an artificial membrane protein reveals determinants for lipid-mediated stabilization
晶格超敏性在不进行微调的情况下放大大肠杆菌中的信号	Sherry, D. M.	PDF	N/A	Lattice ultrasensitivity amplifies signals in E. coli without fine-tuning
RESPAN：一种用于树突棘精确自动化修复、分割和量化的深度学习流程	Garcia, S. B.	PDF	N/A	RESPAN: A Deep Learning Pipeline for Accurate and Automated Restoration, Segmentation, and Quantification of Dendritic Spines
以下是这段文字的中文翻译：

情境依赖的赤拟谷盗幼虫运动协调

翻译说明： - Context-dependent 翻译为“情境依赖的”，表示某种行为或现象会根据不同的情境或环境发生变化。 - coordination of movement 翻译为“运动协调”，指的是生物体在运动过程中各部分动作的协调性。 - Tribolium castaneum 是赤拟谷盗的学名，是一种常见的仓储害虫。 - larvae 翻译为“幼虫”，指的是赤拟谷盗的幼体阶段。

希望这个翻译对你有帮助！ | Xu Ying, B. | PDF | N/A | Context-dependent coordination of movement in Tribolium castaneum larvae | | VASCilia（视觉分析立体纤毛）：一个基于深度学习的耳蜗毛细胞立体纤毛束三维分析的Napari插件 | Kassim, Y. M. | PDF | N/A | VASCilia (Vision Analysis StereoCilia): A Napari Plugin for Deep Learning-Based 3D Analysis of Cochlear Hair Cell Stereocilia Bundles | | 乳酸乳杆菌P118通过促进微生物来源的吲哚代谢物，增强宿主对沙门氏菌感染的耐受性。 | Wang, B. | PDF | N/A | Lacticaseibacillus rhamnosus P118 enhances host tolerance to Salmonella infection by promoting microbe-derived indole metabolites | | 一个动力驱动的简单步行模型修改了恢复率的定义：人类步行在双支撑阶段显著偏离摆锤运动。 | Hosseini-Yazdi, S.-S. | PDF | N/A | A Powered Simple Walking Model Modifies the Rate of Recovery Definition: Human Walking Deviates Drastically from Pendular Motion During the Double Support Phase | | 具有赫布和反赫布抑制性STDP的神经网络中模块性的出现与维持 | Bergoin, R. | PDF | N/A | Emergence and maintenance of modularity in neural networks with Hebbian and anti-Hebbian inhibitory STDP | | 基因型与环境相互作用如何维持互利共生中的变异 | Carlson, C. I. | PDF | N/A | How genotype-by-environment interactions can maintain variation in mutualisms | | 在干旱胁迫下，高粱根系在营养生长期间的转录变化和微生物组动态 | Kabir, A. H. | PDF | N/A | Transcriptional shifts and microbiome dynamics in sorghum roots during vegetative growth under drought stress | | 产前高钙饮食供应对奶绵羊和奶山羊的骨稳态及后代生长的影响 | Brugger, D. | PDF | N/A | Antepartum high dietary supply of calcium affects bone homeostasis and offspring growth in dairy sheep and dairy goats | | HIV-1细胞间传播过程中CARD8炎症小体的激活 | Kulsuptrakul, J. | PDF | N/A | CARD8 inflammasome activation during HIV-1 cell-to-cell transmission | | 核质病毒门（Nucleocytoviricota）的病毒工厂是通过液-液相分离形成的瞬时细胞器。 | Rigou, S. | PDF | N/A | Nucleocytoviricota viral factories are transient organelles made by liquid-liquid phase separation | | 推断小鼠皮层发育过程中神经元亚型之间的配体-受体相互作用 | Mathieu, R. | PDF | N/A | Inferring Ligand-Receptor Interactions between neuronal subtypes during mouse cortical development | | 通过集成多样化模型提升基因组预测性能 | Tomura, S. | PDF | N/A | Improved Genomic Prediction Performance with Ensembles of Diverse Models | | 物体非刚性的各向异性：皮质各向异性的高级感知后果 | Maruya, A. | PDF | N/A | Anisotropy of object nonrigidity: High-level perceptual consequences of cortical anisotropy | | 通过对秀丽隐杆线虫（C. elegans）觅食行为的定量和生态学研究揭示了接受-拒绝决策的机制。 | Haley, J. A. | PDF | N/A | Accept-reject decision-making revealed via a quantitative and ethological study of C. elegans foraging | | Akap11突变小鼠中突触PKA活性升高和纹状体多巴胺信号异常，这是一种精神分裂症和双相情感障碍的遗传模型。 | Song, B. J. | PDF | N/A | Elevated synaptic PKA activity and abnormal striatal dopamine signaling in Akap11 mutant mice, a genetic model of schizophrenia and bipolar disorder | | 在个性化基因组序列上训练深度学习模型可以提高变异效应预测的准确性。 | He, A. Y. | PDF | N/A | Training deep learning models on personalized genomic sequences improves variant effect prediction | | NSAID介导的环氧化酶抑制破坏了蝾螈胚胎中外胚层衍生物的形成。 | Marshall, E. J. | PDF | N/A | NSAID-mediated cyclooxygenase inhibition disrupts ectodermal derivative formation in axolotl embryos | | GeneCover：一种用于无标记基因选择的组合方法 | Wang, A. | PDF | N/A | GeneCover: A Combinatorial Approach for Label-free Marker Gene Selection | | 前向工程肌肉组织驱动的软体机器人游泳器 | Drennan, W. C. | PDF | N/A | A forward-engineered muscle tissue driven soft robotic swimmer | | Numb为成年果蝇中肠的肠道干细胞自我更新提供了一种故障安全机制。 | Li, M. | PDF | N/A | Numb provides a fail-safe mechanism for intestinal stem cell self-renewal in adult Drosophila midgut | | 4-甲基吡唑介导的细胞色素P450 2E1抑制保护肾上皮细胞免受顺铂毒性，但对膀胱癌细胞无保护作用 | Akakpo, J. Y. | PDF | N/A | 4-Methylpyrazole-mediated inhibition of Cytochrome P450 2E1 protects renal epithelial cells, but not bladder cancer cells, from cisplatin toxicity | | 人类单神经元活动受到基底外侧杏仁核颅内θ爆发刺激的调节。 | Campbell, J. M. | PDF | N/A | Human single-neuron activity is modulated by intracranial theta burst stimulation of the basolateral amygdala | | Dnmt3a介导的从头DNA甲基化强化了谱系承诺，并保持了记忆性Th1和Tfh细胞的功能。 | Perkins, B. | PDF | N/A | Dnmt3a-mediated de novo DNA methylation enforces lineage commitment and preserves functionality of memory Th1 and Tfh cells | | 外部干扰后重新选择工作记忆中视觉和运动内容的神经动力学 | Gresch, D. | PDF | N/A | Neural dynamics of reselecting visual and motor contents in working memory after external interference | | 蜜蜂在觅食任务中根据信息内容灵活调整决策策略 | Spaethe, J. | PDF | N/A | Bees flexibly adjust decision strategies to information content in a foraging task | | 长期适应低氧环境的研究为我们提供了深入了解铜绿假单胞菌（Pseudomonas aeruginosa）转变为慢性肺部感染机制的线索。 | Drabinska, J. | PDF | N/A | Long-term adaptation to hypoxia provides insight into mechanisms facilitating the switch of Pseudomonas aeruginosa to chronic lung infections | | 以下是这段英文的中文翻译：

原子级机器学习在糖生物学中的应用：蛋白质-聚糖相互作用及跨手性识别

翻译解释： - "Atom-level Machine Learning" 翻译为 "原子级机器学习"，指的是在原子尺度上应用机器学习技术。 - "Protein-glycan Interactions" 翻译为 "蛋白质-聚糖相互作用"，指的是蛋白质与聚糖之间的相互作用。 - "Cross-chiral Recognition" 翻译为 "跨手性识别"，指的是在分子手性不同的情况下进行识别。 - "Glycobiology" 翻译为 "糖生物学"，是研究糖类在生物系统中的结构和功能的学科。

Cethromycin 单剂量治疗伯氏疟原虫肝期的药代动力学和药效学研究

翻译说明： - Cethromycin 是一种抗生素，通常不翻译，保留英文名称。 - Pharmacokinetics 翻译为“药代动力学”，研究药物在体内的吸收、分布、代谢和排泄过程。 - Pharmacodynamics 翻译为“药效学”，研究药物对机体的作用机制和效果。 - Single Dose Cure 翻译为“单剂量治疗”，指通过一次给药达到治疗效果。 - Plasmodium berghei 翻译为“伯氏疟原虫”，是一种常用于疟疾研究的啮齿动物疟原虫模型。 - Liver Stages 翻译为“肝期”，指疟原虫在肝脏中的发育阶段。

