BioRxiv 2025-02-18 Papers

标题	作者	PDF链接	代码仓库	Title
对一个大型同基因小鼠家族进行深度测序，能够发现复杂的变异并实现精确的表型定位。	Villani, F.	PDF	N/A	Deep sequencing of a large family of isogenic mice enables complex variants discovery and accurate phenotype mapping
SCellBOW：基于表型代数的AI驱动单细胞转录组学肿瘤风险分层	Bhattacharya, N.	PDF	N/A	SCellBOW: AI-Driven Tumor Risk Stratification from Single-Cell Transcriptomics Using Phenotype Algebra
基于图像的微核细胞识别与分离以解析细胞后果	DiPeso, L.	PDF	N/A	Image-based identification and isolation of micronucleated cells to dissect cellular consequences
Labelizer：用于共价荧光标记的蛋白质残基系统选择	Gebhardt, C.	PDF	N/A	Labelizer: systematic selection of protein residues for covalent fluorophore labeling
多样化转变影响吸蜜鸟鸣声进化速率	Hay, E. M.	PDF	N/A	Shifts in diversification influence rates of song evolution in honeyeaters
以下是这段文字的中文翻译：

Cylicocyclus nassatus（马匹最常见的寄生虫）中吡喃妥因抗性的时空多样性和遗传结构

翻译说明： - Spatio-temporal diversity 翻译为“时空多样性”，指的是时间和空间上的多样性。 - genetic architecture 翻译为“遗传结构”，指的是基因层面的组成和特征。 - pyrantel resistance 翻译为“吡喃妥因抗性”，吡喃妥因是一种常用于驱虫的药物。 - Cylicocyclus nassatus 是一种马匹常见的寄生虫，直接保留拉丁学名。 - the most abundant horse parasite 翻译为“马匹最常见的寄生虫”，强调其普遍性。

