BioRxiv 2025-02-22 Papers
| 标题 | 作者 | PDF链接 | 代码仓库 | Title |
|---|---|---|---|---|
| 免疫球蛋白可变区的体细胞超突变模式是在不受局部转录环境影响的情况下建立的。 | Schoeberl, U. E. | N/A | Somatic hypermutation patterns in immunoglobulin variable regions are established independently of the local transcriptional landscape | |
| mzrtsim：基于可重现的气相/液相色谱-质谱联用非靶向代谢组学数据分析的原始数据模拟 | Yu, M. | N/A | mzrtsim: Raw Data Simulation for Reproducible Gas/Liquid Chromatography Mass Spectrometry Based Non-targeted Metabolomics Data Analysis | |
| 基于树的差异测试使用推断不确定性进行RNA-Seq分析 | Singh, N. P. | N/A | Tree-based differential testing using inferentialuncertainty for RNA-Seq | |
| 体内长程化学信号传导受到机械信号的调控。 | Pillai, E. K. | N/A | Long-range chemical signalling in vivo is regulated by mechanical signals | |
| 迈向高效k-mer集合操作：通过函数分配掩码超级字符串 | Sladky, O. | N/A | Towards Efficient k-Mer Set Operations via Function-Assigned Masked Superstrings | |
| Pandora：一种用于评估基因型数据降维稳定性的工具 | Haag, J. | N/A | Pandora: A Tool to Estimate Dimensionality Reduction Stability of Genotype Data | |
| 对膜电位调节离子溶液的反应通过培养细胞和大鼠体内皮层的磁共振成像进行测量 | Min, K. | N/A | Responses to membrane potential-modulating ionic solutions measured by magnetic resonance imaging of cultured cells and in vivo rat cortex | |
| 变革之虫：人为干扰改变了维多利亚湖慈鲷的外寄生虫群落结构 | Gobbin, T. P. | N/A | Worms of change: anthropogenic disturbance changes the ectoparasite community structure of Lake Victoria cichlids | |
| 体型小是一种挑战：濒危鸣禽的近交衰退与其体型大小相关 | Kubacka, J. | N/A | It is hard to be small: Inbreeding depression depends on the body size in a threatened songbird | |
| 脑源性外泌体血红蛋白转移有助于缺氧条件下神经元线粒体的稳态维持。 | Tian, Z. | N/A | Brain-derived exosomal hemoglobin transfer contributes to neuronal mitochondrial homeostasis under hypoxia | |
| 铁蛋白介导的铁稳态和细菌群落变化支撑了高粱的干旱适应能力 | Kabir, A. H. | N/A | Ferritin-mediated iron homeostasis and bacterial shifts underpin drought adaptation in sorghum | |
| 以下是这段文字的中文翻译： |
小胶质细胞在哺乳期母体高脂饮食暴露后代下丘脑AgRP神经支配的发育规范中是必需的
翻译说明： - "Microglia" 翻译为 "小胶质细胞"，是中枢神经系统中的一种免疫细胞。 - "developmental specification" 翻译为 "发育规范"，指在发育过程中特定细胞或结构的形成和功能确定。 - "AgRP" 是 "agouti-related peptide" 的缩写，翻译为 "刺鼠相关肽"，是一种与食欲调节相关的神经肽。 - "innervation" 翻译为 "神经支配"，指神经纤维对特定区域的分布和支配。 - "hypothalamus" 翻译为 "下丘脑"，是大脑中调节多种生理功能的重要区域。 - "offspring" 翻译为 "后代"，指母体的子代。 - "maternal high fat diet" 翻译为 "母体高脂饮食"，指母体在哺乳期摄入高脂肪的饮食。 - "lactation" 翻译为 "哺乳期"，指母体分泌乳汁喂养后代的时期。
整句话的意思是：在哺乳期母体摄入高脂饮食的情况下，后代下丘脑中AgRP神经支配的发育规范需要小胶质细胞的参与。 | Mendoza-Romero, H. N. | PDF | N/A | Microglia are Required for Developmental Specification of AgRP Innervation in the Hypothalamus of Offspring Exposed to Maternal High Fat Diet During Lactation | | 一种高度活跃的细菌肌动蛋白驱动了另一种同工型的聚合，这种同工型对于螺旋体（Spiroplasma）的游动运动至关重要。 | Takahashi, D. | PDF | N/A | A highly active bacterial actin actuates the polymerization of another isoform essential for swimming motility of Spiroplasma | | AI驱动的空间转录组学从组织病理学中解锁大规模乳腺癌生物标志物发现 | Shulman, E. D. | PDF | N/A | AI-Driven Spatial Transcriptomics Unlocks Large-Scale Breast Cancer Biomarker Discovery from Histopathology | | 线粒体ETF（电子传递黄素蛋白）不足通过选择性优化癌症生物能量学驱动肿瘤生长。 | Papadopoli, D. | PDF | N/A | Mitochondrial ETF insufficiency drives neoplastic growth by selectively optimizing cancer bioenergetics | | 有益的优势逆转在波动的杀虫剂选择下维持了抗性多态性。 | Karageorgi, M. | PDF | N/A | Beneficial reversal of dominance maintains a resistance polymorphism under fluctuating insecticide selection | | 共享转录组特征揭示突触修剪是阿尔茨海默病与癫痫之间的联系 | Li, H. | PDF | N/A | Shared Transcriptomic Signatures Reveal Synaptic Pruning as a Link Between Alzheimer's Disease and Epilepsy | | 单目标光片显微镜技术能够实现对果蝇大脑的高分辨率活体成像。 | Tassara, F. J. | PDF | N/A | Single Objective Light Sheet Microscopy allows high-resolution in vivo brain imaging of Drosophila. | | 迈向多模态纵向分析以预测认知衰退 | Ashish, R. M. | PDF | N/A | Towards Multimodal Longitudinal Analysis for Predicting Cognitive Decline | | 鉴定出一个在高表达基因簇中可能编码苯激活酶的基因，该基因存在于一种产甲烷富集培养物中。 | Toth, C. R. A. | PDF | N/A | Identification of a Highly Expressed Gene Cluster Likely Coding for Benzene Activation Enzymes in a Methanogenic Enrichment Culture | | 嵌合肽（GEP44）在饮食诱导的肥胖大鼠中减少了体重、能量摄入以及能量消耗。 | Goldberg, M. E. | PDF | N/A | The Chimeric Peptide (GEP44) Reduces Body Weight and Both Energy Intake, and Energy Expenditure in Diet-Induced Obese Rats | | grepq：一个用Rust编写的应用程序，能够通过将序列与一组正则表达式进行匹配来快速过滤FASTQ文件。 | Crosbie, N. D. | PDF | N/A | grepq: A Rust application that quickly filters FASTQ files by matching sequences to a set of regular expressions | | 脆性X综合征中的丘脑爆发性放电受损 | O'Shea, R. T. | PDF | N/A | Impaired thalamic burst firing in Fragile X syndrome | | 早期视觉皮层的神经反应能够通过具有足够模型复杂度的随机权重卷积神经网络（CNNs）得到很好的预测，而晚期视觉皮层的神经反应则无法被这些模型很好地预测。 | Farahat, A. | PDF | N/A | Neural responses in early, but not late, visual cortex are well predicted by random-weight CNNs with sufficient model complexity | | LimROTS：一种结合经验贝叶斯和重现性优化统计的混合方法，用于稳健的差异表达分析 | Anwar, A. M. | PDF | N/A | LimROTS: A Hybrid Method Integrating Empirical Bayes and Reproducibility-Optimized Statistics for Robust Differential Expression Analysis | | 有机-金属共沉淀有助于红树林土壤中稳定有机碳组分的形成。 | Hamada, K. | PDF | N/A | Organo-metal coprecipitation contributes to stable organic carbon fraction in mangrove soil | | 肥胖对非人类灵长类动物急性期对SARS-CoV-2感染的反应以及COVID-19急性后遗症（PASC）发展的影响 | Sauter, K. A. | PDF | N/A | Effect of obesity on the acute response to SARS-CoV-2 infection and development of post-acute sequelae of COVID-19 (PASC) in nonhuman primates | | CellFIE：整合通路发现与扰动池化分析揭示亨廷顿病通路，包括神经元发育和形态的遗传调节因子 | Kang, B. | PDF | N/A | CellFIE: Integrating Pathway Discovery With Pooled Profiling of Perturbations Uncovers Pathways of Huntington's Disease, Including Genetic Modifiers of Neuronal Development and Morphology | | NIST单克隆抗体（NISTmAb）的N-糖链指纹图谱分析 | Wu, Z. L. | PDF | N/A | N-Glycan Fingerprinting of the NIST monoclonal antibody (NISTmAb) | | S-腺苷甲硫氨酸合成酶的功能特化将磷脂酰胆碱与线粒体功能和应激生存联系起来 | Munden, A. | PDF | N/A | Functional Specialization of S-Adenosylmethionine Synthases Links Phosphatidylcholine to Mitochondrial Function and Stress Survival | | 进化上保守的分离酶在核纤层蛋白调控中的作用 | Cipressa, F. | PDF | N/A | An