希望这个翻译对您有帮助！如果有其他问题，请随时告诉我。 | Kennedy, G. J. | PDF | N/A | Cethromycin Pharmacokinetics and Pharmacodynamics for Single Dose Cure of Plasmodium berghei Liver Stages | | 跨视觉、听觉和视听决策的置信度判断的通用算法 | West, R. K. | PDF | N/A | A common algorithm for confidence judgements across visual, auditory and audio-visual decisions | | 热格栅引发中枢敏化 | Cormie, M. A. | PDF | N/A | The Thermal Grill Elicits Central Sensitization | | TinA 使驱动蛋白-14/KlpA 能够表现出向负端行进的过程性运动。 | Visootsat, A. | PDF | N/A | TinA enables kinesin-14/KlpA to exhibit processive minus-end-directed motility | | 探讨后疫情时代可持续洗手行为背景下日常卫生清洁产品的功效 | Pathak, S. B. | PDF | N/A | Addressing efficacy of everyday hygiene cleansing products in context of sustainable handwashing behavior in the post-pandemic era | | 使用RiboMarker(R)增强的RNA测序技术对球孢子菌不同形态的转录组变化进行表征 | Howard, J. M. | PDF | N/A | Characterization of transcriptomic changes across Coccidioides morphologies using RiboMarker(R)-enhanced RNA sequencing | | 将生物磁小体与胺功能化的治疗性抗体偶联物进行化学偶联。 | Payan, S. M.-C. | PDF | N/A | Chemical coupling of biological magnetosomes with amine-functionalized therapeutic antibody conjugates | | 重新发现中心法则 | Wang, L. | PDF | N/A | Find Central Dogma Again | | 重寻中心法则：在大语言模型中利用多语言迁移 | Wang, L. | PDF | N/A | Find Central Dogma Again: Leveraging Multilingual Transfer in Large Language Models | | MCL-1作为乳腺癌相关成纤维细胞在肌成纤维细胞特征和促血管生成特征之间的分子开关 | Lefebvre, C. C. | PDF | N/A | MCL-1 as a molecular switch between myofibroblastic and pro-angiogenic features of breast cancer-associated fibroblasts | | Helix-8和羧基末端尾对蛋白酶激活受体-4（PAR4）信号传导的调控 | Thibeault, P. E. | PDF | N/A | Helix-8 and Carboxyl Terminal Tail Regulation of Proteinase Activated Receptor-4 (PAR4) signalling | | 使用STARLING准确预测无序蛋白质的构象集合 | Novak, B. | PDF | N/A | Accurate predictions of conformational ensembles of disordered proteins with STARLING | | 抑制卵巢癌细胞增殖与细胞-基质粘附程序的上调以及整合素-β4诱导的细胞对顺铂的保护作用相关。 | Farsinejad, S. | PDF | N/A | Suppression of Ovarian Cancer Cell Proliferation is Associated with Upregulation of Cell-Matrix Adhesion Programs and Integrin-β4-Induced Cell Protection from Cisplatin. | | p16表达赋予了对CDK2抑制剂的敏感性 | Sine, C. | PDF | N/A | p16 expression confers sensitivity to CDK2 inhibitors | | 成年鳉鱼暴露于原油中会影响其第一代和第二代后代的胚胎基因表达和幼体形态。 | Park, J. | PDF | N/A | Adult killifish exposure to crude oil perturbs embryonic gene expression and larval morphology in first- and second-generation offspring | | 遗传和药理学方法纠正视网膜神经节细胞中线粒体自噬功能障碍可挽救青光眼性神经退行性病变 | Maddineni, P. | PDF | N/A | Genetic and pharmacological correction of impaired mitophagy in retinal ganglion cells rescues glaucomatous neurodegeneration | | 马查多-约瑟夫病中ATXN3基因失活的基因编辑：CRISPR-Cas9作为TALEN诱导毒性的治疗替代方案 | Lopes, S. M. | PDF | N/A | Gene Editing for ATXN3 Inactivation in Machado-Joseph disease: CRISPR-Cas9 as a Therapeutic Alternative to TALEN-Induced Toxicity | | 探索KPC变体的突变可能性以实现对头孢地尔的高水平耐药性 | hanna, s. | PDF | N/A | Exploring mutational possibilities of KPC variants to reach high level resistance to cefiderocol | | 功能性记忆T细胞来源于耗竭的克隆，并通过检查点阻断得以扩增。 | Raposo, C. J. | PDF | N/A | Functional memory T cells are derived from exhausted clones and expanded by checkpoint blockade | | 一种针对Candidozyma（念珠菌）auris优化的游离型质粒诱导的Cas9编辑系统揭示了S639F编码的FKS1突变的直接影响 | Doorley, L. A. | PDF | N/A | A Candidozyma (Candida) auris-optimized Episomal Plasmid Induced Cas9-editing system reveals the direct impact of the S639F encoding FKS1 mutation | | 平衡之道：地下水微生物群对水文气候极端事件的适应力与脆弱性 | Wang, H. | PDF | N/A | Balancing Act: Groundwater microbiome''s resilience and vulnerability to hydroclimatic extremes | | MicroRNA-34a通过抑制KLF2，在年龄相关性黄斑变性中通过CXCR4/CXCL12途径促进病理性血管生成。 | Colasanti, J. J. | PDF | N/A | MicroRNA-34a suppresses KLF2 to promote pathological angiogenesis through the CXCR4/CXCL12 pathway in age-related macular degeneration | | 三萜类化合物CDDO-EA通过减少能量摄入来预防高血糖、高胰岛素血症和肥胖 | Cantu, A. E. | PDF | N/A | Triterpenoid CDDO-EA Protects from Hyperglycemia, Hyperinsulinemia, and Obesity by Decreasing Energy Intake | | 对交联位点的分析表明，秀丽隐杆线虫（C. elegans）的PIWI Argonaute蛋白在目标识别过程中表现出灵活的构象。 | Wu, W.-S. | PDF | N/A | Analysis of crosslinking sites suggests C. elegnas PIWI Argonaute exhibits flexible conformations for target recognition | | 浮游植物对特定微生物群落的招募及系统共生模式 | Kim, J.-H. | PDF | N/A | Phytoplankton recruitment of specific microbial assemblages and phylosymbiotic patterns | | 遗传修饰因子影响果蝇对创伤性脑损伤的急性和长期反应 | Molina, B. | PDF | N/A | Genetic Modifiers Influencing the Acute and Long-Term Responses to Traumatic Brain Injury in Drosophila | | 博物馆与动物园：在生物多样性丰富的国家中，快速基因鉴定稀有物种及其在保护与系统学中的实际应用 | Chavez, D. E. | PDF | N/A | Museums and Zoos: Rapid genetic identification of rare species and practical applications for conservation and systematics in a biodiverse country | | 工程化一种微流控辅助的3D生物打印方法，用于分级控制沉积和分区化梯度生物墨水。 | Serpe, F. | PDF | N/A | Engineering a microfluidic-assisted 3D bioprinting approach for the hierarchical control deposition and compartmentalisation of graded bioinks | | LANTERN：利用大型语言模型和Transformer增强分子相互作用 | Ha, C. N. | PDF | N/A | LANTERN: Leveraging Large Language Models and Transformers for Enhanced Molecular Interactions | | GSLab：用于荧光显微镜中高级相位分析的开放源代码平台 | Vallmitjana, A. | PDF | N/A | GSLab: Open-Source Platform for Advanced Phasor Analysis in Fluorescence Microscopy | | gcSV：一个用于全面结构变异检测的统一框架 | Li, G. | PDF | N/A | gcSV: a unified framework for comprehensive structural variant detection | | 单细胞转录组学比较：小肠神经内分泌肿瘤与其祖细胞的对比 | Axling, F. | PDF | N/A | A single-cell transcriptomic comparison between small intestinal neuroendocrine tumors and their progenitor | | 吻肽类似物C6在高催乳素血症小鼠模型中逆转生殖功能障碍 | Beaudou, C. | PDF | N/A | The kisspeptin analog C6 reverses reproductive dysfunction in a mouse model of hyperprolactinaemia | | 使用RealKcat对酶变体动力学进行稳健预测 | Sajeevan, K. A. | PDF | N/A | Robust Prediction of Enzyme Variant Kinetics with RealKcat | | 多药耐药性铜绿假单胞菌感染期间四环素对金属蛋白酶的抑制治疗 | Carr, M. A. | PDF | N/A | Therapeutic Inhibition of Metalloproteases by Tetracyclines during Infection by Multi-Drug Resistant Pseudomonas | | 与Bacillus cereus群菌株在Caco-2细胞中细胞毒性相关的单核苷酸多态性 | Prince, C. | PDF | N/A | Single nucleotide polymorphisms associated with cytotoxicity of Bacillus cereus group strains in Caco-2 cells | | 斑马鱼正向遗传筛选揭示新的真菌调控因子，限制宿主保护性念珠菌与先天免疫的相互作用 | Blair, B. A. A. | PDF | N/A | Forward genetic screen in zebrafish identifies new fungal regulators that limit host-protective Candida-innate immune interaction | | LDL受体介导的大肠杆菌α-溶血素内吞作用介导肾上皮细胞毒性 | Kuhn, H. W. | PDF | N/A | LDL receptor-mediated endocytosis of Escherichia coli α-hemolysin mediates renal epithelial toxicity | | 将加德纳菌（Gardnerella vaginalis）通过双歧杆菌-大肠杆菌穿梭载体质粒进行转化 | Kularatne, B. M. D. N. | PDF | N/A | Transformation of Gardnerella vaginalis with a Bifidobacterium-Escherichia coli shuttle vector plasmid | | 在炎症性关节炎发作时，血管周围RELM阳性的滑膜巨噬细胞会招募单核细胞。 | Schonfeldova, B. | PDF | N/A | Perivascular RELM-positive synovial macrophages recruit monocytes at the onset of inflammatory arthritis | | 以下是这段文字的中文翻译：