希望这段翻译对你有帮助！ | Salle, G. | PDF | N/A | Spatio-temporal diversity and genetic architecture of pyrantel resistance in Cylicocyclus nassatus, the most abundant horse parasite | | 纠缠于纤维之中：裂解性多糖单加氧酶如何结合其几丁质底物 | Sorensen, H. V. | PDF | N/A | Tangled up in fibers: How a lytic polysaccharide monooxygenase binds its chitin substrate | | 基因表达在遗传相同的个体之间的变异预测了生殖特征 | Webster, A. K. | PDF | N/A | Gene expression variation across genetically identical individuals predicts reproductive traits | | 通过两个与外侧纹状体相连的不同回路，由不同过程介导的听觉辨别能力的获得。 | Setogawa, S. | PDF | N/A | Acquisition of Auditory Discrimination Mediated by Different Processes through Two Distinct Circuits Linked to the Lateral Striatum | | 唤醒作为时空大脑动态的通用嵌入 | Raut, R. V. | PDF | N/A | Arousal as a universal embedding for spatiotemporal brain dynamics | | 结合域突变为我们深入了解CTCF与染色质的关系及其在基因调控中的作用提供了线索。 | Do, C. | PDF | N/A | Binding domain mutations provide insight into CTCF's relationship with chromatin and its contribution to gene regulation | | 在人类诱导多能干细胞（iPSCs）向星形胶质细胞分化的过程中，神经祖细胞谱系组成的变化 | Li, Z. | PDF | N/A | Changes in neural progenitor lineage constituent during astrocytic differentiation of human iPSCs | | 早期癌症会导致源自健康组织的游离DNA呈倍数增加。 | Mamis, K. | PDF | N/A | Early-stage cancer results in a multiplicative increase in cell-free DNA originating from healthy tissue | | 外源性线粒体移植减轻心脏骤停后的心肌功能障碍 | Wang, Z. | PDF | N/A | Transplantation of exogenous mitochondria mitigates myocardial dysfunction after cardiac arrest | | VGLL2和TEAD1融合蛋白通过结合p300驱动YAP/TAZ非依赖性肿瘤发生 | Guo, S. | PDF | N/A | VGLL2 and TEAD1 fusion proteins drive YAP/TAZ-independent tumorigenesis by engaging p300 | | 癌细胞与肝细胞之间的异型竞争产生了依赖于环境的异质性表型。 | Spinazzola, A. | PDF | N/A | Heterotypic competition between cancer cells and hepatocytes generates heterogeneous context-dependent phenotypes | | Rtf1 HMD结构域促进全局组蛋白H2B单泛素化，并调控引起脑膜炎的病原体新型隐球菌的形态发生和毒力。 | Jiang, Y. | PDF | N/A | Rtf1 HMD domain facilitates global histone H2B monoubiquitination and regulates morphogenesis and virulence in the meningitis-causing pathogen Cryptococcus neoformans | | 使用同步Ca2+成像和fMRI对小鼠大脑进行多模态识别 | Mandino, F. | PDF | N/A | Multimodal identification of the mouse brain using simultaneous Ca2+ imaging and fMRI | | 反射干涉显微镜的光学切片技术 | Ventalon, C. | PDF | N/A | Optical sectioning for reflection interference microscopy | | 密切匹配的比较表明，可分离的过程介导了上下文大小错觉。 | Yu, X. A. | PDF | N/A | Closely matched comparisons suggest that separable processes mediate contextual size illusions | | 单细胞和批量RNA测序数据的整合分析揭示了铁死亡相关基因介导的肿瘤微环境预测预后，并指导三阴性乳腺癌的药物选择 | Gong, X. | PDF | N/A | Integrated Analysis of Single-Cell and Bulk RNA-Seq Data reveals that Ferroptosis-Related Genes Mediated the Tumor Microenvironment predicts Prognosis, and guides Drug Selection in Triple-Negative Breast Cancer | | MITF和TFE3在黑色素瘤可塑性中的拮抗作用 | Chang, J. | PDF | N/A | Antagonistic Roles for MITF and TFE3 in Melanoma Plasticity | | 现实世界中持续思维的模式及其与心理健康和幸福感的联系 | Mulholland, B. | PDF | N/A | Patterns of Ongoing Thought in the Real World and Their Link to Mental Health and Well-Being | | 高度可扩展的物理交联水凝胶用于高速3D生物打印 | Song, Y. E. | PDF | N/A | Highly extensible physically crosslinked hydrogels for high-speed 3D bioprinting | | 固氮真核生物的基因组揭示了一种非经典的细胞器生成模型 | Frail, S. | PDF | N/A | Genomes of nitrogen-fixing eukaryotes reveal a non-canonical model of organellogenesis | | 多壳层约束球面反卷积的隐式神经表示用于扩散磁共振成像的连续建模 | Hendriks, T. | PDF | N/A | Implicit Neural Representation of Multi-shell Constrained Spherical Deconvolution for Continuous Modeling of Diffusion MRI | | 提升初级视觉区和身体选择性皮层之间的前向连接性，可以减少对身体性别和情绪判断之间的干扰。 | Gandolfo, M. | PDF | N/A | Boosting forward connectivity between primary visual and body selective cortex reduces interference between sex and emotion judgements of bodies | | 花/1 FLWR-1 通过调节质膜 Ca2+-ATPase 来促进突触小泡的回收，从而调控神经元活动。 | Seidenthal, M. | PDF | N/A | Flower/1 FLWR-1 regulates neuronal activity via the plasma membrane Ca2+-ATPase to promote recycling of synaptic vesicles | | 撤回：关于两种亚麻（Linum usitatissimum L.）基因型——Flanders和Astella——在盐胁迫适应性的比较分析，这两种基因型具有对比鲜明的木脂素含量。 | Debnath, A. J. | PDF | N/A | WITHDRAWN: A comparative analysis of salt stress adaptiveness between two flax (Linum usitatissimum L.) genotypes, Flanders and Astella, having contrasting lignan contents | | 新生儿小脑修复过程中活性氧的增加是基础。 | Pakula, A. | PDF | N/A | An increase in reactive oxygen species underlies neonatal cerebellum repair | | Wag31是一种膜系链蛋白，对于分枝杆菌中的脂质稳态至关重要。 | Kapoor, Y. | PDF | N/A | Wag31, a membrane tether, is crucial for lipid homeostasis in mycobacteria | | 共享转录组特征揭示突触修剪是阿尔茨海默病与癫痫之间的关联 | Li, H. | PDF | N/A | Shared Transcriptomic Signatures Reveal Synaptic Pruning as a Link Between Alzheimer's Disease and Epilepsy | | 共享转录组特征揭示突触修剪是阿尔茨海默病与癫痫之间的联系 | Li, H. | PDF | N/A | Shared Transcriptomic Signatures Reveal Synaptic Pruning as a Link Between Alzheimer's Disease and Epilepsy | | 关于心智游移和动态思维的神经基础：一项药物与脑刺激研究 | Rasmussen, T. | PDF | N/A | On the neural substrates of mind wandering and dynamic thought: A drug and brain stimulation study | | 多上下文种子能够实现快速且高精度的读取映射。 | Tolstoganov, I. | PDF | N/A | Multi-context seeds enable fast and high-accuracy read mapping | | 选择和结果的神经编码受到不确定性的调节，这种调节发生在眶额叶皮层，而非次级运动皮层。 | Romero-Sosa, J. L. | PDF | N/A | Neural coding of choice and outcome are modulated by uncertainty in orbitofrontal but not secondary motor cortex | | 三步向前：PTPN5的三种意外结构 | Guerrero, L. | PDF | N/A | Three STEPs forward: A trio of unexpected structures of PTPN5 | | 以下是这段英文的中文翻译：