evolutionarily conserved role for separase in the regulation of nuclear lamins | | 磷酸酶特异性影响细胞周期中CDK底物磷酸化的时间 | Zeisner, T. U. | PDF | N/A | Phosphatase specificity influences phosphorylation timing of CDK substrates during the cell cycle | | 解析PADI6功能揭示卵母细胞质网为基本细胞过程的调控中心 | Williams, J. P. C. | PDF | N/A | Dissecting PADI6 function defines oocyte cytoplasmic lattices as regulatory hubs for fundamental cellular processes | | 通过热梯度环对小鼠产热进行非侵入性和无偏性评估 | de Melo, P. H. | PDF | N/A | Non-invasive and unbiased assessment of thermogenesis in mice through thermal gradient ring | | 使用AlphaFold3预测的蛋白质-配体复合物生成适合虚拟筛选的蛋白质结构 | Yasumitsu, Y. | PDF | N/A | Generation of appropriate protein structures for virtual screening using AlphaFold3 predicted protein-ligand complexes | | 空间转录组学中识别差异表达基因的统计方法比较研究 | Wang, Y. | PDF | N/A | A comparative study of statistical methods for identifying differentially expressed genes in spatial transcriptomics | | 单细胞转录组学分析显示，在暴露于烟草味电子烟的小鼠肺部中，中性粒细胞功能受到抑制，而T细胞的细胞毒性作用则显著增强。 | Kaur, G. | PDF | N/A | Single-cell transcriptomics identifies a dampened neutrophil function and accentuated T-cell cytotoxicity in tobacco flavored e-cigarette exposed mouse lungs | | 在动态网络分析中考虑边缘不确定性的随机行动者导向模型 | Shappell, H. | PDF | N/A | Accounting for Edge Uncertainty in Stochastic Actor-Oriented Models for Dynamic Network Analysis | | 土著肠道微生物调节神经细胞状态及神经退行性疾病易感性 | Blackmer-Raynolds, L. | PDF | N/A | Indigenous gut microbes modulate neural cell state and neurodegenerative disease susceptibility | | HIV-1衍生的复制中间体/寡核苷酸通过STING激活诱导一种I型干扰素依赖的免疫抑制，这种抑制可以通过靶向IFNARI来恢复。 | Svanberg, C. | PDF | N/A | HIV-1 derived replication intermediates/oligonucleotides induce a type I IFN-dependent immune suppression via STING activation that can be restored by targeting IFNARI | | 噬菌体相互作用可能对热液喷口微生物共生体的种群结构和动态产生影响。 | Hauer, M. A. | PDF | N/A | Phage interactions may contribute to the population structure and dynamics of hydrothermal vent microbial symbionts | | MoDorado：通过标签外使用修饰检测工具增强纳米孔测序中tRNA修饰的检测 | Rubsam, F. | PDF | N/A | MoDorado: Enhanced detection of tRNA modifications in nanopore sequencing by off-label use of modification callers | | 农业用地使用导致土壤微生物功能组成的同质化程度高于分类组成的同质化程度。 | Ohigashi, T. | PDF | N/A | Agricultural land use induces broader homogenization of soil microbial functional composition than taxonomic composition | | 线虫Caenorhabditis elegans可以从其共存的真菌微生物组成员Barnettozyma californica中获益。 | Petersen, C. | PDF | N/A | The nematode Caenorhabditis elegans can benefit from its coexisting fungal microbiome member Barnettozyma californica | | CRISPR-CISH：一种用于研究和生命科学教育的原位显色DNA重复序列检测系统 | Potlapalli, B. P. | PDF | N/A | CRISPR-CISH: An in situ chromogenic DNA repeat detection system for research and life science education | | 以下是将“Comparative Transcriptomic Analysis of Perfluoroalkyl Substances-Induced Responses of Exponential and Stationary Phase Escherichia coli”翻译成中文的结果：
全氟烷基物质诱导的指数期和稳定期大肠杆菌反应的转录组比较分析