沙门氏菌感染后γδ T细胞缺陷鸡的补偿机制

这个标题描述了一项研究，探讨了在沙门氏菌感染后，缺乏γδ T细胞的鸡体内可能出现的补偿性免疫机制。γδ T细胞是免疫系统的重要组成部分，研究其缺失后其他免疫细胞或机制如何发挥作用，有助于理解免疫系统的复杂性和适应性。 | Tetzlaff, F. | PDF | N/A | Compensatory Mechanisms in γδ T Cell-Deficient Chickens Following Salmonella infection | | 预测潜在产卵区：一种新的软骨鱼类保护与空间管理框架 | Ruiz-Garcia, D. | PDF | N/A | Predicting Potential Spawning Areas: a novel framework for elasmobranch conservation and spatial management | | 一种测量农药对蜜蜂亚致死效应的趋光性试验 | Sancho, G. | PDF | N/A | A phototaxis assay to measure sublethal effects of pesticides on bees | | 预测全球鸟类物种对农业产量增加的响应 | Busana, M. | PDF | N/A | Predicting the responses of the world's bird species to increases in agricultural production | | 一种新型TRPC6突变导致常染色体显性遗传性局灶节段性肾小球硬化 | Bhattacharya, R. | PDF | N/A | A Novel TRPC6 Mutation Causes Autosomal Dominant FSGS | | 核小体分布的短暂变化和对核酸酶的敏感性定义了THP-1单核细胞向巨噬细胞的转变 | Benoit, J. M. | PDF | N/A | Transient alterations in nucleosome distribution and sensitivity to nuclease define the THP-1 monocyte to macrophage transition | | 基于家系的基因组范围插补使用低密度扩增子面板用于高度多态性的太平洋牡蛎（Magallana）gigas | Sutherland, B. J. G. | PDF | N/A | Pedigree-based genome-wide imputation using a low-density amplicon panel for the highly polymorphic Pacific oyster Crassostrea (Magallana) gigas | | 将一种激动型抗TNFR2双特异性抗体通过在其铰链区插入肽连接子转化为拮抗剂 | Otsuki, T. | PDF | N/A | Conversion of an agonistic anti-TNFR2 biparatopic antibody into an antagonist by insertion of peptide linkers into the hinge region | | 通过基因组插补在单细胞RNA测序中解析样本身份 | Ghosh, R. | PDF | N/A | Deconvolution of Sample Identity in Single-Cell RNA Sequencing via Genome Imputation | | 超越炒作：GPT-4在自动化细胞类型注释中的复杂性 | Kazmi, A. | PDF | N/A | Beyond the Hype: The Complexity of Automated Cell Type Annotations with GPT-4 | | 《校准作为衡量大型语言模型在生物医学研究中可信度的一项研究》 | de Oliveira, R. | PDF | N/A | A Study of Calibration as a Measurement of Trustworthiness of Large Language Models in Biomedical Research | | cfDecon：基于甲基化的准确且可解释的细胞类型反卷积方法，适用于无细胞DNA | Wang, Y. | PDF | N/A | cfDecon: Accurate and Interpretable methylation-based cell type deconvolution for cell-free DNA | | ImmunoMatch 学习并预测重链和轻链免疫球蛋白的配对关系。 | Guo, D. | PDF | N/A | ImmunoMatch learns and predicts cognate pairing of heavy and light immunoglobulin chains | | SMCLMDA：基于统计元路径对比学习的miRNA-疾病多维关系预测 | Zhu, Y. | PDF | N/A | SMCLMDA: statistical meta-paths contrastive learning for predicting miRNA-disease multidimensional relationships | | 使用大型语言模型进行少样本上下文学习以进行抗体表征 | FUNG, S.