伯克霍尔德菌（Burkholderia cenocepacia）蛋白质O-连接聚糖生物合成的后期步骤是条件性必需的。

这个翻译将原标题中的关键术语进行了准确转换： - "Canalization" 译为 "导向作用"，表达了引导和规范的含义 - "circuit assembly" 译为 "神经回路组装"，这是神经科学领域的专业术语 - "δ-protocadherins" 译为 "δ-原钙粘蛋白"，保留了希腊字母和专业名称 - "zebrafish optic tectum" 译为 "斑马鱼视顶盖"，准确表达了研究对象

在细胞中，EDEM（内质网降解增强α-甘露糖苷酶样蛋白）和PDI（蛋白质二硫键异构酶）是两个关键的蛋白质，它们在内质网相关的降解（ERAD）途径中扮演重要角色。ERAD是一种质量控制机制，用于识别和降解错误折叠或未正确组装的蛋白质，以防止它们在细胞内积累并导致疾病。

EDEM和PDI形成的复合物在ERAD途径中起到检查点的作用，确保只有那些确实无法正确折叠的蛋白质被标记为降解。EDEM通过识别和结合错误折叠蛋白质上的特定糖基化模式来启动这一过程，而PDI则负责检测和纠正蛋白质中的二硫键错误，帮助蛋白质重新折叠。如果PDI无法纠正这些错误，EDEM:PDI复合物将引导这些蛋白质进入降解途径。

