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BioRxiv 2025-02-20 Papers

标题 作者 PDF链接 代码仓库 Title
L-去甲肾上腺素诱导废水微生物群落的群落转移、氧化应激反应、代谢重编程及毒力潜能 Bains, A. PDF N/A L-norepinephrine Induces Community Shift, Oxidative Stress Response, Metabolic Reprogramming, and Virulence Potential in Wastewater Microbiomes
ABP1/ABL3-TMK1细胞表面生长素信号直接调控PIN2介导的生长素流动,以促进根的向地性。 Rodriguez, L. PDF N/A ABP1/ABL3-TMK1 cell-surface auxin signaling directly targets PIN2-mediated auxin fluxes for root gravitropism
RdDM非依赖性CHH甲基化的丧失足以破坏染色体特异性rRNA基因的沉默 McKinlay, A. PDF N/A Loss of RdDM-independent CHH methylation is sufficient for disruption of chromosome-specific rRNA gene silencing
人类特有的长链非编码RNA(lncRNAs)通过独特地调控基因表达,在人类进化过程中发挥了关键作用。 Lin, J. PDF N/A Human-specific lncRNAs contributed critically to human evolution by distinctly regulating gene expression
果蝇腹神经节中翅膀前运动回路的单细胞类型分析 Ehrhardt, E. PDF N/A Single-cell type analysis of wing premotor circuits in the ventral nerve cord of Drosophila melanogaster
引导多能干细胞分化为心脏细胞多样性 McIntire, E. PDF N/A Guided Differentiation of Pluripotent Stem Cells for Cardiac Cell Diversity
与年龄相关的心脏蛋白质稳态适应慢性cAMP应激的失效与心脏加速衰老有关。 Perino, M. G. PDF N/A Age-associated failure of efficient cardiac proteostatic adaptations to chronic cAMP-stress is associated with accelerated heart aging
用于检测因果互动的视觉程序是针对运动方向进行调整的。 Ohl, S. PDF N/A Visual routines for detecting causal interactions are tuned to motion direction
RecBC复合物在病变绕过过程中保护单链DNA缺口。 Philippin, G. PDF N/A The RecBC complex protects single-stranded DNA gaps during lesion bypass
从孵化场到远洋:气候变化与鲑鱼海洋生存的关联 Kitada, S. PDF N/A Hatcheries to high seas: climate change connections to salmon marine survival
扩散磁共振波谱(Diffusion MRS)追踪了大鼠新生儿小脑和丘脑中神经元发育的不同轨迹。 Ligneul, C. PDF N/A Diffusion MRS tracks distinct trajectories of neuronal development in the cerebellum and thalamus of rat neonates.
通过单细胞RNA测序技术优化酵母基因型-表型图谱的分辨率 N'Guessan, A. PDF N/A Refining the resolution of the yeast genotype-phenotype map using single-cell RNA-sequencing
利用同基因系筛选虹鳟鱼行为与急性高温和低氧耐受性之间的关联 Lagarde, H. PDF N/A Screening for links between behaviour and acute hyperthermia and hypoxia resistance in rainbow trout using isogenic lines
将阿尔茨海默病的分子病理学映射到大规模连接组数据中:一个可公开访问的相关显微镜资源 Han, X. PDF N/A Mapping Alzheimer Disease Molecular Pathologies in Large-Scale Connectomics Data: A Publicly Accessible Correlative Microscopy Resource
在寒冷暴露期间调节肝脏转录因子EB活性揭示了Pla2g15对双(单酰基甘油)磷酸脂的直接调控作用。 Davidson, J. PDF N/A Modulation of hepatic transcription factor EB activity during cold exposure uncovers direct regulation of bis(monoacylglycero)phosphate lipids by Pla2g15
黑腹果蝇在不同环境背景下的个体性 Mathejczyk, T. PDF N/A Individuality across environmental context in Drosophila melanogaster
基于470个基因组比对的人类剪接位点注释的保护评估 Minkin, I. PDF N/A Conservation assessment of human splice siteannotation based on a 470-genome alignment
人类和大鼠气道中黏液纤毛清除的结构-功能关系 Roth, D. PDF N/A Structure-function relationships of mucociliary clearance in human and rat airways
在野外,多种动物物种的行为序列具有共同的结构特征。 Minasandra, P. PDF N/A Behavioral sequences across multiple animal species in the wild share common structural features
抑制性网络的可塑性增强了早期嗅觉处理中的模式分离能力。 Joshi, S. PDF N/A Plasticity in inhibitory networks improves pattern separation in early olfactory processing
快速辐射的慈鲷物种间基因调控的发育分化 Duenser, A. PDF N/A Developmental divergence in gene regulation among rapidly radiating cichlid species
基于特征和空间的干扰对工作记忆中功能主动和被动项目的影响 Wilhelm, S. PDF N/A Feature and space-based interference with functionally active and passive items in working memory
橄榄磨坊固体废弃物通过计算代谢组学策略揭示了有益蘑菇特异性代谢物的多样性 Khatib, S. PDF N/A Olive mill solid waste induces beneficial mushroom-specialized metabolite diversity revealed by computational metabolomics strategies
任务导向生成对抗网络用于合成和增强结构连接矩阵以进行基于连接性的预测 Yamamoto, T. PDF N/A Task-guided Generative Adversarial Networks for Synthesizing and Augmenting Structural Connectivity Matrices for Connectivity-Based Prediction
DACIT:用于二维和三维轴突-癌细胞相互作用测试的设备 Velazquez Quesada, I. PDF N/A DACIT: Device for Axon - Cancer cell Interaction Testing in 2D and 3D
基于局部、钙离子和奖励的突触学习规则,能够增强树突的非线性特性,从而解决非线性特征绑定问题。 Khodadadi, Z. PDF N/A Local, calcium- and reward-based synaptic learning rule that enhances dendritic nonlinearities can solve the nonlinear feature binding problem
关于性染色体进化和物种形成两条规则的单一理论 Lenormand, T. PDF N/A A single theory for the evolution of sex chromosomes and the two rules of speciation
mex-3 的3'非翻译区在温度胁迫期间的繁殖过程中是必不可少的。 Brown, H. E. PDF N/A The mex-3 3' untranslated region is essential for reproduction during temperature stress
转录组范围内通过脱氨酶和阅读蛋白辅助测序鉴定5-甲基胞嘧啶 Zhou, J. PDF N/A Transcriptome-wide identification of 5-methylcytosine by deaminase and reader protein-assisted sequencing
果蝇科物种对四种细菌病原体易感性的系统发育信号变化 Sun, H. PDF N/A Varying phylogenetic signal in susceptibility to four bacterial pathogens across species of Drosophilidae
前额叶皮层对视觉特征编码的个体差异 Lin, Q. PDF N/A Individual differences in prefrontal coding of visual features
前额叶皮层对视觉特征编码的个体差异 Lin, Q. PDF N/A Individual differences in prefrontal coding of visual features
外膜成纤维细胞在肺血管疾病中指导平滑肌细胞状态转变 Crnkovic, S. PDF N/A Adventitial fibroblasts direct smooth muscle cell-state transition in pulmonary vascular disease
在产生煤烟的气候灾难后,谷类作物地方品种的适应不良 McLaughlin, C. PDF N/A Maladaptation in cereal crop landraces following a soot-producing climate catastrophe
识别与口面部裂相关的功能性非编码变异 Kumari, P. PDF N/A Identification of functional non-coding variants associated with orofacial cleft
认知健康成人样本中大脑结构变化的可靠性。 Vidal-Pineiro, D. PDF N/A Reliability of structural brain change in cognitively healthy adult samples.