-H. | PDF | N/A | Few-shot in-context learning with large language models for antibody characterization | | 人类胰腺导管腺癌中的克隆异质性及其对肿瘤进展的影响 | Kalfakakou, D. | PDF | N/A | Clonal Heterogeneity in Human Pancreatic Ductal Adenocarcinoma and Its Impact on Tumor Progression | | 整合多模态转录组学技术，识别在胰腺导管腺癌（PDAC）进展中具有不同作用的细胞亚型 | Wu, J. | PDF | N/A | Integrating multi-modal transcriptomics identifies cellular subtypes with distinct roles in PDAC progression | | 单细胞分辨率追踪皮肤T细胞淋巴瘤揭示疾病进展中的克隆演化 | Dorando, H. K. | PDF | N/A | Single Cell Resolution Tracking of Cutaneous T-Cell Lymphoma Reveals Clonal Evolution in Disease Progression | | 生殖系和体细胞变异影响肿瘤发生中的核-线粒体相互作用 | Daunesse, M. | PDF | N/A | Germline and somatic variation influence nuclear-mitochondrial crosstalk in tumourigenesis | | 在猪脱细胞基质水凝胶中局部递送的CAR-T细胞可提高切除后胶质母细胞瘤的存活率 | Logun, M. | PDF | N/A | CAR-T cells locally delivered in porcine decellularized matrix hydrogels enhance survival in post-resection glioblastoma | | MYH9相关疾病患者的红细胞膜骨架密度降低 | Sun, S. | PDF | N/A | The membrane skeleton density of red blood cells in MYH9-related disease patients is decreased | | 荟萃分析与实验证据表明，感染蜜蜂微孢子虫（Nosema ceranae）对蜜蜂的碳水化合物消耗没有影响。 | Ostap-Chec, M. | PDF | N/A | Meta-analysis and experimental evidence reveal no impact of Nosema ceranae infection on honeybee carbohydrate consumption | | 过氧化物酶体增殖物激活受体γ（PPARG）介导的心肌保护在急性心肌梗死治疗中的应用，通过左心室卸载和冠状动脉再灌注实现。 | Visker, J. R. | PDF | N/A | Peroxisome proliferator-activated receptor gamma (PPARG)-mediated myocardial salvage in acute myocardial infarction managed with left ventricular unloading and coronary reperfusion | | 单一下降斜坡摩擦冲刺用于自行车骑行中的扭矩-踏频关系评估 | Rozier-Delgado, P. | PDF | N/A | A single decreasing ramp friction sprint for torque-cadence relationship assessment during cycling | | 缺铁饮食通过氧化应激反应途径延长秀丽隐杆线虫的寿命 | Das, P. | PDF | N/A | Iron-deplete diet enhances Caenorhabditis elegans lifespan via oxidative stress response pathways | | 通过tRNA阵列方法在体外同时表达最小21种转移RNA | Miyachi, R. | PDF | N/A | Simultaneous in vitro expression of minimal 21 transfer RNAs by tRNA array method | | 研究微RNA对基因表达噪声的降低作用以及通过mRNA降解的自我反馈调控增强MiRISC的机制 | Tian, S. | PDF | N/A | Investigating Gene Expression Noise Reduction by MicroRNAs and MiRISC Reinforcement by Self-Feedback Regulation of mRNA Degradation | | 固体肿瘤定植过程中细菌种群动态 | Sayin, S. | PDF | N/A | Bacterial population dynamics during colonization of solid tumors | | 机器人问题的细胞解决方案 | Wang, Z. | PDF | N/A | A cellular solution to a robotics problem | | 干细胞-实质细胞融合：通讯与基因调控 | Huang, J. | PDF | N/A | Stem Cell-Parenchymal Fusion: Communication and Gene Regulation | | 中性粒细胞KLF2调控炎症小体依赖性新生儿内毒素血症死亡率 | Mukherjee, D. | PDF | N/A | Neutrophil KLF2 regulates inflammasome-dependent neonatal mortality from endotoxemia | | 评估呼吸道合胞病毒FG嵌合疫苗KD-409在母体和儿科疫苗接种啮齿动物模型中的安全性和有效性 | Yamaue, R. | PDF | N/A | Evaluation of the Safety and Efficacy of the Respiratory Syncytial Virus FG Chimeric Vaccine KD-409 in Rodent Models for Maternal and Pediatric Vaccination | | Swiprosin-1/EFhd2 通过稳定微管促进B细胞在应对固定抗原时的线粒体备用容量。 | Weckwerth, L. | PDF | N/A | Swiprosin-1/EFhd2 promotes mitochondrial spare capacity in response to immobilized antigen in B cells via microtubule stabilization | | 基因组和功能上的适应性变化揭示了蝙蝠抗病毒先天免疫的特殊性——以鸟苷酸结合蛋白5（GBP5）为例 | Le Corf, A. | PDF | N/A | Genomic and functional adaptations in guanylate-binding protein 5 (GBP5) highlight specificities of bat antiviral innate immunity | | 在鼠类模型中，脾脏中的MARCO+边缘区巨噬细胞能够快速产生MCP-1和KC，但对于响应储存红细胞产生的同种抗体生成并非必需。 | Arneja, A. | PDF | N/A | Splenic MARCO+ marginal zone macrophages regulate rapid production of MCP-1 and KC but are dispensable for alloantibody generation in response to stored RBCs in a murine model. | | 通过对全血中乙型肝炎病毒（HBV）特异性T细胞的快速功能表征，揭示了在乙型肝炎感染已确立的临床阶段内，T细胞反应模式的异质性。 | Le Bert, N. | PDF | N/A | Heterogeneous T cell response patterns within established clinical phases of Hepatitis B infection revealed through the rapid functional characterization of HBV-specific T cells in whole blood | | 依赖和不依赖肺炎球菌溶血素的非经典自噬过程介导宿主对肺炎球菌感染的防御 | Michno, B. J. | PDF | N/A | Pneumolysin-dependent and independent non-canonical autophagy processes mediate host defense against pneumococcal infection | | 基于参考的化学-遗传相互作用分析以阐明小分子在结核分枝杆菌中的作用机制 | Bond, A. N. | PDF | N/A | Reference-based chemical-genetic interaction profiling to elucidate small molecule mechanism of action in Mycobacterium tuberculosis | | 高盐环境中的嵌套寄生现象：嗜盐古菌及其纳米级细胞共生体的病毒与病毒卫星 | Zhou, Y. | PDF | N/A | Nested parasitism in hypersaline environments: viruses and virus satellites of haloarchaea and their nanosized cellular symbionts | | 内源性Pfs230:Pfs48/45结构与强效疟疾传播阻断抗体的复合物 | Bekkering, E. T. | PDF | N/A | Structure of endogenous Pfs230:Pfs48/45 in complex with potent malaria transmission-blocking antibodies | | Wnt依赖的骨髓微环境时空重编程驱动纤维化 | Banjanin, B. | PDF | N/A | Wnt-dependent spatiotemporal reprogramming ofbone marrow niches drives fibrosis | | p21激活激酶调控Rab3a囊泡以修复由淀粉样β寡聚体引起的质膜损伤 | Valappil, D. K. | PDF | N/A | p21-activated kinase regulates Rab3a vesicles to repair plasma membrane damage caused by Amyloid-β oligomers | | 尽管受到威胁的物种在进化上并不独特，但在当前的生物多样性危机下，非洲植物生命之树上积累的系统发育多样性中，超过一半可能会受到侵蚀。 | Tiawoun, M. A. P. | PDF | N/A | Over half of the phylogenetic diversity accumulated on the African plant tree of life may be eroded under current biodiversity crisis even though threatened species are not evolutionarily unique | | 祖先重组图中分支长度估计的通用框架 | Deng, Y. | PDF | N/A | A General Framework for Branch Length Estimation in Ancestral Recombination Graphs | | 海洋内阿米巴物种的基因组草图揭示了与致病性相关的基因家族库的减少，以及为适应海洋环境而进行的侧向基因转移。 | Kawano-Sugaya, T. | PDF | N/A | Draft genome of the marine Entamoeba species reveals reduction in the gene family repertoire associated with pathogenicity and lateral gene transfer for adaptation to the marine environment | | DNA四面体和外泌体作为表柔比星药物递送纳米载体在乳腺癌细胞中的能力 | Saleem, A. | PDF | N/A | Competence of DNA Tetrahedron and Exosomes as Nanocarriers for Epirubicin drug delivery in Breast Cancer Cells | | 可逆离子印刷实现可重编程4D组织工程水凝胶支架 | Ding, A. | PDF | N/A | Reprogrammable 4D Tissue Engineering Hydrogel Scaffold via Reversible Ion Printing | | ActSeek：在Alphafold数据库中快速准确的活性位点搜索算法 | Castillo, S. | PDF | N/A | ActSeek: Fast and accurate search algorithm of active sites in Alphafold database | | APV-Sankey：一个用于适配体筛选与可视化的综合工具箱 | Zhang, Y. | PDF | N/A | APV-Sankey: A Comprehensive Toolbox for Aptamer Screening and Visualization | | CyclicBoltz1，利用AlphaFold 3框架快速准确地预测含有非标准氨基酸的环肽及其复合物的结构。 | Xie, X. | PDF | N/A | CyclicBoltz1, fast and accurately predicting structures of cyclic peptides and complexes containing non-canonical amino acids using AlphaFold 3 Framework | | CycleMix：细胞周期的高斯混合模型 | Peplinski, J. | PDF | N/A | CycleMix: Gaussian Mixture Modeling of the Cell Cycle | | 一个统一的卵巢癌单细胞RNA测序图谱，用于解析转移和化疗耐药性背后的疾病异质性 | Sallese, M. R. | PDF | N/A | A harmonized ovarian cancer scRNA-seq atlas to dissect disease heterogeneity underlying metastatization and chemoresistance | | 在喂食高胆固醇饮食的小鼠中，ABCG5和ABCG8非依赖性的机制未能维持固醇平衡。 | Anspach, G. B. | PDF | N/A | ABCG5 ABCG8-independent mechanisms fail to maintain sterol balance in mice fed a high cholesterol diet | | 通过二维相位对比磁共振成像对正常脑脊液在中脑导水管、大脑中动脉周围血管间隙以及Willis环中的流动进行定量评估 | Le, R. F. D. | PDF | N/A | Quantitative evaluation of normal cerebrospinal fluid flow in the Sylvian aqueduct and perivascular spaces of the middle cerebral artery and circle of Willis via 2D phase-contrast MR imaging | | 淋巴结将性别偏向的免疫衰老与抗原识别受损联系起来 | Menzel, L. | PDF | N/A | Lymph nodes link sex-biased immune aging to compromised antigen recognition | | 对獾（Meles meles）同时接种牛结核病疫苗和避孕疫苗的免疫反应研究 | Palphramand, K. L. | PDF | N/A | Immune response to co-administration of bovine tuberculosis and contraceptive vaccines in badgers (Meles meles) | | 邻居密度依赖性促进共存与内部振荡 | Buche, L. | PDF | N/A | Neighbor density-dependent facilitation promotescoexistence and internal oscillation | | 进化拯救促进突变体 | Tuffaha, M. Z. | PDF | N/A | Evolutionary Rescue Promotes Mutators | | 利用染色质可及性优化序列到表达的建模 | Lapohos, O. | PDF | N/A | Refining sequence-to-expression modelling with chromatin accessibility | | 间歇性禁食通过重编程染色质可及性来调节大脑和肌肉中的基因表达 | Fan, Y. | PDF | N/A | Intermittent Fasting Reprograms Chromatin Accessibility to Modulate Gene Expression in Brain and Muscle | | 上皮形态发生运动学关系的体内验证 | Namba, T. | PDF | N/A | In vivo validation of kinematic relationships for epithelial morphogenesis |

medRxiv

标题	作者	PDF链接	代码仓库	Title
慢性肾病前期——连续肌酐监测显示肾小球滤过率下降超过60 mL/min。	Burke, C. O.	PDF	N/A	Pre-chronic kidney disease -- Serial creatinine tracks glomerular filtration rate decline above 60 mL/min
在精神病候诊名单中为青少年实施移动AI聊天机器人干预以应对抑郁症的挑战：一项随机对照研究终止报告	Fujita, J.	PDF	N/A	Challenges in Implementing a Mobile AI Chatbot Intervention for Depression Among Youth on Psychiatric Waiting Lists: A Randomized Control Study Termination Report
因COVID-19住院的精神分裂症患者的严重结局及住院时间：一项基于人群的回顾性队列研究	Gronsbell, J.	PDF	N/A	Severe outcomes and length of stay among people with schizophrenia hospitalized for COVID-19: A population-based retrospective cohort study
以下是这段文字的中文翻译：

临床开发与性能表现：首个用于非处方使用的“First To Know”梅毒自测产品——一种新型快速检测梅毒螺旋体抗体的方法

翻译说明： 1. “Clinical Development and Performance” 翻译为“临床开发与性能表现”，强调该产品的研发过程和实际性能。 2. “First To Know Syphilis Self-Test” 翻译为“First To Know梅毒自测产品”，保留品牌名称“First To Know”。 3. “Over-the-Counter Usage” 翻译为“非处方使用”，指该产品无需医生处方即可购买和使用。 4. “De Novo Rapid Test for Treponemal Antibody” 翻译为“新型快速检测梅毒螺旋体抗体的方法”，其中“De Novo”表示“新型”或“首创”，“Treponemal Antibody”指梅毒螺旋体抗体。