理解EDEM:PDI复合物的结构和功能对于揭示ERAD途径的分子机制至关重要，这有助于开发治疗与蛋白质折叠错误相关疾病的新策略。 | Hitchman, C. J. | PDF | N/A | Structure and function of the EDEM:PDI ERAD checkpoint complex | | 分散相互作用决定了尿素和TMAO在整个蛋白质折叠景观中的热力学效应。 | Pereira, A. F. | PDF | N/A | Dispersive interactions determine Urea and TMAO thermodynamic effects across the protein folding landscape | | 皮质星形胶质细胞激活引发脑膜伤害感受和偏头痛样疼痛 | Bree, D. | PDF | N/A | Cortical astrocyte activation triggers meningeal nociception and migraine-like pain | | 通过删除一个特殊的次要菌毛样基因来刺激新月柄杆菌（Caulobacter crescentus）的表面感应途径。 | Obeid Charrouf, F. | PDF | N/A | Stimulation of the Caulobacter crescentus surface sensing pathway by deletion of a specialized minor pilin-like gene | | 葡萄糖神经酰胺诱导的外泌体在帕金森病中传播致病性α-突触核蛋白 | Jacquemyn, J. | PDF | N/A | Glucosylceramide induced ectosomes propagate pathogenic α-synuclein in Parkinson's disease | | 微孢子虫感染改变了秀丽隐杆线虫的脂质水平 | El Jarkass, H. T. | PDF | N/A | Microsporidia infection alters C. elegans lipid levels | | 一种培养蝾螈端脑神经元的新方法 | Bostan, S. | PDF | N/A | A Novel Method for Culturing Telencephalic Neurons in Axolotls | | 母亲年龄和全基因组减数分裂重组失败与人类三倍体妊娠相关 | Picchetta, L. | PDF | N/A | Maternal age and genome-wide failure of meiotic recombination are associated with triploid conceptions in humans | | Mn-motif蛋白MAP6d1组装纤毛双联微管 | Gopal, D. | PDF | N/A | The Mn-motif protein MAP6d1 assembles ciliary doublet microtubules | | 在体内定向进化出一种来自半厌氧环境的超快RuBisCO，使其具备抗氧性 | McDonald, J. L. | PDF | N/A | In vivo directed evolution of an ultra-fast RuBisCO from a semi-anaerobic environment imparts oxygen resistance | | sFLT1分泌动力学的机制计算建模 | Gill, A. | PDF | N/A | Mechanistic computational modeling of sFLT1 secretion dynamics | | 共享的临床、法医和健康样本中攻击性的大脑基础：一项元分析 | Harju, H. | PDF | N/A | Shared brain basis of aggression in clinical, forensic, and healthy samples: A meta-analysis | | 时机至关重要：模拟妊娠期大麻暴露对发育中杏仁核社会行为和小胶质细胞的影响 | Pham, A. L. | PDF | N/A | Timing matters: modeling the effects of gestational cannabis exposure on social behavior and microglia in the developing amygdala | | 单细胞多组学分析揭示了神经元激活背景下脑部疾病的遗传调控机制 | Liang, L. | PDF | N/A | Single-cell multiomics of neuronal activation reveals context-dependent genetic control of brain disorders | | 人类成年期小脑-海马回路 | Hicks, T. H. | PDF | N/A | The Human Cerebello-Hippocampal Circuit Across Adulthood | | 多种途径促进聚集型多细胞生物中正向选择的进化 | Stoy, K. S. | PDF | N/A | Multiple pathways to the evolution of positive assortment in aggregative multicellularity | | 在人类真菌病原体新型隐球菌中实现近100%效率的同源依赖性基因组工程 | Nalley, M. | PDF | N/A | Near 100% efficient homology-dependent genome engineering in the human fungal pathogen Cryptococcus neoformans | | 火蚁的社会染色体对基因组调控产生了重大影响。 | Jones, B. M. | PDF | N/A | The fire ant social chromosome exerts a major influence on genome regulation | | OTX2调控染色质可及性以指导体细胞与生殖细胞的分化 | Barbieri, E. | PDF | N/A | OTX2 controls chromatin accessibility to direct somatic versus germline differentiation | | 共翻译过程中确定伴侣蛋白工厂中的四级结构 | Philippe, M. | PDF | N/A | Co-translational determination of quaternary structures in chaperone factories | | 来自Cuatro Cienegas盆地的链霉菌PB17的基因组挖掘揭示了新型神经治疗药物的生物合成潜力。 | Martinez-Olivas, M. A. | PDF | N/A | Genome Mining of Streptomyces sp. PB17 from Cuatro Cienegas Basin Reveals Biosynthetic Potential for Novel Neurotherapeutics. | | 生命之树中离子通道的识别与分类：对尚未充分研究的CALHM通道的洞见 | Taujale, R. | PDF | N/A | Identification and classification of ion-channels across the tree of life: Insights into understudied CALHM channels | | 关键残基揭示G蛋白门控内向整流钾通道中双重PIP2依赖性和非依赖性门控机制 | Nguyen, H. | PDF | N/A | Key residue Unlocks Dual PIP2-Dependent and Independent Gating in G Protein-Gated Inwardly Rectifying Potassium Channels | | 靶向SRC的非催化位点可增强SRC激酶抑制剂在实体瘤中的疗效 | Yu, J. | PDF | N/A | Targeting Non-Catalytic Sites of SRC Sensitizes the Efficacy of SRC Kinase Inhibitors in Solid Tumors | | 患者特异性药物基因组学揭示结肠癌中xCT调控通路 | Strecker, M. | PDF | N/A | Patient-Specific Pharmacogenomics unveils xCT Regulation Pathways in Colon Cancer | | 耐力运动重塑肺静脉袖心肌细胞并促进致心律失常的心房基质 | Soattin, L. | PDF | N/A | Endurance exercise remodels pulmonary vein sleeve myocytes and promotes a proarrhythmic atrial substrate | | 星形胶质细胞在脆性X综合征小鼠模型中对感觉过敏的贡献 | Bergdolt, L. | PDF | N/A | Astrocytic contribution to sensory hypersensitivity in a mouse model of fragile X syndrome | | SUMO2通过稳定组蛋白基因座体的相互作用并促进U7小核核糖核蛋白（snRNP）的组装，促进组蛋白前体mRNA的加工。 | He, S. | PDF | N/A | SUMO2 Promotes Histone Pre-mRNA Processing by Stabilizing Histone Locus Body Interactions and Facilitating U7 snRNP Assembly | | TET3在成体神经干细胞重编程过程中保护Dlk1-Dio3印记位点免受DNA低甲基化的影响 | Ferron, S. R. | PDF | N/A | TET3 protects the Dlk1-Dio3 Imprinted Locus from DNA hypomethylation during adult NSC Reprogramming | | 通过全息组学视角研究大西洋鲑鱼中的阿米巴鳃病（AGD） | Thormar, E. A. | PDF | N/A | Amoebic gill disease (AGD) in Atlantic Salmon investigated through a holo-omic lens | | 长期丧失哺乳期幼崽的大鼠：一种新型动物模型中的神经生物学和情感后果 | Demarchi, L. | PDF | N/A | Long-term offspring loss in lactating rats: Neurobiological and emotional consequences in a novel animal model | | 肉芽肿中NK细胞与巨噬细胞的相互作用与有限的结核病病理相关 | Niewold, P. | PDF | N/A | NK cell-macrophage interactions in granulomas correlate with limited tuberculosis pathology | | 近乎完全胼胝体切开术后无断连综合征 | Bekir, S. | PDF | N/A | No Disconnection Syndrome after Near-Complete Callosotomy | | 以下是这段英文的中文翻译：