翻译说明： 1. “Comparative Transcriptomic Analysis” 翻译为“转录组比较分析”，表示对转录组数据进行对比研究。 2. “Perfluoroalkyl Substances-Induced Responses” 翻译为“全氟烷基物质诱导的反应”，指由全氟烷基物质引起的生物学反应。 3. “Exponential and Stationary Phase” 翻译为“指数期和稳定期”，分别指细菌生长的对数期和稳定期。 4. “Escherichia coli” 翻译为“大肠杆菌”，是一种常用的模式生物。
希望翻译结果对您有帮助！ | Wintenberg, M. E. | PDF | N/A | Comparative Transcriptomic Analysis of Perfluoroalkyl Substances-Induced Responses of Exponential and Stationary Phase Escherichia coli | | 使用来自cBioPortal的癌症基因组图谱开发用于机器学习辅助癌症治疗的基因组数据集 | Asaduzzaman, A. | PDF | N/A | Using The Cancer Genome Atlas from cBioPortal to Develop Genomic Datasets for Machine Learning Assisted Cancer Treatment | | 格陵兰鲨基因组：深海生态与寿命极端的洞察 | Yang, K. | PDF | N/A | The Greenland shark genome: insights into deep-sea ecology and lifespan extremes | | 发现针对细菌Arr酶的抑制剂，这些酶能够ADP-核糖基化并使利福霉素类抗生素失活 | Alaviuhkola, J. | PDF | N/A | Discovery of inhibitors for bacterial Arr enzymes ADP-ribosylating and inactivating rifamycin antibiotics | | RTX毒素MbxA的酰化通过与胆固醇的特异性相互作用刺激宿主膜破坏。 | Chacko, F. M. | PDF | N/A | Acylation of the RTX Toxin MbxA stimulates host membrane disruption through a specific interaction with cholesterol | | 使用Rhapsody-2对致病性错义变异进行准确识别和机制评估 | Banerjee, A. | PDF | N/A | Accurate Identification and Mechanistic Evaluation of Pathogenic Missense Variants with Rhapsody-2 | | hERG-LTN：一种使用神经符号与生成式AI嵌入（MegaMolBART、Llama3.2、Gemini、DeepSeek）方法评估hERG心脏毒性的新范式 | Hossain, D. | PDF | N/A | hERG-LTN: A New Paradigm in hERG Cardiotoxicity Assessment Using Neuro-Symbolic and Generative AI Embedding (MegaMolBART, Llama3.2, Gemini, DeepSeek) Approach | | SpliceSelectNet：一种基于分层Transformer的深度学习模型，用于剪接位点预测 | Miyachi, Y. | PDF | N/A | SpliceSelectNet: A Hierarchical Transformer-Based Deep Learning Model for Splice Site Prediction | | 解码DNA甲基化和非编码RNA介导的乳腺癌及邻近正常组织的调控景观 | Kumar, S. | PDF | N/A | Decoding DNA methylation and non-coding RNAs mediated regulatory landscape of breast tumor and adjacent normal tissues | | 在MYC驱动的肿瘤中，通过邻近的PVT1重排实现RAS-MAPK和AKT的协同激活 | Tiwari, A. | PDF | N/A | Synergistic RAS-MAPK and AKT Activation in MYC-Driven Tumors via Adjacent PVT1 Rearrangements | | Chk1-Sp1-CD59轴在DNA损伤应答中阻碍了利妥昔单抗介导的补体依赖性细胞毒性 | Chan, A. S. Y. | PDF | N/A | A Chk1-Sp1-CD59 axis of the DNA damage response impedes rituximab-mediated complement-dependent cytotoxicity | | ETV5/p38信号轴在侵袭性甲状腺癌细胞中的作用 | Houl, J. H. | PDF | N/A | Role of the ETV5/p38 signaling axis in aggressive thyroid cancer cells | | 《敲入图谱：CRISPR/Cas9在人类和小鼠细胞系中靶向蛋白捕获的网络资源》
这个标题指的是一种在线资源，提供了关于使用CRISPR/Cas9技术在人类和小鼠细胞系中进行靶向蛋白捕获的信息。CRISPR/Cas9是一种基因编辑技术，可以用来精确地修改基因组中的特定序列。在这个上下文中，"敲入"（Knock-In）指的是将特定的基因序列插入到基因组中的特定位置，以研究该基因或蛋白质的功能。这个资源可能包含了关于如何进行这种基因编辑实验的指南、工具和数据库。 | Hanai, Y. | PDF | N/A | The Knock-In Atlas: A web resource for targeted protein trap by CRISPR/Cas9 in human and mouse cell lines | | SF3B1突变敏感型隐秘3'剪接位点前体RNA的结构模式 | Herbert, A. | PDF | N/A | Precursor RNA structural patterns at SF3B1 mutation sensitive cryptic 3' splice sites | | 哪种植物特性能够增加土壤碳固存？