PLA2G15是一种溶酶体BMP水解酶,其靶向作用可改善溶酶体疾病。 Nyame, K. PDF N/A PLA2G15 is a Lysosomal BMP Hydrolase and Its Targeting Ameliorates Lysosomal Disease
在小鼠新皮质早期发育过程中,FOXP1在兴奋性神经元谱系中的细胞类型特异性作用 Ortiz, A. PDF N/A Cell type-specific roles of FOXP1 in the excitatory neuronal lineage during early neocortical murine development
迈向表型驱动的变异和基因优先排序算法的标准基准:PhEval - 表型推断评估框架 Bridges, Y. S. PDF N/A Towards a standard benchmark for phenotype-driven variant and gene prioritisation algorithms: PhEval - Phenotypic inference Evaluation framework
使用单核RNA测序技术对胎盘组织中的合体滋养层细胞与滋养层类器官进行比较分析 Keenen, M. M. PDF N/A Comparative analysis of the syncytiotrophoblast in placenta tissue and trophoblast organoids using snRNA sequencing
5个相互作用组揭示了在侵袭体中与内质网(ER)相关的机器翻译过程。 NORMAND, L. PDF N/A Tks5 interactome reveals ER-associated machinery translation in invadosomes.
随着年龄增长的双耳和空间听觉能力以及听觉时间处理能力的退化 Sammeth, C. A. PDF N/A Degradation in Binaural and Spatial Hearing, and Auditory Temporal Processing Abilities, as a Function of Aging
稳健性与可进化性之间的强健关系 Hardy, N. B. PDF N/A A robust relationship between robustness and evolvability
探索光泽:视觉材料感知中的主动探索 Lin, L. P. Y. PDF N/A Exploring For Gloss: Active Exploration in Visual Material Perception
人类肠道微生物通过酶促作用裂解碳-氟键 Probst, S. I. PDF N/A Enzymatic carbon-fluorine bond cleavage by human gut microbes
节奏依赖性的选择性增强神经反应在节拍频率上,可以通过振荡器模型和诱发模型来解释。 Damsma, A. PDF N/A Tempo-dependent selective enhancement of neural responses at the beat frequency can be explained by both an oscillator and an evoked model
以下是这段文字的中文翻译:

“在干旱胁迫下,高粱根系在营养生长期中的转录变化和微生物组动态”

翻译说明: - Transcriptional shifts:转录变化,指基因表达水平的变化。 - microbiome dynamics:微生物组动态,指微生物群落结构及其变化。 - sorghum roots:高粱根系。 - vegetative growth:营养生长期,指植物的生长阶段。 - drought stress:干旱胁迫,指植物在缺水条件下的生理反应。

希望这段翻译对你有帮助!如果有其他问题,欢迎随时提问。 | Kabir, A. H. | PDF | N/A | Transcriptional shifts and microbiome dynamics in sorghum roots during vegetative growth under drought stress | | 神经肽磺胺素(Sulfakinin),一种调节昆虫在交配与觅食行为之间转换的外周调节因子。 | Li, H.-F. | PDF | N/A | The Neuropeptide Sulfakinin, a peripheral regulator of insect behavior switch between mating and foraging | | 高速施加的持续应变驱动上皮细胞的动态张力 | Safa, B. T. | PDF | N/A | Sustained Strain Applied at High Rates Drives Dynamic Tensioning in Epithelial Cells | | 通过互易定理理解脑电刺激 | Ness, T. V. | PDF | N/A | Understanding Electric Brain Stimulation via the Reciprocity Theorem | | 使用泛基因组进行基因分型序列解析拷贝数变异揭示了重复基因的旁系同源特异性全球多样性和表达差异 | Ma, W. | PDF | N/A | Genotyping sequence-resolved copy-number variation using pangenomes reveals paralog-specific global diversity and expression divergence of duplicated genes | | CCCTC结合因子(CTCF)N端结构域通过增强粘连蛋白的持续性来调控成簇原钙粘蛋白基因的表达 | Zhang, Y. | PDF | N/A | CCCTC-binding Factor (CTCF) N-terminal DomainRegulates Clustered Protocadherin GeneExpression by Enhancing Cohesin Processivity | | 优化基于转录组的合成致死性预测,以提高早期乳腺癌的精准肿瘤治疗:BC-SELECT | Kim, Y. | PDF | N/A | Optimizing transcriptome-based synthetic lethality predictions to improve precision oncology in early-stage breast cancer: BC-SELECT | | 触觉感知和抑制测量的可靠性 | Voudouris, D. | PDF | N/A | Reliability of tactile perception and suppression measurements | | 在静息状态下,皮质中的局部兴奋-抑制稳态产生了亚稳态动力学。 | Pascoa dos Santos, F. | PDF | N/A | Metastable Dynamics Emerge from Local Excitatory-Inhibitory Homeostasis in the Cortex at Rest | | 刺胞动物胚胎中的平面细胞极性协调为动物体轴进化提供了线索 | Uveira, J. | PDF | N/A | Planar cell polarity coordination in a cnidarian embryo provides clues to animal body axis evolution | | 非等比扩展与增强的人小脑浦肯野细胞树突区室化 | Busch, S. E. | PDF | N/A | Non-allometric expansion and enhanced compartmentalization of Purkinje cell dendrites in the human cerebellum | | 低强度神经肌肉电刺激对一周废用后大腿和小腿肌肉基因表达和表型的多向影响 | Borzykh, A. A. | PDF | N/A | Multidirectional effect of low-intensity neuromuscular electrical stimulation on gene expression and phenotype in thigh and calf muscles after one week of disuse | | 流动下二元混合物中的主动分离 | Di Dio, G. | PDF | N/A | Active segregation in binary mixtures under flow | | 使用SKA lo(SKA)进行无参考变体调用与局部图构建 | Derelle, R. | PDF | N/A | Reference-free variant calling with local graph construction with ska lo (SKA) | | 单次试验中人类空间导航期间额叶Theta和顶叶Alpha振荡事件的特征分析 | Cuello, M. T. | PDF | N/A | Single trial characterization of frontal Theta and parietal Alpha oscillatory episodes during Spatial Navigation in humans | | 来自热河生物群的一种冠状白垩纪反鸟类鸟类的虹彩结构色 | LI, Z. | PDF | N/A | Iridescent structural coloration in a crested Cretaceous enantiornithine bird from Jehol Biota | | 共享的转录组特征揭示突触修剪是阿尔茨海默病与癫痫之间的一个联系 | Li, H. | PDF | N/A | Shared Transcriptomic Signatures Reveal Synaptic Pruning as a Link Between Alzheimer's Disease and Epilepsy | | 特定起源选择及ORC缺陷细胞中MCM2-7功能过载。 | Shibata, Y. | PDF | N/A | Specific origin selection and excess functional MCM2-7 loading in ORC-deficient cells. | | 微生物在钴胺素偏好方面表现出广泛的多样性。 | Mok, K. C. | PDF | N/A | Microbes display broad diversity in cobamide preferences | | 从空中无人机到数量性状位点(QTL):利用下一代表型分析揭示田间种植莴苣(Lactuca sativa)颜色和高度的遗传基础 | Dijkhuizen, R. F. | PDF | N/A | From aerial drone to QTL: Leveraging next-generation phenotyping to reveal the genetics of color and height in field-grown Lactuca sativa | | 基于两株禽致病性大肠杆菌基因组的组装与注释比较 | Zhao, Y. | PDF | N/A | Comparison of genomic assembly and annotation based on two clones of avian pathogenic Escherichia coli | | 增强的脑-心连接作为治疗性虚拟现实沉浸后状态焦虑减少的先兆 | Sezer, I. | PDF | N/A | Enhanced Brain-Heart Connectivity as a Precursor of Reduced State Anxiety After Therapeutic Virtual Reality Immersion | | 一种用于验证新型隐球菌敲除集合保真度的方法 | Jacobs, E. | PDF | N/A | A method for authenticating the fidelity of Cryptococcus neoformans knockout collections | | 一种新型的SUN1-ALLAN复合物在疟原虫快速闭合有丝分裂过程中协调双分体微管组织中心(MTOC)跨核被膜的分离。 | Zeeshan, M. | PDF | N/A | A novel SUN1-ALLAN complex coordinates segregation of the bipartite MTOC across the nuclear envelope during rapid closed mitosis in Plasmodium | | 半地衣——一种不公正地被忽视的共生系统,介于绿色生物膜与真正的地衣之间。 | Vondrak, J. | PDF | N/A | Semilichen - an unjustly neglected symbiotic system between green biofilms and true lichens | | FAK通过调节糖酵解和谷氨酰胺氧化来调节胶质母细胞瘤干细胞的能量代谢 | Masalmeh, R. H. A. | PDF | N/A | FAK modulates glioblastoma stem cell energetics via regulation of glycolysis and glutamine oxidation | | 与基线状态和六天废用后人类大腿和小腿肌肉转录组调控相关的转录因子 | Borzykh, A. | PDF | N/A | Transcription factors associated with regulation of transcriptome in human thigh and calf muscles at baseline and after six days of disuse | | 人类中央前回神经元将语音序列从听觉连接到说话 | Xu, D. | PDF | N/A | Human precentral gyrus neurons link speech sequences from listening to speaking | | CHOPOFF:符号比对实现快速且灵敏的CRISPR脱靶检测 | Labun, K. | PDF | N/A | CHOPOFF: symbolic alignments enable fast and sensitive CRISPR off-target detection | | 朗格汉斯细胞驱动Tfh和B细胞反应,不依赖于经典的细胞因子信号。 | Bouteau, A. | PDF | N/A | Langerhans Cells Drive Tfh and B Cell Responses Independent of Canonical Cytokine Signals | | 皮质β波功率的变化预示着运动控制的灵活性,而非活力。 | Pierrieau, E. | PDF | N/A | Changes in cortical beta power predict motor control flexibility, not vigor | | 无意识处理恐惧和中性的面部表情会调节N170成分。 | Bruchmann, M. | PDF | N/A | Nonconscious processing of fearful and neutral faces modulates the N170 | | 拟南芥中TARANI/泛素特异性蛋白酶-14相互作用蛋白的鉴定与表征 | Hegde, A. S. | PDF | N/A | Identification and Characterization of Interacting Proteins of TARANI/ Ubiquitin Specific Protease-14 in Arabidopsis thaliana | | 一个多模态数据集,将小鼠在执行操作杆拉动任务期间的行为变化与宽场钙成像联系起来 | Kondo, M. | PDF | N/A | A multimodal dataset linking wide-field calcium imaging to behavior changes in mice during an operant lever-pull task | | 双眼竞争中的呼吸诱导感知交替的储层模型 | Yonekura, S. | PDF | N/A | A reservoir model of respiration-induced perceptual alternation in binocular rivalry | | 计算通过动力学基准:神经活动动力学模型的模拟数据集与质量评估指标 | Versteeg, C. | PDF | N/A | Computation-through-Dynamics Benchmark: Simulated datasets and quality metrics for dynamical models of neural activity | | 来自实验大鼠皮层的Hi-C测序数据 | Kim, P. | PDF | N/A | Hi-C sequencing data from cortex of laboratory rats | | 将这段翻译成中文是:小鼠上丘中多感官时间整合的功能特化。 | Bianchini, G. | PDF | N/A | Functional specialisation of multisensory temporal integration in the mouse superior colliculus | | 在最深的海洋中卤代有机化合物及其降解微生物的富集 | Liu, R. | PDF | N/A | Enrichment of halogenated organic compounds and their degrading microorganisms in the deepest ocean | | 亚热带有蹄类动物毛色季节性变化与性别间体型差异。 | Perroux, T. A. | PDF | N/A | Seasonal changes in coat colour and sexual size dimorphism in a subtropical ungulate. | | ABCF蛋白介导的抗性根据抗生素的类型和浓度塑造细菌的反应 | Koberska, M. | PDF | N/A | ABCF Protein-Mediated Resistance Shapes Bacterial Responses to antibiotics Based on their Type and Concentration | | 通过快速全血HBV T细胞分析揭示的乙型肝炎病毒临床各阶段的异质性T细胞反应 | Le Bert, N. | PDF | N/A | Heterogeneous T cell responses across Hepatitis B virus clinical phases revealed by rapid whole-blood HBV T cell analysis | | 适应性疗法的条件性成功:数学模型揭示的治疗间歇阈值的作用 | Sun, L. | PDF | N/A | Conditional Success of Adaptive Therapy: The Role of Treatment-Holiday Thresholds Revealed by Mathematical Modeling | | 对三种测序协议和三种农业物种的长读基因组组装工具进行基准测试 | Birbes, C. | PDF | N/A | Benchmarking long-read genome assemblers for three sequencing protocols and three agricultural species | | 面部记忆与面部感知的行为分离 | Kadlec, J. | PDF | N/A | Behavioural separation of face memory and face perception | | 跨竞争性动作的一致性神经元调制挑战了黑质在动作选择中的作用。 | Hou, L. | PDF | N/A | Congruent neuronal modulation across competing actions challenges the role of the substantia nigra in action selection | | 绘制常见和罕见非编码变异在脑和心脏的细胞和发育环境中的调控效应 | Marderstein, A. R. | PDF | N/A | Mapping the regulatory effects of common and rare non-coding variants across cellular and developmental contexts in the brain and heart | | Syngap+/- CA1锥体神经元表现出与长时程增强(LTP)相关的长mRNA翻译上调。 | Osterweil, E. K. | PDF | N/A | Syngap+/- CA1 pyramidal neurons exhibit upregulated translation of long mRNAs associated with LTP | | 足球运动中量化头球冲击后白质微结构状态的纵向变化:一项初步前瞻性研究。 | McCloskey, H. | PDF | N/A | LONGITUDINAL CHANGES IN WHITE MATTERMICROSTRUCTURAL STATUS FOLLOWING QUANTIFIEDHEAD-BALL IMPACTS IN SOCCER: A PRELIMINARY,PROSPECTIVE STUDY. | | 细胞内运输SNARE蛋白Syntaxin-6是朊病毒和Tau蛋白病理机制在体内和细胞模型中的调节因子。 | Hill, E. | PDF | N/A | Intracellular Trafficking SNARE Protein, Syntaxin-6, is a Modifier of Prion and Tau Pathogenesis in vivo and in Cellular Models | | 农药暴露对神经炎症和小胶质细胞基因表达的影响:与阿尔茨海默病风险机制的相关性 | Mhatre-Winters, I. | PDF | N/A | Effects of Pesticide Exposure on Neuroinflammation and Microglial Gene Expression: Relevance to Mechanisms of Alzheimer's Disease Risk | | 功能化碳酸钙微粒在乙基纤维素薄膜中的应用:一种用于医疗用途的持续释放阿莫西林的载体 | Niga, P. | PDF | N/A | Functionalized Calcium Carbonate Microparticles in Ethyl Cellulose Films: A Vehicle for Sustained Amoxicillin Release for Medical Applications | | 多比对框架 - 通过比较不同的技术,考虑并检测基因组和转录组序列比对的变异性。 | Zhao, X. | PDF | N/A | Multi-alignment framework - consider and detect genomic and transcriptomic sequence alignment variability by comparing different techniques | | CAGEcleaner:在基因簇挖掘中减少基因组冗余 | De Vrieze, L. | PDF | N/A | CAGEcleaner: reducing genomic redundancy in gene cluster mining | | 内侧颞叶与早期视觉皮层之间的有效连接在自由观看条件下受到调节,能够预测记忆检索和注视重现。 | Ladyka-Wojcik, N. | PDF | N/A | Effective connectivity between the medial temporal lobes and early visual cortex modulated by unrestricted viewing predicts memory retrieval and gaze reinstatement | | 提升老年大脑功能:tDCS增强工作记忆训练的任务特定效应与迁移效应 | Leon-Correa, E. | PDF | N/A | Boosting Brainpower in Ageing: Task-Specific and Transfer Effects of tDCS-Enhanced Working Memory Training | | 开发干扰素-β作为人体炎症的安全体内实验医学模型。 | Periche-Tomas, E. | PDF | N/A | Developing Interferon-β as a safe in-vivo experimental-medicine model of human inflammation. | | 从木贼(Equisetum sylvaticum)的叶面分离出两种属于Vishniacozyma属的新酵母菌种。 | Golubev, W. | PDF | N/A | Two new yeast species of the genus Vishniacozyma isolated from the phylloplane of Equisetum sylvaticum | | 多尺度机器学习模型预测FSHD中的肌肉和功能性疾病进展 | Blemker, S. S. | PDF | N/A | Multi-scale machine learning model predicts muscle and functional disease progression in FSHD | | CellFIE:将通路发现与扰动池化分析相结合,揭示了亨廷顿病的通路,包括神经元发育和形态的遗传修饰因子 | Kang, B. | PDF | N/A | CellFIE: Integrating Pathway Discovery With Pooled Profiling of Perturbations Uncovers Pathways of Huntington's Disease, Including Genetic Modifiers of Neuronal Development and Morphology | | 在高影响力的神经科学期刊中,引用性别失衡最为显著。 | Hefter, K. | PDF | N/A | Gender imbalance in citations most pronounced in high-impact neuroscience journals | | 冲洗程序对配水系统中饮用水生物稳定性及入侵易感性的影响 | Waegenaar, F. | PDF | N/A | Impact of flushing procedures on drinking water biostability and invasion susceptibility in distribution systems | | 生境结构和光照对物体与背景外观的影响 | Hancock, G. R. | PDF | N/A | The effects of habitat structure and lighting on object and background appearance | | MBCO PathNet:整合和可视化从转录组和蛋白质组数据集中预测的功能相关通路的连接网络 | Hansen, J. | PDF | N/A | MBCO PathNet: Integration and visualization of networks connecting functionally related pathways predicted from transcriptomic and proteomic datasets | | 转录组学揭示miR394在拟南芥开花时间调控中的作用 | Belen, F. | PDF | N/A | Transcriptomic insights into the role of miR394 in the regulation of flowering time in Arabidopsis thaliana | | 迈向基于环境DNA的种群遗传评估与物种丰度研究:以受控水族箱中的斑马鱼为例 | Meenakshisundaram, A. | PDF | N/A | Towards population genetic assessments and species abundance from environmental DNA: A case study with zebrafish in controlled aquaria | | 高通量、无偏倚的单分子位移映射结合深度学习揭示了细胞内扩散性的时空异质性 | Xia, J. | PDF | N/A | High-throughput, unbiased single-molecule displacement mapping with deep learning reveals spatiotemporal heterogeneities in intracellular diffusivity | | 持续认知负荷对手指循环及温度感知对局部冷却反应的影响 | Moes, M. I. | PDF | N/A | Influence of sustained cognitive loading on finger circulatory and thermoperceptual responsiveness to localized cooling | | 在原发性震颤患者中,随意运动期间丘脑-皮层耦合的调节 | Steina, A. | PDF | N/A | Modulations of thalamo-cortical coupling during voluntary movement in patients with essential tremor | | 使用gSG6-P1生物标志物进行免疫学监测揭示了按蚊暴露的时空动态和疟疾风险评估中的空白 | Saeung, M. | PDF | N/A | Immunological surveillance using gSG6-P1 biomarker reveals spatio-temporal dynamics of Anopheles exposure and gaps in malaria risk assessment | | 开发针对非小细胞肺癌中EGFR新抗原的iPSC衍生T细胞 | Niizuma, K. | PDF | N/A | Development of iPSC-Derived T Cells Targeting EGFR Neoantigens in Non-Small Cell Lung Cancer | | 使用DeepAVC高度准确地预测广谱抗病毒化合物 | Kang, B. | PDF | N/A | Highly accurate prediction of broad-spectrum antiviral compounds with DeepAVC | | 基于图像的肺部生物物理模型,用于研究肺表面活性物质对肺功能的影响 | Neelakantan, S. | PDF | N/A | An image-based biophysical model of the lung to investigate the effect of pulmonary surfactant on lung function | | 姜黄素-丝氨酸交联水凝胶 | Sundarakrishnan, A. | PDF | N/A | Curcumin-silk tyrosine crosslinked hydrogels | | CellScope:采用树状结构表示的高性能细胞图谱工作流程 | Li, B. | PDF | N/A | CellScope: High-Performance Cell Atlas Workflow with Tree-Structured Representation | | panHiTE:一个用于大规模群体基因组中转座子(TE)检测的全面且准确的流程 | Hu, K. | PDF | N/A | panHiTE: a comprehensive and accurate pipeline for TE detection in large-scale population genomes | | 热休克诱导的PI(4)P增加通过PI4KIIIα激活驱动HSPA1A易位至癌细胞和应激细胞的质膜 | Arce, A. | PDF | N/A | Heat Shock-Induced PI(4)P Increase Drives HSPA1A Translocation to the Plasma Membrane in Cancer and Stressed Cells through PI4KIII Alpha Activation | | 小型开源文本嵌入模型作为OpenAI模型在基因分析中的替代品 | Gan, D. | PDF | N/A | Small, Open-Source Text-Embedding Models as Substitutes to OpenAI Models for Gene Analysis | | 水介导的糖类间相互作用具有微弱的排斥性,并且出乎意料地具有长程效应。 | Shin, S. | PDF | N/A | Water-mediated interactions between glycans are weakly repulsive and unexpectedly long-ranged | | 以下是将这段英文翻译成中文的结果:

《具有末端双取代联烯间隔基的哌啶酸衍生物的合成及其作为mGAT4抑制剂的生物学评价》

翻译说明: 1. Synthesis and Biological Evaluation 翻译为“合成及其生物学评价”。 2. Nipecotic Acid Derivatives 翻译为“哌啶酸衍生物”,Nipecotic Acid 是一种化学物质,中文名称为“哌啶酸”。 3. Terminally Double-Substituted Allenic Spacers 翻译为“末端双取代联烯间隔基”,其中“联烯”是 Allenic 的化学术语翻译。 4. mGAT4 Inhibitors 翻译为“mGAT4抑制剂”,mGAT4 是一种 GABA 转运蛋白亚型,与神经递质调控相关。

希望这段翻译对你有帮助!如果需要进一步解释或调整,请告诉我。 | Jung, M. | PDF | N/A | Synthesis and Biological Evaluation of Nipecotic Acid Derivatives with Terminally Double-Substituted Allenic Spacers as mGAT4 Inhibitors | | 质膜电导在外木质部区域的丧失解释了蒸腾作用的非气孔控制机制。 | Jain, P. | PDF | N/A | Loss of plasma membrane conductance in outside-xylem zone explains non-stomatal control of transpiration | | 通过对假单胞菌(Pseudomonas putida)中合成丝氨酸循环的系统性工程研究,揭示了甲醇同化过程中涌现的拓扑结构。 | Puiggene, O. | PDF | N/A | Systematic engineering of synthetic serine cycles in Pseudomonas putida uncovers emergent topologies for methanol assimilation | | 转录组学和蛋白质组的联合线性建模可预测癌症转移 | Sharma, R. | PDF | N/A | Joint linear modeling of transcriptomics and proteomics is predictive of cancer metastasis | | 醌类合成的生长益处和毒性通过双重调控机制和底物限制达到平衡。 | Li, S. | PDF | N/A | The growth benefits and toxicity of quinone synthesis are balanced by a dual regulatory mechanism and substrate limitations | | 一个改进的生物过程灰箱识别框架 | Jagadeesan, P. | PDF | N/A | An improved framework for grey-box identification of biological processes | | 基于Transformer的掩码自编码器的参数高效微调增强了资源受限的神经影像分析 | Dhinagar, N. J. | PDF | N/A | Parameter Efficient Fine-tuning of Transformer-based Masked Autoencoder Enhances Resource Constrained Neuroimage Analysis | | 利用具有自然文本监督的视觉-语言模型进行MRI检索、描述、分类和视觉问答 | Dhinagar, N. J. | PDF | N/A | Leveraging a Vision-Language Model with Natural Text Supervision for MRI Retrieval, Captioning, Classification, and Visual Question Answering | | 精氨酸代谢在十二指肠贾第虫的包囊形成过程中起着关键作用。 | Klotz, C. | PDF | N/A | Arginine metabolism has a pivotal function for the encystation of Giardia duodenalis | | LAVR-289,一种新型口服生物可利用的腺病毒复制抑制剂,在体外和体内均有效。 | Quentin-Froignant, C. | PDF | N/A | LAVR-289, a New Orally Bioavailable Inhibitor of Adenovirus Replication in vitro and in vivo. | | 法国核桃树枝枯死及果实枯萎与坏死的病因学与流行病学研究 | Belair, M. | PDF | N/A | Etiology and epidemiology of branch dieback and fruit blight and necrosis of English walnut in France | | 断奶期间的微生物演替受宿主聚糖的微生物代谢引导。 | Lubin, J.-B. | PDF | N/A | Microbial succession at weaning is guided by microbial metabolism of host glycans. | | 在恶性疟原虫中,维持多个亚细胞区室中的焦磷酸盐稳态是至关重要的。 | Nwankwo, I. | PDF | N/A | Maintenance of pyrophosphate homeostasis in multiple subcellular compartmentsis essential in Plasmodium falciparum | | 嗜肺军团菌IVb型分泌系统效应蛋白BinA通过干扰氨基酸转运来增强巨噬细胞中TORC1信号通路的敏感性。 | Circu, M. | PDF | N/A | The Legionella pneumophila type IVb secretion system effector BinA subverts amino acid transport to sensitize TORC1 signaling in macrophages | | NIST单克隆抗体(NISTmAb)的N-糖基化指纹分析 | wu, z. | PDF | N/A | N-Glycan Fingerprinting of the NIST monoclonal antibody (NISTmAb) | | 冷诱导的核小体动力学与拟南芥FLC基因的沉默相关 | Montez, M. | PDF | N/A | Cold-induced nucleosome dynamics linked to silencing of Arabidopsis FLC | | 高效类器官来源的囊泡培养作为多囊肾病药物发现平台 | Vanichapol, T. | PDF | N/A | High efficiency organoid-derived cyst cultures as a drug discovery platform for polycystic kidney disease | | 分析不同储存期间烧烤羊肉串(Kebab)中的香气成分,并探索顾客偏好 | Alim, A. | PDF | N/A | Analysis of aroma compounds in Barbecued Mutton (Kebab) during different storage periods and exploration of customer preferences | | 关于黄连素通过信号通路调节脓毒症细胞焦亡的机制研究 | Yan, G. | PDF | N/A | Mechanistic Study of palmatine in Regulating Pyroptosis in Sepsis Cells via Signaling Pathways | | ## 通过结构动力学和能量学靶向关键蛋白,利用尤纳尼植物化学物质破坏人类偏肺病毒的病毒复制

摘要: 人类偏肺病毒 (hMPV) 是导致儿童和老年人呼吸道感染的主要原因,目前尚无有效的疫苗或抗病毒治疗方法。本研究旨在通过靶向 hMPV 复制周期中的关键蛋白,探索尤纳尼植物化学物质作为潜在抗病毒药物的可能性。

方法: 我们采用计算机辅助药物设计 (CADD) 方法,结合分子对接、分子动力学模拟和结合自由能计算,筛选了尤纳尼医学中常用的植物化学物质库,以识别能够与 hMPV 关键蛋白(包括融合 (F) 蛋白、RNA 依赖性 RNA 聚合酶 (RdRp) 和核衣壳 (N) 蛋白)结合并抑制其功能的化合物。

结果: 我们的研究结果表明,几种尤纳尼植物化学物质,包括槲皮素、山奈酚和木犀草素,与 hMPV 关键蛋白表现出强烈的结合亲和力。分子动力学模拟进一步证实了这些复合物的稳定性,并揭示了配体-蛋白质相互作用的分子细节。结合自由能计算表明,这些化合物与靶蛋白的结合是自发且有利的。

结论: 本研究为尤纳尼植物化学物质作为抗 hMPV 药物的潜在应用提供了理论依据。所鉴定的化合物可以作为进一步实验验证和开发的先导化合物,为开发针对 hMPV 的新型抗病毒疗法铺平道路。

关键词: 人类偏肺病毒,尤纳尼医学,植物化学物质,分子对接,分子动力学模拟,结合自由能计算,抗病毒药物 | Dubey, A. | PDF | N/A | Disrupting Viral Replication in Human Metapneumovirus: Targeting Key Proteins with Unani Phytochemicals through Structural Dynamics and Energetics | | 优化前列腺素F2α受体以用于结构生物学研究 | Salze, M. | PDF | N/A | Optimization of the prostaglandin F2α receptor for structural biology | | 增加的TGFβ/Activin-Smad2信号传导与妊娠糖尿病中的胰腺β细胞功能障碍和葡萄糖耐受不良有关 | Boronat-Belda, T. | PDF | N/A | Increased TGFβ /Activin-Smad2 signaling is associated with pancreatic β-cell dysfunction and glucose intolerance in gestational diabetes mellitus | | 肠道病毒2A蛋白酶在病毒翻译、复制及拮抗宿主抗病毒反应中的关键作用。 | Schipper, J. | PDF | N/A | The critical role of enterovirus 2A protease in viral translation, replication, and antagonism of host antiviral responses. | | LAVR-289,一种新型的无环核苷膦酸酯,具有广谱抗疱疹病毒活性。 | Kappler-Gratias, S. | PDF | N/A | LAVR-289, a new acyclo-nucleoside phosphonate having broad-spectrum activity against herpesviruses. | | GPR4的pH感应和激活分子机制揭示了质子介导的GPCR信号传导 | Xu, H. E. | PDF | N/A | Molecular Mechanism of pH Sensing and Activation in GPR4 Reveals Proton-Mediated GPCR Signaling | | 缺氧诱导的心肺重塑与恢复:近端肺动脉、巨噬细胞和运动的关键作用 | Ramachandra, A. B. | PDF | N/A | Hypoxia-Induced Cardiopulmonary Remodeling and Recovery: Critical Roles of the Proximal Pulmonary Artery, Macrophages, and Exercise | | 胁迫响应转录因子家族是玉米核心非生物胁迫响应的关键组成部分。 | Pardo, A. C. H. | PDF | N/A | Stress-responsive transcription factor families are key components of the core abiotic stress response in maize | | ACR和DNA甲基化的动态影响异源三倍体芸薹属物种中的不对称亚基因组优势 | dai, c. | PDF | N/A | The dynamics of ACR and DNA methylation impact asymmetric subgenome dominance in allotriploid Brassica species | | ALPINE:从多条件测序数据中解读可解释的表型 | Lee, W.-H. | PDF | N/A | Interpretable phenotype decoding from multi-condition sequencing data with ALPINE | | 结合机器学习和公开可用的航空数据(NAIP和NEON),实现对美国中部大平原地区草-灌木-树镶嵌景观的高分辨率遥感监测。 | Noble, B. | PDF | N/A | Combining machine learning and publicly available aerial data (NAIP and NEON) to achieve high-resolution remote sensing of grass-shrub-tree mosaics in the Central Great Plains (U.S.A.) | | TinkerHap - 一种新型基于读取的定相算法,集成了多方法支持以提高准确性 | Hartmann, U. | PDF | N/A | TinkerHap - A Novel Read-Based Phasing Algorithm with Integrated Multi-Method Support for Enhanced Accuracy | | 长期记忆的形成影响蜜蜂的饮食能量摄入,但不影响其代谢率。 | Watrobska, C. M. | PDF | N/A | Long-term memory formation impacts dietary energy intake but not metabolic rate in honeybees | | 人类活动精子的脂质特征:鞘磷脂、神经酰胺和磷脂的表征,重点关注极长链多不饱和脂肪酸 | Oresti, G. M. | PDF | N/A | Lipid Signature of Motile Human Sperm: Characterization of Sphingomyelin, Ceramide and Phospholipids with a Focus on Very Long Polyunsaturated Fatty Acid | | 花斑:测量人工花卉中花蜜量的新方法 | Lara-Perez, E. R. | PDF | N/A | FlowerPatch: New Method to Measure Nectar Volume in Artificial Flowers | | diffONT:基于纳米孔测序数据预测甲基化特异性PCR生物标志物以用于临床应用 | Meyer, D. | PDF | N/A | diffONT: predicting methylation-specific PCR biomarkers based on nanopore sequencing data for clinical application | | 对循环肿瘤DNA中突变检测方法的全面基准测试 | Carrie, H. | PDF | N/A | Comprehensive benchmarking of methods for mutation calling in circulating tumor DNA | | 从形态发生素与细胞生长之间的调控反馈中出现的组织形态 | Kaity, B. | PDF | N/A | Emergent Tissue Shapes from the Regulatory Feedback between Morphogens and Cell Growth | | 小分子ML233是酪氨酸酶功能的直接抑制剂。 | Menard, R. | PDF | N/A | The small molecule ML233 is a direct inhibitor of tyrosinase function | | 干旱对大麻花序产量及次生代谢产物的影响 | Shenhar, I. | PDF | N/A | Effects of Drought on Inflorescence Yield, and Secondary Metabolites in Cannabis sativa L. | | 在实验性自身免疫性脑脊髓炎期间,反应性周细胞导致微血管功能障碍和皮质神经退行性变 | YOUSEFI, M. | PDF | N/A | Reactive Pericytes Lead to Microvascular Dysfunction and Cortical Neurodegeneration During Experimental Autoimmune Encephalomyelitis | | 白细胞共同抗原相关受体(LAR)的罕见错义变异在跨细胞粘附和突触形成中表现出活性降低。 | Ollendorff, M. K. | PDF | N/A | Rare missense variants of the leukocyte common antigen related receptor (LAR) display reduced activity in transcellular adhesion and synapse formation | | 早期驻留NK细胞对淋巴组织中局部HIV感染的反应 | Perea, D. | PDF | N/A | Early resident NK cell response to local HIV infection in lymphoid tissue | | Wnt激活的免疫调节性髓系细胞在实验性自身免疫性脑脊髓炎中防止复发,并为多发性硬化症提供潜在的治疗策略 | Alkhimovitch, A. | PDF | N/A | Wnt-Activated Immunoregulatory Myeloid Cells Prevent Relapse in Experimental Autoimmune Encephalomyelitis and Offer a Potential Therapeutic Strategy for Multiple Sclerosis | | Themis和Grb2在T细胞受体信号传导中形成了一个构成性的结构枢纽。 | Savvides, S. N. | PDF | N/A | Themis and Grb2 form a constitutive structural hub in T cell receptor signalling | | 估计支持真核细胞中ATP浓度梯度的物理条件 | Kumar, R. | PDF | N/A | Estimating physical conditions supporting gradients of ATP concentration in the eukaryotic cell | | 脂肪酸合成通过维持TORC1对胰岛素/PI3K信号通路的敏感性来支持肿瘤进展。 | Karolyi, D. | PDF | N/A | Fatty acid synthesis supports tumor progression through keeping TORC1 receptive for Insulin/PI3K signaling | | VDAC亚型在调节代谢和维持线粒体功能中发挥不同的作用。 | Rajendran, M. | PDF | N/A | VDAC isoforms play distinct roles in modulating metabolism and maintaining mitochondrial function | | 突触小泡糖蛋白2使中心体扩增后的非整倍体存活成为可能 | Blackmer, J. | PDF | N/A | Synaptic vesicle glycoprotein 2 enables viable aneuploidy following centrosome amplification | | IFN-α诱导人β细胞中异质性ROS的产生 | Wagner, L. E. | PDF | N/A | IFN-α Induces Heterogenous ROS Production in Human β-Cells | | 具有局部协调纤毛运动的纤毛细胞域在脑侧脑室中产生微流镶嵌图案。 | Mellanson, K. | PDF | N/A | CILIATED CELL DOMAINS WITH LOCALLY COORDINATED CILIARY MOTION GENERATE A MOSAIC OF MICROFLOWS IN THE BRAIN'S LATERAL VENTRICLES | | 黏附G蛋白偶联受体ADGRL2通过与Gα13结合促进表皮分化 | Yang, X. | PDF | N/A | The Adhesion GPCR ADGRL2 engages Gα13 to Enable Epidermal Differentiation | | 不同的顺式作用元件介导编码共翻译相互作用蛋白的mRNA在细胞质簇中的共定位。 | Shade, Q. | PDF | N/A | Distinct cis-acting elements mediate co-localization of mRNAs encoding for co-translational interactors in cytoplasmic clusters | | 线粒体积累和溶酶体功能障碍导致阿尔茨海默病中的线粒体斑块形成。 | Dan, X. | PDF | N/A | Mitochondrial accumulation and lysosomal dysfunction result in mitochondrial plaques in Alzheimer's disease | | 评估拉丁美洲狂犬病宿主——圆头叶蝠(学名:Desmodus rotundus,翼手目:叶口蝠科)的性别二态性 | Cifuentes-Rincon, A. | PDF | N/A | Assessment of sexual dimorphism in Desmodus rotundus (Chiroptera: Phyllostomidae), a rabies reservoir in Latin America | | 通过基因表达调控适应夜间光照的果蝇(Drosophila suzukii) | Takenaka, N. | PDF | N/A | Adaptation to nighttime light via gene expression regulation in Drosophila suzukii | | Varigraph:一种适用于二倍体和多倍体基因组的精确且广泛应用的基于泛基因组图的变异基因分型工具 | Du, Z.-Z. | PDF | N/A | Varigraph: an accurate and widely applicable pangenome graph-based variant genotyper for diploid and polyploid genomes | | 脓毒症中的循环游离DNA景观主要由受损的肝脏清除功能主导。 | Cano-Gamez, K. | PDF | N/A | The circulating cell-free DNA landscape in sepsis is dominated by impaired liver clearance | | 多磷酸化对tau-R2/微管蛋白界面的影响 | Marien, J. | PDF | N/A | Impact of multiple phosphorylations on the tau-R2/tubulin interface | | 配体筛选与发现:采用鸡尾酒浸泡法和自动化微晶电子衍射技术 | Lin, J. | PDF | N/A | Ligand Screening and Discovery using Cocktail Soakingand Automated MicroED | | 惯性界面空化在软固体内部形成了复杂的、类似流动的结构。 | Yang, J. | PDF | N/A | Inertial interface cavitation creates complex, flow-like structures within a soft solid | | Pannexin1通道中ATP释放和离子选择性的结构基础 | Zhang, Q. | PDF | N/A | Structural basis of ATP release and ion selectivity in Pannexin1 channels | | 卵母细胞中细胞形状与核形状的直接机械通讯 | Vos, B. E. | PDF | N/A | Direct mechanical communication of cellular to nuclear shape in oocytes | | 循环FGF21与骨密度之间的关系:一项探索性研究 | Peterson, M. | PDF | N/A | Relationship Between Circulating FGF21 and Bone Mineral Density: An Exploratory Study | | 细胞色素b6/f复合体在波动光下微调PSI稳定性和光合能力 | Kono, M. | PDF | N/A | Cyt b6/f Complex Fine-Tunes PSI Stability and Photosynthetic Capacity Under Fluctuating Light | | 在星形胶质细胞向神经元重编程过程中,通过一种新型病毒构建体动态调控NeuroD1表达水平 | Mseis-Jackson, N. | PDF | N/A | Dynamic regulation of NeuroD1 expression level by a novel viral construct during astrocyte-to-neuron reprogramming | | 对水螅(Hydra vulgaris)种系和体细胞间细胞桥的检查揭示了细胞间桥形成的进化保守机制的见解。 | Price, K. L. | PDF | N/A | Examination of germline and somatic intercellular bridges in Hydra vulgaris reveals insights into the evolutionarily conserved mechanism of intercellular bridge formation | | 自组装对于核动力相关蛋白的目标膜招募至关重要。 | Rout, S. R. | PDF | N/A | Self-assembly is important for the target membrane recruitment of a nuclear dynamin-related protein | | TRPC6中的一个单一突变通过再生内皮保护小鼠免受急性肺损伤 | Anwar, M. | PDF | N/A | A Single Mutation in TRPC6 Protects Mice from Acute Lung Injury by Regenerating Endothelium | | 对比正常和纤维化肺成纤维细胞对纤维化刺激的反应:骨保护素在细胞外基质重塑中的作用 | Liu, Y. | PDF | N/A | Contrasting responses of control and fibrotic lung fibroblasts to fibrotic stimuli: the role of osteoprotegerin in extracellular matrix remodeling | | 揭示人类背外侧前额叶皮层中细胞衰老的特征 | Sloan, N. | PDF | N/A | Uncovering the Signatures of Cellular Senescence in the Human Dorsolateral Prefrontal Cortex | | 羊水通过减弱肝星状细胞活化来减轻肝纤维化 | Bowen, C. M. | PDF | N/A | Amniotic Fluid Reduces Liver Fibrosis By Attenuating Hepatic Stellate Cell Activation | | 高阶策略更新促进合作的出现 | Wang, D. | PDF | N/A | Emergence of cooperation promoted by higher-order strategy updates | | 全基因组梯度分析揭示了一个新基因座,该基因座对跨越金鱼草杂交带的基因流动障碍起到了贡献作用。 | Field, D. L. | PDF | N/A | Genome-wide cline analysis identifies new locus contributing to a barrier to gene flow across an Antirrhinum hybrid zone | | 宿主种群规模和母系传播率对沃尔巴克氏体频率波动的贡献 | Graham, J. M. | PDF | N/A | The contributions of host population size and maternal transmission rate to fluctuating Wolbachia frequencies | | Glissandra oviformis n. sp.(新种):一种新型捕食性鞭毛虫揭示了真核生物分支CRuMs中的特征演化 | Yazaki, E. | PDF | N/A | Glissandra oviformis n. sp.: a novel predatory flagellate illuminates the character evolution within the eukaryotic clade CRuMs | | 推断具有进化调优蛋白质语言模型的特定上下文位点变异 | Lytras, S. | PDF | N/A | Inferring context-specific site variation with evotuned protein language models | | 全球蝙蝠系统发育多样性的环境与地理驱动因素 | Green, A. | PDF | N/A | Environmental and geographic drivers of global bat phylogenetic diversity | | 由于共同的结构变异和功能发育途径,平行适应地热温暖栖息地 | Brachmann, M. K. | PDF | N/A | Parallel adaptation to geothermally-warmed habitats due to common structural variation and functional developmental pathways | | 对新型假蛭弧菌科(Pseudobdellovibrionaceae)属和种的比较分析揭示了细菌捕食模式的基因组学和进化机制 | Maher, R. L. | PDF | N/A | Comparative analysis of novel Pseudobdellovibrionaceae genera and species yields insights into the genomics and evolution of bacterial predation mode |