"感染艾滋病毒的青少年听觉与非听觉区域之间功能连接中断的证据"

解释： - functional connectivity disruptions 指的是大脑不同区域之间功能连接的异常或中断。 - auditory and non-auditory regions 指的是与听觉相关的大脑区域（如听觉皮层）以及非听觉相关的大脑区域（如与认知、情感相关的区域）。 - adolescents living with HIV 指的是感染了艾滋病毒的青少年群体。

整句话的意思是：研究发现，感染艾滋病毒的青少年，其大脑中与听觉相关的区域和非听觉相关的区域之间的功能连接存在异常或中断。 | Madzime, J. S. | PDF | N/A | Evidence of functional connectivity disruptions between auditory and non-auditory regions in adolescents living with HIV | | 犬心丝虫（Dirofilaria immitis）和皮下丝虫（D. repens）在欧洲的研究：关于媒介、宿主范围及20至21世纪空间分布的系统文献综述 | Hattendorf, C. | PDF | N/A | Dirofilaria immitis and D. repens in Europe: a systematic literature review on vectors, host range, and the spatial distribution in the 20th and 21st century | | 微阵列、验证及基因富集方法用于评估肥胖与瘦弱心力衰竭患者中差异表达的循环miRNAs | Soares, D. d. S. | PDF | N/A | Microarray, validation and gene-enrichment approach for assessing differentially expressed circulating miRNAs in obese and lean heart failure patients | | 尽管在亚致死剂量下，吡虫啉增加了西方蜜蜂呼吸和柠檬酸循环中九种化合物中的六种的值，但它总体上降低了总能量产生。 | Paleolog, J. | PDF | N/A | Imidacloprid decreases the total energy production in western honeybees even though, in sublethal doses, it increased the values of six of the nine compounds in the respiratory and citric cycle | | 基因研究的长期创新潜力及其压制 | Chae, J. | PDF | N/A | Long-term innovative potential of genetic research and its suppression | | 路径整合功能受损揭示了主观认知衰退中的早期认知变化 | Segen, V. | PDF | N/A | Path integration impairments reveal early cognitive changes in Subjective Cognitive Decline | | 重新连接蛋白质序列和结构生成模型以增强蛋白质稳定性预测 | Li, Z. | PDF | N/A | Rewiring protein sequence and structure generative models to enhance protein stability prediction | | 肉桂树皮提取物-壳聚糖复合物的纳米制剂开发及其对水稻细菌性穗枯病病原体伯克霍尔德菌（Burkholderia glumae）的抗菌活性研究 | Alsutan, Q. M. | PDF | N/A | Nano formulation development and antibacterial activity of cinnamon bark extract-chitosan composites against burkholderia glumae, the causative agent of bacterialpanicle blight in rice | | 英国细尺度獾运动的数据驱动分析 | Furber, J. R. | PDF | N/A | Data-driven Analysis of Fine-Scale Badger Movement in the UK | | 鸟类群落中快速的结构网络变化 | Rigal, S. | PDF | N/A | Rapid structural network changes in bird communities | | 利用基于光子计数的双能计算机断层扫描技术对半月板钙化进行表征 | Nevanranta, E. A. | PDF | N/A | Characterizing meniscal calcifications with photon counting-based dual-energy computed tomography | | DDS-E-Sim：一种基于Transformer的生成框架，用于模拟DNA数据存储中的易错序列 | Naznin, M. F. S. | PDF | N/A | DDS-E-Sim: A Transformer-Based Generative Framework for Simulating Error-Prone Sequences in DNA Data Storage | | 对三种测序方案和三种农业物种的长读长基因组组装工具进行基准测试 | Birbes, C. | PDF | N/A | Benchmarking long-read genome assemblers for three sequencing protocols and three agricultural species | | 多变量时间序列中的集成事后可解释人工智能：识别驱动疾病预测的医学特征 | Metsch, J. | PDF | N/A | Ensemble Post-hoc Explainable AI in Multivariate Time Series: Identifying Medical Features Driving Disease Prediction | | 使植物组织适用于冷冻电子断层扫描 | Poege, M. | PDF | N/A | Making plant tissue accessible for cryo-electron tomography | | 以下是将这段英文翻译成中文的结果：

一种线粒体衍生的质体转运蛋白调控三角褐指藻（Phaeodactylum tricornutum）的光合作用

翻译说明： - "Mitochondrially Derived" 翻译为“线粒体衍生的”，表示该转运蛋白来源于线粒体。 - "Plastidial Transporter" 翻译为“质体转运蛋白”，指在质体（如叶绿体）中起转运作用的蛋白质。 - "Regulates Photosynthesis" 翻译为“调控光合作用”，表示该蛋白的功能与光合作用相关。 - "Diatom Phaeodactylum tricornutum" 翻译为“三角褐指藻”，是一种硅藻（Diatom）的学名。