来自长期杨树遗传多样性试验的实证证据 | Field, J. L. | PDF | N/A | Which plant traits increase soil carbon sequestration? Empirical evidence from a long-term poplar genetic diversity trial | | 人类药物代谢动力学（ADME/PK）在从计算机模拟（in silico）到体外实验（in vitro）再到体内实验（in vivo）的转化和预测过程中存在信息丢失。 | Fagerholm, U. | PDF | N/A | Human ADME/PK is lost in translation and prediction from in silico to in vitro to in vivo | | 在一项关于射血分数保留型心力衰竭（HFpEF）的小鼠模型中，研究发现中性粒细胞在心肌毛细血管中的滞留会导致缺氧，并损害心脏的舒张功能。 | Small, D. M. | PDF | N/A | Neutrophil arrest in myocardial capillaries drives hypoxia and impairs diastolic function in a mouse model of heart failure with preserved ejection fraction | | 使用大型语言模型提取生物学术语增强了BioSample数据库中元数据的可用性。 | Ikeda, S. | PDF | N/A | Extraction of biological terms using large language models enhances the usability of metadata in the BioSample database | | 同时进行的免疫调节和上皮-间质转化驱动肺腺癌的进展 | Kim, J. | PDF | N/A | Simultaneous immunomodulation and epithelial-to-mesenchymal transition drives lung adenocarcinoma progression | | Gut3Gel：一种用于培养人类肠道微生物群的高通量黏液模型 | Suarez, N. | PDF | N/A | Gut3Gel: A High Throughput Mucus Model for Culturing Human Intestinal Microbiota | | 染色体区室组装对于锥虫亚端粒基因沉默至关重要 | Antunes, L. B. | PDF | N/A | Chromosome compartment assembly is essential for subtelomeric gene silencing in trypanosomes | | 红海中的聚球藻（Synechococcus）对UV-B辐射的抵抗力比微微型真核浮游植物更强。 | Overmans, S. | PDF | N/A | Red Sea Synechococcus exhibits greater resilience to UV-B radiation than pico-eukaryotic phytoplankton | | 用于在M9最小培养基中生长的大肠杆菌BW25113菌株的金属化计算器 | Clough, S. E. | PDF | N/A | Metalation calculator for E. coli strain BW25113 grown in M9 minimal media | | 通过对C1和C2副产物的同化实现木质素单体的共底物自由价值化 | Bergen, D. | PDF | N/A | Co-Substrate Free Valorisation of Lignin Monomers by Assimilation of C1 and C2 By-Products | | 通过MS2Rescore提高宏蛋白质组学的鉴定率和分类特异性 | Van Den Bossche, T. | PDF | N/A | Boosting metaproteomics identification rates and taxonomic specificity with MS2Rescore | | 配对的原发-转移患者来源的类器官和小鼠模型揭示了阑尾癌腹膜转移的表型演变和可药物依赖性 | Mahmoud, A. | PDF | N/A | Paired primary-metastasis patient-derived organoids and mouse models identify phenotypic evolution and druggable dependencies of peritoneal metastasis from appendiceal cancer | | 亚阈值电场通过轴突极化双向调节神经递质释放。 | Aberra, A. S. | PDF | N/A | Subthreshold electric fields bidirectionally modulate neurotransmitter release through axon polarization | | 通过对蓝斑神经递质共释放的研究，实现了对呼吸脑干在多个时间尺度上的对立控制。 | Varga, A. G. | PDF | N/A | Opposing control of the respiratory brainstem on multiple timescales achieved by transmitter co-release from the locus coeruleus | | 将这段翻译成中文：神经回路机制用于将小脑群体动力学转化为猴子的运动控制 | Herzfeld, D. J. | PDF | N/A | Neural circuit mechanisms to transform cerebellar population dynamics for motor control in monkeys | | 《Fascin家族肌动蛋白束蛋白在轴突发育、脑部连接及功能中的关键作用》 | Hardin, K. R. | PDF | N/A | A Critical Role for the Fascin Family of Actin Bundling Proteins in Axon Development, Brain Wiring and Function | | 基于序列的染色质活性建模及利用深度学习预测养殖动物遗传变异的调控影响 | Nguyen, D. T. | PDF | N/A | Sequence-based chromatin activity modeling and regulatory impact prediction of genetic variants in farmed animals using deep learning |